Impaired oxygen demand during exercise is related to oxidative stress and muscle function in facioscapulohumeral muscular dystrophy
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2018 |
| Outros Autores: | , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da UFMG |
| Texto Completo: | https://doi.org/10.1002/j.2617-1619.2018.tb00002.x http://hdl.handle.net/1843/50561 https://orcid.org/0000-0003-0184-5438 https://orcid.org/0000-0003-3381-9744 http://orcid.org/0000-0003-3406-4558 https://orcid.org/0000-0003-4204-7299 https://orcid.org/0000-0001-5228-2255 https://orcid.org/0000-0003-4356-9187 |
Resumo: | Outra Agência |
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2023-03-01T14:18:51Z2023-03-01T14:18:51Z2018-0111113https://doi.org/10.1002/j.2617-1619.2018.tb00002.x2617-1619http://hdl.handle.net/1843/50561https://orcid.org/0000-0003-0184-5438https://orcid.org/0000-0003-3381-9744http://orcid.org/0000-0003-3406-4558https://orcid.org/0000-0003-4204-7299https://orcid.org/0000-0001-5228-2255https://orcid.org/0000-0003-4356-9187Outra AgênciaAims: Facioscapulohumeral muscular dystrophy (FSHD) causes progressive muscle weakness and loss. This study aims to compare changes in quadriceps oxygenation and hemodynamics during maximal voluntary quadriceps isometric contraction (MVCQ) and to determine the relationships between these parameters and systemic oxidative stress markers and muscle structural parameters and muscle volume in patients with FSHD and healthy controls. Methods and results: 17 patients with FSHD and 14 sedentary healthy controls were matched for age and physical activity level. Blood antioxidant status and stress markers were evaluated. The quadriceps tissue oxygenation index was evaluated by near infrared spectroscopy during MVCQ. Quadriceps volume was determined by magnetic resonance imaging. Quadriceps muscle samples were obtained to evaluate muscle fiber typology and mitochondria morphology by transmission electron microcopy (TEM). Groups were compared by the unpaired Student t-test or by the non-parametric Kruskal - Wallis test in case of skewed distributions with p<0.05. Associations were assessed by Spearman correlations. Compared to controls, patients with FSHD displayed a significantly lower local O2 consumption per second that was correlated with significantly lower MVCQ and systemic oxidative stress marker levels. Although no difference in muscle typology was observed between groups, TEM showed abnormal aggregation of mitochondria near blood capillaries in FSHD muscles. Conclusions: These results suggest that patients with FSHD have a lower O2 demand during MVCQ and that TOI measured by NIRS during MVC could be useful to determine the muscle oxidative capacity. Furthermore, these adaptations are related to the muscle structure reorganization linked to the occurrence of oxidative stress.engUniversidade Federal de Minas GeraisUFMGBrasilEEF - DEPARTAMENTO DE ESPORTESJournal of Cachexia, Sarcopenia and MuscleDistrofia muscularEspectroscopia de infravermelhoImagem de ressonancia magneticaContração muscularEstresse oxidativoFacioscapulohumeral muscular dystrophyNear infrared spectroscopyMagnetic resonance imagingMaximal voluntary contractionOxidative stressImpaired oxygen demand during exercise is related to oxidative stress and muscle function in facioscapulohumeral muscular dystrophyinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttps://onlinelibrary.wiley.com/doi/full/10.1002/j.2617-1619.2018.tb00002.xVinicius Dias WilsonClaire ThomasEmilie PasserieuxGérald HugonFabien PillardAndré Gustavo Pereira de AndradeSébastien BommartMarie-Christine PicotJoël PincemailJacques MercierSandrine ArbogastDalila Laoudj-Chenivesseapplication/pdfinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFMGinstname:Universidade Federal de Minas Gerais (UFMG)instacron:UFMGORIGINALImpaired oxygen demand during exercise is related to oxidative stress and muscle function.pdfImpaired oxygen demand during exercise is related to oxidative stress and muscle function.pdfapplication/pdf735267https://repositorio.ufmg.br/bitstream/1843/50561/2/Impaired%20oxygen%20demand%20during%20exercise%20is%20related%20to%20oxidative%20stress%20and%20muscle%20function.pdf1f6ca62c781dbdbc0c9d4d2df377a0a1MD52LICENSELicense.txtLicense.txttext/plain; charset=utf-82042https://repositorio.ufmg.br/bitstream/1843/50561/1/License.txtfa505098d172de0bc8864fc1287ffe22MD511843/505612023-03-01 11:18:51.853oai:repositorio.ufmg.br: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Repositório de PublicaçõesPUBhttps://repositorio.ufmg.br/oaiopendoar:2023-03-01T14:18:51Repositório Institucional da UFMG - Universidade Federal de Minas Gerais (UFMG)false |
| dc.title.pt_BR.fl_str_mv |
Impaired oxygen demand during exercise is related to oxidative stress and muscle function in facioscapulohumeral muscular dystrophy |
| title |
Impaired oxygen demand during exercise is related to oxidative stress and muscle function in facioscapulohumeral muscular dystrophy |
| spellingShingle |
Impaired oxygen demand during exercise is related to oxidative stress and muscle function in facioscapulohumeral muscular dystrophy Vinicius Dias Wilson Facioscapulohumeral muscular dystrophy Near infrared spectroscopy Magnetic resonance imaging Maximal voluntary contraction Oxidative stress Distrofia muscular Espectroscopia de infravermelho Imagem de ressonancia magnetica Contração muscular Estresse oxidativo |
| title_short |
Impaired oxygen demand during exercise is related to oxidative stress and muscle function in facioscapulohumeral muscular dystrophy |
| title_full |
Impaired oxygen demand during exercise is related to oxidative stress and muscle function in facioscapulohumeral muscular dystrophy |
| title_fullStr |
Impaired oxygen demand during exercise is related to oxidative stress and muscle function in facioscapulohumeral muscular dystrophy |
| title_full_unstemmed |
Impaired oxygen demand during exercise is related to oxidative stress and muscle function in facioscapulohumeral muscular dystrophy |
| title_sort |
Impaired oxygen demand during exercise is related to oxidative stress and muscle function in facioscapulohumeral muscular dystrophy |
| author |
Vinicius Dias Wilson |
| author_facet |
Vinicius Dias Wilson Claire Thomas Emilie Passerieux Gérald Hugon Fabien Pillard André Gustavo Pereira de Andrade Sébastien Bommart Marie-Christine Picot Joël Pincemail Jacques Mercier Sandrine Arbogast Dalila Laoudj-Chenivesse |
| author_role |
author |
| author2 |
Claire Thomas Emilie Passerieux Gérald Hugon Fabien Pillard André Gustavo Pereira de Andrade Sébastien Bommart Marie-Christine Picot Joël Pincemail Jacques Mercier Sandrine Arbogast Dalila Laoudj-Chenivesse |
| author2_role |
author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Vinicius Dias Wilson Claire Thomas Emilie Passerieux Gérald Hugon Fabien Pillard André Gustavo Pereira de Andrade Sébastien Bommart Marie-Christine Picot Joël Pincemail Jacques Mercier Sandrine Arbogast Dalila Laoudj-Chenivesse |
| dc.subject.por.fl_str_mv |
Facioscapulohumeral muscular dystrophy Near infrared spectroscopy Magnetic resonance imaging Maximal voluntary contraction Oxidative stress |
| topic |
Facioscapulohumeral muscular dystrophy Near infrared spectroscopy Magnetic resonance imaging Maximal voluntary contraction Oxidative stress Distrofia muscular Espectroscopia de infravermelho Imagem de ressonancia magnetica Contração muscular Estresse oxidativo |
| dc.subject.other.pt_BR.fl_str_mv |
Distrofia muscular Espectroscopia de infravermelho Imagem de ressonancia magnetica Contração muscular Estresse oxidativo |
| description |
Outra Agência |
| publishDate |
2018 |
| dc.date.issued.fl_str_mv |
2018-01 |
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2023-03-01T14:18:51Z |
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2023-03-01T14:18:51Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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http://hdl.handle.net/1843/50561 |
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https://doi.org/10.1002/j.2617-1619.2018.tb00002.x |
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2617-1619 |
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https://orcid.org/0000-0003-0184-5438 https://orcid.org/0000-0003-3381-9744 http://orcid.org/0000-0003-3406-4558 https://orcid.org/0000-0003-4204-7299 https://orcid.org/0000-0001-5228-2255 https://orcid.org/0000-0003-4356-9187 |
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https://doi.org/10.1002/j.2617-1619.2018.tb00002.x http://hdl.handle.net/1843/50561 https://orcid.org/0000-0003-0184-5438 https://orcid.org/0000-0003-3381-9744 http://orcid.org/0000-0003-3406-4558 https://orcid.org/0000-0003-4204-7299 https://orcid.org/0000-0001-5228-2255 https://orcid.org/0000-0003-4356-9187 |
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2617-1619 |
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eng |
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eng |
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Journal of Cachexia, Sarcopenia and Muscle |
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info:eu-repo/semantics/openAccess |
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openAccess |
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application/pdf |
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Universidade Federal de Minas Gerais |
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UFMG |
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Brasil |
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EEF - DEPARTAMENTO DE ESPORTES |
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Universidade Federal de Minas Gerais |
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