Microparticles are related to cognitive and functional status from normal aging to dementia
Autor(a) principal: | |
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Data de Publicação: | 2019 |
Outros Autores: | , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFMG |
Texto Completo: | https://doi.org/10.1016/j.jneuroim.2019.577027 http://hdl.handle.net/1843/46442 |
Resumo: | Recently, we have shown that microparticles (MPs) levels derived from leukocytes (LMPs), endothelium (EMPs), neurons (NMPs) and those expressing tissue factor (TFMPs) were higher in Alzheimer's Disease (AD) patients when compared to cognitively healthy subjects. Therefore, in this study we proposed to investigate the correlation between MPs levels, cognitive performance and functional status in a sample of elderly individuals. We evaluated MPs derived from platelets (PMPs), LMPs, EMPs, NMPs and TFMPs in 43 participants, of whom 12 with probable dementia due to AD, 16 with mild cognitive impairment (MCI) and 15 with no objective cognitive or functional impairment. PMPs, LMPs and TFMPs, were associated with cognitive impairment in this population. LMPs and NMP, were associated to lower functional performance in the elderly sample. These results suggest that MPs may be involved in the pathophysiology of neurodegenerative disorders. |
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2022-10-20T14:50:13Z2022-10-20T14:50:13Z2019-11-1533613https://doi.org/10.1016/j.jneuroim.2019.5770270165-5728http://hdl.handle.net/1843/46442Recently, we have shown that microparticles (MPs) levels derived from leukocytes (LMPs), endothelium (EMPs), neurons (NMPs) and those expressing tissue factor (TFMPs) were higher in Alzheimer's Disease (AD) patients when compared to cognitively healthy subjects. Therefore, in this study we proposed to investigate the correlation between MPs levels, cognitive performance and functional status in a sample of elderly individuals. We evaluated MPs derived from platelets (PMPs), LMPs, EMPs, NMPs and TFMPs in 43 participants, of whom 12 with probable dementia due to AD, 16 with mild cognitive impairment (MCI) and 15 with no objective cognitive or functional impairment. PMPs, LMPs and TFMPs, were associated with cognitive impairment in this population. LMPs and NMP, were associated to lower functional performance in the elderly sample. These results suggest that MPs may be involved in the pathophysiology of neurodegenerative disorders.Recentemente, mostramos que os níveis de micropartículas (MPs) derivadas de leucócitos (LMPs), endotélio (EMPs), neurônios (NMPs) e aquelas que expressam fator tecidual (TFMPs) foram maiores em pacientes com Doença de Alzheimer (DA) quando comparados a indivíduos cognitivamente saudáveis. Portanto, neste estudo propusemos investigar a correlação entre níveis de MPs, desempenho cognitivo e estado funcional em uma amostra de idosos. Foram avaliados MPs derivados de plaquetas (PMPs), LMPs, EMPs, NMPs e TFMPs em 43 participantes, dos quais 12 com provável demência por DA, 16 com comprometimento cognitivo leve (CCL) e 15 sem comprometimento cognitivo ou funcional objetivo. PMPs, LMPs e TFMPs foram associados ao comprometimento cognitivo nesta população. LMPs e NMP, foram associados ao menor desempenho funcional na amostra de idosos. Esses resultados sugerem que os MPs podem estar envolvidos na fisiopatologia de distúrbios neurodegenerativos.CNPq - Conselho Nacional de Desenvolvimento Científico e TecnológicoFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas GeraisCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível SuperiorengUniversidade Federal de Minas GeraisUFMGBrasilFAR - DEPARTAMENTO DE ANÁLISES CLÍNICAS E TOXICOLÓGICASMED - DEPARTAMENTO DE CLÍNICA MÉDICAJournal of NeuroimmunologyDemênciaCogniçãoEstado funcionalMicroparticlesDementiaCognitionFunctional statusMicroparticles are related to cognitive and functional status from normal aging to dementiainfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttps://www.sciencedirect.com/science/article/pii/S0165572819300426Carolina Antunes MagalhãesFernanda Freire Campos NunesCristina de Mello Gomide LouresVanessa Gomes FragaLeonardo Cruz de SouzaHenrique Cerqueira GuimarãesMarco Túlio Gualberto CintraMaria Aparecida Camargos BicalhoMaria das Graças CarvalhoLirlândia Pires de SousaPaulo CaramelliKarina Braga Gomes Borgesapplication/pdfinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFMGinstname:Universidade Federal de Minas Gerais (UFMG)instacron:UFMGLICENSELicense.txtLicense.txttext/plain; charset=utf-82042https://repositorio.ufmg.br/bitstream/1843/46442/1/License.txtfa505098d172de0bc8864fc1287ffe22MD51ORIGINALMicroparticles are related to cognitive and functional status from normal aging to dementia.pdfMicroparticles are related to cognitive and functional status from normal aging to dementia.pdfapplication/pdf386113https://repositorio.ufmg.br/bitstream/1843/46442/2/Microparticles%20are%20related%20to%20cognitive%20and%20functional%20status%20from%20normal%20aging%20to%20dementia.pdfaa007a720bb3baf9a1672469d29c089aMD521843/464422022-10-20 11:50:14.18oai:repositorio.ufmg.br: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Repositório de PublicaçõesPUBhttps://repositorio.ufmg.br/oaiopendoar:2022-10-20T14:50:14Repositório Institucional da UFMG - Universidade Federal de Minas Gerais (UFMG)false |
dc.title.pt_BR.fl_str_mv |
Microparticles are related to cognitive and functional status from normal aging to dementia |
title |
Microparticles are related to cognitive and functional status from normal aging to dementia |
spellingShingle |
Microparticles are related to cognitive and functional status from normal aging to dementia Carolina Antunes Magalhães Microparticles Dementia Cognition Functional status Demência Cognição Estado funcional |
title_short |
Microparticles are related to cognitive and functional status from normal aging to dementia |
title_full |
Microparticles are related to cognitive and functional status from normal aging to dementia |
title_fullStr |
Microparticles are related to cognitive and functional status from normal aging to dementia |
title_full_unstemmed |
Microparticles are related to cognitive and functional status from normal aging to dementia |
title_sort |
Microparticles are related to cognitive and functional status from normal aging to dementia |
author |
Carolina Antunes Magalhães |
author_facet |
Carolina Antunes Magalhães Fernanda Freire Campos Nunes Cristina de Mello Gomide Loures Vanessa Gomes Fraga Leonardo Cruz de Souza Henrique Cerqueira Guimarães Marco Túlio Gualberto Cintra Maria Aparecida Camargos Bicalho Maria das Graças Carvalho Lirlândia Pires de Sousa Paulo Caramelli Karina Braga Gomes Borges |
author_role |
author |
author2 |
Fernanda Freire Campos Nunes Cristina de Mello Gomide Loures Vanessa Gomes Fraga Leonardo Cruz de Souza Henrique Cerqueira Guimarães Marco Túlio Gualberto Cintra Maria Aparecida Camargos Bicalho Maria das Graças Carvalho Lirlândia Pires de Sousa Paulo Caramelli Karina Braga Gomes Borges |
author2_role |
author author author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Carolina Antunes Magalhães Fernanda Freire Campos Nunes Cristina de Mello Gomide Loures Vanessa Gomes Fraga Leonardo Cruz de Souza Henrique Cerqueira Guimarães Marco Túlio Gualberto Cintra Maria Aparecida Camargos Bicalho Maria das Graças Carvalho Lirlândia Pires de Sousa Paulo Caramelli Karina Braga Gomes Borges |
dc.subject.por.fl_str_mv |
Microparticles Dementia Cognition Functional status |
topic |
Microparticles Dementia Cognition Functional status Demência Cognição Estado funcional |
dc.subject.other.pt_BR.fl_str_mv |
Demência Cognição Estado funcional |
description |
Recently, we have shown that microparticles (MPs) levels derived from leukocytes (LMPs), endothelium (EMPs), neurons (NMPs) and those expressing tissue factor (TFMPs) were higher in Alzheimer's Disease (AD) patients when compared to cognitively healthy subjects. Therefore, in this study we proposed to investigate the correlation between MPs levels, cognitive performance and functional status in a sample of elderly individuals. We evaluated MPs derived from platelets (PMPs), LMPs, EMPs, NMPs and TFMPs in 43 participants, of whom 12 with probable dementia due to AD, 16 with mild cognitive impairment (MCI) and 15 with no objective cognitive or functional impairment. PMPs, LMPs and TFMPs, were associated with cognitive impairment in this population. LMPs and NMP, were associated to lower functional performance in the elderly sample. These results suggest that MPs may be involved in the pathophysiology of neurodegenerative disorders. |
publishDate |
2019 |
dc.date.issued.fl_str_mv |
2019-11-15 |
dc.date.accessioned.fl_str_mv |
2022-10-20T14:50:13Z |
dc.date.available.fl_str_mv |
2022-10-20T14:50:13Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/1843/46442 |
dc.identifier.doi.pt_BR.fl_str_mv |
https://doi.org/10.1016/j.jneuroim.2019.577027 |
dc.identifier.issn.pt_BR.fl_str_mv |
0165-5728 |
url |
https://doi.org/10.1016/j.jneuroim.2019.577027 http://hdl.handle.net/1843/46442 |
identifier_str_mv |
0165-5728 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.ispartof.pt_BR.fl_str_mv |
Journal of Neuroimmunology |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
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openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Universidade Federal de Minas Gerais |
dc.publisher.initials.fl_str_mv |
UFMG |
dc.publisher.country.fl_str_mv |
Brasil |
dc.publisher.department.fl_str_mv |
FAR - DEPARTAMENTO DE ANÁLISES CLÍNICAS E TOXICOLÓGICAS MED - DEPARTAMENTO DE CLÍNICA MÉDICA |
publisher.none.fl_str_mv |
Universidade Federal de Minas Gerais |
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reponame:Repositório Institucional da UFMG instname:Universidade Federal de Minas Gerais (UFMG) instacron:UFMG |
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Universidade Federal de Minas Gerais (UFMG) |
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UFMG |
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