Genetic Association of the PERIOD3 (Per3) Clock Gene with Bipolar Disorder
Autor(a) principal: | |
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Data de Publicação: | 2017 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFMG |
Texto Completo: | https://doi.org/10.4306/pi.2017.14.5.674 http://hdl.handle.net/1843/56148 https://orcid.org/0000-0003-2757-1375 |
Resumo: | ObjectiveaaCircadian rhythms have been linked to psychiatric disorders such as Depression and Bipolar Disorder (BD). Given previous evidences of sleep/circadian disturbances as well as the genetic susceptibility for BD, we decided to investigate the possible link between the PERIOD3 (Per3) circadian gene and BD.Methods This is a genetic association case (BD) vs. control study of the Per3 gene. We further subdivided our BD sample into “good sleepers” (PSQI ≤5) and “poor sleepers” (PSQI>5) according to the Pittsburgh Sleep Quality Index (PSQI) global score, and then we asessed genetic association of the Per3 gene with sleep quality in the BD group. ResultsaaThere were 209 cases and 213 controls in our sample. The GT genotype of the SNP rs707467 significantly associated with BD (χ2=8.80; p-value=0.01; adjusted residual=±2.6). We also found significant association of the SNP rs10462020 allele T with BD (χ 2=5.81; p-value=0.01) as well as the genotype TT (χ2= 6.01; p-value=0.04; adjusted residual=±2.4). Conclusion: In this study we demonstrated evidences of genetic association between the Per3 gene and BD. The results of association between the Per3 gene and BD in our sample may bring additional evidence to the former findings of association between the Per3 gene and BD. |
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2023-07-12T21:15:26Z2023-07-12T21:15:26Z2017145674680https://doi.org/10.4306/pi.2017.14.5.67417383684http://hdl.handle.net/1843/56148https://orcid.org/0000-0003-2757-1375ObjectiveaaCircadian rhythms have been linked to psychiatric disorders such as Depression and Bipolar Disorder (BD). Given previous evidences of sleep/circadian disturbances as well as the genetic susceptibility for BD, we decided to investigate the possible link between the PERIOD3 (Per3) circadian gene and BD.Methods This is a genetic association case (BD) vs. control study of the Per3 gene. We further subdivided our BD sample into “good sleepers” (PSQI ≤5) and “poor sleepers” (PSQI>5) according to the Pittsburgh Sleep Quality Index (PSQI) global score, and then we asessed genetic association of the Per3 gene with sleep quality in the BD group. ResultsaaThere were 209 cases and 213 controls in our sample. The GT genotype of the SNP rs707467 significantly associated with BD (χ2=8.80; p-value=0.01; adjusted residual=±2.6). We also found significant association of the SNP rs10462020 allele T with BD (χ 2=5.81; p-value=0.01) as well as the genotype TT (χ2= 6.01; p-value=0.04; adjusted residual=±2.4). Conclusion: In this study we demonstrated evidences of genetic association between the Per3 gene and BD. The results of association between the Per3 gene and BD in our sample may bring additional evidence to the former findings of association between the Per3 gene and BD.engUniversidade Federal de Minas GeraisUFMGBrasilICB - DEPARTAMENTO DE MORFOLOGIAMED - DEPARTAMENTO DE PSIQUIATRIA E NEUROLOGIAMED - DEPARTAMENTO DE SAÚDE MENTALThe Psychiatry InvestigationTranstorno BipolarProteínas Circadianas PeriodRelógios CircadianosPeriodicidadeBipolar disorderPERIOD3GeneCircadianBiological rhythmsGenetic Association of the PERIOD3 (Per3) Clock Gene with Bipolar Disorderinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttps://www.psychiatryinvestigation.org/journal/view.php?doi=10.4306/pi.2017.14.5.674Paulo Marcosbrasil RochaSimone Becho de CamposFernando Silva NevesHumberto Corrêa da Silva Filhoapplication/pdfinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFMGinstname:Universidade Federal de Minas Gerais (UFMG)instacron:UFMGLICENSELicense.txtLicense.txttext/plain; charset=utf-82042https://repositorio.ufmg.br/bitstream/1843/56148/1/License.txtfa505098d172de0bc8864fc1287ffe22MD51ORIGINALGenetic Association of the PERIOD3 (Per3) Clock Gene with Bipolar Disorder pdfa.pdfGenetic Association of the PERIOD3 (Per3) Clock Gene with Bipolar Disorder pdfa.pdfapplication/pdf184535https://repositorio.ufmg.br/bitstream/1843/56148/2/Genetic%20Association%20of%20the%20PERIOD3%20%28Per3%29%20Clock%20Gene%20with%20Bipolar%20Disorder%20pdfa.pdf48d3b9c4c49ccab020eeff8898a608e9MD521843/561482023-07-12 18:34:54.245oai:repositorio.ufmg.br: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Repositório de PublicaçõesPUBhttps://repositorio.ufmg.br/oaiopendoar:2023-07-12T21:34:54Repositório Institucional da UFMG - Universidade Federal de Minas Gerais (UFMG)false |
dc.title.pt_BR.fl_str_mv |
Genetic Association of the PERIOD3 (Per3) Clock Gene with Bipolar Disorder |
title |
Genetic Association of the PERIOD3 (Per3) Clock Gene with Bipolar Disorder |
spellingShingle |
Genetic Association of the PERIOD3 (Per3) Clock Gene with Bipolar Disorder Paulo Marcosbrasil Rocha Bipolar disorder PERIOD3 Gene Circadian Biological rhythms Transtorno Bipolar Proteínas Circadianas Period Relógios Circadianos Periodicidade |
title_short |
Genetic Association of the PERIOD3 (Per3) Clock Gene with Bipolar Disorder |
title_full |
Genetic Association of the PERIOD3 (Per3) Clock Gene with Bipolar Disorder |
title_fullStr |
Genetic Association of the PERIOD3 (Per3) Clock Gene with Bipolar Disorder |
title_full_unstemmed |
Genetic Association of the PERIOD3 (Per3) Clock Gene with Bipolar Disorder |
title_sort |
Genetic Association of the PERIOD3 (Per3) Clock Gene with Bipolar Disorder |
author |
Paulo Marcosbrasil Rocha |
author_facet |
Paulo Marcosbrasil Rocha Simone Becho de Campos Fernando Silva Neves Humberto Corrêa da Silva Filho |
author_role |
author |
author2 |
Simone Becho de Campos Fernando Silva Neves Humberto Corrêa da Silva Filho |
author2_role |
author author author |
dc.contributor.author.fl_str_mv |
Paulo Marcosbrasil Rocha Simone Becho de Campos Fernando Silva Neves Humberto Corrêa da Silva Filho |
dc.subject.por.fl_str_mv |
Bipolar disorder PERIOD3 Gene Circadian Biological rhythms |
topic |
Bipolar disorder PERIOD3 Gene Circadian Biological rhythms Transtorno Bipolar Proteínas Circadianas Period Relógios Circadianos Periodicidade |
dc.subject.other.pt_BR.fl_str_mv |
Transtorno Bipolar Proteínas Circadianas Period Relógios Circadianos Periodicidade |
description |
ObjectiveaaCircadian rhythms have been linked to psychiatric disorders such as Depression and Bipolar Disorder (BD). Given previous evidences of sleep/circadian disturbances as well as the genetic susceptibility for BD, we decided to investigate the possible link between the PERIOD3 (Per3) circadian gene and BD.Methods This is a genetic association case (BD) vs. control study of the Per3 gene. We further subdivided our BD sample into “good sleepers” (PSQI ≤5) and “poor sleepers” (PSQI>5) according to the Pittsburgh Sleep Quality Index (PSQI) global score, and then we asessed genetic association of the Per3 gene with sleep quality in the BD group. ResultsaaThere were 209 cases and 213 controls in our sample. The GT genotype of the SNP rs707467 significantly associated with BD (χ2=8.80; p-value=0.01; adjusted residual=±2.6). We also found significant association of the SNP rs10462020 allele T with BD (χ 2=5.81; p-value=0.01) as well as the genotype TT (χ2= 6.01; p-value=0.04; adjusted residual=±2.4). Conclusion: In this study we demonstrated evidences of genetic association between the Per3 gene and BD. The results of association between the Per3 gene and BD in our sample may bring additional evidence to the former findings of association between the Per3 gene and BD. |
publishDate |
2017 |
dc.date.issued.fl_str_mv |
2017 |
dc.date.accessioned.fl_str_mv |
2023-07-12T21:15:26Z |
dc.date.available.fl_str_mv |
2023-07-12T21:15:26Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/1843/56148 |
dc.identifier.doi.pt_BR.fl_str_mv |
https://doi.org/10.4306/pi.2017.14.5.674 |
dc.identifier.issn.pt_BR.fl_str_mv |
17383684 |
dc.identifier.orcid.pt_BR.fl_str_mv |
https://orcid.org/0000-0003-2757-1375 |
url |
https://doi.org/10.4306/pi.2017.14.5.674 http://hdl.handle.net/1843/56148 https://orcid.org/0000-0003-2757-1375 |
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17383684 |
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eng |
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eng |
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The Psychiatry Investigation |
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openAccess |
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Universidade Federal de Minas Gerais |
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Brasil |
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ICB - DEPARTAMENTO DE MORFOLOGIA MED - DEPARTAMENTO DE PSIQUIATRIA E NEUROLOGIA MED - DEPARTAMENTO DE SAÚDE MENTAL |
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Universidade Federal de Minas Gerais |
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