Clinical characteristics and prognosis in children and adolescents with autoimmune hepatitis and overlap syndrome
Autor(a) principal: | |
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Data de Publicação: | 2016 |
Outros Autores: | , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFMG |
Texto Completo: | http://hdl.handle.net/1843/57183 |
Resumo: | Objectives: This is a cohort study of 134 children and adolescents with a known diagnosis of autoimmune hepatitis (AIH). During follow-up, some of them developed autoimmune sclerosing cholangitis (ASC). This study describes the characteristics of the patients upon diagnosis, and their response to treatment and any complications, and compares the patients who developed ASC during follow-up (ASC group) with those who did not (AIH group). Methods: A total of 73.1% of the patients were girls with a median age upon diagnosis of 10.41 (7.41–12.53) years. Results: Of 134 patients, 28 (20.9%) developed cholestatic manifestations, with features of ASC. A few differences were observed between the AIH and ASC groups when they were analyzed by x2 test, such as the smaller predominance of girls in ASC group (P ¼ 0.04), and more common asymptomatic presentation in the ASC group (P ¼ 0.01). Cirrhosis was observed in 68% of biopsies, with no significant difference between groups (P ¼ 0.43). Of 16 deaths, 15 were in the AIH group and 1 in the ASC group (P ¼ 0.22). Of 11 transplants, 10 were in the AIH group and one in the ASC group (P ¼ 0.53). The presence of cirrhosis at baseline was associated with a smaller survival probability (P ¼ 0.015). The survival rate by Kaplan-Meier method was 94% at 5 years and 80% at 10 years, and was similar in both the groups (P ¼ 0.08). Conclusions: No statistically significant difference was observed between the groups in relation to prognosis and response to treatment. |
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2023-07-28T22:13:27Z2023-07-28T22:13:27Z2016-07631768110.1097/mpg.000000000000112502772116http://hdl.handle.net/1843/57183Objectives: This is a cohort study of 134 children and adolescents with a known diagnosis of autoimmune hepatitis (AIH). During follow-up, some of them developed autoimmune sclerosing cholangitis (ASC). This study describes the characteristics of the patients upon diagnosis, and their response to treatment and any complications, and compares the patients who developed ASC during follow-up (ASC group) with those who did not (AIH group). Methods: A total of 73.1% of the patients were girls with a median age upon diagnosis of 10.41 (7.41–12.53) years. Results: Of 134 patients, 28 (20.9%) developed cholestatic manifestations, with features of ASC. A few differences were observed between the AIH and ASC groups when they were analyzed by x2 test, such as the smaller predominance of girls in ASC group (P ¼ 0.04), and more common asymptomatic presentation in the ASC group (P ¼ 0.01). Cirrhosis was observed in 68% of biopsies, with no significant difference between groups (P ¼ 0.43). Of 16 deaths, 15 were in the AIH group and 1 in the ASC group (P ¼ 0.22). Of 11 transplants, 10 were in the AIH group and one in the ASC group (P ¼ 0.53). The presence of cirrhosis at baseline was associated with a smaller survival probability (P ¼ 0.015). The survival rate by Kaplan-Meier method was 94% at 5 years and 80% at 10 years, and was similar in both the groups (P ¼ 0.08). Conclusions: No statistically significant difference was observed between the groups in relation to prognosis and response to treatment.engUniversidade Federal de Minas GeraisUFMGBrasilMED - DEPARTAMENTO DE CIRURGIAMED - DEPARTAMENTO DE PEDIATRIAJournal of Pediatric Gastroenterology and NutritionHepatite AutoimuneCriançaPrognósticoAutoimmune hepatitisChildrenOverlap syndromePrognosticClinical characteristics and prognosis in children and adolescents with autoimmune hepatitis and overlap syndromeinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttps://journals.lww.com/jpgn/Fulltext/2016/07000/Clinical_Characteristics_and_Prognosis_in_Children.17.aspxAdriana TeixeirarodriguesLuiz Ronaldo AlbertiPriscila Menezes Ferri LiuEleonora Druve Tavares FagundesThaís Costa Nascentes QueirozPamela de Souza Haueisen BarbosaSoraya Luiza Campos SilvaAna Cristina Simões e SilvaDébora Marques MirandaAlexandre Rodrigues Ferreiraapplication/pdfinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFMGinstname:Universidade Federal de Minas Gerais (UFMG)instacron:UFMGLICENSELicense.txtLicense.txttext/plain; charset=utf-82042https://repositorio.ufmg.br/bitstream/1843/57183/1/License.txtfa505098d172de0bc8864fc1287ffe22MD51ORIGINALClinical_Characteristics_and_Prognosis_in_Children.17 pdfa.pdfClinical_Characteristics_and_Prognosis_in_Children.17 pdfa.pdfapplication/pdf114245https://repositorio.ufmg.br/bitstream/1843/57183/2/Clinical_Characteristics_and_Prognosis_in_Children.17%20pdfa.pdf799522471b71a15844c4e530fa9fac76MD521843/571832023-07-31 13:36:17.149oai:repositorio.ufmg.br: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Repositório de PublicaçõesPUBhttps://repositorio.ufmg.br/oaiopendoar:2023-07-31T16:36:17Repositório Institucional da UFMG - Universidade Federal de Minas Gerais (UFMG)false |
dc.title.pt_BR.fl_str_mv |
Clinical characteristics and prognosis in children and adolescents with autoimmune hepatitis and overlap syndrome |
title |
Clinical characteristics and prognosis in children and adolescents with autoimmune hepatitis and overlap syndrome |
spellingShingle |
Clinical characteristics and prognosis in children and adolescents with autoimmune hepatitis and overlap syndrome Adriana Teixeirarodrigues Autoimmune hepatitis Children Overlap syndrome Prognostic Hepatite Autoimune Criança Prognóstico |
title_short |
Clinical characteristics and prognosis in children and adolescents with autoimmune hepatitis and overlap syndrome |
title_full |
Clinical characteristics and prognosis in children and adolescents with autoimmune hepatitis and overlap syndrome |
title_fullStr |
Clinical characteristics and prognosis in children and adolescents with autoimmune hepatitis and overlap syndrome |
title_full_unstemmed |
Clinical characteristics and prognosis in children and adolescents with autoimmune hepatitis and overlap syndrome |
title_sort |
Clinical characteristics and prognosis in children and adolescents with autoimmune hepatitis and overlap syndrome |
author |
Adriana Teixeirarodrigues |
author_facet |
Adriana Teixeirarodrigues Luiz Ronaldo Alberti Priscila Menezes Ferri Liu Eleonora Druve Tavares Fagundes Thaís Costa Nascentes Queiroz Pamela de Souza Haueisen Barbosa Soraya Luiza Campos Silva Ana Cristina Simões e Silva Débora Marques Miranda Alexandre Rodrigues Ferreira |
author_role |
author |
author2 |
Luiz Ronaldo Alberti Priscila Menezes Ferri Liu Eleonora Druve Tavares Fagundes Thaís Costa Nascentes Queiroz Pamela de Souza Haueisen Barbosa Soraya Luiza Campos Silva Ana Cristina Simões e Silva Débora Marques Miranda Alexandre Rodrigues Ferreira |
author2_role |
author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Adriana Teixeirarodrigues Luiz Ronaldo Alberti Priscila Menezes Ferri Liu Eleonora Druve Tavares Fagundes Thaís Costa Nascentes Queiroz Pamela de Souza Haueisen Barbosa Soraya Luiza Campos Silva Ana Cristina Simões e Silva Débora Marques Miranda Alexandre Rodrigues Ferreira |
dc.subject.por.fl_str_mv |
Autoimmune hepatitis Children Overlap syndrome Prognostic |
topic |
Autoimmune hepatitis Children Overlap syndrome Prognostic Hepatite Autoimune Criança Prognóstico |
dc.subject.other.pt_BR.fl_str_mv |
Hepatite Autoimune Criança Prognóstico |
description |
Objectives: This is a cohort study of 134 children and adolescents with a known diagnosis of autoimmune hepatitis (AIH). During follow-up, some of them developed autoimmune sclerosing cholangitis (ASC). This study describes the characteristics of the patients upon diagnosis, and their response to treatment and any complications, and compares the patients who developed ASC during follow-up (ASC group) with those who did not (AIH group). Methods: A total of 73.1% of the patients were girls with a median age upon diagnosis of 10.41 (7.41–12.53) years. Results: Of 134 patients, 28 (20.9%) developed cholestatic manifestations, with features of ASC. A few differences were observed between the AIH and ASC groups when they were analyzed by x2 test, such as the smaller predominance of girls in ASC group (P ¼ 0.04), and more common asymptomatic presentation in the ASC group (P ¼ 0.01). Cirrhosis was observed in 68% of biopsies, with no significant difference between groups (P ¼ 0.43). Of 16 deaths, 15 were in the AIH group and 1 in the ASC group (P ¼ 0.22). Of 11 transplants, 10 were in the AIH group and one in the ASC group (P ¼ 0.53). The presence of cirrhosis at baseline was associated with a smaller survival probability (P ¼ 0.015). The survival rate by Kaplan-Meier method was 94% at 5 years and 80% at 10 years, and was similar in both the groups (P ¼ 0.08). Conclusions: No statistically significant difference was observed between the groups in relation to prognosis and response to treatment. |
publishDate |
2016 |
dc.date.issued.fl_str_mv |
2016-07 |
dc.date.accessioned.fl_str_mv |
2023-07-28T22:13:27Z |
dc.date.available.fl_str_mv |
2023-07-28T22:13:27Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/1843/57183 |
dc.identifier.doi.pt_BR.fl_str_mv |
10.1097/mpg.0000000000001125 |
dc.identifier.issn.pt_BR.fl_str_mv |
02772116 |
identifier_str_mv |
10.1097/mpg.0000000000001125 02772116 |
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http://hdl.handle.net/1843/57183 |
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eng |
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eng |
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Journal of Pediatric Gastroenterology and Nutrition |
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info:eu-repo/semantics/openAccess |
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openAccess |
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application/pdf |
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Universidade Federal de Minas Gerais |
dc.publisher.initials.fl_str_mv |
UFMG |
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Brasil |
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MED - DEPARTAMENTO DE CIRURGIA MED - DEPARTAMENTO DE PEDIATRIA |
publisher.none.fl_str_mv |
Universidade Federal de Minas Gerais |
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