Obesity and malnutrition similarly alter the renin-angiotensin system and inflammation in mice and human adipose
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2017 |
| Outros Autores: | , , , , , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da UFMG |
| Texto Completo: | https://doi.org/10.1016/j.jnutbio.2017.06.008 http://hdl.handle.net/1843/44360 |
Resumo: | CNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico |
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2022-08-18T14:15:16Z2022-08-18T14:15:16Z2017-10487482https://doi.org/10.1016/j.jnutbio.2017.06.0080955-2863http://hdl.handle.net/1843/44360CNPq - Conselho Nacional de Desenvolvimento Científico e TecnológicoFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas GeraisCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível SuperiorOutra AgênciaThe main goal of the present study was to evaluate the metabolic profile, inflammatory markers and the gene expression of the renin–angiotensin system (RAS) components in the visceral adipose tissue of eutrophic, obese and malnourished individuals and mice models of obesity and food restriction. Male Swiss mice were divided into eight groups and fed different levels of food restriction (20%, 40%, or 60%) using standard or high-fat diet. Metabolic profile and adipose tissues were assessed. The expression of AGT (Angiotensinogen), ACE (Angiotensin-converting enzyme), ACE2 (Angiotensin-converting enzyme 2), interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-α) in the mice epididymal adipose tissue and the human visceral adipose tissue was assessed. The main findings showed reduced body weight, improved metabolism, decreased adipose tissues weight and reduced adipocyte area in mice submitted to food restriction. Diminished expression of IL-6, TNF-α, AGT, AT1 and ACE was detected in the 20% and 40% food restriction animal groups, although they were increased in the 60% malnourished group. Increased expression of IL-6, TNF-α, AGT and ACE in obese and malnourished individuals was observed. Adipocytes size was increased in obese individuals and reduced in malnutrition. In conclusion, we found that food restriction of 20% and 40% improved the metabolic profile, ameliorated the inflammatory status and down-regulated the RAS in mice. Severe 60% food restriction (malnutrition), however, stimulated a proinflammatory state and increased AGT and ACE expression in the adipose tissue of mice. A similar profile was observed in the adipose tissue of obese and malnourished humans, supporting the critical role of inflammation and RAS as mediators of metabolic disorders.engUniversidade Federal de Minas GeraisUFMGBrasilICA - INSTITUTO DE CIÊNCIAS AGRÁRIASThe Journal of Nutritional BiochemistryObesidadeDesnutriçãoDieta de baixa caloriaSistema renina-angiotensinaTecido adiposoDistúrbios alimentaresObesity and malnutrition similarly alter the renin-angiotensin system and inflammation in mice and human adiposeinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttps://www.sciencedirect.com/science/article/pii/S0955286317302413?via%3DihubThales de Almeida PinheiroAntônio Sérgio Barcala JorgeJoão Marcus Oliveira AndradeThaisa de Almeida PinheiroEmíllio César Neves FerreiraThaisa Soares CrespoGislaine Cândida Batista-JorgeCássio André VieiraDeborah de Farias LelisAlanna Fernandes ParaísoUgo Borges PinheiroMariane BertagnolliCarlos Juliano Brant AlbuquerqueAndré Luiz Sena GuimarãesAlfredo Maurício Batista de PaulaAntônio Prates CaldeiraSérgio Henrique Sousa Santosinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFMGinstname:Universidade Federal de Minas Gerais (UFMG)instacron:UFMGLICENSELicense.txtLicense.txttext/plain; charset=utf-82042https://repositorio.ufmg.br/bitstream/1843/44360/1/License.txtfa505098d172de0bc8864fc1287ffe22MD51ORIGINALObesity and malnutrition similarly alter the renin–angiotensin system and inflammation in mice and human adipose.pdfObesity and malnutrition similarly alter the renin–angiotensin system and inflammation in mice and human adipose.pdfapplication/pdf1390535https://repositorio.ufmg.br/bitstream/1843/44360/2/Obesity%20and%20malnutrition%20similarly%20alter%20the%20renin%e2%80%93angiotensin%20system%20and%20inflammation%20in%20mice%20and%20human%20adipose.pdfc1a5d7c71f57da11499e8ff070f72b37MD521843/443602022-08-18 11:15:16.543oai:repositorio.ufmg.br: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Repositório de PublicaçõesPUBhttps://repositorio.ufmg.br/oaiopendoar:2022-08-18T14:15:16Repositório Institucional da UFMG - Universidade Federal de Minas Gerais (UFMG)false |
| dc.title.pt_BR.fl_str_mv |
Obesity and malnutrition similarly alter the renin-angiotensin system and inflammation in mice and human adipose |
| title |
Obesity and malnutrition similarly alter the renin-angiotensin system and inflammation in mice and human adipose |
| spellingShingle |
Obesity and malnutrition similarly alter the renin-angiotensin system and inflammation in mice and human adipose Thales de Almeida Pinheiro Obesidade Desnutrição Dieta de baixa caloria Sistema renina-angiotensina Tecido adiposo Distúrbios alimentares |
| title_short |
Obesity and malnutrition similarly alter the renin-angiotensin system and inflammation in mice and human adipose |
| title_full |
Obesity and malnutrition similarly alter the renin-angiotensin system and inflammation in mice and human adipose |
| title_fullStr |
Obesity and malnutrition similarly alter the renin-angiotensin system and inflammation in mice and human adipose |
| title_full_unstemmed |
Obesity and malnutrition similarly alter the renin-angiotensin system and inflammation in mice and human adipose |
| title_sort |
Obesity and malnutrition similarly alter the renin-angiotensin system and inflammation in mice and human adipose |
| author |
Thales de Almeida Pinheiro |
| author_facet |
Thales de Almeida Pinheiro Antônio Sérgio Barcala Jorge João Marcus Oliveira Andrade Thaisa de Almeida Pinheiro Emíllio César Neves Ferreira Thaisa Soares Crespo Gislaine Cândida Batista-Jorge Cássio André Vieira Deborah de Farias Lelis Alanna Fernandes Paraíso Ugo Borges Pinheiro Mariane Bertagnolli Carlos Juliano Brant Albuquerque André Luiz Sena Guimarães Alfredo Maurício Batista de Paula Antônio Prates Caldeira Sérgio Henrique Sousa Santos |
| author_role |
author |
| author2 |
Antônio Sérgio Barcala Jorge João Marcus Oliveira Andrade Thaisa de Almeida Pinheiro Emíllio César Neves Ferreira Thaisa Soares Crespo Gislaine Cândida Batista-Jorge Cássio André Vieira Deborah de Farias Lelis Alanna Fernandes Paraíso Ugo Borges Pinheiro Mariane Bertagnolli Carlos Juliano Brant Albuquerque André Luiz Sena Guimarães Alfredo Maurício Batista de Paula Antônio Prates Caldeira Sérgio Henrique Sousa Santos |
| author2_role |
author author author author author author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Thales de Almeida Pinheiro Antônio Sérgio Barcala Jorge João Marcus Oliveira Andrade Thaisa de Almeida Pinheiro Emíllio César Neves Ferreira Thaisa Soares Crespo Gislaine Cândida Batista-Jorge Cássio André Vieira Deborah de Farias Lelis Alanna Fernandes Paraíso Ugo Borges Pinheiro Mariane Bertagnolli Carlos Juliano Brant Albuquerque André Luiz Sena Guimarães Alfredo Maurício Batista de Paula Antônio Prates Caldeira Sérgio Henrique Sousa Santos |
| dc.subject.other.pt_BR.fl_str_mv |
Obesidade Desnutrição Dieta de baixa caloria Sistema renina-angiotensina Tecido adiposo Distúrbios alimentares |
| topic |
Obesidade Desnutrição Dieta de baixa caloria Sistema renina-angiotensina Tecido adiposo Distúrbios alimentares |
| description |
CNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico |
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2017 |
| dc.date.issued.fl_str_mv |
2017-10 |
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2022-08-18T14:15:16Z |
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2022-08-18T14:15:16Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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publishedVersion |
| dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/1843/44360 |
| dc.identifier.doi.pt_BR.fl_str_mv |
https://doi.org/10.1016/j.jnutbio.2017.06.008 |
| dc.identifier.issn.pt_BR.fl_str_mv |
0955-2863 |
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https://doi.org/10.1016/j.jnutbio.2017.06.008 http://hdl.handle.net/1843/44360 |
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0955-2863 |
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eng |
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eng |
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The Journal of Nutritional Biochemistry |
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info:eu-repo/semantics/openAccess |
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openAccess |
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Universidade Federal de Minas Gerais |
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UFMG |
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Brasil |
| dc.publisher.department.fl_str_mv |
ICA - INSTITUTO DE CIÊNCIAS AGRÁRIAS |
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Universidade Federal de Minas Gerais |
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reponame:Repositório Institucional da UFMG instname:Universidade Federal de Minas Gerais (UFMG) instacron:UFMG |
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UFMG |
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