Type 1 diabetes mellitus: can coaching improve health outcomes?
Autor(a) principal: | |
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Data de Publicação: | 2018 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFMG |
Texto Completo: | http://hdl.handle.net/1843/60757 |
Resumo: | Objective:This study aimed to evaluate the association between different renal biomarkers with D-Dimer levels in diabetes mellitus (DM1) patients group classified as: low D-Dimer levels (< 318 ng/mL), which included first and second D-Dimer tertiles, and high D-Dimer levels (≥ 318 ng/mL), which included third D-Dimer tertile.Materials and methods:D-Dimer and cystatin C were measured by ELISA. Creatinine and urea were determined by enzymatic method. Estimated glomerular filtration rate (eGFR) was calculated using CKD-EPI equation. Albuminuria was assessed by immunoturbidimetry. Presence of renal disease was evaluated using each renal biomarker: creatinine, urea, cystatin C, eGFR and albuminuria. Bivariate logistic regression analysis was performed to assess which renal biomarkers are associated with high D-Dimer levels and odds ratio was calculated. After, multivariate logistic regression analysis was performed to assess which renal biomarkers are associated with high D-Dimer levels (after adjusting for sex and age) and odds ratio was calculated.Results:Cystatin C presented a better association [OR of 9.8 (3.8–25.5)] with high D-Dimer levels than albuminuria, creatinine, eGFR and urea [OR of 5.3 (2.2–12.9), 8.4 (2.5–25.4), 9.1 (2.6–31.4) and 3.5 (1.4–8.4), respectively] after adjusting for sex and age. All biomarkers showed a good association with D-Dimer levels, and consequently, with hypercoagulability status, and cystatin C showed the best association among them. Conclusion Therefore, cystatin C might be useful to detect patients with incipient diabetic kidney disease that present an increased risk of cardiovascular disease, contributing to an early adoption of reno and cardioprotective therapies |
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2023-11-09T22:33:57Z2023-11-09T22:33:57Z201862448548910.20945/2359-399700000005823593997http://hdl.handle.net/1843/60757Objective:This study aimed to evaluate the association between different renal biomarkers with D-Dimer levels in diabetes mellitus (DM1) patients group classified as: low D-Dimer levels (< 318 ng/mL), which included first and second D-Dimer tertiles, and high D-Dimer levels (≥ 318 ng/mL), which included third D-Dimer tertile.Materials and methods:D-Dimer and cystatin C were measured by ELISA. Creatinine and urea were determined by enzymatic method. Estimated glomerular filtration rate (eGFR) was calculated using CKD-EPI equation. Albuminuria was assessed by immunoturbidimetry. Presence of renal disease was evaluated using each renal biomarker: creatinine, urea, cystatin C, eGFR and albuminuria. Bivariate logistic regression analysis was performed to assess which renal biomarkers are associated with high D-Dimer levels and odds ratio was calculated. After, multivariate logistic regression analysis was performed to assess which renal biomarkers are associated with high D-Dimer levels (after adjusting for sex and age) and odds ratio was calculated.Results:Cystatin C presented a better association [OR of 9.8 (3.8–25.5)] with high D-Dimer levels than albuminuria, creatinine, eGFR and urea [OR of 5.3 (2.2–12.9), 8.4 (2.5–25.4), 9.1 (2.6–31.4) and 3.5 (1.4–8.4), respectively] after adjusting for sex and age. All biomarkers showed a good association with D-Dimer levels, and consequently, with hypercoagulability status, and cystatin C showed the best association among them. Conclusion Therefore, cystatin C might be useful to detect patients with incipient diabetic kidney disease that present an increased risk of cardiovascular disease, contributing to an early adoption of reno and cardioprotective therapiesengUniversidade Federal de Minas GeraisUFMGBrasilMED - DEPARTAMENTO DE CLÍNICA MÉDICAArchives of Endocrinology and MetabolismDiabetes Mellitus, Type 1HealtSelf-ManagementType 1 diabetes mellitusself-managementhealthType 1 diabetes mellitus: can coaching improve health outcomes?info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttps://www.scielo.br/j/aem/a/W3Cr6pMXfj4g5wf7J7CmSQd/?lang=enTais Pereira Costa MagalhãesRodrigo Bastos FóscoloAleida Nazareth SoaresJanice Sepúlveda Reisapplication/pdfinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFMGinstname:Universidade Federal de Minas Gerais (UFMG)instacron:UFMGLICENSELicense.txtLicense.txttext/plain; charset=utf-82042https://repositorio.ufmg.br/bitstream/1843/60757/1/License.txtfa505098d172de0bc8864fc1287ffe22MD51ORIGINALType 1 diabetes mellitus pdfa.pdfType 1 diabetes mellitus pdfa.pdfapplication/pdf308742https://repositorio.ufmg.br/bitstream/1843/60757/2/Type%201%20diabetes%20mellitus%20pdfa.pdff4b8527b32f7d6efb030533e23259dd8MD521843/607572023-11-09 20:45:20.963oai:repositorio.ufmg.br:1843/60757Repositório de PublicaçõesPUBhttps://repositorio.ufmg.br/oaiopendoar:2023-11-09T23:45:20Repositório Institucional da UFMG - Universidade Federal de Minas Gerais (UFMG)false |
dc.title.pt_BR.fl_str_mv |
Type 1 diabetes mellitus: can coaching improve health outcomes? |
title |
Type 1 diabetes mellitus: can coaching improve health outcomes? |
spellingShingle |
Type 1 diabetes mellitus: can coaching improve health outcomes? Tais Pereira Costa Magalhães Type 1 diabetes mellitus self-management health Diabetes Mellitus, Type 1 Healt Self-Management |
title_short |
Type 1 diabetes mellitus: can coaching improve health outcomes? |
title_full |
Type 1 diabetes mellitus: can coaching improve health outcomes? |
title_fullStr |
Type 1 diabetes mellitus: can coaching improve health outcomes? |
title_full_unstemmed |
Type 1 diabetes mellitus: can coaching improve health outcomes? |
title_sort |
Type 1 diabetes mellitus: can coaching improve health outcomes? |
author |
Tais Pereira Costa Magalhães |
author_facet |
Tais Pereira Costa Magalhães Rodrigo Bastos Fóscolo Aleida Nazareth Soares Janice Sepúlveda Reis |
author_role |
author |
author2 |
Rodrigo Bastos Fóscolo Aleida Nazareth Soares Janice Sepúlveda Reis |
author2_role |
author author author |
dc.contributor.author.fl_str_mv |
Tais Pereira Costa Magalhães Rodrigo Bastos Fóscolo Aleida Nazareth Soares Janice Sepúlveda Reis |
dc.subject.por.fl_str_mv |
Type 1 diabetes mellitus self-management health |
topic |
Type 1 diabetes mellitus self-management health Diabetes Mellitus, Type 1 Healt Self-Management |
dc.subject.other.pt_BR.fl_str_mv |
Diabetes Mellitus, Type 1 Healt Self-Management |
description |
Objective:This study aimed to evaluate the association between different renal biomarkers with D-Dimer levels in diabetes mellitus (DM1) patients group classified as: low D-Dimer levels (< 318 ng/mL), which included first and second D-Dimer tertiles, and high D-Dimer levels (≥ 318 ng/mL), which included third D-Dimer tertile.Materials and methods:D-Dimer and cystatin C were measured by ELISA. Creatinine and urea were determined by enzymatic method. Estimated glomerular filtration rate (eGFR) was calculated using CKD-EPI equation. Albuminuria was assessed by immunoturbidimetry. Presence of renal disease was evaluated using each renal biomarker: creatinine, urea, cystatin C, eGFR and albuminuria. Bivariate logistic regression analysis was performed to assess which renal biomarkers are associated with high D-Dimer levels and odds ratio was calculated. After, multivariate logistic regression analysis was performed to assess which renal biomarkers are associated with high D-Dimer levels (after adjusting for sex and age) and odds ratio was calculated.Results:Cystatin C presented a better association [OR of 9.8 (3.8–25.5)] with high D-Dimer levels than albuminuria, creatinine, eGFR and urea [OR of 5.3 (2.2–12.9), 8.4 (2.5–25.4), 9.1 (2.6–31.4) and 3.5 (1.4–8.4), respectively] after adjusting for sex and age. All biomarkers showed a good association with D-Dimer levels, and consequently, with hypercoagulability status, and cystatin C showed the best association among them. Conclusion Therefore, cystatin C might be useful to detect patients with incipient diabetic kidney disease that present an increased risk of cardiovascular disease, contributing to an early adoption of reno and cardioprotective therapies |
publishDate |
2018 |
dc.date.issued.fl_str_mv |
2018 |
dc.date.accessioned.fl_str_mv |
2023-11-09T22:33:57Z |
dc.date.available.fl_str_mv |
2023-11-09T22:33:57Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/1843/60757 |
dc.identifier.doi.pt_BR.fl_str_mv |
10.20945/2359-3997000000058 |
dc.identifier.issn.pt_BR.fl_str_mv |
23593997 |
identifier_str_mv |
10.20945/2359-3997000000058 23593997 |
url |
http://hdl.handle.net/1843/60757 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.ispartof.none.fl_str_mv |
Archives of Endocrinology and Metabolism |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Universidade Federal de Minas Gerais |
dc.publisher.initials.fl_str_mv |
UFMG |
dc.publisher.country.fl_str_mv |
Brasil |
dc.publisher.department.fl_str_mv |
MED - DEPARTAMENTO DE CLÍNICA MÉDICA |
publisher.none.fl_str_mv |
Universidade Federal de Minas Gerais |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UFMG instname:Universidade Federal de Minas Gerais (UFMG) instacron:UFMG |
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