Systemic mastocytosis with terminal leukemic manifestation in two dogs
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2017 |
| Outros Autores: | , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da UFMG |
| Texto Completo: | http://bjvp.org.br/wp-content/uploads/2017/11/v10-n3-5.pdf http://hdl.handle.net/1843/67191 https://orcid.org/0000-0002-8052-5389 https://orcid.org/0009-0003-9218-060X https://orcid.org/0000-0002-2035-8961 https://orcid.org/0000-0002-4013-0147 https://orcid.org/0000-0002-1366-7352 |
Resumo: | CNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico |
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2024-04-15T19:53:25Z2024-04-15T19:53:25Z2017103117123http://bjvp.org.br/wp-content/uploads/2017/11/v10-n3-5.pdf1983-0246http://hdl.handle.net/1843/67191https://orcid.org/0000-0002-8052-5389https://orcid.org/0009-0003-9218-060Xhttps://orcid.org/0000-0002-2035-8961https://orcid.org/0000-0002-4013-0147https://orcid.org/0000-0002-1366-7352CNPq - Conselho Nacional de Desenvolvimento Científico e TecnológicoCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível SuperiorSystemic mastocytosis (SM) with leukemic manifestation is rarely reported in veterinary patients. Here, we describe two cases of systemic mastocytosis with leukemic spread of neoplastic mast cells in adult dogs, including their clinical signs, clinical and anatomic pathology, and immunohistochemical analysis of c-KIT as a diagnostic tool. In both cases, hematologic examination revealed normocytic and normochromic anaemia, leucocytosis with segmented neutrophils, and mastocytosis. Cytological analyses of the peritoneal fluid revealed many neoplastic mast cells. Case 1 was associated with a subcutaneous mast cell tumor and Case 2 was not associated with a cutaneous or subcutaneous mast cell tumor. Neoplastic mast cells were found in the lymph nodes, spleen, liver, and kidneys, and a diagnosis of visceral mastocytosis was established. SM with terminal leukemic manifestation was confirmed by the mastocythemia intensity associated with the morphological changes of the mast cells in the blood and bone marrow.engUniversidade Federal de Minas GeraisUFMGBrasilVET - DEPARTAMENTO DE CLÍNICA E CIRURGIABrazilian Journal of Veterinary PathologyMedula ósseaHistopatologiaLeucemia de mastócitosMastocitoseBone marrowc-KITHistopathologyMast cell leukemiaMastocytosisSystemic mastocytosis with terminal leukemic manifestation in two dogsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttps://bjvp.org.br/vol-10-n-3-november-2017/Roselene EccoAnna L. F. V. AssumpçãoRodrigo de Macedo CoutoRachel L. A. L. T. NetoPâmela Cristina Lopes Gurgel ValenteConrado O. GambaFabiola de Oliveira Paes LemePaulo Ricardo de Oliveira Paesinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFMGinstname:Universidade Federal de Minas Gerais (UFMG)instacron:UFMGLICENSELicense.txtLicense.txttext/plain; charset=utf-82042https://repositorio.ufmg.br/bitstream/1843/67191/1/License.txtfa505098d172de0bc8864fc1287ffe22MD51ORIGINALSystemic mastocytosis with terminal leukemic manifestation in two dogs.pdfSystemic mastocytosis with terminal leukemic manifestation in two dogs.pdfapplication/pdf638649https://repositorio.ufmg.br/bitstream/1843/67191/2/Systemic%20mastocytosis%20with%20terminal%20leukemic%20manifestation%20in%20two%20dogs.pdfb337f9bab092dd16203fee6e4433ea01MD521843/671912024-04-15 16:53:26.458oai:repositorio.ufmg.br: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Repositório de PublicaçõesPUBhttps://repositorio.ufmg.br/oaiopendoar:2024-04-15T19:53:26Repositório Institucional da UFMG - Universidade Federal de Minas Gerais (UFMG)false |
| dc.title.pt_BR.fl_str_mv |
Systemic mastocytosis with terminal leukemic manifestation in two dogs |
| title |
Systemic mastocytosis with terminal leukemic manifestation in two dogs |
| spellingShingle |
Systemic mastocytosis with terminal leukemic manifestation in two dogs Roselene Ecco Bone marrow c-KIT Histopathology Mast cell leukemia Mastocytosis Medula óssea Histopatologia Leucemia de mastócitos Mastocitose |
| title_short |
Systemic mastocytosis with terminal leukemic manifestation in two dogs |
| title_full |
Systemic mastocytosis with terminal leukemic manifestation in two dogs |
| title_fullStr |
Systemic mastocytosis with terminal leukemic manifestation in two dogs |
| title_full_unstemmed |
Systemic mastocytosis with terminal leukemic manifestation in two dogs |
| title_sort |
Systemic mastocytosis with terminal leukemic manifestation in two dogs |
| author |
Roselene Ecco |
| author_facet |
Roselene Ecco Anna L. F. V. Assumpção Rodrigo de Macedo Couto Rachel L. A. L. T. Neto Pâmela Cristina Lopes Gurgel Valente Conrado O. Gamba Fabiola de Oliveira Paes Leme Paulo Ricardo de Oliveira Paes |
| author_role |
author |
| author2 |
Anna L. F. V. Assumpção Rodrigo de Macedo Couto Rachel L. A. L. T. Neto Pâmela Cristina Lopes Gurgel Valente Conrado O. Gamba Fabiola de Oliveira Paes Leme Paulo Ricardo de Oliveira Paes |
| author2_role |
author author author author author author author |
| dc.contributor.author.fl_str_mv |
Roselene Ecco Anna L. F. V. Assumpção Rodrigo de Macedo Couto Rachel L. A. L. T. Neto Pâmela Cristina Lopes Gurgel Valente Conrado O. Gamba Fabiola de Oliveira Paes Leme Paulo Ricardo de Oliveira Paes |
| dc.subject.por.fl_str_mv |
Bone marrow c-KIT Histopathology Mast cell leukemia Mastocytosis |
| topic |
Bone marrow c-KIT Histopathology Mast cell leukemia Mastocytosis Medula óssea Histopatologia Leucemia de mastócitos Mastocitose |
| dc.subject.other.pt_BR.fl_str_mv |
Medula óssea Histopatologia Leucemia de mastócitos Mastocitose |
| description |
CNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico |
| publishDate |
2017 |
| dc.date.issued.fl_str_mv |
2017 |
| dc.date.accessioned.fl_str_mv |
2024-04-15T19:53:25Z |
| dc.date.available.fl_str_mv |
2024-04-15T19:53:25Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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publishedVersion |
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http://hdl.handle.net/1843/67191 |
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http://bjvp.org.br/wp-content/uploads/2017/11/v10-n3-5.pdf |
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1983-0246 |
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https://orcid.org/0000-0002-8052-5389 https://orcid.org/0009-0003-9218-060X https://orcid.org/0000-0002-2035-8961 https://orcid.org/0000-0002-4013-0147 https://orcid.org/0000-0002-1366-7352 |
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http://bjvp.org.br/wp-content/uploads/2017/11/v10-n3-5.pdf http://hdl.handle.net/1843/67191 https://orcid.org/0000-0002-8052-5389 https://orcid.org/0009-0003-9218-060X https://orcid.org/0000-0002-2035-8961 https://orcid.org/0000-0002-4013-0147 https://orcid.org/0000-0002-1366-7352 |
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1983-0246 |
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eng |
| language |
eng |
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Brazilian Journal of Veterinary Pathology |
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info:eu-repo/semantics/openAccess |
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openAccess |
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Universidade Federal de Minas Gerais |
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UFMG |
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Brasil |
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VET - DEPARTAMENTO DE CLÍNICA E CIRURGIA |
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Universidade Federal de Minas Gerais |
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reponame:Repositório Institucional da UFMG instname:Universidade Federal de Minas Gerais (UFMG) instacron:UFMG |
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