Conditioned fear stress increases bone resorption in apical periodontitislesions in Wistar male rats
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2019 |
| Outros Autores: | , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da UFMG |
| Texto Completo: | https://doi.org/10.1016/j.archoralbio.2018.10.004 http://hdl.handle.net/1843/44483 |
Resumo: | CNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico |
| id |
UFMG_6016be14b705b57c65ae15cca2c2b747 |
|---|---|
| oai_identifier_str |
oai:repositorio.ufmg.br:1843/44483 |
| network_acronym_str |
UFMG |
| network_name_str |
Repositório Institucional da UFMG |
| repository_id_str |
|
| spelling |
2022-08-23T13:20:13Z2022-08-23T13:20:13Z2019-01973541https://doi.org/10.1016/j.archoralbio.2018.10.0040003-9969http://hdl.handle.net/1843/44483CNPq - Conselho Nacional de Desenvolvimento Científico e TecnológicoFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas GeraisCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível SuperiorObjective: because the impact of conditioned fear stress on apical bone resorption is unknown, the aim of the current studywas to use a rat model to evaluate the impact of conditioned fear stress on the bone resorption of inflammatory apical periodontitis lesions. Methods: twenty-five animals were divided into two groups. They underwent a surgical procedure in the first left lower molar tooth to expose the dental pulp and induce inflammatory apical periodontitis lesions through the retention of contamination (bacterial infection) during a 56-day period. The animals in the case group were stressed daily by using electrical stimuli (1.10 mA), whereas the animals in the control group were absent from the stressful stimuli (shocks). The open field test was performed to validate the stress methodology. The jaws were removed and collected for histological and radiographic analyses. Results: stressed animals presented increased levels of bone loss and inflammatory cells in the root apex in comparison with the control group (P = 0.0001). However, no radiographic differences were observed between the groups (P > 0.05). Conclusions: our results demonstrated that conditioned fear stress could modify a periapical lesion by increasing the size of bone loss there. Conditioned fear stress also increased the total number of inflammatory cells compared with the control group. Studies evaluating the impact of conditioned fear stress on human periapical inflammatory lesions should be encouraged.engUniversidade Federal de Minas GeraisUFMGBrasilICA - INSTITUTO DE CIÊNCIAS AGRÁRIASArchives of Oral BiologyPeriodontiteEndodontiaOsteoporoseStress (Psicologia)Conditioned fear stress increases bone resorption in apical periodontitislesions in Wistar male ratsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttps://www.sciencedirect.com/science/article/pii/S0003996918303662Emisael Stênio Batista GomesLucyana Conceição FariasLuiz Henrique SilveiraCarlos Ícaro de JesusRogério Gonçalves da RochaGuilherme Veloso RamosHanna Thaynara Alves Teixeira MagalhãesManoel Brito JúniorSérgio Henrique Sousa SantosBruno Correia JhamAlfredo Maurício Batista de PaulaAndré Luiz Sena Guimarãesinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFMGinstname:Universidade Federal de Minas Gerais (UFMG)instacron:UFMGLICENSELicense.txtLicense.txttext/plain; charset=utf-82042https://repositorio.ufmg.br/bitstream/1843/44483/1/License.txtfa505098d172de0bc8864fc1287ffe22MD51ORIGINALConditioned fear stress increases bone resorption in apical periodontitislesions in Wistar male rats.pdfConditioned fear stress increases bone resorption in apical periodontitislesions in Wistar male rats.pdfapplication/pdf5277956https://repositorio.ufmg.br/bitstream/1843/44483/2/Conditioned%20fear%20stress%20increases%20bone%20resorption%20in%20apical%20periodontitislesions%20in%20Wistar%20male%20rats.pdf12351a3bbce9363c2df7d324f466dfc0MD521843/444832022-08-23 10:20:13.565oai:repositorio.ufmg.br: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Repositório de PublicaçõesPUBhttps://repositorio.ufmg.br/oaiopendoar:2022-08-23T13:20:13Repositório Institucional da UFMG - Universidade Federal de Minas Gerais (UFMG)false |
| dc.title.pt_BR.fl_str_mv |
Conditioned fear stress increases bone resorption in apical periodontitislesions in Wistar male rats |
| title |
Conditioned fear stress increases bone resorption in apical periodontitislesions in Wistar male rats |
| spellingShingle |
Conditioned fear stress increases bone resorption in apical periodontitislesions in Wistar male rats Emisael Stênio Batista Gomes Periodontite Endodontia Osteoporose Stress (Psicologia) |
| title_short |
Conditioned fear stress increases bone resorption in apical periodontitislesions in Wistar male rats |
| title_full |
Conditioned fear stress increases bone resorption in apical periodontitislesions in Wistar male rats |
| title_fullStr |
Conditioned fear stress increases bone resorption in apical periodontitislesions in Wistar male rats |
| title_full_unstemmed |
Conditioned fear stress increases bone resorption in apical periodontitislesions in Wistar male rats |
| title_sort |
Conditioned fear stress increases bone resorption in apical periodontitislesions in Wistar male rats |
| author |
Emisael Stênio Batista Gomes |
| author_facet |
Emisael Stênio Batista Gomes Lucyana Conceição Farias Luiz Henrique Silveira Carlos Ícaro de Jesus Rogério Gonçalves da Rocha Guilherme Veloso Ramos Hanna Thaynara Alves Teixeira Magalhães Manoel Brito Júnior Sérgio Henrique Sousa Santos Bruno Correia Jham Alfredo Maurício Batista de Paula André Luiz Sena Guimarães |
| author_role |
author |
| author2 |
Lucyana Conceição Farias Luiz Henrique Silveira Carlos Ícaro de Jesus Rogério Gonçalves da Rocha Guilherme Veloso Ramos Hanna Thaynara Alves Teixeira Magalhães Manoel Brito Júnior Sérgio Henrique Sousa Santos Bruno Correia Jham Alfredo Maurício Batista de Paula André Luiz Sena Guimarães |
| author2_role |
author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Emisael Stênio Batista Gomes Lucyana Conceição Farias Luiz Henrique Silveira Carlos Ícaro de Jesus Rogério Gonçalves da Rocha Guilherme Veloso Ramos Hanna Thaynara Alves Teixeira Magalhães Manoel Brito Júnior Sérgio Henrique Sousa Santos Bruno Correia Jham Alfredo Maurício Batista de Paula André Luiz Sena Guimarães |
| dc.subject.other.pt_BR.fl_str_mv |
Periodontite Endodontia Osteoporose Stress (Psicologia) |
| topic |
Periodontite Endodontia Osteoporose Stress (Psicologia) |
| description |
CNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico |
| publishDate |
2019 |
| dc.date.issued.fl_str_mv |
2019-01 |
| dc.date.accessioned.fl_str_mv |
2022-08-23T13:20:13Z |
| dc.date.available.fl_str_mv |
2022-08-23T13:20:13Z |
| dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
| dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/1843/44483 |
| dc.identifier.doi.pt_BR.fl_str_mv |
https://doi.org/10.1016/j.archoralbio.2018.10.004 |
| dc.identifier.issn.pt_BR.fl_str_mv |
0003-9969 |
| url |
https://doi.org/10.1016/j.archoralbio.2018.10.004 http://hdl.handle.net/1843/44483 |
| identifier_str_mv |
0003-9969 |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
| dc.relation.ispartof.pt_BR.fl_str_mv |
Archives of Oral Biology |
| dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
| eu_rights_str_mv |
openAccess |
| dc.publisher.none.fl_str_mv |
Universidade Federal de Minas Gerais |
| dc.publisher.initials.fl_str_mv |
UFMG |
| dc.publisher.country.fl_str_mv |
Brasil |
| dc.publisher.department.fl_str_mv |
ICA - INSTITUTO DE CIÊNCIAS AGRÁRIAS |
| publisher.none.fl_str_mv |
Universidade Federal de Minas Gerais |
| dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UFMG instname:Universidade Federal de Minas Gerais (UFMG) instacron:UFMG |
| instname_str |
Universidade Federal de Minas Gerais (UFMG) |
| instacron_str |
UFMG |
| institution |
UFMG |
| reponame_str |
Repositório Institucional da UFMG |
| collection |
Repositório Institucional da UFMG |
| bitstream.url.fl_str_mv |
https://repositorio.ufmg.br/bitstream/1843/44483/1/License.txt https://repositorio.ufmg.br/bitstream/1843/44483/2/Conditioned%20fear%20stress%20increases%20bone%20resorption%20in%20apical%20periodontitislesions%20in%20Wistar%20male%20rats.pdf |
| bitstream.checksum.fl_str_mv |
fa505098d172de0bc8864fc1287ffe22 12351a3bbce9363c2df7d324f466dfc0 |
| bitstream.checksumAlgorithm.fl_str_mv |
MD5 MD5 |
| repository.name.fl_str_mv |
Repositório Institucional da UFMG - Universidade Federal de Minas Gerais (UFMG) |
| repository.mail.fl_str_mv |
|
| _version_ |
1803589282923806720 |