Data in support of Rap2a GTPase expression, activation and effects in LPS-mediated innate immune response and NF-kB activation

Detalhes bibliográficos
Autor(a) principal: Brener Cunha Carvalho
Data de Publicação: 2019
Outros Autores: Aristóbolo Silva, Leonardo Oliveira, Carolina Rocha, Heliana de Barros Fernandes, Isadora Oliveira, Felipe Leão, Thalita Valverde, Igor Rego, Sankar Gosh
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFMG
Texto Completo: http://hdl.handle.net/1843/44234
Resumo: We present here the data to support the understanding of the implication of Rap2a GTPase in LPS-induced innate immune response and NF-κB activation. The data presented are related to molecular tools that were generated, acquired, optimized or validated to investigate Rap2a expression, activation and its effects in mammalian cells including RAW264.7 macrophages and THP-1 monocytes under inflammatory conditions. These data supplement important technical and biological information on immune function of Rap2a in macrophages activated by LPS, recently reported by us (Carvalho et al., 2019) [1].
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spelling 2022-08-12T17:16:25Z2022-08-12T17:16:25Z201910927372352-3409http://hdl.handle.net/1843/44234We present here the data to support the understanding of the implication of Rap2a GTPase in LPS-induced innate immune response and NF-κB activation. The data presented are related to molecular tools that were generated, acquired, optimized or validated to investigate Rap2a expression, activation and its effects in mammalian cells including RAW264.7 macrophages and THP-1 monocytes under inflammatory conditions. These data supplement important technical and biological information on immune function of Rap2a in macrophages activated by LPS, recently reported by us (Carvalho et al., 2019) [1].Apresentamos aqui os dados para apoiar a compreensão da implicação de Rap2a GTPase na resposta imune inata induzida por LPS e ativação de NF-κB. Os dados apresentados estão relacionados a ferramentas moleculares que foram geradas, adquiridas, otimizadas ou validadas para investigar a expressão, ativação e seus efeitos de Rap2a em células de mamíferos, incluindo macrófagos RAW264.7 e monócitos THP-1 em condições inflamatórias. Esses dados complementam informações técnicas e biológicas importantes sobre a função imune de Rap2a em macrófagos ativados por LPS, recentemente relatadas por nós (Carvalho et al., 2019) [1].engUniversidade Federal de Minas GeraisUFMGBrasilICB - INSTITUTO DE CIÊNCIAS BIOLOGICASData in BriefMorfologiaBioquímicaRap2a small GTPaseLPSInnate Immune ResponseNF-kappaBData in support of Rap2a GTPase expression, activation and effects in LPS-mediated innate immune response and NF-kB activationDados em suporte à expressão Rap2a GTPase, ativação e efeitos na inata mediada por LPS resposta imune e ativação de NF-kBinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttps://www.sciencedirect.com/science/article/pii/S235234091930318X?via%3DihubBrener Cunha CarvalhoAristóbolo SilvaLeonardo OliveiraCarolina RochaHeliana de Barros FernandesIsadora OliveiraFelipe LeãoThalita ValverdeIgor RegoSankar Goshapplication/pdfinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFMGinstname:Universidade Federal de Minas Gerais (UFMG)instacron:UFMGLICENSELicense.txtLicense.txttext/plain; charset=utf-82042https://repositorio.ufmg.br/bitstream/1843/44234/1/License.txtfa505098d172de0bc8864fc1287ffe22MD51ORIGINAL2019_Data in support of Rap2a GTPase expression, activation and effects in LPS-mediated innate immune response and NF-κB activation.pdf2019_Data in support of Rap2a GTPase expression, activation and effects in LPS-mediated innate immune response and NF-κB activation.pdfapplication/pdf1928952https://repositorio.ufmg.br/bitstream/1843/44234/2/2019_Data%20in%20support%20of%20Rap2a%20GTPase%20expression%2c%20activation%20and%20effects%20in%20LPS-mediated%20innate%20immune%20response%20and%20NF-%ce%baB%20activation.pdf6d0b4f839d91b07d18ca895a1409680eMD521843/442342022-08-12 14:16:25.411oai:repositorio.ufmg.br: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Repositório de PublicaçõesPUBhttps://repositorio.ufmg.br/oaiopendoar:2022-08-12T17:16:25Repositório Institucional da UFMG - Universidade Federal de Minas Gerais (UFMG)false
dc.title.pt_BR.fl_str_mv Data in support of Rap2a GTPase expression, activation and effects in LPS-mediated innate immune response and NF-kB activation
dc.title.alternative.pt_BR.fl_str_mv Dados em suporte à expressão Rap2a GTPase, ativação e efeitos na inata mediada por LPS resposta imune e ativação de NF-kB
title Data in support of Rap2a GTPase expression, activation and effects in LPS-mediated innate immune response and NF-kB activation
spellingShingle Data in support of Rap2a GTPase expression, activation and effects in LPS-mediated innate immune response and NF-kB activation
Brener Cunha Carvalho
Rap2a small GTPase
LPS
Innate Immune Response
NF-kappaB
Morfologia
Bioquímica
title_short Data in support of Rap2a GTPase expression, activation and effects in LPS-mediated innate immune response and NF-kB activation
title_full Data in support of Rap2a GTPase expression, activation and effects in LPS-mediated innate immune response and NF-kB activation
title_fullStr Data in support of Rap2a GTPase expression, activation and effects in LPS-mediated innate immune response and NF-kB activation
title_full_unstemmed Data in support of Rap2a GTPase expression, activation and effects in LPS-mediated innate immune response and NF-kB activation
title_sort Data in support of Rap2a GTPase expression, activation and effects in LPS-mediated innate immune response and NF-kB activation
author Brener Cunha Carvalho
author_facet Brener Cunha Carvalho
Aristóbolo Silva
Leonardo Oliveira
Carolina Rocha
Heliana de Barros Fernandes
Isadora Oliveira
Felipe Leão
Thalita Valverde
Igor Rego
Sankar Gosh
author_role author
author2 Aristóbolo Silva
Leonardo Oliveira
Carolina Rocha
Heliana de Barros Fernandes
Isadora Oliveira
Felipe Leão
Thalita Valverde
Igor Rego
Sankar Gosh
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Brener Cunha Carvalho
Aristóbolo Silva
Leonardo Oliveira
Carolina Rocha
Heliana de Barros Fernandes
Isadora Oliveira
Felipe Leão
Thalita Valverde
Igor Rego
Sankar Gosh
dc.subject.por.fl_str_mv Rap2a small GTPase
LPS
Innate Immune Response
NF-kappaB
topic Rap2a small GTPase
LPS
Innate Immune Response
NF-kappaB
Morfologia
Bioquímica
dc.subject.other.pt_BR.fl_str_mv Morfologia
Bioquímica
description We present here the data to support the understanding of the implication of Rap2a GTPase in LPS-induced innate immune response and NF-κB activation. The data presented are related to molecular tools that were generated, acquired, optimized or validated to investigate Rap2a expression, activation and its effects in mammalian cells including RAW264.7 macrophages and THP-1 monocytes under inflammatory conditions. These data supplement important technical and biological information on immune function of Rap2a in macrophages activated by LPS, recently reported by us (Carvalho et al., 2019) [1].
publishDate 2019
dc.date.issued.fl_str_mv 2019
dc.date.accessioned.fl_str_mv 2022-08-12T17:16:25Z
dc.date.available.fl_str_mv 2022-08-12T17:16:25Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/1843/44234
dc.identifier.issn.pt_BR.fl_str_mv 2352-3409
identifier_str_mv 2352-3409
url http://hdl.handle.net/1843/44234
dc.language.iso.fl_str_mv eng
language eng
dc.relation.ispartof.pt_BR.fl_str_mv Data in Brief
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Universidade Federal de Minas Gerais
dc.publisher.initials.fl_str_mv UFMG
dc.publisher.country.fl_str_mv Brasil
dc.publisher.department.fl_str_mv ICB - INSTITUTO DE CIÊNCIAS BIOLOGICAS
publisher.none.fl_str_mv Universidade Federal de Minas Gerais
dc.source.none.fl_str_mv reponame:Repositório Institucional da UFMG
instname:Universidade Federal de Minas Gerais (UFMG)
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instname_str Universidade Federal de Minas Gerais (UFMG)
instacron_str UFMG
institution UFMG
reponame_str Repositório Institucional da UFMG
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