Data in support of Rap2a GTPase expression, activation and effects in LPS-mediated innate immune response and NF-kB activation
Autor(a) principal: | |
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Data de Publicação: | 2019 |
Outros Autores: | , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFMG |
Texto Completo: | http://hdl.handle.net/1843/44234 |
Resumo: | We present here the data to support the understanding of the implication of Rap2a GTPase in LPS-induced innate immune response and NF-κB activation. The data presented are related to molecular tools that were generated, acquired, optimized or validated to investigate Rap2a expression, activation and its effects in mammalian cells including RAW264.7 macrophages and THP-1 monocytes under inflammatory conditions. These data supplement important technical and biological information on immune function of Rap2a in macrophages activated by LPS, recently reported by us (Carvalho et al., 2019) [1]. |
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2022-08-12T17:16:25Z2022-08-12T17:16:25Z201910927372352-3409http://hdl.handle.net/1843/44234We present here the data to support the understanding of the implication of Rap2a GTPase in LPS-induced innate immune response and NF-κB activation. The data presented are related to molecular tools that were generated, acquired, optimized or validated to investigate Rap2a expression, activation and its effects in mammalian cells including RAW264.7 macrophages and THP-1 monocytes under inflammatory conditions. These data supplement important technical and biological information on immune function of Rap2a in macrophages activated by LPS, recently reported by us (Carvalho et al., 2019) [1].Apresentamos aqui os dados para apoiar a compreensão da implicação de Rap2a GTPase na resposta imune inata induzida por LPS e ativação de NF-κB. Os dados apresentados estão relacionados a ferramentas moleculares que foram geradas, adquiridas, otimizadas ou validadas para investigar a expressão, ativação e seus efeitos de Rap2a em células de mamíferos, incluindo macrófagos RAW264.7 e monócitos THP-1 em condições inflamatórias. Esses dados complementam informações técnicas e biológicas importantes sobre a função imune de Rap2a em macrófagos ativados por LPS, recentemente relatadas por nós (Carvalho et al., 2019) [1].engUniversidade Federal de Minas GeraisUFMGBrasilICB - INSTITUTO DE CIÊNCIAS BIOLOGICASData in BriefMorfologiaBioquímicaRap2a small GTPaseLPSInnate Immune ResponseNF-kappaBData in support of Rap2a GTPase expression, activation and effects in LPS-mediated innate immune response and NF-kB activationDados em suporte à expressão Rap2a GTPase, ativação e efeitos na inata mediada por LPS resposta imune e ativação de NF-kBinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttps://www.sciencedirect.com/science/article/pii/S235234091930318X?via%3DihubBrener Cunha CarvalhoAristóbolo SilvaLeonardo OliveiraCarolina RochaHeliana de Barros FernandesIsadora OliveiraFelipe LeãoThalita ValverdeIgor RegoSankar Goshapplication/pdfinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFMGinstname:Universidade Federal de Minas Gerais (UFMG)instacron:UFMGLICENSELicense.txtLicense.txttext/plain; charset=utf-82042https://repositorio.ufmg.br/bitstream/1843/44234/1/License.txtfa505098d172de0bc8864fc1287ffe22MD51ORIGINAL2019_Data in support of Rap2a GTPase expression, activation and effects in LPS-mediated innate immune response and NF-κB activation.pdf2019_Data in support of Rap2a GTPase expression, activation and effects in LPS-mediated innate immune response and NF-κB activation.pdfapplication/pdf1928952https://repositorio.ufmg.br/bitstream/1843/44234/2/2019_Data%20in%20support%20of%20Rap2a%20GTPase%20expression%2c%20activation%20and%20effects%20in%20LPS-mediated%20innate%20immune%20response%20and%20NF-%ce%baB%20activation.pdf6d0b4f839d91b07d18ca895a1409680eMD521843/442342022-08-12 14:16:25.411oai:repositorio.ufmg.br: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Repositório de PublicaçõesPUBhttps://repositorio.ufmg.br/oaiopendoar:2022-08-12T17:16:25Repositório Institucional da UFMG - Universidade Federal de Minas Gerais (UFMG)false |
dc.title.pt_BR.fl_str_mv |
Data in support of Rap2a GTPase expression, activation and effects in LPS-mediated innate immune response and NF-kB activation |
dc.title.alternative.pt_BR.fl_str_mv |
Dados em suporte à expressão Rap2a GTPase, ativação e efeitos na inata mediada por LPS resposta imune e ativação de NF-kB |
title |
Data in support of Rap2a GTPase expression, activation and effects in LPS-mediated innate immune response and NF-kB activation |
spellingShingle |
Data in support of Rap2a GTPase expression, activation and effects in LPS-mediated innate immune response and NF-kB activation Brener Cunha Carvalho Rap2a small GTPase LPS Innate Immune Response NF-kappaB Morfologia Bioquímica |
title_short |
Data in support of Rap2a GTPase expression, activation and effects in LPS-mediated innate immune response and NF-kB activation |
title_full |
Data in support of Rap2a GTPase expression, activation and effects in LPS-mediated innate immune response and NF-kB activation |
title_fullStr |
Data in support of Rap2a GTPase expression, activation and effects in LPS-mediated innate immune response and NF-kB activation |
title_full_unstemmed |
Data in support of Rap2a GTPase expression, activation and effects in LPS-mediated innate immune response and NF-kB activation |
title_sort |
Data in support of Rap2a GTPase expression, activation and effects in LPS-mediated innate immune response and NF-kB activation |
author |
Brener Cunha Carvalho |
author_facet |
Brener Cunha Carvalho Aristóbolo Silva Leonardo Oliveira Carolina Rocha Heliana de Barros Fernandes Isadora Oliveira Felipe Leão Thalita Valverde Igor Rego Sankar Gosh |
author_role |
author |
author2 |
Aristóbolo Silva Leonardo Oliveira Carolina Rocha Heliana de Barros Fernandes Isadora Oliveira Felipe Leão Thalita Valverde Igor Rego Sankar Gosh |
author2_role |
author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Brener Cunha Carvalho Aristóbolo Silva Leonardo Oliveira Carolina Rocha Heliana de Barros Fernandes Isadora Oliveira Felipe Leão Thalita Valverde Igor Rego Sankar Gosh |
dc.subject.por.fl_str_mv |
Rap2a small GTPase LPS Innate Immune Response NF-kappaB |
topic |
Rap2a small GTPase LPS Innate Immune Response NF-kappaB Morfologia Bioquímica |
dc.subject.other.pt_BR.fl_str_mv |
Morfologia Bioquímica |
description |
We present here the data to support the understanding of the implication of Rap2a GTPase in LPS-induced innate immune response and NF-κB activation. The data presented are related to molecular tools that were generated, acquired, optimized or validated to investigate Rap2a expression, activation and its effects in mammalian cells including RAW264.7 macrophages and THP-1 monocytes under inflammatory conditions. These data supplement important technical and biological information on immune function of Rap2a in macrophages activated by LPS, recently reported by us (Carvalho et al., 2019) [1]. |
publishDate |
2019 |
dc.date.issued.fl_str_mv |
2019 |
dc.date.accessioned.fl_str_mv |
2022-08-12T17:16:25Z |
dc.date.available.fl_str_mv |
2022-08-12T17:16:25Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/1843/44234 |
dc.identifier.issn.pt_BR.fl_str_mv |
2352-3409 |
identifier_str_mv |
2352-3409 |
url |
http://hdl.handle.net/1843/44234 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.ispartof.pt_BR.fl_str_mv |
Data in Brief |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Universidade Federal de Minas Gerais |
dc.publisher.initials.fl_str_mv |
UFMG |
dc.publisher.country.fl_str_mv |
Brasil |
dc.publisher.department.fl_str_mv |
ICB - INSTITUTO DE CIÊNCIAS BIOLOGICAS |
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Universidade Federal de Minas Gerais |
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reponame:Repositório Institucional da UFMG instname:Universidade Federal de Minas Gerais (UFMG) instacron:UFMG |
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Universidade Federal de Minas Gerais (UFMG) |
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UFMG |
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UFMG |
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Repositório Institucional da UFMG |
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Repositório Institucional da UFMG |
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