Monitoring the Establishment of VOC Gamma in Minas Gerais, Brazil: A Retrospective Epidemiological and Genomic Surveillance Study
Autor(a) principal: | |
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Data de Publicação: | 2022 |
Outros Autores: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFMG |
Texto Completo: | https://doi.org/10.3390/v14122747 http://hdl.handle.net/1843/61649 https://orcid.org/0000-0001-9469-9673 https://orcid.org/0000-0002-8103-9235 https://orcid.org/0000-0002-9603-455X https://orcid.org/0000-0002-6607-8818 https://orcid.org/0000-0001-6863-7970 https://orcid.org/0000-0002-4178-0387 https://orcid.org/0000-0002-0358-6161 |
Resumo: | CNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico |
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2023-12-01T21:08:56Z2023-12-01T21:08:56Z2022-12-091412274715https://doi.org/10.3390/v141227471999-4915http://hdl.handle.net/1843/61649https://orcid.org/0000-0001-9469-9673https://orcid.org/0000-0002-8103-9235https://orcid.org/0000-0002-9603-455Xhttps://orcid.org/0000-0002-6607-8818https://orcid.org/0000-0001-6863-7970https://orcid.org/0000-0002-4178-0387https://orcid.org/0000-0002-0358-6161CNPq - Conselho Nacional de Desenvolvimento Científico e TecnológicoFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas GeraisCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível SuperiorFINEP - Financiadora de Estudos e Projetos, Financiadora de Estudos e ProjetosFAPERJ - Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de JaneiroSince its first identification in Brazil, the variant of concern (VOC) Gamma has been associated with increased infection and transmission rates, hospitalizations, and deaths. Minas Gerais (MG), the second-largest populated Brazilian state with more than 20 million inhabitants, observed a peak of cases and deaths in March–April 2021. We conducted a surveillance study in 1240 COVID-19-positive samples from 305 municipalities distributed across MG’s 28 Regional Health Units (RHU) between 1 March to 27 April 2021. The most common variant was the VOC Gamma (71.2%), followed by the variant of interest (VOI) zeta (12.4%) and VOC alpha (9.6%). Although the predominance of Gamma was found in most of the RHUs, clusters of Zeta and Alpha variants were observed. One Alpha-clustered RHU has a history of high human mobility from countries with Alpha predominance. Other less frequent lineages, such as P.4, P.5, and P.7, were also identified. With our genomic characterization approach, we estimated the introduction of Gamma on 7 January 2021, at RHU Belo Horizonte. Differences in mortality between the Zeta, Gamma and Alpha variants were not observed. We reinforce the importance of vaccination programs to prevent severe cases and deaths during transmission peaks.engUniversidade Federal de Minas GeraisUFMGBrasilFAR - DEPARTAMENTO DE FARMÁCIA SOCIALFARMACIA - FACULDADE DE FARMACIAVirusesSARS-CoV-2COVID-19GenomasPhylodinamicsPCR-genotypingSARS-CoV-2 spreadGenome sequencingVariantsMonitoring the Establishment of VOC Gamma in Minas Gerais, Brazil: A Retrospective Epidemiological and Genomic Surveillance Studyinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttps://www.mdpi.com/1999-4915/14/12/2747Hugo José AlvesWalyson Coelho CostaJaqueline Silva de OliveiraEva Lídia Arcoverde MedeirosCarolina Senra Alves de SouzaJuliana Wilke SalibaAndré Luiz MenezesEneida Santos de OliveiraTalita Emile Ribeiro AdelinoNatalia Rocha GuimaraesAdriana Aparecida RibeiroJoão Locke Ferreira de AraújoRennan Garcias MoreiraDanielle Alves Gomes ZauliJoice do Prado SilvaFrederico Scott Varella MaltaAlessandro Clayton de Souza FerreiraAna Valesca Fernandes Gilson SilvaPoliane Alfenas-zerbiniFlavia Oliveira de SouzaAdriano de Paula SabinoLaura do Amaral XavierPaula Luize Camargos FonsecaNatália Virtude CarobinAlex Fiorini de CarvalhoKarine Lima LourençoSantuza Maria Ribeiro TeixeiraAna Paula Salles Moura FernandesFlavio Guimarães da FonsecaJônatas Santos AbrahãoFelipe Campos de Melo IaniRodrigo Araújo Lima RodriguesRenan Pedra de SouzaFilipe Romero Rebello MoreiraRenato Santana AguiarDiego Menezes BonfimDaniel Costa QueirozLucyene MiguitaRafael Marques de SouzaVictor Emmanuel Viana Geddesapplication/pdfinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFMGinstname:Universidade Federal de Minas Gerais (UFMG)instacron:UFMGLICENSELicense.txtLicense.txttext/plain; charset=utf-82042https://repositorio.ufmg.br/bitstream/1843/61649/1/License.txtfa505098d172de0bc8864fc1287ffe22MD51ORIGINALMonitoring the Establishment of VOC Gamma in Minas Gerais, Brazil_ A Retrospective Epidemiological and Genomic Surveillance Study.pdfMonitoring the Establishment of VOC Gamma in Minas Gerais, Brazil_ A Retrospective Epidemiological and Genomic Surveillance Study.pdfapplication/pdf2136922https://repositorio.ufmg.br/bitstream/1843/61649/2/Monitoring%20the%20Establishment%20of%20VOC%20Gamma%20in%20Minas%20Gerais%2c%20Brazil_%20A%20Retrospective%20Epidemiological%20and%20Genomic%20Surveillance%20Study.pdfcbd83d7f54edf2f8b15edd6082e11b0dMD521843/616492023-12-01 18:08:56.783oai:repositorio.ufmg.br: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Repositório de PublicaçõesPUBhttps://repositorio.ufmg.br/oaiopendoar:2023-12-01T21:08:56Repositório Institucional da UFMG - Universidade Federal de Minas Gerais (UFMG)false |
dc.title.pt_BR.fl_str_mv |
Monitoring the Establishment of VOC Gamma in Minas Gerais, Brazil: A Retrospective Epidemiological and Genomic Surveillance Study |
title |
Monitoring the Establishment of VOC Gamma in Minas Gerais, Brazil: A Retrospective Epidemiological and Genomic Surveillance Study |
spellingShingle |
Monitoring the Establishment of VOC Gamma in Minas Gerais, Brazil: A Retrospective Epidemiological and Genomic Surveillance Study Hugo José Alves Phylodinamics PCR-genotyping SARS-CoV-2 spread Genome sequencing Variants SARS-CoV-2 COVID-19 Genomas |
title_short |
Monitoring the Establishment of VOC Gamma in Minas Gerais, Brazil: A Retrospective Epidemiological and Genomic Surveillance Study |
title_full |
Monitoring the Establishment of VOC Gamma in Minas Gerais, Brazil: A Retrospective Epidemiological and Genomic Surveillance Study |
title_fullStr |
Monitoring the Establishment of VOC Gamma in Minas Gerais, Brazil: A Retrospective Epidemiological and Genomic Surveillance Study |
title_full_unstemmed |
Monitoring the Establishment of VOC Gamma in Minas Gerais, Brazil: A Retrospective Epidemiological and Genomic Surveillance Study |
title_sort |
Monitoring the Establishment of VOC Gamma in Minas Gerais, Brazil: A Retrospective Epidemiological and Genomic Surveillance Study |
author |
Hugo José Alves |
author_facet |
Hugo José Alves Walyson Coelho Costa Jaqueline Silva de Oliveira Eva Lídia Arcoverde Medeiros Carolina Senra Alves de Souza Juliana Wilke Saliba André Luiz Menezes Eneida Santos de Oliveira Talita Emile Ribeiro Adelino Natalia Rocha Guimaraes Adriana Aparecida Ribeiro João Locke Ferreira de Araújo Rennan Garcias Moreira Danielle Alves Gomes Zauli Joice do Prado Silva Frederico Scott Varella Malta Alessandro Clayton de Souza Ferreira Ana Valesca Fernandes Gilson Silva Poliane Alfenas-zerbini Flavia Oliveira de Souza Adriano de Paula Sabino Laura do Amaral Xavier Paula Luize Camargos Fonseca Natália Virtude Carobin Alex Fiorini de Carvalho Karine Lima Lourenço Santuza Maria Ribeiro Teixeira Ana Paula Salles Moura Fernandes Flavio Guimarães da Fonseca Jônatas Santos Abrahão Felipe Campos de Melo Iani Rodrigo Araújo Lima Rodrigues Renan Pedra de Souza Filipe Romero Rebello Moreira Renato Santana Aguiar Diego Menezes Bonfim Daniel Costa Queiroz Lucyene Miguita Rafael Marques de Souza Victor Emmanuel Viana Geddes |
author_role |
author |
author2 |
Walyson Coelho Costa Jaqueline Silva de Oliveira Eva Lídia Arcoverde Medeiros Carolina Senra Alves de Souza Juliana Wilke Saliba André Luiz Menezes Eneida Santos de Oliveira Talita Emile Ribeiro Adelino Natalia Rocha Guimaraes Adriana Aparecida Ribeiro João Locke Ferreira de Araújo Rennan Garcias Moreira Danielle Alves Gomes Zauli Joice do Prado Silva Frederico Scott Varella Malta Alessandro Clayton de Souza Ferreira Ana Valesca Fernandes Gilson Silva Poliane Alfenas-zerbini Flavia Oliveira de Souza Adriano de Paula Sabino Laura do Amaral Xavier Paula Luize Camargos Fonseca Natália Virtude Carobin Alex Fiorini de Carvalho Karine Lima Lourenço Santuza Maria Ribeiro Teixeira Ana Paula Salles Moura Fernandes Flavio Guimarães da Fonseca Jônatas Santos Abrahão Felipe Campos de Melo Iani Rodrigo Araújo Lima Rodrigues Renan Pedra de Souza Filipe Romero Rebello Moreira Renato Santana Aguiar Diego Menezes Bonfim Daniel Costa Queiroz Lucyene Miguita Rafael Marques de Souza Victor Emmanuel Viana Geddes |
author2_role |
author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Hugo José Alves Walyson Coelho Costa Jaqueline Silva de Oliveira Eva Lídia Arcoverde Medeiros Carolina Senra Alves de Souza Juliana Wilke Saliba André Luiz Menezes Eneida Santos de Oliveira Talita Emile Ribeiro Adelino Natalia Rocha Guimaraes Adriana Aparecida Ribeiro João Locke Ferreira de Araújo Rennan Garcias Moreira Danielle Alves Gomes Zauli Joice do Prado Silva Frederico Scott Varella Malta Alessandro Clayton de Souza Ferreira Ana Valesca Fernandes Gilson Silva Poliane Alfenas-zerbini Flavia Oliveira de Souza Adriano de Paula Sabino Laura do Amaral Xavier Paula Luize Camargos Fonseca Natália Virtude Carobin Alex Fiorini de Carvalho Karine Lima Lourenço Santuza Maria Ribeiro Teixeira Ana Paula Salles Moura Fernandes Flavio Guimarães da Fonseca Jônatas Santos Abrahão Felipe Campos de Melo Iani Rodrigo Araújo Lima Rodrigues Renan Pedra de Souza Filipe Romero Rebello Moreira Renato Santana Aguiar Diego Menezes Bonfim Daniel Costa Queiroz Lucyene Miguita Rafael Marques de Souza Victor Emmanuel Viana Geddes |
dc.subject.por.fl_str_mv |
Phylodinamics PCR-genotyping SARS-CoV-2 spread Genome sequencing Variants |
topic |
Phylodinamics PCR-genotyping SARS-CoV-2 spread Genome sequencing Variants SARS-CoV-2 COVID-19 Genomas |
dc.subject.other.pt_BR.fl_str_mv |
SARS-CoV-2 COVID-19 Genomas |
description |
CNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico |
publishDate |
2022 |
dc.date.issued.fl_str_mv |
2022-12-09 |
dc.date.accessioned.fl_str_mv |
2023-12-01T21:08:56Z |
dc.date.available.fl_str_mv |
2023-12-01T21:08:56Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/1843/61649 |
dc.identifier.doi.pt_BR.fl_str_mv |
https://doi.org/10.3390/v14122747 |
dc.identifier.issn.pt_BR.fl_str_mv |
1999-4915 |
dc.identifier.orcid.pt_BR.fl_str_mv |
https://orcid.org/0000-0001-9469-9673 https://orcid.org/0000-0002-8103-9235 https://orcid.org/0000-0002-9603-455X https://orcid.org/0000-0002-6607-8818 https://orcid.org/0000-0001-6863-7970 https://orcid.org/0000-0002-4178-0387 https://orcid.org/0000-0002-0358-6161 |
url |
https://doi.org/10.3390/v14122747 http://hdl.handle.net/1843/61649 https://orcid.org/0000-0001-9469-9673 https://orcid.org/0000-0002-8103-9235 https://orcid.org/0000-0002-9603-455X https://orcid.org/0000-0002-6607-8818 https://orcid.org/0000-0001-6863-7970 https://orcid.org/0000-0002-4178-0387 https://orcid.org/0000-0002-0358-6161 |
identifier_str_mv |
1999-4915 |
dc.language.iso.fl_str_mv |
eng |
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eng |
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Viruses |
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info:eu-repo/semantics/openAccess |
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openAccess |
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Universidade Federal de Minas Gerais |
dc.publisher.initials.fl_str_mv |
UFMG |
dc.publisher.country.fl_str_mv |
Brasil |
dc.publisher.department.fl_str_mv |
FAR - DEPARTAMENTO DE FARMÁCIA SOCIAL FARMACIA - FACULDADE DE FARMACIA |
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Universidade Federal de Minas Gerais |
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reponame:Repositório Institucional da UFMG instname:Universidade Federal de Minas Gerais (UFMG) instacron:UFMG |
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