A novel wistar rat model of obesity-related nonalcoholic fatty liver disease induced by sucrose-rich diet

Detalhes bibliográficos
Autor(a) principal: Maria Luíza R. P. Lima
Data de Publicação: 2016
Outros Autores: Laura H. R. Leite, Carolina R. Gioda, Fabiola de Oliveira Paes Leme, Claudia A. Couto, Cândido C. Coimbra, Virginia H. R. Leite, Teresa Cristina A. Ferrari
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFMG
Texto Completo: https://doi.org/10.1155/2016/9127076
http://hdl.handle.net/1843/67137
https://orcid.org/0000-0002-4013-0147
Resumo: FAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Gerais
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spelling 2024-04-12T20:15:00Z2024-04-12T20:15:00Z20162016https://doi.org/10.1155/2016/91270762314-6753http://hdl.handle.net/1843/67137https://orcid.org/0000-0002-4013-0147FAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas GeraisThe pathogenesis of nonalcoholic fatty liver disease (NAFLD) is not fully understood, and experimental models are an alternative to study this issue. We investigated the effects of a simple carbohydrate-rich diet on the development of obesity-related NAFLD and the impact of physical training on the metabolic abnormalities associated with this disorder. Sixty Wistar rats were randomly separated into experimental and control groups, which were fed with sucrose-enriched (18% simple carbohydrates) and standard diet, respectively. At the end of each experimental period (5, 10, 20, and 30 weeks), 6 animals from each group were sacrificed for blood tests and liver histology and immunohistochemistry. From weeks 25 to 30, 6 animals from each group underwent physical training. The experimental group animals developed obesity and NAFLD, characterized histopathologically by steatosis and hepatocellular ballooning, clinically by increased thoracic circumference and body mass index associated with hyperleptinemia, and metabolically by hyperglycemia, hyperinsulinemia, hypertriglyceridemia, increased levels of very low-density lipoprotein- (VLDL-) cholesterol, depletion of the antioxidants liver enzymes superoxide dismutase and catalase, and increased hepatic levels of malondialdehyde, an oxidative stress marker. Rats that underwent physical training showed increased high-density lipoprotein- (HDL-) cholesterol levels. In conclusion, a sucrose-rich diet induced obesity, insulin resistance, oxidative stress, and NAFLD in rats.engUniversidade Federal de Minas GeraisUFMGBrasilICB - DEPARTAMENTO DE FISIOLOGIA E BIOFÍSICAMED - DEPARTAMENTO DE CLÍNICA MÉDICAVET - DEPARTAMENTO DE CLÍNICA E CIRURGIAJournal of Diabetes ResearchRatos WistarHepatopatia gordurosa não alcoólicaSacarose na dietaObesidadeWistar RatNonalcoholic fatty liver diseaseSucrose-rich dietObesityA novel wistar rat model of obesity-related nonalcoholic fatty liver disease induced by sucrose-rich dietinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttps://www.hindawi.com/journals/jdr/2016/9127076/Maria Luíza R. P. LimaLaura H. R. LeiteCarolina R. GiodaFabiola de Oliveira Paes LemeClaudia A. CoutoCândido C. CoimbraVirginia H. R. LeiteTeresa Cristina A. Ferrariinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFMGinstname:Universidade Federal de Minas Gerais (UFMG)instacron:UFMGLICENSELicense.txtLicense.txttext/plain; charset=utf-82042https://repositorio.ufmg.br/bitstream/1843/67137/1/License.txtfa505098d172de0bc8864fc1287ffe22MD51ORIGINALA novel wistar rat model of obesity-related nonalcoholic fatty liver disease induced by sucrose-rich diet.pdfA novel wistar rat model of obesity-related nonalcoholic fatty liver disease induced by sucrose-rich diet.pdfapplication/pdf753616https://repositorio.ufmg.br/bitstream/1843/67137/2/A%20novel%20wistar%20rat%20model%20of%20obesity-related%20nonalcoholic%20fatty%20liver%20disease%20induced%20by%20sucrose-rich%20diet.pdfd37169307e086595ae1888e8da72af82MD521843/671372024-04-12 17:15:01.683oai:repositorio.ufmg.br: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Repositório de PublicaçõesPUBhttps://repositorio.ufmg.br/oaiopendoar:2024-04-12T20:15:01Repositório Institucional da UFMG - Universidade Federal de Minas Gerais (UFMG)false
dc.title.pt_BR.fl_str_mv A novel wistar rat model of obesity-related nonalcoholic fatty liver disease induced by sucrose-rich diet
title A novel wistar rat model of obesity-related nonalcoholic fatty liver disease induced by sucrose-rich diet
spellingShingle A novel wistar rat model of obesity-related nonalcoholic fatty liver disease induced by sucrose-rich diet
Maria Luíza R. P. Lima
Wistar Rat
Nonalcoholic fatty liver disease
Sucrose-rich diet
Obesity
Ratos Wistar
Hepatopatia gordurosa não alcoólica
Sacarose na dieta
Obesidade
title_short A novel wistar rat model of obesity-related nonalcoholic fatty liver disease induced by sucrose-rich diet
title_full A novel wistar rat model of obesity-related nonalcoholic fatty liver disease induced by sucrose-rich diet
title_fullStr A novel wistar rat model of obesity-related nonalcoholic fatty liver disease induced by sucrose-rich diet
title_full_unstemmed A novel wistar rat model of obesity-related nonalcoholic fatty liver disease induced by sucrose-rich diet
title_sort A novel wistar rat model of obesity-related nonalcoholic fatty liver disease induced by sucrose-rich diet
author Maria Luíza R. P. Lima
author_facet Maria Luíza R. P. Lima
Laura H. R. Leite
Carolina R. Gioda
Fabiola de Oliveira Paes Leme
Claudia A. Couto
Cândido C. Coimbra
Virginia H. R. Leite
Teresa Cristina A. Ferrari
author_role author
author2 Laura H. R. Leite
Carolina R. Gioda
Fabiola de Oliveira Paes Leme
Claudia A. Couto
Cândido C. Coimbra
Virginia H. R. Leite
Teresa Cristina A. Ferrari
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Maria Luíza R. P. Lima
Laura H. R. Leite
Carolina R. Gioda
Fabiola de Oliveira Paes Leme
Claudia A. Couto
Cândido C. Coimbra
Virginia H. R. Leite
Teresa Cristina A. Ferrari
dc.subject.por.fl_str_mv Wistar Rat
Nonalcoholic fatty liver disease
Sucrose-rich diet
Obesity
topic Wistar Rat
Nonalcoholic fatty liver disease
Sucrose-rich diet
Obesity
Ratos Wistar
Hepatopatia gordurosa não alcoólica
Sacarose na dieta
Obesidade
dc.subject.other.pt_BR.fl_str_mv Ratos Wistar
Hepatopatia gordurosa não alcoólica
Sacarose na dieta
Obesidade
description FAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Gerais
publishDate 2016
dc.date.issued.fl_str_mv 2016
dc.date.accessioned.fl_str_mv 2024-04-12T20:15:00Z
dc.date.available.fl_str_mv 2024-04-12T20:15:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/1843/67137
dc.identifier.doi.pt_BR.fl_str_mv https://doi.org/10.1155/2016/9127076
dc.identifier.issn.pt_BR.fl_str_mv 2314-6753
dc.identifier.orcid.pt_BR.fl_str_mv https://orcid.org/0000-0002-4013-0147
url https://doi.org/10.1155/2016/9127076
http://hdl.handle.net/1843/67137
https://orcid.org/0000-0002-4013-0147
identifier_str_mv 2314-6753
dc.language.iso.fl_str_mv eng
language eng
dc.relation.ispartof.pt_BR.fl_str_mv Journal of Diabetes Research
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Universidade Federal de Minas Gerais
dc.publisher.initials.fl_str_mv UFMG
dc.publisher.country.fl_str_mv Brasil
dc.publisher.department.fl_str_mv ICB - DEPARTAMENTO DE FISIOLOGIA E BIOFÍSICA
MED - DEPARTAMENTO DE CLÍNICA MÉDICA
VET - DEPARTAMENTO DE CLÍNICA E CIRURGIA
publisher.none.fl_str_mv Universidade Federal de Minas Gerais
dc.source.none.fl_str_mv reponame:Repositório Institucional da UFMG
instname:Universidade Federal de Minas Gerais (UFMG)
instacron:UFMG
instname_str Universidade Federal de Minas Gerais (UFMG)
instacron_str UFMG
institution UFMG
reponame_str Repositório Institucional da UFMG
collection Repositório Institucional da UFMG
bitstream.url.fl_str_mv https://repositorio.ufmg.br/bitstream/1843/67137/1/License.txt
https://repositorio.ufmg.br/bitstream/1843/67137/2/A%20novel%20wistar%20rat%20model%20of%20obesity-related%20nonalcoholic%20fatty%20liver%20disease%20induced%20by%20sucrose-rich%20diet.pdf
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repository.name.fl_str_mv Repositório Institucional da UFMG - Universidade Federal de Minas Gerais (UFMG)
repository.mail.fl_str_mv
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