Inflammaging in endemic areas for infectious diseases
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2020 |
| Outros Autores: | , , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da UFMG |
| Texto Completo: | https://doi.org/10.3389/fimmu.2020.579972 http://hdl.handle.net/1843/66192 https://orcid.org/0000-0002-7538-3208 |
Resumo: | CNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico |
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2024-03-20T20:10:02Z2024-03-20T20:10:02Z2020-11-111157997218https://doi.org/10.3389/fimmu.2020.5799721664-3224http://hdl.handle.net/1843/66192https://orcid.org/0000-0002-7538-3208CNPq - Conselho Nacional de Desenvolvimento Científico e TecnológicoFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas GeraisImmunosenescence is marked by a systemic process named inflammaging along with a series of defects in the immunological activity that results in poor responses to infectious agents and to vaccination. Inflammaging, a state of low-grade chronic inflammation, usually leads to chronic inflammatory diseases and frailty in the elderly. However, some elderly escape from frailty and reach advanced age free of the consequences of inflammaging. This process has been called immunological remodeling, and it is the hallmark of healthy aging as described in the studies of centenarians in Italy. The biological markers of healthy aging are still a matter of debate, and the studies on the topic have focused on inflammatory versus remodeling processes and molecules. The sub-clinical inflammatory status associated with aging might be a deleterious event for populations living in countries where chronic infectious diseases are not prevalent. Nevertheless, in other parts of the world where they are, two possibilities may occur. Inflammatory responses may have a protective effect against these infectious agents. At the same time, the long-term consequences of protective immune responses during chronic infections may result in accelerated immunosenescence in these individuals. Therefore, the biological markers of healthy aging can vary according to environmental, cultural, and geographical settings that reflect worldwide, and in a non-biased, non-westernized perspective, the changes that we experience regarding our contacts with microorganisms and the outcomes of such contactsengUniversidade Federal de Minas GeraisUFMGBrasilENF - DEPARTAMENTO DE NUTRIÇÃOENFERMAGEM - ESCOLA DE ENFERMAGEMICB - DEPARTAMENTO DE BIOQUÍMICA E IMUNOLOGIAMED - DEPARTAMENTO DE CLÍNICA MÉDICAFrontiers in ImmunologyDietaInflamaçãoMicrobiotaGenéticaInfecção PersistenteEnvelhecimentoAgingInflammationChronic infectionGeneticsMicrobiotaDietary componentsInflammagingInflammaging in endemic areas for infectious diseasesinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttps://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2020.579972/fullMarina Andrade BatistaTatiani Uceli MaioliRodrigo Ribeiro Dos SantosPatrizia BrigidiClaudio FranceschiAna Maria Caetano FariaFernanda Calvo-fortesGabriela Silveira-nunesGiovanna Caliman CamattaElaine SpezialiSilvia TurroniAndrea Teixeira-carvalhoOlindo A. Martins-FilhoNicola Nerettiapplication/pdfinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFMGinstname:Universidade Federal de Minas Gerais (UFMG)instacron:UFMGLICENSELicense.txtLicense.txttext/plain; charset=utf-82042https://repositorio.ufmg.br/bitstream/1843/66192/1/License.txtfa505098d172de0bc8864fc1287ffe22MD51ORIGINALInflammaging in Endemic Areas for Infectious Diseases.pdfInflammaging in Endemic Areas for Infectious Diseases.pdfapplication/pdf552215https://repositorio.ufmg.br/bitstream/1843/66192/2/Inflammaging%20in%20Endemic%20Areas%20for%20Infectious%20Diseases.pdfcf557e2e330cc6fbb3b591b12d0b8d7dMD521843/661922024-03-20 17:10:02.556oai:repositorio.ufmg.br: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Repositório de PublicaçõesPUBhttps://repositorio.ufmg.br/oaiopendoar:2024-03-20T20:10:02Repositório Institucional da UFMG - Universidade Federal de Minas Gerais (UFMG)false |
| dc.title.pt_BR.fl_str_mv |
Inflammaging in endemic areas for infectious diseases |
| title |
Inflammaging in endemic areas for infectious diseases |
| spellingShingle |
Inflammaging in endemic areas for infectious diseases Marina Andrade Batista Aging Inflammation Chronic infection Genetics Microbiota Dietary components Inflammaging Dieta Inflamação Microbiota Genética Infecção Persistente Envelhecimento |
| title_short |
Inflammaging in endemic areas for infectious diseases |
| title_full |
Inflammaging in endemic areas for infectious diseases |
| title_fullStr |
Inflammaging in endemic areas for infectious diseases |
| title_full_unstemmed |
Inflammaging in endemic areas for infectious diseases |
| title_sort |
Inflammaging in endemic areas for infectious diseases |
| author |
Marina Andrade Batista |
| author_facet |
Marina Andrade Batista Tatiani Uceli Maioli Rodrigo Ribeiro Dos Santos Patrizia Brigidi Claudio Franceschi Ana Maria Caetano Faria Fernanda Calvo-fortes Gabriela Silveira-nunes Giovanna Caliman Camatta Elaine Speziali Silvia Turroni Andrea Teixeira-carvalho Olindo A. Martins-Filho Nicola Neretti |
| author_role |
author |
| author2 |
Tatiani Uceli Maioli Rodrigo Ribeiro Dos Santos Patrizia Brigidi Claudio Franceschi Ana Maria Caetano Faria Fernanda Calvo-fortes Gabriela Silveira-nunes Giovanna Caliman Camatta Elaine Speziali Silvia Turroni Andrea Teixeira-carvalho Olindo A. Martins-Filho Nicola Neretti |
| author2_role |
author author author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Marina Andrade Batista Tatiani Uceli Maioli Rodrigo Ribeiro Dos Santos Patrizia Brigidi Claudio Franceschi Ana Maria Caetano Faria Fernanda Calvo-fortes Gabriela Silveira-nunes Giovanna Caliman Camatta Elaine Speziali Silvia Turroni Andrea Teixeira-carvalho Olindo A. Martins-Filho Nicola Neretti |
| dc.subject.por.fl_str_mv |
Aging Inflammation Chronic infection Genetics Microbiota Dietary components Inflammaging |
| topic |
Aging Inflammation Chronic infection Genetics Microbiota Dietary components Inflammaging Dieta Inflamação Microbiota Genética Infecção Persistente Envelhecimento |
| dc.subject.other.pt_BR.fl_str_mv |
Dieta Inflamação Microbiota Genética Infecção Persistente Envelhecimento |
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CNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico |
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2020 |
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2020-11-11 |
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2024-03-20T20:10:02Z |
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2024-03-20T20:10:02Z |
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https://doi.org/10.3389/fimmu.2020.579972 |
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1664-3224 |
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Frontiers in Immunology |
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