Involvement of oxidative stress and nitric oxide in fibromyalgia pathophysiology: a relationship to be elucidated.
Autor(a) principal: | |
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Data de Publicação: | 2016 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFMG |
Texto Completo: | http://hdl.handle.net/1843/61999 |
Resumo: | Fibromyalgia (FM) is a rheumatic syndrome characterized by chronic widespread pain that is often associated with other signs and symptoms such as sleep disturbances, headache, fatigue and morning stiffness. To date, the pathogenesis of fibromyalgia is unknown, several studies have been conducted in or to clarify it. Genetic and psychological abnormalities, dysfunctions of the central nervous system, endocrine and immunological disorders as well as abnormalities of the peripheral microcirculation have been identified in FM patients, demonstrating that many factors may interact in the pathogenesis of this condition. Recent research suggest that oxidative stress (OS) and nitric oxide (NO) may be directly involved in the pathophysiology of this syndrome, however, the mechanism by which such interference takes place is not fully elucidated. Currently, there is an increasing number of research papers that demonstrate both, altered concentrations of oxidants resulting from the OS mechanism, and antioxidants as for example NO among patients with FM. Thus, the purpose of this review was to gather and organize part of the information available about the participation of NO in the OS in the symptoms of FM. |
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2023-12-14T19:57:38Z2023-12-14T19:57:38Z201611171000105http://hdl.handle.net/1843/61999Fibromyalgia (FM) is a rheumatic syndrome characterized by chronic widespread pain that is often associated with other signs and symptoms such as sleep disturbances, headache, fatigue and morning stiffness. To date, the pathogenesis of fibromyalgia is unknown, several studies have been conducted in or to clarify it. Genetic and psychological abnormalities, dysfunctions of the central nervous system, endocrine and immunological disorders as well as abnormalities of the peripheral microcirculation have been identified in FM patients, demonstrating that many factors may interact in the pathogenesis of this condition. Recent research suggest that oxidative stress (OS) and nitric oxide (NO) may be directly involved in the pathophysiology of this syndrome, however, the mechanism by which such interference takes place is not fully elucidated. Currently, there is an increasing number of research papers that demonstrate both, altered concentrations of oxidants resulting from the OS mechanism, and antioxidants as for example NO among patients with FM. Thus, the purpose of this review was to gather and organize part of the information available about the participation of NO in the OS in the symptoms of FM.A fibromialgia (FM) é uma síndrome reumática caracterizada por dor crônica generalizada que está frequentemente associada a outros sinais e sintomas, como distúrbios do sono, dor de cabeça, fadiga e rigidez matinal. Até o momento, a patogênese da fibromialgia é desconhecida, vários estudos foram realizados para esclarecê-la. Anormalidades genéticas e psicológicas, disfunções do sistema nervoso central, distúrbios endócrinos e imunológicos, bem como anormalidades da microcirculação periférica foram identificadas em pacientes com FM, demonstrando que muitos fatores podem interagir na patogênese desta condição. Pesquisas recentes sugerem que o estresse oxidativo (EO) e o óxido nítrico (NO) podem estar diretamente envolvidos na fisiopatologia desta síndrome, porém, o mecanismo pelo qual tal interferência ocorre não está totalmente elucidado. Atualmente, há um número crescente de trabalhos de pesquisa que demonstram concentrações alteradas de oxidantes resultantes do mecanismo OS e antioxidantes como, por exemplo, NO entre pacientes com FM. Assim, o objetivo desta revisão foi reunir e organizar parte da informação disponível sobre a participação do NO no EO nos sintomas da FM.engUniversidade Federal de Minas GeraisUFMGBrasilICB - DEPARTAMENTO DE MORFOLOGIAFibromyalgia: Open AccessFibromialgiaÓxido nítricoEstresse oxidativoFibromyalgiaNitric oxideOxidative stressInvolvement of oxidative stress and nitric oxide in fibromyalgia pathophysiology: a relationship to be elucidated.Envolvimento do estresse oxidativo e do óxido nítrico na fisiopatologia da fibromialgia: uma relação a ser elucidada.info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttps://www.omicsonline.org/open-access/involvement-of-oxidative-stress-and-nitric-oxide-in-fibromyalgiapathophysiology-a-relationship-to-be-elucidated-foa-1000105.php?aid=69176Andrei Pereira PernambucoLuana Pereira Leite SchetinoLuciana de Souza Cota CarvalhoDebora Davila Reisapplication/pdfinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFMGinstname:Universidade Federal de Minas Gerais (UFMG)instacron:UFMGLICENSELicense.txtLicense.txttext/plain; charset=utf-82042https://repositorio.ufmg.br/bitstream/1843/61999/1/License.txtfa505098d172de0bc8864fc1287ffe22MD51ORIGINALInvolvement of Oxidative Stress and Nitric Oxide in Fibromyalgia Pathophysiology A Relationship to be Elucidated.pdfInvolvement of Oxidative Stress and Nitric Oxide in Fibromyalgia Pathophysiology A Relationship to be Elucidated.pdfapplication/pdf471036https://repositorio.ufmg.br/bitstream/1843/61999/2/Involvement%20of%20Oxidative%20Stress%20and%20Nitric%20Oxide%20in%20Fibromyalgia%20Pathophysiology%20A%20Relationship%20to%20be%20Elucidated.pdfd80532b8522bed8ee418967430d33b01MD521843/619992023-12-14 17:26:41.459oai:repositorio.ufmg.br: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Repositório de PublicaçõesPUBhttps://repositorio.ufmg.br/oaiopendoar:2023-12-14T20:26:41Repositório Institucional da UFMG - Universidade Federal de Minas Gerais (UFMG)false |
dc.title.pt_BR.fl_str_mv |
Involvement of oxidative stress and nitric oxide in fibromyalgia pathophysiology: a relationship to be elucidated. |
dc.title.alternative.pt_BR.fl_str_mv |
Envolvimento do estresse oxidativo e do óxido nítrico na fisiopatologia da fibromialgia: uma relação a ser elucidada. |
title |
Involvement of oxidative stress and nitric oxide in fibromyalgia pathophysiology: a relationship to be elucidated. |
spellingShingle |
Involvement of oxidative stress and nitric oxide in fibromyalgia pathophysiology: a relationship to be elucidated. Andrei Pereira Pernambuco Fibromyalgia Nitric oxide Oxidative stress Fibromialgia Óxido nítrico Estresse oxidativo |
title_short |
Involvement of oxidative stress and nitric oxide in fibromyalgia pathophysiology: a relationship to be elucidated. |
title_full |
Involvement of oxidative stress and nitric oxide in fibromyalgia pathophysiology: a relationship to be elucidated. |
title_fullStr |
Involvement of oxidative stress and nitric oxide in fibromyalgia pathophysiology: a relationship to be elucidated. |
title_full_unstemmed |
Involvement of oxidative stress and nitric oxide in fibromyalgia pathophysiology: a relationship to be elucidated. |
title_sort |
Involvement of oxidative stress and nitric oxide in fibromyalgia pathophysiology: a relationship to be elucidated. |
author |
Andrei Pereira Pernambuco |
author_facet |
Andrei Pereira Pernambuco Luana Pereira Leite Schetino Luciana de Souza Cota Carvalho Debora Davila Reis |
author_role |
author |
author2 |
Luana Pereira Leite Schetino Luciana de Souza Cota Carvalho Debora Davila Reis |
author2_role |
author author author |
dc.contributor.author.fl_str_mv |
Andrei Pereira Pernambuco Luana Pereira Leite Schetino Luciana de Souza Cota Carvalho Debora Davila Reis |
dc.subject.por.fl_str_mv |
Fibromyalgia Nitric oxide Oxidative stress |
topic |
Fibromyalgia Nitric oxide Oxidative stress Fibromialgia Óxido nítrico Estresse oxidativo |
dc.subject.other.pt_BR.fl_str_mv |
Fibromialgia Óxido nítrico Estresse oxidativo |
description |
Fibromyalgia (FM) is a rheumatic syndrome characterized by chronic widespread pain that is often associated with other signs and symptoms such as sleep disturbances, headache, fatigue and morning stiffness. To date, the pathogenesis of fibromyalgia is unknown, several studies have been conducted in or to clarify it. Genetic and psychological abnormalities, dysfunctions of the central nervous system, endocrine and immunological disorders as well as abnormalities of the peripheral microcirculation have been identified in FM patients, demonstrating that many factors may interact in the pathogenesis of this condition. Recent research suggest that oxidative stress (OS) and nitric oxide (NO) may be directly involved in the pathophysiology of this syndrome, however, the mechanism by which such interference takes place is not fully elucidated. Currently, there is an increasing number of research papers that demonstrate both, altered concentrations of oxidants resulting from the OS mechanism, and antioxidants as for example NO among patients with FM. Thus, the purpose of this review was to gather and organize part of the information available about the participation of NO in the OS in the symptoms of FM. |
publishDate |
2016 |
dc.date.issued.fl_str_mv |
2016 |
dc.date.accessioned.fl_str_mv |
2023-12-14T19:57:38Z |
dc.date.available.fl_str_mv |
2023-12-14T19:57:38Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
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article |
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publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/1843/61999 |
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1000105 |
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1000105 |
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http://hdl.handle.net/1843/61999 |
dc.language.iso.fl_str_mv |
eng |
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eng |
dc.relation.ispartof.none.fl_str_mv |
Fibromyalgia: Open Access |
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info:eu-repo/semantics/openAccess |
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openAccess |
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application/pdf |
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Universidade Federal de Minas Gerais |
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UFMG |
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Brasil |
dc.publisher.department.fl_str_mv |
ICB - DEPARTAMENTO DE MORFOLOGIA |
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Universidade Federal de Minas Gerais |
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