Ação probiótica da levedura Saccharomyces boulardii

Detalhes bibliográficos
Autor(a) principal: Silvia Helena Sousa Pietra Pedroso
Data de Publicação: 2011
Tipo de documento: Trabalho de conclusão de curso
Idioma: por
Título da fonte: Repositório Institucional da UFMG
Texto Completo: http://hdl.handle.net/1843/BUOS-99VFQB
Resumo: The microorganisms which when administered in sufficient amounts, confer health benefits of the host are called probiotics. These microorganisms are used in pharmaceutical preparations or fermented products. Saccharomyces boulardii, a nonpathogenic yeast, was isolated from lychee fruit in Indochina, and grows at 37 °C. It has been used to treat different kinds of diarrhea, like: antibiotics associated diarrhea, Clostridium difficile-associated diarrhea, traveler's diarrhea and diarrhea in HIV-infected patients. In the present study, was assessed the current knowledge about the beneficial effects of S. boulardii in diseases of the gastrointestinal tract and the mechanisms of action of this probiotic. It has been shown that this yeast has proven clinical efficacy and presents different mechanisms of action, which can be classified into three main areas: action in the lumen, trophic actions and effects of anti-inflammatory signaling in the mucosa. However, although yeast have proven clinical effectiveness in the prevention and treatment of diarrhea, the claim that probiotics have a beneficial effect on the host, requires rigorous evaluation and their mechanisms of action need to be better understood before any final statement on the clinical value of these products in the pharmaceutical and food industries.
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spelling Ação probiótica da levedura Saccharomyces boulardiiMecanismos de açãoProbióticosS boulardiiMicrobiologiaSaccharomyces boulardiiProbióticosLeveduras (Fungos)The microorganisms which when administered in sufficient amounts, confer health benefits of the host are called probiotics. These microorganisms are used in pharmaceutical preparations or fermented products. Saccharomyces boulardii, a nonpathogenic yeast, was isolated from lychee fruit in Indochina, and grows at 37 °C. It has been used to treat different kinds of diarrhea, like: antibiotics associated diarrhea, Clostridium difficile-associated diarrhea, traveler's diarrhea and diarrhea in HIV-infected patients. In the present study, was assessed the current knowledge about the beneficial effects of S. boulardii in diseases of the gastrointestinal tract and the mechanisms of action of this probiotic. It has been shown that this yeast has proven clinical efficacy and presents different mechanisms of action, which can be classified into three main areas: action in the lumen, trophic actions and effects of anti-inflammatory signaling in the mucosa. However, although yeast have proven clinical effectiveness in the prevention and treatment of diarrhea, the claim that probiotics have a beneficial effect on the host, requires rigorous evaluation and their mechanisms of action need to be better understood before any final statement on the clinical value of these products in the pharmaceutical and food industries.Os micro-organismos vivos que, quando administrados em quantidadesuficiente, conferem benefício à saúde do hospedeiro são denominados probióticos. Tais micro-organismos são utilizados em preparações farmacêuticas ou produtos fermentados. Saccharomyces boulardii, uma levedura não patogênica, foi isolada da fruta lichia, na Indochina, e cresce na temperatura de 37°C. Ela tem sido utilizada para o tratamento de diferentes tipos de diarréias como: diarréia associada ao uso de antibióticos, diarréia associada ao Clostridium difficile, diarréia do viajante e diarréia em pacientes infectados pelo HIV. No presente estudo, foi avaliado o atual conhecimento sobre os efeitos benéficos que S. boulardii possui nas doenças do trato gastrointestinal e os mecanismos de ação desse probiótico. Foi demonstrado que essa levedura apresenta eficácia clínica comprovada e que possui diferentestipos de mecanismos de ação, que por sua vez, podem ser classificados em três áreas principais: ação no lúmen, ação trófica e efeitos de sinalização antiinflamatórios na mucosa. No entanto, apesar da levedura apresentar eficiência clínica comprovada na prevenção e tratamento de diarréias, a afirmação de que os probióticos possuem efeito benéfico para o hospedeiro, necessita de avaliação rigorosa e seus mecanismos de ação precisam ser mais bem compreendidos antes de qualquer declaração final sobre o valor clínico destes produtos disponíveis na indústria farmacêutica e alimentícia.Universidade Federal de Minas GeraisUFMGFlaviano dos Santos MartinsSilvia Helena Sousa Pietra Pedroso2019-08-12T00:31:53Z2019-08-12T00:31:53Z2011-12-20info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/bachelorThesisapplication/pdfhttp://hdl.handle.net/1843/BUOS-99VFQBinfo:eu-repo/semantics/openAccessporreponame:Repositório Institucional da UFMGinstname:Universidade Federal de Minas Gerais (UFMG)instacron:UFMG2019-11-14T10:07:53Zoai:repositorio.ufmg.br:1843/BUOS-99VFQBRepositório InstitucionalPUBhttps://repositorio.ufmg.br/oairepositorio@ufmg.bropendoar:2019-11-14T10:07:53Repositório Institucional da UFMG - Universidade Federal de Minas Gerais (UFMG)false
dc.title.none.fl_str_mv Ação probiótica da levedura Saccharomyces boulardii
title Ação probiótica da levedura Saccharomyces boulardii
spellingShingle Ação probiótica da levedura Saccharomyces boulardii
Silvia Helena Sousa Pietra Pedroso
Mecanismos de ação
Probióticos
S boulardii
Microbiologia
Saccharomyces boulardii
Probióticos
Leveduras (Fungos)
title_short Ação probiótica da levedura Saccharomyces boulardii
title_full Ação probiótica da levedura Saccharomyces boulardii
title_fullStr Ação probiótica da levedura Saccharomyces boulardii
title_full_unstemmed Ação probiótica da levedura Saccharomyces boulardii
title_sort Ação probiótica da levedura Saccharomyces boulardii
author Silvia Helena Sousa Pietra Pedroso
author_facet Silvia Helena Sousa Pietra Pedroso
author_role author
dc.contributor.none.fl_str_mv Flaviano dos Santos Martins
dc.contributor.author.fl_str_mv Silvia Helena Sousa Pietra Pedroso
dc.subject.por.fl_str_mv Mecanismos de ação
Probióticos
S boulardii
Microbiologia
Saccharomyces boulardii
Probióticos
Leveduras (Fungos)
topic Mecanismos de ação
Probióticos
S boulardii
Microbiologia
Saccharomyces boulardii
Probióticos
Leveduras (Fungos)
description The microorganisms which when administered in sufficient amounts, confer health benefits of the host are called probiotics. These microorganisms are used in pharmaceutical preparations or fermented products. Saccharomyces boulardii, a nonpathogenic yeast, was isolated from lychee fruit in Indochina, and grows at 37 °C. It has been used to treat different kinds of diarrhea, like: antibiotics associated diarrhea, Clostridium difficile-associated diarrhea, traveler's diarrhea and diarrhea in HIV-infected patients. In the present study, was assessed the current knowledge about the beneficial effects of S. boulardii in diseases of the gastrointestinal tract and the mechanisms of action of this probiotic. It has been shown that this yeast has proven clinical efficacy and presents different mechanisms of action, which can be classified into three main areas: action in the lumen, trophic actions and effects of anti-inflammatory signaling in the mucosa. However, although yeast have proven clinical effectiveness in the prevention and treatment of diarrhea, the claim that probiotics have a beneficial effect on the host, requires rigorous evaluation and their mechanisms of action need to be better understood before any final statement on the clinical value of these products in the pharmaceutical and food industries.
publishDate 2011
dc.date.none.fl_str_mv 2011-12-20
2019-08-12T00:31:53Z
2019-08-12T00:31:53Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/bachelorThesis
format bachelorThesis
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/1843/BUOS-99VFQB
url http://hdl.handle.net/1843/BUOS-99VFQB
dc.language.iso.fl_str_mv por
language por
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Universidade Federal de Minas Gerais
UFMG
publisher.none.fl_str_mv Universidade Federal de Minas Gerais
UFMG
dc.source.none.fl_str_mv reponame:Repositório Institucional da UFMG
instname:Universidade Federal de Minas Gerais (UFMG)
instacron:UFMG
instname_str Universidade Federal de Minas Gerais (UFMG)
instacron_str UFMG
institution UFMG
reponame_str Repositório Institucional da UFMG
collection Repositório Institucional da UFMG
repository.name.fl_str_mv Repositório Institucional da UFMG - Universidade Federal de Minas Gerais (UFMG)
repository.mail.fl_str_mv repositorio@ufmg.br
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