Ação probiótica da levedura Saccharomyces boulardii
Autor(a) principal: | |
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Data de Publicação: | 2011 |
Tipo de documento: | Trabalho de conclusão de curso |
Idioma: | por |
Título da fonte: | Repositório Institucional da UFMG |
Texto Completo: | http://hdl.handle.net/1843/BUOS-99VFQB |
Resumo: | The microorganisms which when administered in sufficient amounts, confer health benefits of the host are called probiotics. These microorganisms are used in pharmaceutical preparations or fermented products. Saccharomyces boulardii, a nonpathogenic yeast, was isolated from lychee fruit in Indochina, and grows at 37 °C. It has been used to treat different kinds of diarrhea, like: antibiotics associated diarrhea, Clostridium difficile-associated diarrhea, traveler's diarrhea and diarrhea in HIV-infected patients. In the present study, was assessed the current knowledge about the beneficial effects of S. boulardii in diseases of the gastrointestinal tract and the mechanisms of action of this probiotic. It has been shown that this yeast has proven clinical efficacy and presents different mechanisms of action, which can be classified into three main areas: action in the lumen, trophic actions and effects of anti-inflammatory signaling in the mucosa. However, although yeast have proven clinical effectiveness in the prevention and treatment of diarrhea, the claim that probiotics have a beneficial effect on the host, requires rigorous evaluation and their mechanisms of action need to be better understood before any final statement on the clinical value of these products in the pharmaceutical and food industries. |
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Ação probiótica da levedura Saccharomyces boulardiiMecanismos de açãoProbióticosS boulardiiMicrobiologiaSaccharomyces boulardiiProbióticosLeveduras (Fungos)The microorganisms which when administered in sufficient amounts, confer health benefits of the host are called probiotics. These microorganisms are used in pharmaceutical preparations or fermented products. Saccharomyces boulardii, a nonpathogenic yeast, was isolated from lychee fruit in Indochina, and grows at 37 °C. It has been used to treat different kinds of diarrhea, like: antibiotics associated diarrhea, Clostridium difficile-associated diarrhea, traveler's diarrhea and diarrhea in HIV-infected patients. In the present study, was assessed the current knowledge about the beneficial effects of S. boulardii in diseases of the gastrointestinal tract and the mechanisms of action of this probiotic. It has been shown that this yeast has proven clinical efficacy and presents different mechanisms of action, which can be classified into three main areas: action in the lumen, trophic actions and effects of anti-inflammatory signaling in the mucosa. However, although yeast have proven clinical effectiveness in the prevention and treatment of diarrhea, the claim that probiotics have a beneficial effect on the host, requires rigorous evaluation and their mechanisms of action need to be better understood before any final statement on the clinical value of these products in the pharmaceutical and food industries.Os micro-organismos vivos que, quando administrados em quantidadesuficiente, conferem benefício à saúde do hospedeiro são denominados probióticos. Tais micro-organismos são utilizados em preparações farmacêuticas ou produtos fermentados. Saccharomyces boulardii, uma levedura não patogênica, foi isolada da fruta lichia, na Indochina, e cresce na temperatura de 37°C. Ela tem sido utilizada para o tratamento de diferentes tipos de diarréias como: diarréia associada ao uso de antibióticos, diarréia associada ao Clostridium difficile, diarréia do viajante e diarréia em pacientes infectados pelo HIV. No presente estudo, foi avaliado o atual conhecimento sobre os efeitos benéficos que S. boulardii possui nas doenças do trato gastrointestinal e os mecanismos de ação desse probiótico. Foi demonstrado que essa levedura apresenta eficácia clínica comprovada e que possui diferentestipos de mecanismos de ação, que por sua vez, podem ser classificados em três áreas principais: ação no lúmen, ação trófica e efeitos de sinalização antiinflamatórios na mucosa. No entanto, apesar da levedura apresentar eficiência clínica comprovada na prevenção e tratamento de diarréias, a afirmação de que os probióticos possuem efeito benéfico para o hospedeiro, necessita de avaliação rigorosa e seus mecanismos de ação precisam ser mais bem compreendidos antes de qualquer declaração final sobre o valor clínico destes produtos disponíveis na indústria farmacêutica e alimentícia.Universidade Federal de Minas GeraisUFMGFlaviano dos Santos MartinsSilvia Helena Sousa Pietra Pedroso2019-08-12T00:31:53Z2019-08-12T00:31:53Z2011-12-20info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/bachelorThesisapplication/pdfhttp://hdl.handle.net/1843/BUOS-99VFQBinfo:eu-repo/semantics/openAccessporreponame:Repositório Institucional da UFMGinstname:Universidade Federal de Minas Gerais (UFMG)instacron:UFMG2019-11-14T10:07:53Zoai:repositorio.ufmg.br:1843/BUOS-99VFQBRepositório InstitucionalPUBhttps://repositorio.ufmg.br/oairepositorio@ufmg.bropendoar:2019-11-14T10:07:53Repositório Institucional da UFMG - Universidade Federal de Minas Gerais (UFMG)false |
dc.title.none.fl_str_mv |
Ação probiótica da levedura Saccharomyces boulardii |
title |
Ação probiótica da levedura Saccharomyces boulardii |
spellingShingle |
Ação probiótica da levedura Saccharomyces boulardii Silvia Helena Sousa Pietra Pedroso Mecanismos de ação Probióticos S boulardii Microbiologia Saccharomyces boulardii Probióticos Leveduras (Fungos) |
title_short |
Ação probiótica da levedura Saccharomyces boulardii |
title_full |
Ação probiótica da levedura Saccharomyces boulardii |
title_fullStr |
Ação probiótica da levedura Saccharomyces boulardii |
title_full_unstemmed |
Ação probiótica da levedura Saccharomyces boulardii |
title_sort |
Ação probiótica da levedura Saccharomyces boulardii |
author |
Silvia Helena Sousa Pietra Pedroso |
author_facet |
Silvia Helena Sousa Pietra Pedroso |
author_role |
author |
dc.contributor.none.fl_str_mv |
Flaviano dos Santos Martins |
dc.contributor.author.fl_str_mv |
Silvia Helena Sousa Pietra Pedroso |
dc.subject.por.fl_str_mv |
Mecanismos de ação Probióticos S boulardii Microbiologia Saccharomyces boulardii Probióticos Leveduras (Fungos) |
topic |
Mecanismos de ação Probióticos S boulardii Microbiologia Saccharomyces boulardii Probióticos Leveduras (Fungos) |
description |
The microorganisms which when administered in sufficient amounts, confer health benefits of the host are called probiotics. These microorganisms are used in pharmaceutical preparations or fermented products. Saccharomyces boulardii, a nonpathogenic yeast, was isolated from lychee fruit in Indochina, and grows at 37 °C. It has been used to treat different kinds of diarrhea, like: antibiotics associated diarrhea, Clostridium difficile-associated diarrhea, traveler's diarrhea and diarrhea in HIV-infected patients. In the present study, was assessed the current knowledge about the beneficial effects of S. boulardii in diseases of the gastrointestinal tract and the mechanisms of action of this probiotic. It has been shown that this yeast has proven clinical efficacy and presents different mechanisms of action, which can be classified into three main areas: action in the lumen, trophic actions and effects of anti-inflammatory signaling in the mucosa. However, although yeast have proven clinical effectiveness in the prevention and treatment of diarrhea, the claim that probiotics have a beneficial effect on the host, requires rigorous evaluation and their mechanisms of action need to be better understood before any final statement on the clinical value of these products in the pharmaceutical and food industries. |
publishDate |
2011 |
dc.date.none.fl_str_mv |
2011-12-20 2019-08-12T00:31:53Z 2019-08-12T00:31:53Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/bachelorThesis |
format |
bachelorThesis |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/1843/BUOS-99VFQB |
url |
http://hdl.handle.net/1843/BUOS-99VFQB |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Universidade Federal de Minas Gerais UFMG |
publisher.none.fl_str_mv |
Universidade Federal de Minas Gerais UFMG |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UFMG instname:Universidade Federal de Minas Gerais (UFMG) instacron:UFMG |
instname_str |
Universidade Federal de Minas Gerais (UFMG) |
instacron_str |
UFMG |
institution |
UFMG |
reponame_str |
Repositório Institucional da UFMG |
collection |
Repositório Institucional da UFMG |
repository.name.fl_str_mv |
Repositório Institucional da UFMG - Universidade Federal de Minas Gerais (UFMG) |
repository.mail.fl_str_mv |
repositorio@ufmg.br |
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1823248255560974336 |