Oxidative and biochemical profile of Gyr dairy heifers during the peripartum period
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFMG |
Texto Completo: | https://doi.org/10.1590/1678-4162-12258 http://hdl.handle.net/1843/67514 http://orcid.org/0000-0003-4774-3226 http://orcid.org/0000-0002-4013-0147 http://orcid.org/0000-0002-0506-0075 http://orcid.org/0000-0001-6875-8625 http://orcid.org/0000-0001-5656-5260 http://orcid.org/0000-0002-1508-4097 |
Resumo: | The transition period in dairy cows increases oxygen supply to tissues and the production of reactive oxygen species. Along with the impairment of the antioxidant system, it generates oxidative stress, which may be linked to the development of various diseases. This study aimed to evaluate oxidative stress in 35 Gir dairy heifers during the peripartum period. Uric acid, copper, iron, zinc, albumin, total bilirubin, superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) were analyzed. A linear model with Poisson distribution was applied using the GENMOD procedure. The first measurement (30d before birth) was considered as reference (T0), and samples were collected 16 days before birth (T1) and seven (T2), 14 (T3), 28 (T4) and 42 days postpartum. childbirth (T5). Copper, zinc and albumin varied within the reference range, although there was an increase in copper of 45.92% at T3. Uric acid levels increased during the transition period, with no significant difference until 16 days pre-partum, when an increase of 67.57% was observed, with its highest concentration observed in T4. SOD had a greater increase (300%) than GSH-Px (36%) at the end of the experimental period, accompanied by biochemical adaptations to ensure an effective antioxidant response. Therefore, it can be concluded that the peripartum period causes oxidative stress in Gir dairy heifers. |
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2024-04-19T19:40:35Z2024-04-19T19:40:35Z202173510141022https://doi.org/10.1590/1678-4162-122581678-4162http://hdl.handle.net/1843/67514http://orcid.org/0000-0003-4774-3226http://orcid.org/0000-0002-4013-0147http://orcid.org/0000-0002-0506-0075http://orcid.org/0000-0001-6875-8625http://orcid.org/0000-0001-5656-5260http://orcid.org/0000-0002-1508-4097The transition period in dairy cows increases oxygen supply to tissues and the production of reactive oxygen species. Along with the impairment of the antioxidant system, it generates oxidative stress, which may be linked to the development of various diseases. This study aimed to evaluate oxidative stress in 35 Gir dairy heifers during the peripartum period. Uric acid, copper, iron, zinc, albumin, total bilirubin, superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) were analyzed. A linear model with Poisson distribution was applied using the GENMOD procedure. The first measurement (30d before birth) was considered as reference (T0), and samples were collected 16 days before birth (T1) and seven (T2), 14 (T3), 28 (T4) and 42 days postpartum. childbirth (T5). Copper, zinc and albumin varied within the reference range, although there was an increase in copper of 45.92% at T3. Uric acid levels increased during the transition period, with no significant difference until 16 days pre-partum, when an increase of 67.57% was observed, with its highest concentration observed in T4. SOD had a greater increase (300%) than GSH-Px (36%) at the end of the experimental period, accompanied by biochemical adaptations to ensure an effective antioxidant response. Therefore, it can be concluded that the peripartum period causes oxidative stress in Gir dairy heifers.O período de transição em vacas leiteiras aumenta o suprimento de oxigênio aos tecidos e a produção de espécies reativas de oxigênio. Junto com o comprometimento do sistema antioxidante, gera estresse oxidativo, que pode estar ligado ao desenvolvimento de diversas doenças. Este estudo teve como objetivo avaliar o estresse oxidativo em 35 novilhas leiteiras Gir, durante o período periparto. Foram analisados ácido úrico, cobre, ferro, zinco, albumina, bilirrubina total, superóxido dismutase (SOD) e glutationa peroxidase (GSH-Px). Um modelo linear com distribuição de Poisson foi aplicado usando o procedimento GENMOD. A primeira medida (30d antes do parto) foi considerada como referência (T0), e as amostras foram coletadas 16 dias antes do parto (T1) e sete (T2), 14 (T3), 28 (T4) e 42 dias pós-parto (T5). Cobre, zinco e albumina variaram dentro da faixa de referência, apesar de ter havido aumento no cobre de 45,92% no T3. Os níveis de ácido úrico aumentaram durante o período de transição, sem diferença significativa até 16 dias pré-parto, quando foi observado aumento de 67,57%, sendo sua maior concentração observada em T4. A SOD teve um aumento maior (300%) do que a GSH-Px (36%) no final do período experimental, acompanhada por adaptações bioquímicas para garantir uma resposta antioxidante eficaz. Dessa forma, pode-se concluir que o período periparto causa estresse oxidativo em novilhas leiteiras Gir.CNPq - Conselho Nacional de Desenvolvimento Científico e TecnológicoCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível SuperiorFAPESP - Fundação de Amparo à Pesquisa do Estado de São PauloengUniversidade Federal de Minas GeraisUFMGBrasilVET - DEPARTAMENTO DE CLÍNICA E CIRURGIAArquivo Brasileiro de Medicina Veterinária e ZootecniaBovino de leiteEstresse oxidativoSuperóxido dismutaseGlutationa peroxidasePeríodo de transiçãoEstresse oxidativoSuperóxido dismutaseGlutationa peroxidaseOxidative and biochemical profile of Gyr dairy heifers during the peripartum periodPerfil oxidativo e bioquímico em novilhas Gir leiteiras durante o peripartoinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttps://www.scielo.br/j/abmvz/a/ZrJZ7kmBdSFdybYx87gZs3k/?lang=en#Helena Corrêa Pinto de Mendonça MendesFabiola de Oliveira Paes LemePaula Maria Pires do Nascimento PenidoAndre OliveiraLissandra ArnholdLenira El Faro Zadrainfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFMGinstname:Universidade Federal de Minas Gerais (UFMG)instacron:UFMGLICENSELicense.txtLicense.txttext/plain; charset=utf-82042https://repositorio.ufmg.br/bitstream/1843/67514/1/License.txtfa505098d172de0bc8864fc1287ffe22MD51ORIGINALOxidative and biochemical profile of Gyr dairy heifers during the peripartum period.pdfOxidative and biochemical profile of Gyr dairy heifers during the peripartum period.pdfapplication/pdf263535https://repositorio.ufmg.br/bitstream/1843/67514/2/Oxidative%20and%20biochemical%20profile%20of%20Gyr%20dairy%20heifers%20during%20the%20peripartum%20period.pdfc58d28e8848ff67b16a361e10f9c3936MD521843/675142024-04-19 16:40:36.483oai:repositorio.ufmg.br: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Repositório de PublicaçõesPUBhttps://repositorio.ufmg.br/oaiopendoar:2024-04-19T19:40:36Repositório Institucional da UFMG - Universidade Federal de Minas Gerais (UFMG)false |
dc.title.pt_BR.fl_str_mv |
Oxidative and biochemical profile of Gyr dairy heifers during the peripartum period |
dc.title.alternative.pt_BR.fl_str_mv |
Perfil oxidativo e bioquímico em novilhas Gir leiteiras durante o periparto |
title |
Oxidative and biochemical profile of Gyr dairy heifers during the peripartum period |
spellingShingle |
Oxidative and biochemical profile of Gyr dairy heifers during the peripartum period Helena Corrêa Pinto de Mendonça Mendes Período de transição Estresse oxidativo Superóxido dismutase Glutationa peroxidase Bovino de leite Estresse oxidativo Superóxido dismutase Glutationa peroxidase |
title_short |
Oxidative and biochemical profile of Gyr dairy heifers during the peripartum period |
title_full |
Oxidative and biochemical profile of Gyr dairy heifers during the peripartum period |
title_fullStr |
Oxidative and biochemical profile of Gyr dairy heifers during the peripartum period |
title_full_unstemmed |
Oxidative and biochemical profile of Gyr dairy heifers during the peripartum period |
title_sort |
Oxidative and biochemical profile of Gyr dairy heifers during the peripartum period |
author |
Helena Corrêa Pinto de Mendonça Mendes |
author_facet |
Helena Corrêa Pinto de Mendonça Mendes Fabiola de Oliveira Paes Leme Paula Maria Pires do Nascimento Penido Andre Oliveira Lissandra Arnhold Lenira El Faro Zadra |
author_role |
author |
author2 |
Fabiola de Oliveira Paes Leme Paula Maria Pires do Nascimento Penido Andre Oliveira Lissandra Arnhold Lenira El Faro Zadra |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Helena Corrêa Pinto de Mendonça Mendes Fabiola de Oliveira Paes Leme Paula Maria Pires do Nascimento Penido Andre Oliveira Lissandra Arnhold Lenira El Faro Zadra |
dc.subject.por.fl_str_mv |
Período de transição Estresse oxidativo Superóxido dismutase Glutationa peroxidase |
topic |
Período de transição Estresse oxidativo Superóxido dismutase Glutationa peroxidase Bovino de leite Estresse oxidativo Superóxido dismutase Glutationa peroxidase |
dc.subject.other.pt_BR.fl_str_mv |
Bovino de leite Estresse oxidativo Superóxido dismutase Glutationa peroxidase |
description |
The transition period in dairy cows increases oxygen supply to tissues and the production of reactive oxygen species. Along with the impairment of the antioxidant system, it generates oxidative stress, which may be linked to the development of various diseases. This study aimed to evaluate oxidative stress in 35 Gir dairy heifers during the peripartum period. Uric acid, copper, iron, zinc, albumin, total bilirubin, superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) were analyzed. A linear model with Poisson distribution was applied using the GENMOD procedure. The first measurement (30d before birth) was considered as reference (T0), and samples were collected 16 days before birth (T1) and seven (T2), 14 (T3), 28 (T4) and 42 days postpartum. childbirth (T5). Copper, zinc and albumin varied within the reference range, although there was an increase in copper of 45.92% at T3. Uric acid levels increased during the transition period, with no significant difference until 16 days pre-partum, when an increase of 67.57% was observed, with its highest concentration observed in T4. SOD had a greater increase (300%) than GSH-Px (36%) at the end of the experimental period, accompanied by biochemical adaptations to ensure an effective antioxidant response. Therefore, it can be concluded that the peripartum period causes oxidative stress in Gir dairy heifers. |
publishDate |
2021 |
dc.date.issued.fl_str_mv |
2021 |
dc.date.accessioned.fl_str_mv |
2024-04-19T19:40:35Z |
dc.date.available.fl_str_mv |
2024-04-19T19:40:35Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/1843/67514 |
dc.identifier.doi.pt_BR.fl_str_mv |
https://doi.org/10.1590/1678-4162-12258 |
dc.identifier.issn.pt_BR.fl_str_mv |
1678-4162 |
dc.identifier.orcid.pt_BR.fl_str_mv |
http://orcid.org/0000-0003-4774-3226 http://orcid.org/0000-0002-4013-0147 http://orcid.org/0000-0002-0506-0075 http://orcid.org/0000-0001-6875-8625 http://orcid.org/0000-0001-5656-5260 http://orcid.org/0000-0002-1508-4097 |
url |
https://doi.org/10.1590/1678-4162-12258 http://hdl.handle.net/1843/67514 http://orcid.org/0000-0003-4774-3226 http://orcid.org/0000-0002-4013-0147 http://orcid.org/0000-0002-0506-0075 http://orcid.org/0000-0001-6875-8625 http://orcid.org/0000-0001-5656-5260 http://orcid.org/0000-0002-1508-4097 |
identifier_str_mv |
1678-4162 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.ispartof.pt_BR.fl_str_mv |
Arquivo Brasileiro de Medicina Veterinária e Zootecnia |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.publisher.none.fl_str_mv |
Universidade Federal de Minas Gerais |
dc.publisher.initials.fl_str_mv |
UFMG |
dc.publisher.country.fl_str_mv |
Brasil |
dc.publisher.department.fl_str_mv |
VET - DEPARTAMENTO DE CLÍNICA E CIRURGIA |
publisher.none.fl_str_mv |
Universidade Federal de Minas Gerais |
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reponame:Repositório Institucional da UFMG instname:Universidade Federal de Minas Gerais (UFMG) instacron:UFMG |
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Universidade Federal de Minas Gerais (UFMG) |
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UFMG |
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UFMG |
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Repositório Institucional da UFMG |
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Repositório Institucional da UFMG |
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