Calm before the storm: a glimpse into the Secondary Metabolism of Aspergillus welwitschiae, the etiologic agent of the sisal bole rot
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2019 |
| Outros Autores: | , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da UFMG |
| Texto Completo: | https://doi.org/10.3390/toxins11110631 http://hdl.handle.net/1843/55211 https://orcid.org/0000-0002-7476-5845 https://orcid.org/0000-0001-5968-525X https://orcid.org/0000-0002-6582-7434 https://orcid.org/0000-0002-8667-502X https://orcid.org/0000-0002-4775-2280 https://orcid.org/0000-0002-7635-9656 https://orcid.org/0000-0002-8143-5756 https://orcid.org/0000-0002-4014-1794 https://orcid.org/0000-0002-7692-6243 |
Resumo: | CNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico |
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2023-06-21T20:02:34Z2023-06-21T20:02:34Z20191111https://doi.org/10.3390/toxins111106312072-6651http://hdl.handle.net/1843/55211https://orcid.org/0000-0002-7476-5845https://orcid.org/0000-0001-5968-525Xhttps://orcid.org/0000-0002-6582-7434https://orcid.org/0000-0002-8667-502Xhttps://orcid.org/0000-0002-4775-2280https://orcid.org/0000-0002-7635-9656https://orcid.org/0000-0002-8143-5756https://orcid.org/0000-0002-4014-1794https://orcid.org/0000-0002-7692-6243CNPq - Conselho Nacional de Desenvolvimento Científico e TecnológicoCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível SuperiorOutra AgênciaAspergillus welwitschiae is a species of the Nigri section of the genus Aspergillus. In nature, it is usually a saprotroph, decomposing plant material. However, it causes the bole rot disease of Agave sisalana (sisal), a plant species used for the extraction of hard natural fibers, causing great economic loss to this culture. In this study, we isolated and sequenced one genome of A. welwitschiae (isolate CCMB 674 (Collection of Cultures of Microorganisms of Bahia)) from the stem tissues of sisal and performed in silico and wet lab experimental strategies to describe its ability to produce mycotoxins. CCMB 674 possesses 64 secondary metabolite gene clusters (SMGCs) and, under normal conditions, it produces secondary metabolism compounds that could disturb the cellular cycle of sisal or induce abnormalities in plant growth, such as malformin C. This isolate also produces a pigment that might explain the characteristic red color of the affected tissues. Additionally, this isolate is defective for the production of fumonisin B1, and, despite bearing the full cluster for the synthesis of this compound, it did not produce ochratoxin A. Altogether, these results provide new information on possible strategies used by the fungi during the sisal bole rot, helping to better understand this disease and how to control it.engUniversidade Federal de Minas GeraisUFMGBrasilICB - DEPARTAMENTO DE MICROBIOLOGIAToxinsAspergillusMicotoxinasPhytotoxicMycotoxinRed rot of sisalCalm before the storm: a glimpse into the Secondary Metabolism of Aspergillus welwitschiae, the etiologic agent of the sisal bole rotinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttps://www.mdpi.com/2072-6651/11/11/631Gabriel Quintanilha-PeixotoRosimére Oliveira TorresIsabella Mary Alves ReisThiago Alves Santos de OliveiraDener Eduardo BortoliniElizabeth Amélia Alves DuarteVasco Ariston de Carvalho AzevedoBertram BrenigEric Roberto Guimarães Rocha AguiarAna Cristina Fermino SoaresAristóteles Góes-NetoAlexsandro Brancoapplication/pdfinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFMGinstname:Universidade Federal de Minas Gerais (UFMG)instacron:UFMGLICENSELicense.txtLicense.txttext/plain; charset=utf-82042https://repositorio.ufmg.br/bitstream/1843/55211/1/License.txtfa505098d172de0bc8864fc1287ffe22MD51ORIGINALCalm Before the Storm_ A Glimpse into the Secondary Metabolism of Aspergillus welwitschiae, the Etiologic Agent of the Sisal Bole Rot.pdfCalm Before the Storm_ A Glimpse into the Secondary Metabolism of Aspergillus welwitschiae, the Etiologic Agent of the Sisal Bole Rot.pdfapplication/pdf27811680https://repositorio.ufmg.br/bitstream/1843/55211/2/Calm%20Before%20the%20Storm_%20A%20Glimpse%20into%20the%20Secondary%20Metabolism%20of%20Aspergillus%20welwitschiae%2c%20the%20Etiologic%20Agent%20of%20the%20Sisal%20Bole%20Rot.pdf1f705bbf3457f6cad4f0658be630703aMD521843/552112023-06-21 17:02:34.973oai:repositorio.ufmg.br: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Repositório de PublicaçõesPUBhttps://repositorio.ufmg.br/oaiopendoar:2023-06-21T20:02:34Repositório Institucional da UFMG - Universidade Federal de Minas Gerais (UFMG)false |
| dc.title.pt_BR.fl_str_mv |
Calm before the storm: a glimpse into the Secondary Metabolism of Aspergillus welwitschiae, the etiologic agent of the sisal bole rot |
| title |
Calm before the storm: a glimpse into the Secondary Metabolism of Aspergillus welwitschiae, the etiologic agent of the sisal bole rot |
| spellingShingle |
Calm before the storm: a glimpse into the Secondary Metabolism of Aspergillus welwitschiae, the etiologic agent of the sisal bole rot Gabriel Quintanilha-Peixoto Phytotoxic Mycotoxin Red rot of sisal Aspergillus Micotoxinas |
| title_short |
Calm before the storm: a glimpse into the Secondary Metabolism of Aspergillus welwitschiae, the etiologic agent of the sisal bole rot |
| title_full |
Calm before the storm: a glimpse into the Secondary Metabolism of Aspergillus welwitschiae, the etiologic agent of the sisal bole rot |
| title_fullStr |
Calm before the storm: a glimpse into the Secondary Metabolism of Aspergillus welwitschiae, the etiologic agent of the sisal bole rot |
| title_full_unstemmed |
Calm before the storm: a glimpse into the Secondary Metabolism of Aspergillus welwitschiae, the etiologic agent of the sisal bole rot |
| title_sort |
Calm before the storm: a glimpse into the Secondary Metabolism of Aspergillus welwitschiae, the etiologic agent of the sisal bole rot |
| author |
Gabriel Quintanilha-Peixoto |
| author_facet |
Gabriel Quintanilha-Peixoto Rosimére Oliveira Torres Isabella Mary Alves Reis Thiago Alves Santos de Oliveira Dener Eduardo Bortolini Elizabeth Amélia Alves Duarte Vasco Ariston de Carvalho Azevedo Bertram Brenig Eric Roberto Guimarães Rocha Aguiar Ana Cristina Fermino Soares Aristóteles Góes-Neto Alexsandro Branco |
| author_role |
author |
| author2 |
Rosimére Oliveira Torres Isabella Mary Alves Reis Thiago Alves Santos de Oliveira Dener Eduardo Bortolini Elizabeth Amélia Alves Duarte Vasco Ariston de Carvalho Azevedo Bertram Brenig Eric Roberto Guimarães Rocha Aguiar Ana Cristina Fermino Soares Aristóteles Góes-Neto Alexsandro Branco |
| author2_role |
author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Gabriel Quintanilha-Peixoto Rosimére Oliveira Torres Isabella Mary Alves Reis Thiago Alves Santos de Oliveira Dener Eduardo Bortolini Elizabeth Amélia Alves Duarte Vasco Ariston de Carvalho Azevedo Bertram Brenig Eric Roberto Guimarães Rocha Aguiar Ana Cristina Fermino Soares Aristóteles Góes-Neto Alexsandro Branco |
| dc.subject.por.fl_str_mv |
Phytotoxic Mycotoxin Red rot of sisal |
| topic |
Phytotoxic Mycotoxin Red rot of sisal Aspergillus Micotoxinas |
| dc.subject.other.pt_BR.fl_str_mv |
Aspergillus Micotoxinas |
| description |
CNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico |
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2019 |
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2019 |
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2023-06-21T20:02:34Z |
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2023-06-21T20:02:34Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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http://hdl.handle.net/1843/55211 |
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https://doi.org/10.3390/toxins11110631 |
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2072-6651 |
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https://orcid.org/0000-0002-7476-5845 https://orcid.org/0000-0001-5968-525X https://orcid.org/0000-0002-6582-7434 https://orcid.org/0000-0002-8667-502X https://orcid.org/0000-0002-4775-2280 https://orcid.org/0000-0002-7635-9656 https://orcid.org/0000-0002-8143-5756 https://orcid.org/0000-0002-4014-1794 https://orcid.org/0000-0002-7692-6243 |
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https://doi.org/10.3390/toxins11110631 http://hdl.handle.net/1843/55211 https://orcid.org/0000-0002-7476-5845 https://orcid.org/0000-0001-5968-525X https://orcid.org/0000-0002-6582-7434 https://orcid.org/0000-0002-8667-502X https://orcid.org/0000-0002-4775-2280 https://orcid.org/0000-0002-7635-9656 https://orcid.org/0000-0002-8143-5756 https://orcid.org/0000-0002-4014-1794 https://orcid.org/0000-0002-7692-6243 |
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Brasil |
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ICB - DEPARTAMENTO DE MICROBIOLOGIA |
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Universidade Federal de Minas Gerais |
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