Intra-tumor genetic heterogeneity in wilms? tumor samples
Autor(a) principal: | |
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Data de Publicação: | 2019 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFMG |
Texto Completo: | http://hdl.handle.net/1843/60893 |
Resumo: | Childhood renal tumors account for ~7% of all childhood cancers, and most cases are embryonic Wilms’ tumors (WT). Children with WT are usually treated by either COG or SIOP. The later treats the children using preoperative chemotherapy, but both have around 90% of overall survival in five years. WT is a genetically heterogeneous group with a low prevalence of known somatic alterations. Only around 30% of the cases present mutation in known genes, and there is a relatively high degree of intra-tumor genetic heterogeneity (ITGH). Besides potentially having an impact on the clinical outcome of patients, ITGH may interfere with the search for molecular markers that are prospectively being tested by COG and SIOP. In this review, we present the proposal of the current UMBRELLA SIOP Study 2017/Brazilian Renal Tumor Group that requires the multi-sampling collection of each tumor to better evaluate possible molecular markers, as well as to understand WT biology |
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2023-11-13T20:09:57Z2023-11-13T20:09:57Z201965121496150110.1590/1806-9282.65.12.149601044230http://hdl.handle.net/1843/60893Childhood renal tumors account for ~7% of all childhood cancers, and most cases are embryonic Wilms’ tumors (WT). Children with WT are usually treated by either COG or SIOP. The later treats the children using preoperative chemotherapy, but both have around 90% of overall survival in five years. WT is a genetically heterogeneous group with a low prevalence of known somatic alterations. Only around 30% of the cases present mutation in known genes, and there is a relatively high degree of intra-tumor genetic heterogeneity (ITGH). Besides potentially having an impact on the clinical outcome of patients, ITGH may interfere with the search for molecular markers that are prospectively being tested by COG and SIOP. In this review, we present the proposal of the current UMBRELLA SIOP Study 2017/Brazilian Renal Tumor Group that requires the multi-sampling collection of each tumor to better evaluate possible molecular markers, as well as to understand WT biologyengUniversidade Federal de Minas GeraisUFMGBrasilMED - DEPARTAMENTO DE PEDIATRIARevista da Associação Médica BrasileiraWilms tumorBiomarkersGenetic HeterogeneityWilms tumorBiomarkersGenetic HeterogeneityIntra-tumor genetic heterogeneity in wilms? tumor samplesinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttps://doi.org/10.1590/1806-9282.65.12.1496Paulo a. FariaBruna m. de sá PereiraRafaela Montalvão de AzevedoJoaquim Caetano de Aguirre NetoClarice Franco MenezesKarla Emilia de sa RodriguesBeatriz de CamargoMariana Maschiettoapplication/pdfinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFMGinstname:Universidade Federal de Minas Gerais (UFMG)instacron:UFMGLICENSELicense.txtLicense.txttext/plain; charset=utf-82042https://repositorio.ufmg.br/bitstream/1843/60893/1/License.txtfa505098d172de0bc8864fc1287ffe22MD51ORIGINALIntra-tumor genetic heterogeneity in Wilms pdfa.pdfIntra-tumor genetic heterogeneity in Wilms pdfa.pdfapplication/pdf255647https://repositorio.ufmg.br/bitstream/1843/60893/2/Intra-tumor%20genetic%20heterogeneity%20in%20Wilms%20pdfa.pdfcbf3b653a6ad0b1ef5e28b8c28a5f6deMD521843/608932023-11-13 18:30:12.382oai:repositorio.ufmg.br:1843/60893Repositório de PublicaçõesPUBhttps://repositorio.ufmg.br/oaiopendoar:2023-11-13T21:30:12Repositório Institucional da UFMG - Universidade Federal de Minas Gerais (UFMG)false |
dc.title.pt_BR.fl_str_mv |
Intra-tumor genetic heterogeneity in wilms? tumor samples |
title |
Intra-tumor genetic heterogeneity in wilms? tumor samples |
spellingShingle |
Intra-tumor genetic heterogeneity in wilms? tumor samples Paulo a. Faria Wilms tumor Biomarkers Genetic Heterogeneity Wilms tumor Biomarkers Genetic Heterogeneity |
title_short |
Intra-tumor genetic heterogeneity in wilms? tumor samples |
title_full |
Intra-tumor genetic heterogeneity in wilms? tumor samples |
title_fullStr |
Intra-tumor genetic heterogeneity in wilms? tumor samples |
title_full_unstemmed |
Intra-tumor genetic heterogeneity in wilms? tumor samples |
title_sort |
Intra-tumor genetic heterogeneity in wilms? tumor samples |
author |
Paulo a. Faria |
author_facet |
Paulo a. Faria Bruna m. de sá Pereira Rafaela Montalvão de Azevedo Joaquim Caetano de Aguirre Neto Clarice Franco Menezes Karla Emilia de sa Rodrigues Beatriz de Camargo Mariana Maschietto |
author_role |
author |
author2 |
Bruna m. de sá Pereira Rafaela Montalvão de Azevedo Joaquim Caetano de Aguirre Neto Clarice Franco Menezes Karla Emilia de sa Rodrigues Beatriz de Camargo Mariana Maschietto |
author2_role |
author author author author author author author |
dc.contributor.author.fl_str_mv |
Paulo a. Faria Bruna m. de sá Pereira Rafaela Montalvão de Azevedo Joaquim Caetano de Aguirre Neto Clarice Franco Menezes Karla Emilia de sa Rodrigues Beatriz de Camargo Mariana Maschietto |
dc.subject.por.fl_str_mv |
Wilms tumor Biomarkers Genetic Heterogeneity |
topic |
Wilms tumor Biomarkers Genetic Heterogeneity Wilms tumor Biomarkers Genetic Heterogeneity |
dc.subject.other.pt_BR.fl_str_mv |
Wilms tumor Biomarkers Genetic Heterogeneity |
description |
Childhood renal tumors account for ~7% of all childhood cancers, and most cases are embryonic Wilms’ tumors (WT). Children with WT are usually treated by either COG or SIOP. The later treats the children using preoperative chemotherapy, but both have around 90% of overall survival in five years. WT is a genetically heterogeneous group with a low prevalence of known somatic alterations. Only around 30% of the cases present mutation in known genes, and there is a relatively high degree of intra-tumor genetic heterogeneity (ITGH). Besides potentially having an impact on the clinical outcome of patients, ITGH may interfere with the search for molecular markers that are prospectively being tested by COG and SIOP. In this review, we present the proposal of the current UMBRELLA SIOP Study 2017/Brazilian Renal Tumor Group that requires the multi-sampling collection of each tumor to better evaluate possible molecular markers, as well as to understand WT biology |
publishDate |
2019 |
dc.date.issued.fl_str_mv |
2019 |
dc.date.accessioned.fl_str_mv |
2023-11-13T20:09:57Z |
dc.date.available.fl_str_mv |
2023-11-13T20:09:57Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/1843/60893 |
dc.identifier.doi.pt_BR.fl_str_mv |
10.1590/1806-9282.65.12.1496 |
dc.identifier.issn.pt_BR.fl_str_mv |
01044230 |
identifier_str_mv |
10.1590/1806-9282.65.12.1496 01044230 |
url |
http://hdl.handle.net/1843/60893 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.ispartof.none.fl_str_mv |
Revista da Associação Médica Brasileira |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Universidade Federal de Minas Gerais |
dc.publisher.initials.fl_str_mv |
UFMG |
dc.publisher.country.fl_str_mv |
Brasil |
dc.publisher.department.fl_str_mv |
MED - DEPARTAMENTO DE PEDIATRIA |
publisher.none.fl_str_mv |
Universidade Federal de Minas Gerais |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UFMG instname:Universidade Federal de Minas Gerais (UFMG) instacron:UFMG |
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Universidade Federal de Minas Gerais (UFMG) |
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UFMG |
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UFMG |
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Repositório Institucional da UFMG |
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Repositório Institucional da UFMG |
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