Hemophagocytic lymphohistiocytosis and visceral leishmaniasis in children: a serie of cases and literature review
Autor(a) principal: | |
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Data de Publicação: | 2020 |
Outros Autores: | , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFMG |
Texto Completo: | https://doi.org/10.1590/1984-0462/2022/40/2020269 http://hdl.handle.net/1843/57436 |
Resumo: | Objective: Hemophagocytic lymphohistiocytosis syndrome (HLHS) is characterized by an immunological hyperactivation of cytotoxic T cells, natural killer cells, and macrophages, leading to the secretion of proinflammatory cytokines. HLHS associated with Visceral Leishmaniasis might be difficult to diagnose once symptoms are similar, resulting in the death of untreated patients. Our aim is to describe a series of cases of Visceral Leishmaniasis with HLHS admitted to a referral hospital for infectious diseases. Case description: All 115 cases of Visceral Leishmaniasis referred to a referral center for pediatric infectious diseases were reviewed to identify the cases of HLHS. Five cases (4.5%) were confirmed with HLHS and they presented fever, splenomegaly, cytopenia, hypertriglyceridemia or hypofibrinogenemia, increased ferritin and hemophagocytosis in the bone marrow.Comments: It important to rule out HLHS in children with infectious diseases that do not respond adequately to treatment or in patients with severe symptoms, especially in leishmaniasis endemic area. |
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2023-08-03T20:06:11Z2023-08-03T20:06:11Z2020-10-1240e2020269https://doi.org/10.1590/1984-0462/2022/40/202026919840462http://hdl.handle.net/1843/574360000-0002-3319-7597Objective: Hemophagocytic lymphohistiocytosis syndrome (HLHS) is characterized by an immunological hyperactivation of cytotoxic T cells, natural killer cells, and macrophages, leading to the secretion of proinflammatory cytokines. HLHS associated with Visceral Leishmaniasis might be difficult to diagnose once symptoms are similar, resulting in the death of untreated patients. Our aim is to describe a series of cases of Visceral Leishmaniasis with HLHS admitted to a referral hospital for infectious diseases. Case description: All 115 cases of Visceral Leishmaniasis referred to a referral center for pediatric infectious diseases were reviewed to identify the cases of HLHS. Five cases (4.5%) were confirmed with HLHS and they presented fever, splenomegaly, cytopenia, hypertriglyceridemia or hypofibrinogenemia, increased ferritin and hemophagocytosis in the bone marrow.Comments: It important to rule out HLHS in children with infectious diseases that do not respond adequately to treatment or in patients with severe symptoms, especially in leishmaniasis endemic area.Objetivo: Linfo-histiocitose hemofagocítica (LHH) é uma síndrome caracterizada pela hiperativação de linfócitos T citotóxicos, células natural killer e macrófagos, levando à secreção de citocinas pró-inflamatórias. Linfo-histiocitose hemofagocítica associada a Leishmaniose Visceral é um quadro de grande desafio para o diagnóstico, considerando que os sintomas são semelhantes, podendo levar ao óbito pacientes não tratados. Nosso objetivo é descrever uma série de casos de Leishmaniose Visceral com LHH admitidos em um hospital de referência para doenças infecciosas. Descrição do caso: Todos os 115 casos de Leishmaniose Visceral encaminhados ao centro de referência em doenças infecciosas pediátricas foram revistos para identificar os casos de LHH. Cinco casos (4,5%) foram confirmados com LHH e apresentaram febre, esplenomegalia, citopenia, hipertrigliceridemia ouhipofibrinogenemia, aumento de ferritina e hemafagocitose em medula óssea.Comentários: Deve-se suspeitar de LHH em crianças com doenças infecciosas que não respondem adequadamente ao tratamento ou em pacientes com sintomas graves, principalmente em áreas endêmicas da leishmaniose.engUniversidade Federal de Minas GeraisUFMGBrasilMED - DEPARTAMENTO DE PEDIATRIARevista Paulista de PediatriaLeishmaniose VisceralLinfo-Histiocitose HemofagocíticaLinfo-Histiocitose HemofagocíticaTratamento FarmacológicoLeishmaniasis, visceralLymphohistiocytosisHemophagocyticDrug therapyHemophagocytic lymphohistiocytosis and visceral leishmaniasis in children: a serie of cases and literature reviewLinfo-histiocitose hemofagocítica e leishmaniose em crianças: série de casos e revisão da literaturainfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttps://www.scielo.br/j/rpp/a/T3vNnF9y7hYBWDqZB7TtzCz/?lang=enNatália Fernanda Ferreira BrumJulia Sampaio CoelhoLaís Silva CarvalhoMatheus Nascimento Otoni VieiraAline Almeida BentesEricka Viana Machado CarellosLílian Martins de Oliveira DinizAndrea Lucchesi de CarvalhoRoberta Maia Castro Romanelliapplication/pdfinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFMGinstname:Universidade Federal de Minas Gerais (UFMG)instacron:UFMGLICENSELicense.txtLicense.txttext/plain; charset=utf-82042https://repositorio.ufmg.br/bitstream/1843/57436/1/License.txtfa505098d172de0bc8864fc1287ffe22MD51ORIGINALHemophagocytic lymphohistiocytosis and visceral leishmaniasis in children a series of cases and literature review pdfa.pdfHemophagocytic lymphohistiocytosis and visceral leishmaniasis in children a series of cases and literature review pdfa.pdfapplication/pdf146524https://repositorio.ufmg.br/bitstream/1843/57436/2/Hemophagocytic%20lymphohistiocytosis%20and%20visceral%20leishmaniasis%20in%20children%20a%20series%20of%20cases%20and%20literature%20review%20pdfa.pdf62e55acd50dabdb79d195531a915e502MD521843/574362023-08-03 18:34:03.989oai:repositorio.ufmg.br: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Repositório de PublicaçõesPUBhttps://repositorio.ufmg.br/oaiopendoar:2023-08-03T21:34:03Repositório Institucional da UFMG - Universidade Federal de Minas Gerais (UFMG)false |
dc.title.pt_BR.fl_str_mv |
Hemophagocytic lymphohistiocytosis and visceral leishmaniasis in children: a serie of cases and literature review |
dc.title.alternative.pt_BR.fl_str_mv |
Linfo-histiocitose hemofagocítica e leishmaniose em crianças: série de casos e revisão da literatura |
title |
Hemophagocytic lymphohistiocytosis and visceral leishmaniasis in children: a serie of cases and literature review |
spellingShingle |
Hemophagocytic lymphohistiocytosis and visceral leishmaniasis in children: a serie of cases and literature review Natália Fernanda Ferreira Brum Leishmaniasis, visceral Lymphohistiocytosis Hemophagocytic Drug therapy Leishmaniose Visceral Linfo-Histiocitose Hemofagocítica Linfo-Histiocitose Hemofagocítica Tratamento Farmacológico |
title_short |
Hemophagocytic lymphohistiocytosis and visceral leishmaniasis in children: a serie of cases and literature review |
title_full |
Hemophagocytic lymphohistiocytosis and visceral leishmaniasis in children: a serie of cases and literature review |
title_fullStr |
Hemophagocytic lymphohistiocytosis and visceral leishmaniasis in children: a serie of cases and literature review |
title_full_unstemmed |
Hemophagocytic lymphohistiocytosis and visceral leishmaniasis in children: a serie of cases and literature review |
title_sort |
Hemophagocytic lymphohistiocytosis and visceral leishmaniasis in children: a serie of cases and literature review |
author |
Natália Fernanda Ferreira Brum |
author_facet |
Natália Fernanda Ferreira Brum Julia Sampaio Coelho Laís Silva Carvalho Matheus Nascimento Otoni Vieira Aline Almeida Bentes Ericka Viana Machado Carellos Lílian Martins de Oliveira Diniz Andrea Lucchesi de Carvalho Roberta Maia Castro Romanelli |
author_role |
author |
author2 |
Julia Sampaio Coelho Laís Silva Carvalho Matheus Nascimento Otoni Vieira Aline Almeida Bentes Ericka Viana Machado Carellos Lílian Martins de Oliveira Diniz Andrea Lucchesi de Carvalho Roberta Maia Castro Romanelli |
author2_role |
author author author author author author author author |
dc.contributor.author.fl_str_mv |
Natália Fernanda Ferreira Brum Julia Sampaio Coelho Laís Silva Carvalho Matheus Nascimento Otoni Vieira Aline Almeida Bentes Ericka Viana Machado Carellos Lílian Martins de Oliveira Diniz Andrea Lucchesi de Carvalho Roberta Maia Castro Romanelli |
dc.subject.por.fl_str_mv |
Leishmaniasis, visceral Lymphohistiocytosis Hemophagocytic Drug therapy |
topic |
Leishmaniasis, visceral Lymphohistiocytosis Hemophagocytic Drug therapy Leishmaniose Visceral Linfo-Histiocitose Hemofagocítica Linfo-Histiocitose Hemofagocítica Tratamento Farmacológico |
dc.subject.other.pt_BR.fl_str_mv |
Leishmaniose Visceral Linfo-Histiocitose Hemofagocítica Linfo-Histiocitose Hemofagocítica Tratamento Farmacológico |
description |
Objective: Hemophagocytic lymphohistiocytosis syndrome (HLHS) is characterized by an immunological hyperactivation of cytotoxic T cells, natural killer cells, and macrophages, leading to the secretion of proinflammatory cytokines. HLHS associated with Visceral Leishmaniasis might be difficult to diagnose once symptoms are similar, resulting in the death of untreated patients. Our aim is to describe a series of cases of Visceral Leishmaniasis with HLHS admitted to a referral hospital for infectious diseases. Case description: All 115 cases of Visceral Leishmaniasis referred to a referral center for pediatric infectious diseases were reviewed to identify the cases of HLHS. Five cases (4.5%) were confirmed with HLHS and they presented fever, splenomegaly, cytopenia, hypertriglyceridemia or hypofibrinogenemia, increased ferritin and hemophagocytosis in the bone marrow.Comments: It important to rule out HLHS in children with infectious diseases that do not respond adequately to treatment or in patients with severe symptoms, especially in leishmaniasis endemic area. |
publishDate |
2020 |
dc.date.issued.fl_str_mv |
2020-10-12 |
dc.date.accessioned.fl_str_mv |
2023-08-03T20:06:11Z |
dc.date.available.fl_str_mv |
2023-08-03T20:06:11Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/1843/57436 |
dc.identifier.doi.pt_BR.fl_str_mv |
https://doi.org/10.1590/1984-0462/2022/40/2020269 |
dc.identifier.issn.pt_BR.fl_str_mv |
19840462 |
dc.identifier.orcid.pt_BR.fl_str_mv |
0000-0002-3319-7597 |
url |
https://doi.org/10.1590/1984-0462/2022/40/2020269 http://hdl.handle.net/1843/57436 |
identifier_str_mv |
19840462 0000-0002-3319-7597 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
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Revista Paulista de Pediatria |
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info:eu-repo/semantics/openAccess |
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openAccess |
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application/pdf |
dc.publisher.none.fl_str_mv |
Universidade Federal de Minas Gerais |
dc.publisher.initials.fl_str_mv |
UFMG |
dc.publisher.country.fl_str_mv |
Brasil |
dc.publisher.department.fl_str_mv |
MED - DEPARTAMENTO DE PEDIATRIA |
publisher.none.fl_str_mv |
Universidade Federal de Minas Gerais |
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reponame:Repositório Institucional da UFMG instname:Universidade Federal de Minas Gerais (UFMG) instacron:UFMG |
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UFMG |
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