Gestational Diabetes Mellitus Changes Human Colostrum Immune Composition
Autor(a) principal: | |
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Data de Publicação: | 2022 |
Outros Autores: | , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFMG |
Texto Completo: | https://doi.org/10.3389/fimmu.2022.910807 http://hdl.handle.net/1843/66319 https://orcid.org/0000-0002-7538-3208 |
Resumo: | CNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico |
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2024-03-21T14:19:56Z2024-03-21T14:19:56Z2022-06-19139108079https://doi.org/10.3389/fimmu.2022.9108071664-3224http://hdl.handle.net/1843/66319https://orcid.org/0000-0002-7538-3208CNPq - Conselho Nacional de Desenvolvimento Científico e TecnológicoFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas GeraisBreast milk is considered a complete food for babies. Up to 7 days postpartum, it is known as colostrum, rich in immunological compounds, responsible for providing nutrition and ensuring immune protection. However, some maternal factors, such as gestational diabetes mellitus (GDM), can change the concentration of bioactive compounds present in the colostrum and may affect the development of the newborn’s immune system. The effect of GDM on colostrum cytokine, chemokine, and growth factors is not well described. Thus, the present study evaluated whether the occurrence of GDM changes the concentration of biomarkers in the colostrum. A cross-sectional study was carried out on postpartum women who had healthy pregnancies and women who had been diagnosed with GDM. A sample of colostrum was collected for Luminex analysis. Our results showed that GDM mothers had higher secretion of cytokines and chemokines in the colostrum, with a higher concentration of IFN-g, IL-6, and IL-15, and a lower concentration of IL-1ra. Among growth factors, we identified a decreased concentration of GM-CSF in the colostrum of GDM mothers. Thus, the data obtained support the idea that the disease leads to immune alterations in the colostrum.engUniversidade Federal de Minas GeraisUFMGBrasilENF - DEPARTAMENTO DE NUTRIÇÃOENFERMAGEM - ESCOLA DE ENFERMAGEMICB - DEPARTAMENTO DE BIOQUÍMICA E IMUNOLOGIAFrontiers in ImmunologyDiabetes MellitusGravidezColostroSistema ImunitárioCitocinasQuimiocinasPeptídeos e Proteínas de Sinalização IntercelularGestational diabetes mellitusColostrumImmune systemCytokinesChemokinesGrowth factorsGestational Diabetes Mellitus Changes Human Colostrum Immune Compositioninfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttps://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2022.910807/fullAna Carolina Sena AvellarMariana Naves OliveiraFelipe CaixetaRafaela Cristina Vieira e SouzaElaine Speziali FariaAndréa TeixeiraAna Maria Caetano FariaGabriela Silveira NunesTatiani Uceli Maioliapplication/pdfinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFMGinstname:Universidade Federal de Minas Gerais (UFMG)instacron:UFMGLICENSELicense.txtLicense.txttext/plain; charset=utf-82042https://repositorio.ufmg.br/bitstream/1843/66319/1/License.txtfa505098d172de0bc8864fc1287ffe22MD51ORIGINALGestational Diabetes Mellitus Changes Human Colostrum Immune Composition.pdfGestational Diabetes Mellitus Changes Human Colostrum Immune Composition.pdfapplication/pdf1776390https://repositorio.ufmg.br/bitstream/1843/66319/2/Gestational%20Diabetes%20Mellitus%20Changes%20Human%20Colostrum%20Immune%20Composition.pdf66b7d474a6caf2a79141634fc80431daMD521843/663192024-03-21 11:19:57.084oai:repositorio.ufmg.br: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Repositório de PublicaçõesPUBhttps://repositorio.ufmg.br/oaiopendoar:2024-03-21T14:19:57Repositório Institucional da UFMG - Universidade Federal de Minas Gerais (UFMG)false |
dc.title.pt_BR.fl_str_mv |
Gestational Diabetes Mellitus Changes Human Colostrum Immune Composition |
title |
Gestational Diabetes Mellitus Changes Human Colostrum Immune Composition |
spellingShingle |
Gestational Diabetes Mellitus Changes Human Colostrum Immune Composition Ana Carolina Sena Avellar Gestational diabetes mellitus Colostrum Immune system Cytokines Chemokines Growth factors Diabetes Mellitus Gravidez Colostro Sistema Imunitário Citocinas Quimiocinas Peptídeos e Proteínas de Sinalização Intercelular |
title_short |
Gestational Diabetes Mellitus Changes Human Colostrum Immune Composition |
title_full |
Gestational Diabetes Mellitus Changes Human Colostrum Immune Composition |
title_fullStr |
Gestational Diabetes Mellitus Changes Human Colostrum Immune Composition |
title_full_unstemmed |
Gestational Diabetes Mellitus Changes Human Colostrum Immune Composition |
title_sort |
Gestational Diabetes Mellitus Changes Human Colostrum Immune Composition |
author |
Ana Carolina Sena Avellar |
author_facet |
Ana Carolina Sena Avellar Mariana Naves Oliveira Felipe Caixeta Rafaela Cristina Vieira e Souza Elaine Speziali Faria Andréa Teixeira Ana Maria Caetano Faria Gabriela Silveira Nunes Tatiani Uceli Maioli |
author_role |
author |
author2 |
Mariana Naves Oliveira Felipe Caixeta Rafaela Cristina Vieira e Souza Elaine Speziali Faria Andréa Teixeira Ana Maria Caetano Faria Gabriela Silveira Nunes Tatiani Uceli Maioli |
author2_role |
author author author author author author author author |
dc.contributor.author.fl_str_mv |
Ana Carolina Sena Avellar Mariana Naves Oliveira Felipe Caixeta Rafaela Cristina Vieira e Souza Elaine Speziali Faria Andréa Teixeira Ana Maria Caetano Faria Gabriela Silveira Nunes Tatiani Uceli Maioli |
dc.subject.por.fl_str_mv |
Gestational diabetes mellitus Colostrum Immune system Cytokines Chemokines Growth factors |
topic |
Gestational diabetes mellitus Colostrum Immune system Cytokines Chemokines Growth factors Diabetes Mellitus Gravidez Colostro Sistema Imunitário Citocinas Quimiocinas Peptídeos e Proteínas de Sinalização Intercelular |
dc.subject.other.pt_BR.fl_str_mv |
Diabetes Mellitus Gravidez Colostro Sistema Imunitário Citocinas Quimiocinas Peptídeos e Proteínas de Sinalização Intercelular |
description |
CNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico |
publishDate |
2022 |
dc.date.issued.fl_str_mv |
2022-06-19 |
dc.date.accessioned.fl_str_mv |
2024-03-21T14:19:56Z |
dc.date.available.fl_str_mv |
2024-03-21T14:19:56Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/1843/66319 |
dc.identifier.doi.pt_BR.fl_str_mv |
https://doi.org/10.3389/fimmu.2022.910807 |
dc.identifier.issn.pt_BR.fl_str_mv |
1664-3224 |
dc.identifier.orcid.pt_BR.fl_str_mv |
https://orcid.org/0000-0002-7538-3208 |
url |
https://doi.org/10.3389/fimmu.2022.910807 http://hdl.handle.net/1843/66319 https://orcid.org/0000-0002-7538-3208 |
identifier_str_mv |
1664-3224 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.ispartof.pt_BR.fl_str_mv |
Frontiers in Immunology |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Universidade Federal de Minas Gerais |
dc.publisher.initials.fl_str_mv |
UFMG |
dc.publisher.country.fl_str_mv |
Brasil |
dc.publisher.department.fl_str_mv |
ENF - DEPARTAMENTO DE NUTRIÇÃO ENFERMAGEM - ESCOLA DE ENFERMAGEM ICB - DEPARTAMENTO DE BIOQUÍMICA E IMUNOLOGIA |
publisher.none.fl_str_mv |
Universidade Federal de Minas Gerais |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UFMG instname:Universidade Federal de Minas Gerais (UFMG) instacron:UFMG |
instname_str |
Universidade Federal de Minas Gerais (UFMG) |
instacron_str |
UFMG |
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UFMG |
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Repositório Institucional da UFMG |
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Repositório Institucional da UFMG |
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