Metabotropic glutamate receptor 5 knockout rescues obesity phenotype in a mouse model of Huntington’s disease.
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2022 |
| Outros Autores: | , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da UFMG |
| Texto Completo: | https://doi.org/10.1038/s41598-022-08924-4 http://hdl.handle.net/1843/60288 https://orcid.org/0000-0002-3496-6749 |
Resumo: | CNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico |
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2023-10-30T21:34:16Z2023-10-30T21:34:16Z202212https://doi.org/10.1038/s41598-022-08924-42045-2322http://hdl.handle.net/1843/60288https://orcid.org/0000-0002-3496-6749CNPq - Conselho Nacional de Desenvolvimento Científico e TecnológicoFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas GeraisObesity represents a global health problem and is characterized by metabolic dysfunctions and a low-grade chronic inflammatory state, which can increase the risk of comorbidities, such as atherosclerosis, diabetes and insulin resistance. Here we tested the hypothesis that the genetic deletion of metabotropic glutamate receptor 5 (mGluR5) may rescue metabolic and inflammatory features present in BACHD mice, a mouse model of Huntington’s disease (HD) with an obese phenotype. For that, we crossed BACHD and mGluR5 knockout mice (mGluR5−/−) in order to obtain the following groups: Wild type (WT), mGluR5−/−, BACHD and BACHD/mGluR5−/− (double mutant mice). Our results showed that the double mutant mice present decreased body weight as compared to BACHD mice in all tested ages and reduced visceral adiposity as compared to BACHD at 6 months of age. Additionally, 12-month-old double mutant mice present increased adipose tissue levels of adiponectin, decreased leptin levels, and increased IL-10/TNF ratio as compared to BACHD mice. Taken together, our preliminary data propose that the absence of mGluR5 reduce weight gain and visceral adiposity in BACHD mice, along with a decrease in the inflammatory state in the visceral adipose tissue (VAT), which may indicate that mGluR5 may play a role in adiposity modulation.engUniversidade Federal de Minas GeraisUFMGBrasilICB - DEPARTAMENTO DE FARMACOLOGIAScientific ReportsReceptores de Glutamato Metabotrópico 5ObesidadeDoença de HuntingtonCamundongos knockoutMetabotropic glutamate receptor 5ObesityHuntington’s diseaseKnockout miceMetabotropic glutamate receptor 5 knockout rescues obesity phenotype in a mouse model of Huntington’s disease.info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttps://www.nature.com/articles/s41598-022-08924-4Rebeca P. M. SantosRoberta RibeiroTalita H. Ferreira-VieiraRosaria D. AiresJessica M. de SouzaBruna S. OliveiraAnna Luiza D. LimaAntônio Carlos P. de OliveiraHelton J. ReisAline S. de MirandaErica M. L. VieiraFabiola M. RibeiroLuciene Bruno Vieiraapplication/pdfinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFMGinstname:Universidade Federal de Minas Gerais (UFMG)instacron:UFMGLICENSELicense.txtLicense.txttext/plain; charset=utf-82042https://repositorio.ufmg.br/bitstream/1843/60288/1/License.txtfa505098d172de0bc8864fc1287ffe22MD51ORIGINALMetabotropic glutamate receptor 5 knockout rescues obesity phenotype in a mouse model of Huntington’s disease.pdfMetabotropic glutamate receptor 5 knockout rescues obesity phenotype in a mouse model of Huntington’s disease.pdfapplication/pdf1527347https://repositorio.ufmg.br/bitstream/1843/60288/2/Metabotropic%20glutamate%20receptor%205%20knockout%20rescues%20obesity%20phenotype%20in%20a%20mouse%20model%20of%20Huntington%e2%80%99s%20disease.pdf8fdb335113a3cef49c62106448996f23MD521843/602882023-10-30 18:34:17.128oai:repositorio.ufmg.br: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Repositório de PublicaçõesPUBhttps://repositorio.ufmg.br/oaiopendoar:2023-10-30T21:34:17Repositório Institucional da UFMG - Universidade Federal de Minas Gerais (UFMG)false |
| dc.title.pt_BR.fl_str_mv |
Metabotropic glutamate receptor 5 knockout rescues obesity phenotype in a mouse model of Huntington’s disease. |
| title |
Metabotropic glutamate receptor 5 knockout rescues obesity phenotype in a mouse model of Huntington’s disease. |
| spellingShingle |
Metabotropic glutamate receptor 5 knockout rescues obesity phenotype in a mouse model of Huntington’s disease. Rebeca P. M. Santos Metabotropic glutamate receptor 5 Obesity Huntington’s disease Knockout mice Receptores de Glutamato Metabotrópico 5 Obesidade Doença de Huntington Camundongos knockout |
| title_short |
Metabotropic glutamate receptor 5 knockout rescues obesity phenotype in a mouse model of Huntington’s disease. |
| title_full |
Metabotropic glutamate receptor 5 knockout rescues obesity phenotype in a mouse model of Huntington’s disease. |
| title_fullStr |
Metabotropic glutamate receptor 5 knockout rescues obesity phenotype in a mouse model of Huntington’s disease. |
| title_full_unstemmed |
Metabotropic glutamate receptor 5 knockout rescues obesity phenotype in a mouse model of Huntington’s disease. |
| title_sort |
Metabotropic glutamate receptor 5 knockout rescues obesity phenotype in a mouse model of Huntington’s disease. |
| author |
Rebeca P. M. Santos |
| author_facet |
Rebeca P. M. Santos Roberta Ribeiro Talita H. Ferreira-Vieira Rosaria D. Aires Jessica M. de Souza Bruna S. Oliveira Anna Luiza D. Lima Antônio Carlos P. de Oliveira Helton J. Reis Aline S. de Miranda Erica M. L. Vieira Fabiola M. Ribeiro Luciene Bruno Vieira |
| author_role |
author |
| author2 |
Roberta Ribeiro Talita H. Ferreira-Vieira Rosaria D. Aires Jessica M. de Souza Bruna S. Oliveira Anna Luiza D. Lima Antônio Carlos P. de Oliveira Helton J. Reis Aline S. de Miranda Erica M. L. Vieira Fabiola M. Ribeiro Luciene Bruno Vieira |
| author2_role |
author author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Rebeca P. M. Santos Roberta Ribeiro Talita H. Ferreira-Vieira Rosaria D. Aires Jessica M. de Souza Bruna S. Oliveira Anna Luiza D. Lima Antônio Carlos P. de Oliveira Helton J. Reis Aline S. de Miranda Erica M. L. Vieira Fabiola M. Ribeiro Luciene Bruno Vieira |
| dc.subject.por.fl_str_mv |
Metabotropic glutamate receptor 5 Obesity Huntington’s disease Knockout mice |
| topic |
Metabotropic glutamate receptor 5 Obesity Huntington’s disease Knockout mice Receptores de Glutamato Metabotrópico 5 Obesidade Doença de Huntington Camundongos knockout |
| dc.subject.other.pt_BR.fl_str_mv |
Receptores de Glutamato Metabotrópico 5 Obesidade Doença de Huntington Camundongos knockout |
| description |
CNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico |
| publishDate |
2022 |
| dc.date.issued.fl_str_mv |
2022 |
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2023-10-30T21:34:16Z |
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2023-10-30T21:34:16Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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http://hdl.handle.net/1843/60288 |
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https://doi.org/10.1038/s41598-022-08924-4 |
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2045-2322 |
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https://orcid.org/0000-0002-3496-6749 |
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https://doi.org/10.1038/s41598-022-08924-4 http://hdl.handle.net/1843/60288 https://orcid.org/0000-0002-3496-6749 |
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2045-2322 |
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eng |
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eng |
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Scientific Reports |
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info:eu-repo/semantics/openAccess |
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openAccess |
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Universidade Federal de Minas Gerais |
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UFMG |
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Brasil |
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ICB - DEPARTAMENTO DE FARMACOLOGIA |
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Universidade Federal de Minas Gerais |
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reponame:Repositório Institucional da UFMG instname:Universidade Federal de Minas Gerais (UFMG) instacron:UFMG |
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