Performance of new biomarkers of nephropathy in patients with type 1 diabetes mellitus
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2016 |
| Outros Autores: | , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da UFMG |
| Texto Completo: | https://doi.org/10.9734/BJMMR/2016/23476 http://hdl.handle.net/1843/40274 |
Resumo: | CNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico |
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2022-03-21T16:05:09Z2022-03-21T16:05:09Z2016153114https://doi.org/10.9734/BJMMR/2016/234762231-0614http://hdl.handle.net/1843/40274CNPq - Conselho Nacional de Desenvolvimento Científico e TecnológicoCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível SuperiorIntroduction: It is known that laboratorial tests (urinary albumin excretion and glomerular filtration rate), routinely used for nephropathy diagnosis in type 1 diabetes (T1DM), have limitations that justify the evaluation of new renal biomarkers. This study assessed the performance of cystatin C, alkaline phosphatase (AP) and gamma-glutamyl transferase (GGT) for nephropathy diagnosis in T1DM patients. The reduction of economic cost and increase in sensibility and specificity from correct biochemical diagnosis of diabetic nephropathy is an important objective of this work. Methods: Cystatin C, AP and GGT were determined in plasma and urine of healthy individuals (N=35) and T1DM patients with (N=45) and without nephropathy (N=80). Results: The plasma levels of cystatin C, AP and GGT, as well as urinary levels of cystatin C and AP were able to differentiate diabetic patients with and without nephropathy. Plasma cystatin C better followed the progression of albuminuria. Cystatin C and AP discriminated the onset of nephropathy in T1DM patients better than creatinine. AP plasma/urine ratio progressively increased from the controls to the diabetic patients without and with nephropathy. Conclusion: The plasma levels of cystatin C and AP may be useful, with the classical markers of renal function, for nephropathy diagnosis and monitoring in T1DM patients.engUniversidade Federal de Minas GeraisUFMGBrasilFAR - DEPARTAMENTO DE ANÁLISES CLÍNICAS E TOXICOLÓGICASICB - DEPARTAMENTO DE MICROBIOLOGIABritish Journal of Medicine and Medical ResearchNefropatias diabéticasDiabetes mellitusCistatina CFosfatase alcalinaGama-glutamiltransferaseDiabetic nephropathyCystatin CAlkaline phosphataseGamma-glutamyl transferasePerformance of new biomarkers of nephropathy in patients with type 1 diabetes mellitusinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttps://www.journaljammr.com/index.php/JAMMR/article/view/10278Manuelle Maria Pereira NatividadeCaroline Pereira DominguetiAna Paula Salles Moura FernandesRodrigo Bastos FóscoloJanice Sepúlveda ReisLuci Maria SantAna DusseCamila Stefanie Fonseca de OliveiraJoão Paulo Amaral HaddadLara Carvalho GodoiKarina Braga Gomes BorgesHenrique Pimenta Barroso Magalhãesapplication/pdfinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFMGinstname:Universidade Federal de Minas Gerais (UFMG)instacron:UFMGLICENSELicense.txtLicense.txttext/plain; charset=utf-82042https://repositorio.ufmg.br/bitstream/1843/40274/1/License.txtfa505098d172de0bc8864fc1287ffe22MD51ORIGINALPerformance of new biomarkers of nephropathy inpatients withtype 1 Diabetes mellitus.pdfPerformance of new biomarkers of nephropathy inpatients withtype 1 Diabetes mellitus.pdfapplication/pdf318198https://repositorio.ufmg.br/bitstream/1843/40274/2/Performance%20of%20new%20biomarkers%20of%20nephropathy%20inpatients%20withtype%201%20Diabetes%20mellitus.pdf7ac73a388a0dd20a6a77ab89ea3113dcMD521843/402742022-03-21 13:05:09.628oai:repositorio.ufmg.br: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Repositório de PublicaçõesPUBhttps://repositorio.ufmg.br/oaiopendoar:2022-03-21T16:05:09Repositório Institucional da UFMG - Universidade Federal de Minas Gerais (UFMG)false |
| dc.title.pt_BR.fl_str_mv |
Performance of new biomarkers of nephropathy in patients with type 1 diabetes mellitus |
| title |
Performance of new biomarkers of nephropathy in patients with type 1 diabetes mellitus |
| spellingShingle |
Performance of new biomarkers of nephropathy in patients with type 1 diabetes mellitus Manuelle Maria Pereira Natividade Diabetic nephropathy Cystatin C Alkaline phosphatase Gamma-glutamyl transferase Nefropatias diabéticas Diabetes mellitus Cistatina C Fosfatase alcalina Gama-glutamiltransferase |
| title_short |
Performance of new biomarkers of nephropathy in patients with type 1 diabetes mellitus |
| title_full |
Performance of new biomarkers of nephropathy in patients with type 1 diabetes mellitus |
| title_fullStr |
Performance of new biomarkers of nephropathy in patients with type 1 diabetes mellitus |
| title_full_unstemmed |
Performance of new biomarkers of nephropathy in patients with type 1 diabetes mellitus |
| title_sort |
Performance of new biomarkers of nephropathy in patients with type 1 diabetes mellitus |
| author |
Manuelle Maria Pereira Natividade |
| author_facet |
Manuelle Maria Pereira Natividade Caroline Pereira Domingueti Ana Paula Salles Moura Fernandes Rodrigo Bastos Fóscolo Janice Sepúlveda Reis Luci Maria SantAna Dusse Camila Stefanie Fonseca de Oliveira João Paulo Amaral Haddad Lara Carvalho Godoi Karina Braga Gomes Borges Henrique Pimenta Barroso Magalhães |
| author_role |
author |
| author2 |
Caroline Pereira Domingueti Ana Paula Salles Moura Fernandes Rodrigo Bastos Fóscolo Janice Sepúlveda Reis Luci Maria SantAna Dusse Camila Stefanie Fonseca de Oliveira João Paulo Amaral Haddad Lara Carvalho Godoi Karina Braga Gomes Borges Henrique Pimenta Barroso Magalhães |
| author2_role |
author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Manuelle Maria Pereira Natividade Caroline Pereira Domingueti Ana Paula Salles Moura Fernandes Rodrigo Bastos Fóscolo Janice Sepúlveda Reis Luci Maria SantAna Dusse Camila Stefanie Fonseca de Oliveira João Paulo Amaral Haddad Lara Carvalho Godoi Karina Braga Gomes Borges Henrique Pimenta Barroso Magalhães |
| dc.subject.por.fl_str_mv |
Diabetic nephropathy Cystatin C Alkaline phosphatase Gamma-glutamyl transferase |
| topic |
Diabetic nephropathy Cystatin C Alkaline phosphatase Gamma-glutamyl transferase Nefropatias diabéticas Diabetes mellitus Cistatina C Fosfatase alcalina Gama-glutamiltransferase |
| dc.subject.other.pt_BR.fl_str_mv |
Nefropatias diabéticas Diabetes mellitus Cistatina C Fosfatase alcalina Gama-glutamiltransferase |
| description |
CNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico |
| publishDate |
2016 |
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2016 |
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2022-03-21T16:05:09Z |
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2022-03-21T16:05:09Z |
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http://hdl.handle.net/1843/40274 |
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https://doi.org/10.9734/BJMMR/2016/23476 |
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2231-0614 |
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https://doi.org/10.9734/BJMMR/2016/23476 http://hdl.handle.net/1843/40274 |
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British Journal of Medicine and Medical Research |
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openAccess |
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Universidade Federal de Minas Gerais |
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Brasil |
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FAR - DEPARTAMENTO DE ANÁLISES CLÍNICAS E TOXICOLÓGICAS ICB - DEPARTAMENTO DE MICROBIOLOGIA |
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Universidade Federal de Minas Gerais |
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