Human visceral leishmaniasis: from diagnosis to treatmant
Autor(a) principal: | |
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Data de Publicação: | 2020 |
Outros Autores: | , , , , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFMG |
Texto Completo: | https://doi.org/10.37118/ijdr.20263.11.2020 http://hdl.handle.net/1843/48008 https://orcid.org/0000-0001-6759-9730 |
Resumo: | Leishmaniasis is a parasitic disease caused by the protozoan of the genus Leishmania, which affects millions of individuals, particularly in tropical and subtropical regions, and is therefore responsible for high mortality and morbidity. Due to the relevance of this pathology, the objective was to build a literature review with emphasis on its diagnosis and treatment, addressing its clinical-pathological characteristics. The bibliographic research was built based on the analysis of articles from the electronic databases SciELO (Scientific Library Eletronic) and PUBMED. In men, the disease is characterized clinically and laboratorially by fever, anemia, hepatosplenomegaly, pancytopenia and changes in the cellular immune response, affecting mainly children. The disease is usually fatal when left untreated, and death results from complications such as secondary bacterial infections and coagulation disorders. The diagnosis is routinely made based on clinical and epidemiological parameters, associated with parasitological, serological and immunological methods. As for treatment, antimonial compounds are still the drugs of choice for the treatment of the disease. Of all the great endemics, leishmaniasis are certainly the ones with the greatest number of knowledge gaps and for this reason many doubts still need to be clarified. |
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2022-12-15T12:04:50Z2022-12-15T12:04:50Z202010114220842211https://doi.org/10.37118/ijdr.20263.11.20202230-9926http://hdl.handle.net/1843/48008https://orcid.org/0000-0001-6759-9730Leishmaniasis is a parasitic disease caused by the protozoan of the genus Leishmania, which affects millions of individuals, particularly in tropical and subtropical regions, and is therefore responsible for high mortality and morbidity. Due to the relevance of this pathology, the objective was to build a literature review with emphasis on its diagnosis and treatment, addressing its clinical-pathological characteristics. The bibliographic research was built based on the analysis of articles from the electronic databases SciELO (Scientific Library Eletronic) and PUBMED. In men, the disease is characterized clinically and laboratorially by fever, anemia, hepatosplenomegaly, pancytopenia and changes in the cellular immune response, affecting mainly children. The disease is usually fatal when left untreated, and death results from complications such as secondary bacterial infections and coagulation disorders. The diagnosis is routinely made based on clinical and epidemiological parameters, associated with parasitological, serological and immunological methods. As for treatment, antimonial compounds are still the drugs of choice for the treatment of the disease. Of all the great endemics, leishmaniasis are certainly the ones with the greatest number of knowledge gaps and for this reason many doubts still need to be clarified.engUniversidade Federal de Minas GeraisUFMGBrasilICA - INSTITUTO DE CIÊNCIAS AGRÁRIASInternational Journal of Development ResearchLeishmaniose visceralLeishmaniose -- DiagnosticoLeishmaniose -- TratamentoHuman visceral leishmaniasis: from diagnosis to treatmantinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://journalijdr.com/human-visceral-leishmaniasis-diagnosis-treatmentEva Bethania Araújo de FreitasRenata ResstelFlávia de Jesus RamettaFilipe de Jesus RamettaLetícia Prates Morais RamettaJorge Carlos Neves de Souza JuniorTalita Antunes GuimarãesDaniela Fernanda de FreitasFlávio Júnior Barbosa FigueiredoFranciellen Morais-CostaBerenilde Valéria de Oliveira SousaMaria de Fátima de Matos MaiaOtávio Cardoso FilhoDemerson Arruda SanglardClaúdio Ildeu Costa Nascimentoinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFMGinstname:Universidade Federal de Minas Gerais (UFMG)instacron:UFMGLICENSELicense.txtLicense.txttext/plain; charset=utf-82042https://repositorio.ufmg.br/bitstream/1843/48008/1/License.txtfa505098d172de0bc8864fc1287ffe22MD51ORIGINALHuman visceral leishmaniasis - from diagnosis to treatmant.pdfHuman visceral leishmaniasis - from diagnosis to treatmant.pdfapplication/pdf277032https://repositorio.ufmg.br/bitstream/1843/48008/2/Human%20visceral%20leishmaniasis%20-%20from%20diagnosis%20to%20treatmant.pdff436f2be17ac08f78cf41a2b422ba1a3MD521843/480082022-12-15 09:04:51.07oai:repositorio.ufmg.br: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Repositório de PublicaçõesPUBhttps://repositorio.ufmg.br/oaiopendoar:2022-12-15T12:04:51Repositório Institucional da UFMG - Universidade Federal de Minas Gerais (UFMG)false |
dc.title.pt_BR.fl_str_mv |
Human visceral leishmaniasis: from diagnosis to treatmant |
title |
Human visceral leishmaniasis: from diagnosis to treatmant |
spellingShingle |
Human visceral leishmaniasis: from diagnosis to treatmant Eva Bethania Araújo de Freitas Leishmaniose visceral Leishmaniose -- Diagnostico Leishmaniose -- Tratamento |
title_short |
Human visceral leishmaniasis: from diagnosis to treatmant |
title_full |
Human visceral leishmaniasis: from diagnosis to treatmant |
title_fullStr |
Human visceral leishmaniasis: from diagnosis to treatmant |
title_full_unstemmed |
Human visceral leishmaniasis: from diagnosis to treatmant |
title_sort |
Human visceral leishmaniasis: from diagnosis to treatmant |
author |
Eva Bethania Araújo de Freitas |
author_facet |
Eva Bethania Araújo de Freitas Renata Resstel Flávia de Jesus Rametta Filipe de Jesus Rametta Letícia Prates Morais Rametta Jorge Carlos Neves de Souza Junior Talita Antunes Guimarães Daniela Fernanda de Freitas Flávio Júnior Barbosa Figueiredo Franciellen Morais-Costa Berenilde Valéria de Oliveira Sousa Maria de Fátima de Matos Maia Otávio Cardoso Filho Demerson Arruda Sanglard Claúdio Ildeu Costa Nascimento |
author_role |
author |
author2 |
Renata Resstel Flávia de Jesus Rametta Filipe de Jesus Rametta Letícia Prates Morais Rametta Jorge Carlos Neves de Souza Junior Talita Antunes Guimarães Daniela Fernanda de Freitas Flávio Júnior Barbosa Figueiredo Franciellen Morais-Costa Berenilde Valéria de Oliveira Sousa Maria de Fátima de Matos Maia Otávio Cardoso Filho Demerson Arruda Sanglard Claúdio Ildeu Costa Nascimento |
author2_role |
author author author author author author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Eva Bethania Araújo de Freitas Renata Resstel Flávia de Jesus Rametta Filipe de Jesus Rametta Letícia Prates Morais Rametta Jorge Carlos Neves de Souza Junior Talita Antunes Guimarães Daniela Fernanda de Freitas Flávio Júnior Barbosa Figueiredo Franciellen Morais-Costa Berenilde Valéria de Oliveira Sousa Maria de Fátima de Matos Maia Otávio Cardoso Filho Demerson Arruda Sanglard Claúdio Ildeu Costa Nascimento |
dc.subject.other.pt_BR.fl_str_mv |
Leishmaniose visceral Leishmaniose -- Diagnostico Leishmaniose -- Tratamento |
topic |
Leishmaniose visceral Leishmaniose -- Diagnostico Leishmaniose -- Tratamento |
description |
Leishmaniasis is a parasitic disease caused by the protozoan of the genus Leishmania, which affects millions of individuals, particularly in tropical and subtropical regions, and is therefore responsible for high mortality and morbidity. Due to the relevance of this pathology, the objective was to build a literature review with emphasis on its diagnosis and treatment, addressing its clinical-pathological characteristics. The bibliographic research was built based on the analysis of articles from the electronic databases SciELO (Scientific Library Eletronic) and PUBMED. In men, the disease is characterized clinically and laboratorially by fever, anemia, hepatosplenomegaly, pancytopenia and changes in the cellular immune response, affecting mainly children. The disease is usually fatal when left untreated, and death results from complications such as secondary bacterial infections and coagulation disorders. The diagnosis is routinely made based on clinical and epidemiological parameters, associated with parasitological, serological and immunological methods. As for treatment, antimonial compounds are still the drugs of choice for the treatment of the disease. Of all the great endemics, leishmaniasis are certainly the ones with the greatest number of knowledge gaps and for this reason many doubts still need to be clarified. |
publishDate |
2020 |
dc.date.issued.fl_str_mv |
2020 |
dc.date.accessioned.fl_str_mv |
2022-12-15T12:04:50Z |
dc.date.available.fl_str_mv |
2022-12-15T12:04:50Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
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article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/1843/48008 |
dc.identifier.doi.pt_BR.fl_str_mv |
https://doi.org/10.37118/ijdr.20263.11.2020 |
dc.identifier.issn.pt_BR.fl_str_mv |
2230-9926 |
dc.identifier.orcid.pt_BR.fl_str_mv |
https://orcid.org/0000-0001-6759-9730 |
url |
https://doi.org/10.37118/ijdr.20263.11.2020 http://hdl.handle.net/1843/48008 https://orcid.org/0000-0001-6759-9730 |
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2230-9926 |
dc.language.iso.fl_str_mv |
eng |
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eng |
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International Journal of Development Research |
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info:eu-repo/semantics/openAccess |
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openAccess |
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Universidade Federal de Minas Gerais |
dc.publisher.initials.fl_str_mv |
UFMG |
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Brasil |
dc.publisher.department.fl_str_mv |
ICA - INSTITUTO DE CIÊNCIAS AGRÁRIAS |
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Universidade Federal de Minas Gerais |
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