The use of cyproterone acetate/ethinyl estradiol in hyperandrogenic skin symptoms - a review
Autor(a) principal: | |
---|---|
Data de Publicação: | 2017 |
Outros Autores: | , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFMG |
Texto Completo: | https://doi.org/10.1080/13625187.2017.1317339 http://hdl.handle.net/1843/51673 https://orcid.org/0000-0002-8486-7861 |
Resumo: | Introduction: Hyperandrogenism affects approximately 10–20% of women of reproductive age. Hyperandrogenic skin symptoms such as hirsutism, acne, seborrhea and alopecia are associated with significant quality of life and psychological impairment. Women with abnormalities in androgen metabolism may have accompanying anovulation and/or polycystic ovary syndrome (PCOS), both of which have reproductive and metabolic implications if left untreated. Cyproterone acetate (CPA), combined with ethinylestradiol (EE), is indicated for the treatment of moderate to severe acne related to androgen-sensitivity (with or without seborrhea) and/or hirsutism, in women of reproductive age. Objective: To review the data on the efficacy and safety of CPA 2 mg/EE 35 lg for the treatment of hyperandrogenic skin symptoms in women. Methods: A non-systematic narrative review based on a literature search of the PubMed database. Results: Seventy eight studies were identified. The majority of sufficiently powered studies show a high efficacy of CPA 2mg/EE 35 lg in the treatment of severe acne and hirsutism. Studies show that therapeutic response in women with hirsutism requires a long-term approach and that hyperandrogenic skin symptoms in patients with PCOS are efficiently treated. Additional benefits include cycle control and, in some women, improvement in mood and perception of body image. Safety and tolerability data are summarized by the pharmacovigilance risk assessment committee (PRAC) of the European Medicine’s Agency’s (EMA). Conclusions: This review provides a comprehensive overview about the efficacy of CPA 2mg/EE 35 lg in the treatment of hyperandrogenic skin symptoms, thus allowing both health care professionals and women to balance the risks and benefits of treatment based on evidence. |
id |
UFMG_bb2deb6158efb44fbd9f2e10c85f8c12 |
---|---|
oai_identifier_str |
oai:repositorio.ufmg.br:1843/51673 |
network_acronym_str |
UFMG |
network_name_str |
Repositório Institucional da UFMG |
repository_id_str |
|
spelling |
2023-04-05T23:59:36Z2023-04-05T23:59:36Z2017-04-27223172182https://doi.org/10.1080/13625187.2017.13173391473-0782http://hdl.handle.net/1843/51673https://orcid.org/0000-0002-8486-7861Introduction: Hyperandrogenism affects approximately 10–20% of women of reproductive age. Hyperandrogenic skin symptoms such as hirsutism, acne, seborrhea and alopecia are associated with significant quality of life and psychological impairment. Women with abnormalities in androgen metabolism may have accompanying anovulation and/or polycystic ovary syndrome (PCOS), both of which have reproductive and metabolic implications if left untreated. Cyproterone acetate (CPA), combined with ethinylestradiol (EE), is indicated for the treatment of moderate to severe acne related to androgen-sensitivity (with or without seborrhea) and/or hirsutism, in women of reproductive age. Objective: To review the data on the efficacy and safety of CPA 2 mg/EE 35 lg for the treatment of hyperandrogenic skin symptoms in women. Methods: A non-systematic narrative review based on a literature search of the PubMed database. Results: Seventy eight studies were identified. The majority of sufficiently powered studies show a high efficacy of CPA 2mg/EE 35 lg in the treatment of severe acne and hirsutism. Studies show that therapeutic response in women with hirsutism requires a long-term approach and that hyperandrogenic skin symptoms in patients with PCOS are efficiently treated. Additional benefits include cycle control and, in some women, improvement in mood and perception of body image. Safety and tolerability data are summarized by the pharmacovigilance risk assessment committee (PRAC) of the European Medicine’s Agency’s (EMA). Conclusions: This review provides a comprehensive overview about the efficacy of CPA 2mg/EE 35 lg in the treatment of hyperandrogenic skin symptoms, thus allowing both health care professionals and women to balance the risks and benefits of treatment based on evidence.engUniversidade Federal de Minas GeraisUFMGBrasilMED - DEPARTAMENTO DE GINECOLOGIA OBSTETRÍCIAThe European Journal of Contraception & Reproductive Health CareHiperandrogenismoAcetato de ciproteronaEtinilestradiolHirsutismoAcne vulgarDermatite seborreicaAlopeciaSíndrome do ovário policísticoHyperandrogenismCyproterone acetateEthinylestradiolHirsutismAcneSeborrheaAlopeciaPolycystic ovary syndromeThe use of cyproterone acetate/ethinyl estradiol in hyperandrogenic skin symptoms - a reviewinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttps://www.tandfonline.com/doi/full/10.1080/13625187.2017.1317339Johannes BitzerThomas RömerAgnaldo Lopes da Silva Filhoapplication/pdfinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFMGinstname:Universidade Federal de Minas Gerais (UFMG)instacron:UFMGORIGINALThe use of cyproterone acetate ethinyl estradiol in hyperandrogenic skin symptoms a review.pdfThe use of cyproterone acetate ethinyl estradiol in hyperandrogenic skin symptoms a review.pdfapplication/pdf683253https://repositorio.ufmg.br/bitstream/1843/51673/2/The%20use%20of%20cyproterone%20acetate%20ethinyl%20estradiol%20in%20hyperandrogenic%20skin%20symptoms%20a%20review.pdfd6e36c9ddc00c16a4d62d320249cf226MD52LICENSELicense.txtLicense.txttext/plain; charset=utf-82042https://repositorio.ufmg.br/bitstream/1843/51673/1/License.txtfa505098d172de0bc8864fc1287ffe22MD511843/516732023-04-05 21:20:20.553oai:repositorio.ufmg.br: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Repositório de PublicaçõesPUBhttps://repositorio.ufmg.br/oaiopendoar:2023-04-06T00:20:20Repositório Institucional da UFMG - Universidade Federal de Minas Gerais (UFMG)false |
dc.title.pt_BR.fl_str_mv |
The use of cyproterone acetate/ethinyl estradiol in hyperandrogenic skin symptoms - a review |
title |
The use of cyproterone acetate/ethinyl estradiol in hyperandrogenic skin symptoms - a review |
spellingShingle |
The use of cyproterone acetate/ethinyl estradiol in hyperandrogenic skin symptoms - a review Johannes Bitzer Hyperandrogenism Cyproterone acetate Ethinylestradiol Hirsutism Acne Seborrhea Alopecia Polycystic ovary syndrome Hiperandrogenismo Acetato de ciproterona Etinilestradiol Hirsutismo Acne vulgar Dermatite seborreica Alopecia Síndrome do ovário policístico |
title_short |
The use of cyproterone acetate/ethinyl estradiol in hyperandrogenic skin symptoms - a review |
title_full |
The use of cyproterone acetate/ethinyl estradiol in hyperandrogenic skin symptoms - a review |
title_fullStr |
The use of cyproterone acetate/ethinyl estradiol in hyperandrogenic skin symptoms - a review |
title_full_unstemmed |
The use of cyproterone acetate/ethinyl estradiol in hyperandrogenic skin symptoms - a review |
title_sort |
The use of cyproterone acetate/ethinyl estradiol in hyperandrogenic skin symptoms - a review |
author |
Johannes Bitzer |
author_facet |
Johannes Bitzer Thomas Römer Agnaldo Lopes da Silva Filho |
author_role |
author |
author2 |
Thomas Römer Agnaldo Lopes da Silva Filho |
author2_role |
author author |
dc.contributor.author.fl_str_mv |
Johannes Bitzer Thomas Römer Agnaldo Lopes da Silva Filho |
dc.subject.por.fl_str_mv |
Hyperandrogenism Cyproterone acetate Ethinylestradiol Hirsutism Acne Seborrhea Alopecia Polycystic ovary syndrome |
topic |
Hyperandrogenism Cyproterone acetate Ethinylestradiol Hirsutism Acne Seborrhea Alopecia Polycystic ovary syndrome Hiperandrogenismo Acetato de ciproterona Etinilestradiol Hirsutismo Acne vulgar Dermatite seborreica Alopecia Síndrome do ovário policístico |
dc.subject.other.pt_BR.fl_str_mv |
Hiperandrogenismo Acetato de ciproterona Etinilestradiol Hirsutismo Acne vulgar Dermatite seborreica Alopecia Síndrome do ovário policístico |
description |
Introduction: Hyperandrogenism affects approximately 10–20% of women of reproductive age. Hyperandrogenic skin symptoms such as hirsutism, acne, seborrhea and alopecia are associated with significant quality of life and psychological impairment. Women with abnormalities in androgen metabolism may have accompanying anovulation and/or polycystic ovary syndrome (PCOS), both of which have reproductive and metabolic implications if left untreated. Cyproterone acetate (CPA), combined with ethinylestradiol (EE), is indicated for the treatment of moderate to severe acne related to androgen-sensitivity (with or without seborrhea) and/or hirsutism, in women of reproductive age. Objective: To review the data on the efficacy and safety of CPA 2 mg/EE 35 lg for the treatment of hyperandrogenic skin symptoms in women. Methods: A non-systematic narrative review based on a literature search of the PubMed database. Results: Seventy eight studies were identified. The majority of sufficiently powered studies show a high efficacy of CPA 2mg/EE 35 lg in the treatment of severe acne and hirsutism. Studies show that therapeutic response in women with hirsutism requires a long-term approach and that hyperandrogenic skin symptoms in patients with PCOS are efficiently treated. Additional benefits include cycle control and, in some women, improvement in mood and perception of body image. Safety and tolerability data are summarized by the pharmacovigilance risk assessment committee (PRAC) of the European Medicine’s Agency’s (EMA). Conclusions: This review provides a comprehensive overview about the efficacy of CPA 2mg/EE 35 lg in the treatment of hyperandrogenic skin symptoms, thus allowing both health care professionals and women to balance the risks and benefits of treatment based on evidence. |
publishDate |
2017 |
dc.date.issued.fl_str_mv |
2017-04-27 |
dc.date.accessioned.fl_str_mv |
2023-04-05T23:59:36Z |
dc.date.available.fl_str_mv |
2023-04-05T23:59:36Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/1843/51673 |
dc.identifier.doi.pt_BR.fl_str_mv |
https://doi.org/10.1080/13625187.2017.1317339 |
dc.identifier.issn.pt_BR.fl_str_mv |
1473-0782 |
dc.identifier.orcid.pt_BR.fl_str_mv |
https://orcid.org/0000-0002-8486-7861 |
url |
https://doi.org/10.1080/13625187.2017.1317339 http://hdl.handle.net/1843/51673 https://orcid.org/0000-0002-8486-7861 |
identifier_str_mv |
1473-0782 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.ispartof.none.fl_str_mv |
The European Journal of Contraception & Reproductive Health Care |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Universidade Federal de Minas Gerais |
dc.publisher.initials.fl_str_mv |
UFMG |
dc.publisher.country.fl_str_mv |
Brasil |
dc.publisher.department.fl_str_mv |
MED - DEPARTAMENTO DE GINECOLOGIA OBSTETRÍCIA |
publisher.none.fl_str_mv |
Universidade Federal de Minas Gerais |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UFMG instname:Universidade Federal de Minas Gerais (UFMG) instacron:UFMG |
instname_str |
Universidade Federal de Minas Gerais (UFMG) |
instacron_str |
UFMG |
institution |
UFMG |
reponame_str |
Repositório Institucional da UFMG |
collection |
Repositório Institucional da UFMG |
bitstream.url.fl_str_mv |
https://repositorio.ufmg.br/bitstream/1843/51673/2/The%20use%20of%20cyproterone%20acetate%20ethinyl%20estradiol%20in%20hyperandrogenic%20skin%20symptoms%20a%20review.pdf https://repositorio.ufmg.br/bitstream/1843/51673/1/License.txt |
bitstream.checksum.fl_str_mv |
d6e36c9ddc00c16a4d62d320249cf226 fa505098d172de0bc8864fc1287ffe22 |
bitstream.checksumAlgorithm.fl_str_mv |
MD5 MD5 |
repository.name.fl_str_mv |
Repositório Institucional da UFMG - Universidade Federal de Minas Gerais (UFMG) |
repository.mail.fl_str_mv |
|
_version_ |
1801676786077007872 |