Disparities in breast, lung, and cervical cancer trials worldwide

Detalhes bibliográficos
Autor(a) principal: Ramya Ramaswami
Data de Publicação: 2018
Outros Autores: Eduardo Paulino, Adriana Barrichello, Angélica Nogueira Rodrigues, Alexandra Bukowski, Jessica St. Louis, Paul e. Goss
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFMG
Texto Completo: http://hdl.handle.net/1843/57767
Resumo: Purpose As cancer burden has risen worldwide, physicians, patients, and their advocates have become aware that the clinical cancer trial research paradigm is not ubiquitous. Furthermore, the number and characteristics of trials that are registered in low- and middle-income countries (LMICs) compared with that in high-income countries (HICs) are unknown.Methods We collected retrospective data on trials for breast, lung, and cervical cancer registered in ClinicalTrials.gov or with the WHO International Clinical Trial Registry Platform between 2010 and 2017. The data were then classified as trials within LMICs or HICs using definitions from the World Bank.Results Included in these analyses were 6,710 trials, of which 3,164 (47%) were breast cancer trials, 3,283 (49%) were lung cancer trials, and 263 (4%) were cervical cancer trials. There were 1,951 (29%) trials from LMICs and 4,759 (71%) trials from HICs (P < .001). Although the proportion of phase III trials in HICs versus LMICs was similar (18% v 17%; P = .66), the number of phase I trials in LMICs was significantly lower than that of HICs (20% v 2%; P < .001). For several LMICs with the highest mortality-to-incidence ratios for breast, lung, or cervical cancer, there were no cancer trials registered in the registration data bases searched for this work.Conclusion There are differences in access to cancer clinical trials in LMICs compared with HICs. Several factors, such as excessive cost and a lack of infrastructure and expertise, may explain these differences.
id UFMG_c148db15678a6cf8667ab4c125de7ab7
oai_identifier_str oai:repositorio.ufmg.br:1843/57767
network_acronym_str UFMG
network_name_str Repositório Institucional da UFMG
repository_id_str
spelling Disparities in breast, lung, and cervical cancer trials worldwideBreast CancerCervical CancerLung CancerNeoplasias da MamaNeoplasias PulmonaresNeoplasias do Colo do ÚteroPurpose As cancer burden has risen worldwide, physicians, patients, and their advocates have become aware that the clinical cancer trial research paradigm is not ubiquitous. Furthermore, the number and characteristics of trials that are registered in low- and middle-income countries (LMICs) compared with that in high-income countries (HICs) are unknown.Methods We collected retrospective data on trials for breast, lung, and cervical cancer registered in ClinicalTrials.gov or with the WHO International Clinical Trial Registry Platform between 2010 and 2017. The data were then classified as trials within LMICs or HICs using definitions from the World Bank.Results Included in these analyses were 6,710 trials, of which 3,164 (47%) were breast cancer trials, 3,283 (49%) were lung cancer trials, and 263 (4%) were cervical cancer trials. There were 1,951 (29%) trials from LMICs and 4,759 (71%) trials from HICs (P < .001). Although the proportion of phase III trials in HICs versus LMICs was similar (18% v 17%; P = .66), the number of phase I trials in LMICs was significantly lower than that of HICs (20% v 2%; P < .001). For several LMICs with the highest mortality-to-incidence ratios for breast, lung, or cervical cancer, there were no cancer trials registered in the registration data bases searched for this work.Conclusion There are differences in access to cancer clinical trials in LMICs compared with HICs. Several factors, such as excessive cost and a lack of infrastructure and expertise, may explain these differences.Universidade Federal de Minas GeraisBrasilMED - DEPARTAMENTO DE CLÍNICA MÉDICAUFMG2023-08-11T20:32:11Z2023-08-11T20:32:11Z2018info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlepdfapplication/pdf10.1200/JGO.17.002262378-9506http://hdl.handle.net/1843/57767engJournal of Global OncologyRamya RamaswamiEduardo PaulinoAdriana BarrichelloAngélica Nogueira RodriguesAlexandra BukowskiJessica St. LouisPaul e. Gossinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFMGinstname:Universidade Federal de Minas Gerais (UFMG)instacron:UFMG2023-08-11T20:42:33Zoai:repositorio.ufmg.br:1843/57767Repositório InstitucionalPUBhttps://repositorio.ufmg.br/oairepositorio@ufmg.bropendoar:2023-08-11T20:42:33Repositório Institucional da UFMG - Universidade Federal de Minas Gerais (UFMG)false
dc.title.none.fl_str_mv Disparities in breast, lung, and cervical cancer trials worldwide
title Disparities in breast, lung, and cervical cancer trials worldwide
spellingShingle Disparities in breast, lung, and cervical cancer trials worldwide
Ramya Ramaswami
Breast Cancer
Cervical Cancer
Lung Cancer
Neoplasias da Mama
Neoplasias Pulmonares
Neoplasias do Colo do Útero
title_short Disparities in breast, lung, and cervical cancer trials worldwide
title_full Disparities in breast, lung, and cervical cancer trials worldwide
title_fullStr Disparities in breast, lung, and cervical cancer trials worldwide
title_full_unstemmed Disparities in breast, lung, and cervical cancer trials worldwide
title_sort Disparities in breast, lung, and cervical cancer trials worldwide
author Ramya Ramaswami
author_facet Ramya Ramaswami
Eduardo Paulino
Adriana Barrichello
Angélica Nogueira Rodrigues
Alexandra Bukowski
Jessica St. Louis
Paul e. Goss
author_role author
author2 Eduardo Paulino
Adriana Barrichello
Angélica Nogueira Rodrigues
Alexandra Bukowski
Jessica St. Louis
Paul e. Goss
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Ramya Ramaswami
Eduardo Paulino
Adriana Barrichello
Angélica Nogueira Rodrigues
Alexandra Bukowski
Jessica St. Louis
Paul e. Goss
dc.subject.por.fl_str_mv Breast Cancer
Cervical Cancer
Lung Cancer
Neoplasias da Mama
Neoplasias Pulmonares
Neoplasias do Colo do Útero
topic Breast Cancer
Cervical Cancer
Lung Cancer
Neoplasias da Mama
Neoplasias Pulmonares
Neoplasias do Colo do Útero
description Purpose As cancer burden has risen worldwide, physicians, patients, and their advocates have become aware that the clinical cancer trial research paradigm is not ubiquitous. Furthermore, the number and characteristics of trials that are registered in low- and middle-income countries (LMICs) compared with that in high-income countries (HICs) are unknown.Methods We collected retrospective data on trials for breast, lung, and cervical cancer registered in ClinicalTrials.gov or with the WHO International Clinical Trial Registry Platform between 2010 and 2017. The data were then classified as trials within LMICs or HICs using definitions from the World Bank.Results Included in these analyses were 6,710 trials, of which 3,164 (47%) were breast cancer trials, 3,283 (49%) were lung cancer trials, and 263 (4%) were cervical cancer trials. There were 1,951 (29%) trials from LMICs and 4,759 (71%) trials from HICs (P < .001). Although the proportion of phase III trials in HICs versus LMICs was similar (18% v 17%; P = .66), the number of phase I trials in LMICs was significantly lower than that of HICs (20% v 2%; P < .001). For several LMICs with the highest mortality-to-incidence ratios for breast, lung, or cervical cancer, there were no cancer trials registered in the registration data bases searched for this work.Conclusion There are differences in access to cancer clinical trials in LMICs compared with HICs. Several factors, such as excessive cost and a lack of infrastructure and expertise, may explain these differences.
publishDate 2018
dc.date.none.fl_str_mv 2018
2023-08-11T20:32:11Z
2023-08-11T20:32:11Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv 10.1200/JGO.17.00226
2378-9506
http://hdl.handle.net/1843/57767
identifier_str_mv 10.1200/JGO.17.00226
2378-9506
url http://hdl.handle.net/1843/57767
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Journal of Global Oncology
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv pdf
application/pdf
dc.publisher.none.fl_str_mv Universidade Federal de Minas Gerais
Brasil
MED - DEPARTAMENTO DE CLÍNICA MÉDICA
UFMG
publisher.none.fl_str_mv Universidade Federal de Minas Gerais
Brasil
MED - DEPARTAMENTO DE CLÍNICA MÉDICA
UFMG
dc.source.none.fl_str_mv reponame:Repositório Institucional da UFMG
instname:Universidade Federal de Minas Gerais (UFMG)
instacron:UFMG
instname_str Universidade Federal de Minas Gerais (UFMG)
instacron_str UFMG
institution UFMG
reponame_str Repositório Institucional da UFMG
collection Repositório Institucional da UFMG
repository.name.fl_str_mv Repositório Institucional da UFMG - Universidade Federal de Minas Gerais (UFMG)
repository.mail.fl_str_mv repositorio@ufmg.br
_version_ 1816829590159491072