Indices in dental image exams for bone mineral density evaluation of aromatase inhibitor users
Autor(a) principal: | |
---|---|
Data de Publicação: | 2022 |
Outros Autores: | , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFMG |
Texto Completo: | https://doi.org/10.1590/1807-3107bor-2022.vol36.0138 http://hdl.handle.net/1843/59909 http://orcid.org/0000-0002-0464-6429 http://orcid.org/0000-0002-6599-3950 http://orcid.org/0000-0001-6923-9229 http://orcid.org/0000-0001-6691-3943 http://orcid.org/0000-0002-3132-6455 http://orcid.org/0000-0003-3292-9159 http://orcid.org/0000-0002-9479-4993 http://orcid.org/0000-0002-4125-2971 http://orcid.org/0000-0001-7643-6589 http://orcid.org/0000-0001-9623-7835 http://orcid.org/0000-0003-2258-8071 http://orcid.org/0000-0003-3207-4007 |
Resumo: | We evaluated the accuracy of radiomorphometric indices (RI) and fractal dimension (FD) for screening bone mineral density (BMD) in postmenopausal patients who had breast cancer and were using aromatase inhibitors (AI). The sample consisted of 40 participants. Digital panoramic radiography (DPR) and cone beam computed tomography (CBCT) were evaluated along with dual-energy X-ray absorptiometry (DXA), which is the gold standard for detecting low BMD. According to the T-scores of DXA, the subjects were assigned into two groups: with normal BMD and with low BMD (osteopenia and osteoporosis). The area under the curve (AUC), sensitivity, and specificity with their respective confidence intervals were determined for DPR and CBCT. For DPR indices, AUC ranged from 52.6 to 75.8%. The mandibular cortical width (MCW) had the highest AUC. For FD, the total trabecular index had the highest sensitivity, while the index anterior to the mental foramen (MF) had the highest specificity. In CBCT, the AUC ranged from 51.8 to 62.0%. The indices with the highest AUC were the molar (M) and anterior (A). The symphysis (S) index had the highest sensitivity and the posterior (P) index had the highest specificity. Sensitivity and specificity were adequate for the computed tomography index (Inferior; CTI [I]). Therefore, MCW, FD of the mandible angle, and total trabecular ROI in DPR and the CTI (I), M, P, and A indices in CBCT proved to be promising tools in distinguishing individuals with low BMD. Cutoff point for these indices could be a useful tool to investigate low BMD in postmenopausal women taking AI. |
id |
UFMG_c5aea846f5b3cb189a3a10bc25123358 |
---|---|
oai_identifier_str |
oai:repositorio.ufmg.br:1843/59909 |
network_acronym_str |
UFMG |
network_name_str |
Repositório Institucional da UFMG |
repository_id_str |
|
spelling |
2023-10-23T22:09:09Z2023-10-23T22:09:09Z202236https://doi.org/10.1590/1807-3107bor-2022.vol36.01381807-3107http://hdl.handle.net/1843/59909http://orcid.org/0000-0002-0464-6429http://orcid.org/0000-0002-6599-3950http://orcid.org/0000-0001-6923-9229http://orcid.org/0000-0001-6691-3943http://orcid.org/0000-0002-3132-6455http://orcid.org/0000-0003-3292-9159http://orcid.org/0000-0002-9479-4993http://orcid.org/0000-0002-4125-2971http://orcid.org/0000-0001-7643-6589http://orcid.org/0000-0001-9623-7835http://orcid.org/0000-0003-2258-8071http://orcid.org/0000-0003-3207-4007We evaluated the accuracy of radiomorphometric indices (RI) and fractal dimension (FD) for screening bone mineral density (BMD) in postmenopausal patients who had breast cancer and were using aromatase inhibitors (AI). The sample consisted of 40 participants. Digital panoramic radiography (DPR) and cone beam computed tomography (CBCT) were evaluated along with dual-energy X-ray absorptiometry (DXA), which is the gold standard for detecting low BMD. According to the T-scores of DXA, the subjects were assigned into two groups: with normal BMD and with low BMD (osteopenia and osteoporosis). The area under the curve (AUC), sensitivity, and specificity with their respective confidence intervals were determined for DPR and CBCT. For DPR indices, AUC ranged from 52.6 to 75.8%. The mandibular cortical width (MCW) had the highest AUC. For FD, the total trabecular index had the highest sensitivity, while the index anterior to the mental foramen (MF) had the highest specificity. In CBCT, the AUC ranged from 51.8 to 62.0%. The indices with the highest AUC were the molar (M) and anterior (A). The symphysis (S) index had the highest sensitivity and the posterior (P) index had the highest specificity. Sensitivity and specificity were adequate for the computed tomography index (Inferior; CTI [I]). Therefore, MCW, FD of the mandible angle, and total trabecular ROI in DPR and the CTI (I), M, P, and A indices in CBCT proved to be promising tools in distinguishing individuals with low BMD. Cutoff point for these indices could be a useful tool to investigate low BMD in postmenopausal women taking AI.Avaliamos a acurácia dos índices radiomorfométricos (IR) e da dimensão fractal (DF) para triagem de densidade mineral óssea (DMO) em pacientes na pós-menopausa que tiveram câncer de mama e estavam em uso de inibidores de aromatase (IA). A amostra foi composta por 40 participantes. A radiografia panorâmica digital (DPR) e a tomografia computadorizada de feixe cônico (TCFC) foram avaliadas juntamente com a absorciometria de raios X de dupla energia (DXA), que é o padrão ouro para detectar baixa DMO. De acordo com os escores T da DXA, os sujeitos foram divididos em dois grupos: com DMO normal e com DMO baixa (osteopenia e osteoporose). A área sob a curva (AUC), sensibilidade e especificidade com seus respectivos intervalos de confiança foram determinadas para DPR e TCFC. Para os índices DPR, a AUC variou de 52,6 a 75,8%. A largura cortical mandibular (MCW) teve a maior AUC. Para DF, o índice trabecular total apresentou maior sensibilidade, enquanto o índice anterior ao forame mentoniano (MF) apresentou maior especificidade. Na TCFC, a AUC variou de 51,8 a 62,0%. Os índices com maior AUC foram o molar (M) e anterior (A). O índice de sínfise (S) apresentou maior sensibilidade e o índice posterior (P) apresentou maior especificidade. A sensibilidade e a especificidade foram adequadas para o índice de tomografia computadorizada (Inferior; CTI [I]). Portanto, MCW, FD do ângulo da mandíbula e ROI trabecular total no DPR e os índices CTI (I), M, P e A na TCFC mostraram-se ferramentas promissoras na distinção de indivíduos com baixa DMO. O ponto de corte para esses índices poderia ser uma ferramenta útil para investigar baixa DMO em mulheres na pós-menopausa em uso de IA.CNPq - Conselho Nacional de Desenvolvimento Científico e TecnológicoCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível SuperiorengUniversidade Federal de Minas GeraisUFMGBrasilENF - DEPARTAMENTO DE NUTRIÇÃOFAO - DEPARTAMENTO DE ODONTOLOGIA RESTAURADORAFAO - DEPARTAMENTO DE ODONTOPEDIATRIA E ORTODONTIABrazilian Oral ResearchDensidade ósseaTomografia computadorizada de feixe cônicoInibidores da aromataseBone densityCone-beam computed tomographyAromatase inhibitorsIndices in dental image exams for bone mineral density evaluation of aromatase inhibitor usersÍndices em exames de imagem odontológica para avaliação da densidade mineral óssea de usuários de inibidores de aromataseinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttps://www.scielo.br/j/bor/a/rKWNnM6WtNK5KfKBKvd3kYf/?lang=en#Sâmila Gonçalves BarraJosé Alcides Almeida de ArrudaAlessandra Figueiredo de SouzaCláudia Borges BrasileiroBruno Muzzi CamargosEnaldo Melo de LimaLeandro Napier de SouzaMarina Chaves de OliveiraSoraia MacariTarcília Aparecida da SilvaLucas Guimarães AbreuRicardo Alves de Mesquitaapplication/pdfinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFMGinstname:Universidade Federal de Minas Gerais (UFMG)instacron:UFMGLICENSELicense.txtLicense.txttext/plain; charset=utf-82042https://repositorio.ufmg.br/bitstream/1843/59909/1/License.txtfa505098d172de0bc8864fc1287ffe22MD51ORIGINALIndices in dental image exams for bone mineral density evaluation of aromatase inhibitor users.pdfIndices in dental image exams for bone mineral density evaluation of aromatase inhibitor users.pdfapplication/pdf989242https://repositorio.ufmg.br/bitstream/1843/59909/2/Indices%20in%20dental%20image%20exams%20for%20bone%20mineral%20density%20evaluation%20of%20aromatase%20inhibitor%20users.pdf48f6fa73c5899365bfda353765be86dfMD521843/599092023-10-23 19:09:09.626oai:repositorio.ufmg.br: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Repositório de PublicaçõesPUBhttps://repositorio.ufmg.br/oaiopendoar:2023-10-23T22:09:09Repositório Institucional da UFMG - Universidade Federal de Minas Gerais (UFMG)false |
dc.title.pt_BR.fl_str_mv |
Indices in dental image exams for bone mineral density evaluation of aromatase inhibitor users |
dc.title.alternative.pt_BR.fl_str_mv |
Índices em exames de imagem odontológica para avaliação da densidade mineral óssea de usuários de inibidores de aromatase |
title |
Indices in dental image exams for bone mineral density evaluation of aromatase inhibitor users |
spellingShingle |
Indices in dental image exams for bone mineral density evaluation of aromatase inhibitor users Sâmila Gonçalves Barra Bone density Cone-beam computed tomography Aromatase inhibitors Densidade óssea Tomografia computadorizada de feixe cônico Inibidores da aromatase |
title_short |
Indices in dental image exams for bone mineral density evaluation of aromatase inhibitor users |
title_full |
Indices in dental image exams for bone mineral density evaluation of aromatase inhibitor users |
title_fullStr |
Indices in dental image exams for bone mineral density evaluation of aromatase inhibitor users |
title_full_unstemmed |
Indices in dental image exams for bone mineral density evaluation of aromatase inhibitor users |
title_sort |
Indices in dental image exams for bone mineral density evaluation of aromatase inhibitor users |
author |
Sâmila Gonçalves Barra |
author_facet |
Sâmila Gonçalves Barra José Alcides Almeida de Arruda Alessandra Figueiredo de Souza Cláudia Borges Brasileiro Bruno Muzzi Camargos Enaldo Melo de Lima Leandro Napier de Souza Marina Chaves de Oliveira Soraia Macari Tarcília Aparecida da Silva Lucas Guimarães Abreu Ricardo Alves de Mesquita |
author_role |
author |
author2 |
José Alcides Almeida de Arruda Alessandra Figueiredo de Souza Cláudia Borges Brasileiro Bruno Muzzi Camargos Enaldo Melo de Lima Leandro Napier de Souza Marina Chaves de Oliveira Soraia Macari Tarcília Aparecida da Silva Lucas Guimarães Abreu Ricardo Alves de Mesquita |
author2_role |
author author author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Sâmila Gonçalves Barra José Alcides Almeida de Arruda Alessandra Figueiredo de Souza Cláudia Borges Brasileiro Bruno Muzzi Camargos Enaldo Melo de Lima Leandro Napier de Souza Marina Chaves de Oliveira Soraia Macari Tarcília Aparecida da Silva Lucas Guimarães Abreu Ricardo Alves de Mesquita |
dc.subject.por.fl_str_mv |
Bone density Cone-beam computed tomography Aromatase inhibitors |
topic |
Bone density Cone-beam computed tomography Aromatase inhibitors Densidade óssea Tomografia computadorizada de feixe cônico Inibidores da aromatase |
dc.subject.other.pt_BR.fl_str_mv |
Densidade óssea Tomografia computadorizada de feixe cônico Inibidores da aromatase |
description |
We evaluated the accuracy of radiomorphometric indices (RI) and fractal dimension (FD) for screening bone mineral density (BMD) in postmenopausal patients who had breast cancer and were using aromatase inhibitors (AI). The sample consisted of 40 participants. Digital panoramic radiography (DPR) and cone beam computed tomography (CBCT) were evaluated along with dual-energy X-ray absorptiometry (DXA), which is the gold standard for detecting low BMD. According to the T-scores of DXA, the subjects were assigned into two groups: with normal BMD and with low BMD (osteopenia and osteoporosis). The area under the curve (AUC), sensitivity, and specificity with their respective confidence intervals were determined for DPR and CBCT. For DPR indices, AUC ranged from 52.6 to 75.8%. The mandibular cortical width (MCW) had the highest AUC. For FD, the total trabecular index had the highest sensitivity, while the index anterior to the mental foramen (MF) had the highest specificity. In CBCT, the AUC ranged from 51.8 to 62.0%. The indices with the highest AUC were the molar (M) and anterior (A). The symphysis (S) index had the highest sensitivity and the posterior (P) index had the highest specificity. Sensitivity and specificity were adequate for the computed tomography index (Inferior; CTI [I]). Therefore, MCW, FD of the mandible angle, and total trabecular ROI in DPR and the CTI (I), M, P, and A indices in CBCT proved to be promising tools in distinguishing individuals with low BMD. Cutoff point for these indices could be a useful tool to investigate low BMD in postmenopausal women taking AI. |
publishDate |
2022 |
dc.date.issued.fl_str_mv |
2022 |
dc.date.accessioned.fl_str_mv |
2023-10-23T22:09:09Z |
dc.date.available.fl_str_mv |
2023-10-23T22:09:09Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/1843/59909 |
dc.identifier.doi.pt_BR.fl_str_mv |
https://doi.org/10.1590/1807-3107bor-2022.vol36.0138 |
dc.identifier.issn.pt_BR.fl_str_mv |
1807-3107 |
dc.identifier.orcid.pt_BR.fl_str_mv |
http://orcid.org/0000-0002-0464-6429 http://orcid.org/0000-0002-6599-3950 http://orcid.org/0000-0001-6923-9229 http://orcid.org/0000-0001-6691-3943 http://orcid.org/0000-0002-3132-6455 http://orcid.org/0000-0003-3292-9159 http://orcid.org/0000-0002-9479-4993 http://orcid.org/0000-0002-4125-2971 http://orcid.org/0000-0001-7643-6589 http://orcid.org/0000-0001-9623-7835 http://orcid.org/0000-0003-2258-8071 http://orcid.org/0000-0003-3207-4007 |
url |
https://doi.org/10.1590/1807-3107bor-2022.vol36.0138 http://hdl.handle.net/1843/59909 http://orcid.org/0000-0002-0464-6429 http://orcid.org/0000-0002-6599-3950 http://orcid.org/0000-0001-6923-9229 http://orcid.org/0000-0001-6691-3943 http://orcid.org/0000-0002-3132-6455 http://orcid.org/0000-0003-3292-9159 http://orcid.org/0000-0002-9479-4993 http://orcid.org/0000-0002-4125-2971 http://orcid.org/0000-0001-7643-6589 http://orcid.org/0000-0001-9623-7835 http://orcid.org/0000-0003-2258-8071 http://orcid.org/0000-0003-3207-4007 |
identifier_str_mv |
1807-3107 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.ispartof.pt_BR.fl_str_mv |
Brazilian Oral Research |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Universidade Federal de Minas Gerais |
dc.publisher.initials.fl_str_mv |
UFMG |
dc.publisher.country.fl_str_mv |
Brasil |
dc.publisher.department.fl_str_mv |
ENF - DEPARTAMENTO DE NUTRIÇÃO FAO - DEPARTAMENTO DE ODONTOLOGIA RESTAURADORA FAO - DEPARTAMENTO DE ODONTOPEDIATRIA E ORTODONTIA |
publisher.none.fl_str_mv |
Universidade Federal de Minas Gerais |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UFMG instname:Universidade Federal de Minas Gerais (UFMG) instacron:UFMG |
instname_str |
Universidade Federal de Minas Gerais (UFMG) |
instacron_str |
UFMG |
institution |
UFMG |
reponame_str |
Repositório Institucional da UFMG |
collection |
Repositório Institucional da UFMG |
bitstream.url.fl_str_mv |
https://repositorio.ufmg.br/bitstream/1843/59909/1/License.txt https://repositorio.ufmg.br/bitstream/1843/59909/2/Indices%20in%20dental%20image%20exams%20for%20bone%20mineral%20density%20evaluation%20of%20aromatase%20inhibitor%20users.pdf |
bitstream.checksum.fl_str_mv |
fa505098d172de0bc8864fc1287ffe22 48f6fa73c5899365bfda353765be86df |
bitstream.checksumAlgorithm.fl_str_mv |
MD5 MD5 |
repository.name.fl_str_mv |
Repositório Institucional da UFMG - Universidade Federal de Minas Gerais (UFMG) |
repository.mail.fl_str_mv |
|
_version_ |
1803589392959275008 |