Circulating leptin levels as a potential biomarker in inflammatory bowel diseases: a systematic review and meta-analysis

Detalhes bibliográficos
Autor(a) principal: Larissa Gabriela Ferreira de Carvalho
Data de Publicação: 2021
Outros Autores: William Gustavo Lima, Luiz Gonzaga Vaz Coelho, Valbert Nascimento Cardoso, Simone Odília Antunes Fernandes
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFMG
Texto Completo: http://hdl.handle.net/1843/40672
Resumo: CAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
id UFMG_ca1240f5495a8d0a041642a016fcd94b
oai_identifier_str oai:repositorio.ufmg.br:1843/40672
network_acronym_str UFMG
network_name_str Repositório Institucional da UFMG
repository_id_str
spelling 2022-03-31T20:29:29Z2022-03-31T20:29:29Z2021-02-2527216918110.1093/ibd/izaa0371078-0998http://hdl.handle.net/1843/40672CAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível SuperiorBackground The differential diagnosis of inflammatory bowel diseases (IBDs) between Crohn’s disease (CD) and ulcerative colitis (UC) is important for designing an effective therapeutic regimen. However, without any adequate gold standard method for differential diagnosis currently, therapeutic design remains a major challenge in clinical practice. In this context, recent studies have showed that circulating leptin stands out as a potential biomarker for the categorization of IBDs. Thus, we aimed to summarize the current understanding of the prognostic and diagnostic value of serum leptin in patients with IBDs. Methods A systematic search was performed in PubMed/MEDLINE, Scopus, Cochrane Library, and Web of Science databases. Articles that aimed to study the relationship between circulating levels of leptin and IBDs were included. Finally, the meta-analysis was performed with the mean serum leptin levels in patients with IBDs and healthy controls using RevMan 5.3 software, with I2 > 50% as a criterion for substantial heterogeneity. Results Nineteen studies were included. Serum leptin levels among patients with IBDs and healthy controls did not show a significant difference (95% CI, −2.15 to 0.57; I2, 86%, P ≤ 0.00001). Similarly, there was no association of leptin levels with the activity of IBDs (95% CI, −0.24 to 0.06; I2, 50%; P = 0.13). However, serum leptin levels were significantly higher in patients with CD than those in patients with UC (95% CI, −2.09 to −0.37; I2, 7%; P ≤ 0.36). Conclusion This review suggested that serum leptin levels might be a promising biomarker to help in the differentiation between CD and UC.engUniversidade Federal de Minas GeraisUFMGBrasilFAR - DEPARTAMENTO DE ALIMENTOSFAR - DEPARTAMENTO DE ANÁLISES CLÍNICAS E TOXICOLÓGICASMED - DEPARTAMENTO DE CLÍNICA MÉDICAInflammatory Bowel DiseasesDoenças inflamatórias intestinaisRevisão sistemáticaAdipokinesCrohn’s diseaseUlcerative colitisPrognosisDifferential diagnosisCirculating leptin levels as a potential biomarker in inflammatory bowel diseases: a systematic review and meta-analysisinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttps://academic.oup.com/ibdjournal/article/27/2/169/5756067Larissa Gabriela Ferreira de CarvalhoWilliam Gustavo LimaLuiz Gonzaga Vaz CoelhoValbert Nascimento CardosoSimone Odília Antunes Fernandesapplication/pdfinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFMGinstname:Universidade Federal de Minas Gerais (UFMG)instacron:UFMGLICENSELicense.txtLicense.txttext/plain; charset=utf-82042https://repositorio.ufmg.br/bitstream/1843/40672/1/License.txtfa505098d172de0bc8864fc1287ffe22MD51ORIGINALCirculating Leptin Levels as a Potential Biomarker in Inflammatory Bowel Diseases A Systematic Review and Meta-Analysis.pdfCirculating Leptin Levels as a Potential Biomarker in Inflammatory Bowel Diseases A Systematic Review and Meta-Analysis.pdfapplication/pdf4645042https://repositorio.ufmg.br/bitstream/1843/40672/2/Circulating%20Leptin%20Levels%20as%20a%20Potential%20Biomarker%20in%20Inflammatory%20Bowel%20Diseases%20A%20Systematic%20Review%20and%20Meta-Analysis.pdfa485e92518db8b55ccd5193a08447f8dMD521843/406722022-03-31 17:29:29.594oai:repositorio.ufmg.br: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Repositório de PublicaçõesPUBhttps://repositorio.ufmg.br/oaiopendoar:2022-03-31T20:29:29Repositório Institucional da UFMG - Universidade Federal de Minas Gerais (UFMG)false
dc.title.pt_BR.fl_str_mv Circulating leptin levels as a potential biomarker in inflammatory bowel diseases: a systematic review and meta-analysis
title Circulating leptin levels as a potential biomarker in inflammatory bowel diseases: a systematic review and meta-analysis
spellingShingle Circulating leptin levels as a potential biomarker in inflammatory bowel diseases: a systematic review and meta-analysis
Larissa Gabriela Ferreira de Carvalho
Adipokines
Crohn’s disease
Ulcerative colitis
Prognosis
Differential diagnosis
Doenças inflamatórias intestinais
Revisão sistemática
title_short Circulating leptin levels as a potential biomarker in inflammatory bowel diseases: a systematic review and meta-analysis
title_full Circulating leptin levels as a potential biomarker in inflammatory bowel diseases: a systematic review and meta-analysis
title_fullStr Circulating leptin levels as a potential biomarker in inflammatory bowel diseases: a systematic review and meta-analysis
title_full_unstemmed Circulating leptin levels as a potential biomarker in inflammatory bowel diseases: a systematic review and meta-analysis
title_sort Circulating leptin levels as a potential biomarker in inflammatory bowel diseases: a systematic review and meta-analysis
author Larissa Gabriela Ferreira de Carvalho
author_facet Larissa Gabriela Ferreira de Carvalho
William Gustavo Lima
Luiz Gonzaga Vaz Coelho
Valbert Nascimento Cardoso
Simone Odília Antunes Fernandes
author_role author
author2 William Gustavo Lima
Luiz Gonzaga Vaz Coelho
Valbert Nascimento Cardoso
Simone Odília Antunes Fernandes
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Larissa Gabriela Ferreira de Carvalho
William Gustavo Lima
Luiz Gonzaga Vaz Coelho
Valbert Nascimento Cardoso
Simone Odília Antunes Fernandes
dc.subject.por.fl_str_mv Adipokines
Crohn’s disease
Ulcerative colitis
Prognosis
Differential diagnosis
topic Adipokines
Crohn’s disease
Ulcerative colitis
Prognosis
Differential diagnosis
Doenças inflamatórias intestinais
Revisão sistemática
dc.subject.other.pt_BR.fl_str_mv Doenças inflamatórias intestinais
Revisão sistemática
description CAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
publishDate 2021
dc.date.issued.fl_str_mv 2021-02-25
dc.date.accessioned.fl_str_mv 2022-03-31T20:29:29Z
dc.date.available.fl_str_mv 2022-03-31T20:29:29Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/1843/40672
dc.identifier.doi.pt_BR.fl_str_mv 10.1093/ibd/izaa037
dc.identifier.issn.pt_BR.fl_str_mv 1078-0998
identifier_str_mv 10.1093/ibd/izaa037
1078-0998
url http://hdl.handle.net/1843/40672
dc.language.iso.fl_str_mv eng
language eng
dc.relation.ispartof.pt_BR.fl_str_mv Inflammatory Bowel Diseases
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Universidade Federal de Minas Gerais
dc.publisher.initials.fl_str_mv UFMG
dc.publisher.country.fl_str_mv Brasil
dc.publisher.department.fl_str_mv FAR - DEPARTAMENTO DE ALIMENTOS
FAR - DEPARTAMENTO DE ANÁLISES CLÍNICAS E TOXICOLÓGICAS
MED - DEPARTAMENTO DE CLÍNICA MÉDICA
publisher.none.fl_str_mv Universidade Federal de Minas Gerais
dc.source.none.fl_str_mv reponame:Repositório Institucional da UFMG
instname:Universidade Federal de Minas Gerais (UFMG)
instacron:UFMG
instname_str Universidade Federal de Minas Gerais (UFMG)
instacron_str UFMG
institution UFMG
reponame_str Repositório Institucional da UFMG
collection Repositório Institucional da UFMG
bitstream.url.fl_str_mv https://repositorio.ufmg.br/bitstream/1843/40672/1/License.txt
https://repositorio.ufmg.br/bitstream/1843/40672/2/Circulating%20Leptin%20Levels%20as%20a%20Potential%20Biomarker%20in%20Inflammatory%20Bowel%20Diseases%20A%20Systematic%20Review%20and%20Meta-Analysis.pdf
bitstream.checksum.fl_str_mv fa505098d172de0bc8864fc1287ffe22
a485e92518db8b55ccd5193a08447f8d
bitstream.checksumAlgorithm.fl_str_mv MD5
MD5
repository.name.fl_str_mv Repositório Institucional da UFMG - Universidade Federal de Minas Gerais (UFMG)
repository.mail.fl_str_mv
_version_ 1803589448051458048

Registros relacionados