Circulating leptin levels as a potential biomarker in inflammatory bowel diseases: a systematic review and meta-analysis
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFMG |
Texto Completo: | http://hdl.handle.net/1843/40672 |
Resumo: | CAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superior |
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2022-03-31T20:29:29Z2022-03-31T20:29:29Z2021-02-2527216918110.1093/ibd/izaa0371078-0998http://hdl.handle.net/1843/40672CAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível SuperiorBackground The differential diagnosis of inflammatory bowel diseases (IBDs) between Crohn’s disease (CD) and ulcerative colitis (UC) is important for designing an effective therapeutic regimen. However, without any adequate gold standard method for differential diagnosis currently, therapeutic design remains a major challenge in clinical practice. In this context, recent studies have showed that circulating leptin stands out as a potential biomarker for the categorization of IBDs. Thus, we aimed to summarize the current understanding of the prognostic and diagnostic value of serum leptin in patients with IBDs. Methods A systematic search was performed in PubMed/MEDLINE, Scopus, Cochrane Library, and Web of Science databases. Articles that aimed to study the relationship between circulating levels of leptin and IBDs were included. Finally, the meta-analysis was performed with the mean serum leptin levels in patients with IBDs and healthy controls using RevMan 5.3 software, with I2 > 50% as a criterion for substantial heterogeneity. Results Nineteen studies were included. Serum leptin levels among patients with IBDs and healthy controls did not show a significant difference (95% CI, −2.15 to 0.57; I2, 86%, P ≤ 0.00001). Similarly, there was no association of leptin levels with the activity of IBDs (95% CI, −0.24 to 0.06; I2, 50%; P = 0.13). However, serum leptin levels were significantly higher in patients with CD than those in patients with UC (95% CI, −2.09 to −0.37; I2, 7%; P ≤ 0.36). Conclusion This review suggested that serum leptin levels might be a promising biomarker to help in the differentiation between CD and UC.engUniversidade Federal de Minas GeraisUFMGBrasilFAR - DEPARTAMENTO DE ALIMENTOSFAR - DEPARTAMENTO DE ANÁLISES CLÍNICAS E TOXICOLÓGICASMED - DEPARTAMENTO DE CLÍNICA MÉDICAInflammatory Bowel DiseasesDoenças inflamatórias intestinaisRevisão sistemáticaAdipokinesCrohn’s diseaseUlcerative colitisPrognosisDifferential diagnosisCirculating leptin levels as a potential biomarker in inflammatory bowel diseases: a systematic review and meta-analysisinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttps://academic.oup.com/ibdjournal/article/27/2/169/5756067Larissa Gabriela Ferreira de CarvalhoWilliam Gustavo LimaLuiz Gonzaga Vaz CoelhoValbert Nascimento CardosoSimone Odília Antunes Fernandesapplication/pdfinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFMGinstname:Universidade Federal de Minas Gerais (UFMG)instacron:UFMGLICENSELicense.txtLicense.txttext/plain; charset=utf-82042https://repositorio.ufmg.br/bitstream/1843/40672/1/License.txtfa505098d172de0bc8864fc1287ffe22MD51ORIGINALCirculating Leptin Levels as a Potential Biomarker in Inflammatory Bowel Diseases A Systematic Review and Meta-Analysis.pdfCirculating Leptin Levels as a Potential Biomarker in Inflammatory Bowel Diseases A Systematic Review and Meta-Analysis.pdfapplication/pdf4645042https://repositorio.ufmg.br/bitstream/1843/40672/2/Circulating%20Leptin%20Levels%20as%20a%20Potential%20Biomarker%20in%20Inflammatory%20Bowel%20Diseases%20A%20Systematic%20Review%20and%20Meta-Analysis.pdfa485e92518db8b55ccd5193a08447f8dMD521843/406722022-03-31 17:29:29.594oai:repositorio.ufmg.br:1843/40672TElDRU7vv71BIERFIERJU1RSSUJVSe+/ve+/vU8gTu+/vU8tRVhDTFVTSVZBIERPIFJFUE9TSVTvv71SSU8gSU5TVElUVUNJT05BTCBEQSBVRk1HCiAKCkNvbSBhIGFwcmVzZW50Ye+/ve+/vW8gZGVzdGEgbGljZW7vv71hLCB2b2Pvv70gKG8gYXV0b3IgKGVzKSBvdSBvIHRpdHVsYXIgZG9zIGRpcmVpdG9zIGRlIGF1dG9yKSBjb25jZWRlIGFvIFJlcG9zaXTvv71yaW8gSW5zdGl0dWNpb25hbCBkYSBVRk1HIChSSS1VRk1HKSBvIGRpcmVpdG8gbu+/vW8gZXhjbHVzaXZvIGUgaXJyZXZvZ++/vXZlbCBkZSByZXByb2R1emlyIGUvb3UgZGlzdHJpYnVpciBhIHN1YSBwdWJsaWNh77+977+9byAoaW5jbHVpbmRvIG8gcmVzdW1vKSBwb3IgdG9kbyBvIG11bmRvIG5vIGZvcm1hdG8gaW1wcmVzc28gZSBlbGV0cu+/vW5pY28gZSBlbSBxdWFscXVlciBtZWlvLCBpbmNsdWluZG8gb3MgZm9ybWF0b3Mg77+9dWRpbyBvdSB277+9ZGVvLgoKVm9j77+9IGRlY2xhcmEgcXVlIGNvbmhlY2UgYSBwb2zvv710aWNhIGRlIGNvcHlyaWdodCBkYSBlZGl0b3JhIGRvIHNldSBkb2N1bWVudG8gZSBxdWUgY29uaGVjZSBlIGFjZWl0YSBhcyBEaXJldHJpemVzIGRvIFJJLVVGTUcuCgpWb2Pvv70gY29uY29yZGEgcXVlIG8gUmVwb3NpdO+/vXJpbyBJbnN0aXR1Y2lvbmFsIGRhIFVGTUcgcG9kZSwgc2VtIGFsdGVyYXIgbyBjb250Ze+/vWRvLCB0cmFuc3BvciBhIHN1YSBwdWJsaWNh77+977+9byBwYXJhIHF1YWxxdWVyIG1laW8gb3UgZm9ybWF0byBwYXJhIGZpbnMgZGUgcHJlc2VydmHvv73vv71vLgoKVm9j77+9IHRhbWLvv71tIGNvbmNvcmRhIHF1ZSBvIFJlcG9zaXTvv71yaW8gSW5zdGl0dWNpb25hbCBkYSBVRk1HIHBvZGUgbWFudGVyIG1haXMgZGUgdW1hIGPvv71waWEgZGUgc3VhIHB1YmxpY2Hvv73vv71vIHBhcmEgZmlucyBkZSBzZWd1cmFu77+9YSwgYmFjay11cCBlIHByZXNlcnZh77+977+9by4KClZvY++/vSBkZWNsYXJhIHF1ZSBhIHN1YSBwdWJsaWNh77+977+9byDvv70gb3JpZ2luYWwgZSBxdWUgdm9j77+9IHRlbSBvIHBvZGVyIGRlIGNvbmNlZGVyIG9zIGRpcmVpdG9zIGNvbnRpZG9zIG5lc3RhIGxpY2Vu77+9YS4gVm9j77+9IHRhbWLvv71tIGRlY2xhcmEgcXVlIG8gZGVw77+9c2l0byBkZSBzdWEgcHVibGljYe+/ve+/vW8gbu+/vW8sIHF1ZSBzZWphIGRlIHNldSBjb25oZWNpbWVudG8sIGluZnJpbmdlIGRpcmVpdG9zIGF1dG9yYWlzIGRlIG5pbmd177+9bS4KCkNhc28gYSBzdWEgcHVibGljYe+/ve+/vW8gY29udGVuaGEgbWF0ZXJpYWwgcXVlIHZvY++/vSBu77+9byBwb3NzdWkgYSB0aXR1bGFyaWRhZGUgZG9zIGRpcmVpdG9zIGF1dG9yYWlzLCB2b2Pvv70gZGVjbGFyYSBxdWUgb2J0ZXZlIGEgcGVybWlzc++/vW8gaXJyZXN0cml0YSBkbyBkZXRlbnRvciBkb3MgZGlyZWl0b3MgYXV0b3JhaXMgcGFyYSBjb25jZWRlciBhbyBSZXBvc2l077+9cmlvIEluc3RpdHVjaW9uYWwgZGEgVUZNRyBvcyBkaXJlaXRvcyBhcHJlc2VudGFkb3MgbmVzdGEgbGljZW7vv71hLCBlIHF1ZSBlc3NlIG1hdGVyaWFsIGRlIHByb3ByaWVkYWRlIGRlIHRlcmNlaXJvcyBlc3Tvv70gY2xhcmFtZW50ZSBpZGVudGlmaWNhZG8gZSByZWNvbmhlY2lkbyBubyB0ZXh0byBvdSBubyBjb250Ze+/vWRvIGRhIHB1YmxpY2Hvv73vv71vIG9yYSBkZXBvc2l0YWRhLgoKQ0FTTyBBIFBVQkxJQ0Hvv73vv71PIE9SQSBERVBPU0lUQURBIFRFTkhBIFNJRE8gUkVTVUxUQURPIERFIFVNIFBBVFJPQ++/vU5JTyBPVSBBUE9JTyBERSBVTUEgQUfvv71OQ0lBIERFIEZPTUVOVE8gT1UgT1VUUk8gT1JHQU5JU01PLCBWT0Pvv70gREVDTEFSQSBRVUUgUkVTUEVJVE9VIFRPRE9TIEUgUVVBSVNRVUVSIERJUkVJVE9TIERFIFJFVklT77+9TyBDT01PIFRBTULvv71NIEFTIERFTUFJUyBPQlJJR0Hvv73vv71FUyBFWElHSURBUyBQT1IgQ09OVFJBVE8gT1UgQUNPUkRPLgoKTyBSZXBvc2l077+9cmlvIEluc3RpdHVjaW9uYWwgZGEgVUZNRyBzZSBjb21wcm9tZXRlIGEgaWRlbnRpZmljYXIgY2xhcmFtZW50ZSBvIHNldSBub21lKHMpIG91IG8ocykgbm9tZXMocykgZG8ocykgZGV0ZW50b3IoZXMpIGRvcyBkaXJlaXRvcyBhdXRvcmFpcyBkYSBwdWJsaWNh77+977+9bywgZSBu77+9byBmYXLvv70gcXVhbHF1ZXIgYWx0ZXJh77+977+9bywgYWzvv71tIGRhcXVlbGFzIGNvbmNlZGlkYXMgcG9yIGVzdGEgbGljZW7vv71hLgo=Repositório de PublicaçõesPUBhttps://repositorio.ufmg.br/oaiopendoar:2022-03-31T20:29:29Repositório Institucional da UFMG - Universidade Federal de Minas Gerais (UFMG)false |
dc.title.pt_BR.fl_str_mv |
Circulating leptin levels as a potential biomarker in inflammatory bowel diseases: a systematic review and meta-analysis |
title |
Circulating leptin levels as a potential biomarker in inflammatory bowel diseases: a systematic review and meta-analysis |
spellingShingle |
Circulating leptin levels as a potential biomarker in inflammatory bowel diseases: a systematic review and meta-analysis Larissa Gabriela Ferreira de Carvalho Adipokines Crohn’s disease Ulcerative colitis Prognosis Differential diagnosis Doenças inflamatórias intestinais Revisão sistemática |
title_short |
Circulating leptin levels as a potential biomarker in inflammatory bowel diseases: a systematic review and meta-analysis |
title_full |
Circulating leptin levels as a potential biomarker in inflammatory bowel diseases: a systematic review and meta-analysis |
title_fullStr |
Circulating leptin levels as a potential biomarker in inflammatory bowel diseases: a systematic review and meta-analysis |
title_full_unstemmed |
Circulating leptin levels as a potential biomarker in inflammatory bowel diseases: a systematic review and meta-analysis |
title_sort |
Circulating leptin levels as a potential biomarker in inflammatory bowel diseases: a systematic review and meta-analysis |
author |
Larissa Gabriela Ferreira de Carvalho |
author_facet |
Larissa Gabriela Ferreira de Carvalho William Gustavo Lima Luiz Gonzaga Vaz Coelho Valbert Nascimento Cardoso Simone Odília Antunes Fernandes |
author_role |
author |
author2 |
William Gustavo Lima Luiz Gonzaga Vaz Coelho Valbert Nascimento Cardoso Simone Odília Antunes Fernandes |
author2_role |
author author author author |
dc.contributor.author.fl_str_mv |
Larissa Gabriela Ferreira de Carvalho William Gustavo Lima Luiz Gonzaga Vaz Coelho Valbert Nascimento Cardoso Simone Odília Antunes Fernandes |
dc.subject.por.fl_str_mv |
Adipokines Crohn’s disease Ulcerative colitis Prognosis Differential diagnosis |
topic |
Adipokines Crohn’s disease Ulcerative colitis Prognosis Differential diagnosis Doenças inflamatórias intestinais Revisão sistemática |
dc.subject.other.pt_BR.fl_str_mv |
Doenças inflamatórias intestinais Revisão sistemática |
description |
CAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superior |
publishDate |
2021 |
dc.date.issued.fl_str_mv |
2021-02-25 |
dc.date.accessioned.fl_str_mv |
2022-03-31T20:29:29Z |
dc.date.available.fl_str_mv |
2022-03-31T20:29:29Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/1843/40672 |
dc.identifier.doi.pt_BR.fl_str_mv |
10.1093/ibd/izaa037 |
dc.identifier.issn.pt_BR.fl_str_mv |
1078-0998 |
identifier_str_mv |
10.1093/ibd/izaa037 1078-0998 |
url |
http://hdl.handle.net/1843/40672 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.ispartof.pt_BR.fl_str_mv |
Inflammatory Bowel Diseases |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Universidade Federal de Minas Gerais |
dc.publisher.initials.fl_str_mv |
UFMG |
dc.publisher.country.fl_str_mv |
Brasil |
dc.publisher.department.fl_str_mv |
FAR - DEPARTAMENTO DE ALIMENTOS FAR - DEPARTAMENTO DE ANÁLISES CLÍNICAS E TOXICOLÓGICAS MED - DEPARTAMENTO DE CLÍNICA MÉDICA |
publisher.none.fl_str_mv |
Universidade Federal de Minas Gerais |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UFMG instname:Universidade Federal de Minas Gerais (UFMG) instacron:UFMG |
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Universidade Federal de Minas Gerais (UFMG) |
instacron_str |
UFMG |
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UFMG |
reponame_str |
Repositório Institucional da UFMG |
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Repositório Institucional da UFMG |
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