Weissella paramesenteroides WpK4 plays an immunobiotic role in gut-brain axis, reducing gut permeability, anxiety-like and depressive-like behaviors in murine models of colitis and chronic stress

• Autor(a) principal: Sávio Henrique de Cicco Sandes
• Data de Publicação: 2020
• Outros Autores: Naiara Chaves Figueiredo, Sílvia Helena Sousa Pietra Pedroso, Felipe Machado de Sant’Anna, Leonardo Borges Acurcio, Mário Abatemarco Júnior, Patrícia Aparecida Vieira de Barros, Fabrício Marcus Silva Oliveira, Valbert Nascimento Cardoso, Simone de Vasconcelos Generoso, Marcelo Vidigal Caliari, Jacques Robert Nicoli, Elisabeth Neumann, Álvaro Cantini Nunes
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Institucional da UFMG
• Texto Completo: https://doi.org/10.1016/j.foodres.2020.109741; http://hdl.handle.net/1843/51150
• topic: Colitis; Comorbidity; Mood disorder; Probiotics; Psychobiotics; Colite; Comorbidade; Probióticos

The relationship between inflammatory bowel disease (IBD) and mood disorders is complex and involves overlapping metabolic pathways, which may determine comorbidity. Several studies have been shown that this comorbidity could worsen IBD clinical course. The treatment of ulcerative colitis is complex, and involves traditional therapy to promote the function of epithelial barrier, reducing exacerbated inflammatory responses. Recently, it has been shown that some probiotic strains could modulate gut-brain axis, reducing depressive and anxiety scores in humans, including IBD patients. Accordingly, this study aimed to evaluate the role of Weissella paramesenteroides WpK4 in murine models of ulcerative colitis and chronic stress. It was observed that bacterium ingestion improved health of colitis mice, reducing intestinal permeability, besides improving colon histopathological appearance. In stressed mice, bacterial consumption was associated with a reduced anxiety-like and depressive-like behaviors. In both assays, the beneficial role of W. paramesenteroides WpK4 was related to its immunomodulatory feature. It is possible to state that W. paramesenteroides WpK4 exerted their beneficial roles in gut-brain axis through their immunomodulatory effects with consequences in several metabolic pathways related to intestinal permeability and hippocampal physiology.