Weight loss and improved mood after aerobic exercise training are linked to lower plasma anandamide in healthy people

Detalhes bibliográficos
Autor(a) principal: Arão Belitardo de Oliveira
Data de Publicação: 2019
Outros Autores: Marco Túlio de Mello, Sérgio Brasil Tufik, Mário Fernando Prieto Peres
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFMG
Texto Completo: https://doi.org/10.1016/j.physbeh.2018.12.018
http://hdl.handle.net/1843/43576
http://orcid.org/0000-0001-6408-0634
https://orcid.org/ 0000-0003-3896-2208
http://orcid.org/0000-0002-4012-4951
http://orcid.org/0000-0002-0068-1905
Resumo: CAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
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spelling 2022-07-25T12:05:57Z2022-07-25T12:05:57Z2019-03201191197https://doi.org/10.1016/j.physbeh.2018.12.0180031-9384http://hdl.handle.net/1843/43576http://orcid.org/0000-0001-6408-0634https://orcid.org/ 0000-0003-3896-2208http://orcid.org/0000-0002-4012-4951http://orcid.org/0000-0002-0068-1905CAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível SuperiorAnandamide, a major endocannabinoid, participates in energy metabolism homeostasis and neurobehavioral processes. In a secondary analysis of an open-label, randomized controlled trial, we investigated the long-term effect of aerobic exercise on resting plasma anandamide, and explored its relationship with changes in body weight, cardiorespiratory fitness, and mood status in healthy, physically inactive individuals. Participants recruited between March 2013 to August 2015 at the UNIFESP's Neurology/Psychobiology Department were randomly allocated into a 12-weeks supervised moderate exercise program, or into waitlist, control condition. Thirty-four participants (age = 38 ± 11.5, BMI = 26.6 ± 3.6) were intention to treat-analysed (Exercise: n = 17; Control: n = 17). After intervention, there were significant decreases in plasma anandamide (p < .01), anger, anxiety, and body weight (all p < .05), whereas cardiorespiratory fitness increased (p < .05) in the exercise group. There were no significant changes in any variable for the control group. In the whole cohort, adjusted R2 of multiple linear regressions showed that 12.2% of change body weight was explained by changes in anandamide (β = 0.391, p = .033), while 27% of change in mood disturbance (β = 0.546, p = .003), and 13.1% of change in anger (β = 0.404, p = .03) was explained by changes in anandamide. Our data suggest that the weight loss and mood improvement through regular moderate exercise may involve changes in anandamide metabolism/signaling. Trials registration: #NCT01972607.engUniversidade Federal de Minas GeraisUFMGBrasilEEF - DEPARTAMENTO DE ESPORTESPhysiology and BehaviorEndocanabinóidesPerda de pesoExercícios físicosSaúde mentalConsumo de oxigênioOxigênio / metabolismoEndocannabinoidsWeight lossPhysical activityExerciseMental healthPeak oxygen uptakeWeight loss and improved mood after aerobic exercise training are linked to lower plasma anandamide in healthy peopleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttps://www.sciencedirect.com/science/article/pii/S0031938418308254?via%3Dihub#!Arão Belitardo de OliveiraMarco Túlio de MelloSérgio Brasil TufikMário Fernando Prieto Peresapplication/pdfinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFMGinstname:Universidade Federal de Minas Gerais (UFMG)instacron:UFMGORIGINALWeight loss and improved mood after aerobic exercise training are linked to lower plasma anandamide in healthy people.pdfWeight loss and improved mood after aerobic exercise training are linked to lower plasma anandamide in healthy people.pdfapplication/pdf2158627https://repositorio.ufmg.br/bitstream/1843/43576/2/Weight%20loss%20and%20improved%20mood%20after%20aerobic%20exercise%20training%20are%20linked%20to%20lower%20plasma%20anandamide%20in%20healthy%20people.pdfa2cde992d333035b03ca7c78cf8641f4MD52LICENSELicense.txtLicense.txttext/plain; charset=utf-82042https://repositorio.ufmg.br/bitstream/1843/43576/1/License.txtfa505098d172de0bc8864fc1287ffe22MD511843/435762022-07-25 09:05:57.817oai:repositorio.ufmg.br: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Repositório de PublicaçõesPUBhttps://repositorio.ufmg.br/oaiopendoar:2022-07-25T12:05:57Repositório Institucional da UFMG - Universidade Federal de Minas Gerais (UFMG)false
dc.title.pt_BR.fl_str_mv Weight loss and improved mood after aerobic exercise training are linked to lower plasma anandamide in healthy people
title Weight loss and improved mood after aerobic exercise training are linked to lower plasma anandamide in healthy people
spellingShingle Weight loss and improved mood after aerobic exercise training are linked to lower plasma anandamide in healthy people
Arão Belitardo de Oliveira
Endocannabinoids
Weight loss
Physical activity
Exercise
Mental health
Peak oxygen uptake
Endocanabinóides
Perda de peso
Exercícios físicos
Saúde mental
Consumo de oxigênio
Oxigênio / metabolismo
title_short Weight loss and improved mood after aerobic exercise training are linked to lower plasma anandamide in healthy people
title_full Weight loss and improved mood after aerobic exercise training are linked to lower plasma anandamide in healthy people
title_fullStr Weight loss and improved mood after aerobic exercise training are linked to lower plasma anandamide in healthy people
title_full_unstemmed Weight loss and improved mood after aerobic exercise training are linked to lower plasma anandamide in healthy people
title_sort Weight loss and improved mood after aerobic exercise training are linked to lower plasma anandamide in healthy people
author Arão Belitardo de Oliveira
author_facet Arão Belitardo de Oliveira
Marco Túlio de Mello
Sérgio Brasil Tufik
Mário Fernando Prieto Peres
author_role author
author2 Marco Túlio de Mello
Sérgio Brasil Tufik
Mário Fernando Prieto Peres
author2_role author
author
author
dc.contributor.author.fl_str_mv Arão Belitardo de Oliveira
Marco Túlio de Mello
Sérgio Brasil Tufik
Mário Fernando Prieto Peres
dc.subject.por.fl_str_mv Endocannabinoids
Weight loss
Physical activity
Exercise
Mental health
Peak oxygen uptake
topic Endocannabinoids
Weight loss
Physical activity
Exercise
Mental health
Peak oxygen uptake
Endocanabinóides
Perda de peso
Exercícios físicos
Saúde mental
Consumo de oxigênio
Oxigênio / metabolismo
dc.subject.other.pt_BR.fl_str_mv Endocanabinóides
Perda de peso
Exercícios físicos
Saúde mental
Consumo de oxigênio
Oxigênio / metabolismo
description CAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
publishDate 2019
dc.date.issued.fl_str_mv 2019-03
dc.date.accessioned.fl_str_mv 2022-07-25T12:05:57Z
dc.date.available.fl_str_mv 2022-07-25T12:05:57Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/1843/43576
dc.identifier.doi.pt_BR.fl_str_mv https://doi.org/10.1016/j.physbeh.2018.12.018
dc.identifier.issn.pt_BR.fl_str_mv 0031-9384
dc.identifier.orcid.pt_BR.fl_str_mv http://orcid.org/0000-0001-6408-0634
https://orcid.org/ 0000-0003-3896-2208
http://orcid.org/0000-0002-4012-4951
http://orcid.org/0000-0002-0068-1905
url https://doi.org/10.1016/j.physbeh.2018.12.018
http://hdl.handle.net/1843/43576
http://orcid.org/0000-0001-6408-0634
https://orcid.org/ 0000-0003-3896-2208
http://orcid.org/0000-0002-4012-4951
http://orcid.org/0000-0002-0068-1905
identifier_str_mv 0031-9384
dc.language.iso.fl_str_mv eng
language eng
dc.relation.ispartof.pt_BR.fl_str_mv Physiology and Behavior
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Universidade Federal de Minas Gerais
dc.publisher.initials.fl_str_mv UFMG
dc.publisher.country.fl_str_mv Brasil
dc.publisher.department.fl_str_mv EEF - DEPARTAMENTO DE ESPORTES
publisher.none.fl_str_mv Universidade Federal de Minas Gerais
dc.source.none.fl_str_mv reponame:Repositório Institucional da UFMG
instname:Universidade Federal de Minas Gerais (UFMG)
instacron:UFMG
instname_str Universidade Federal de Minas Gerais (UFMG)
instacron_str UFMG
institution UFMG
reponame_str Repositório Institucional da UFMG
collection Repositório Institucional da UFMG
bitstream.url.fl_str_mv https://repositorio.ufmg.br/bitstream/1843/43576/2/Weight%20loss%20and%20improved%20mood%20after%20aerobic%20exercise%20training%20are%20linked%20to%20lower%20plasma%20anandamide%20in%20healthy%20people.pdf
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