Diagnostic accuracy of tests using recombinant protein antigens of Mycobacterium leprae for leprosy: A systematic review

Detalhes bibliográficos
Autor(a) principal: Ana Laura Grosside Oliveira
Data de Publicação: 2020
Outros Autores: Vanêssa Gomes Fraga, Nathalia Sernizon-guimarães, Mariana Santos Cardoso, Agostinho Gonçalves Viana, Lilian Lacerda Bueno, Daniella Castanheira Bartholomeu, Cristiane Alves da Silva Menezes, Ricardo Toshio Fujiwara
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFMG
Texto Completo: http://hdl.handle.net/1843/41355
Resumo: The aim of this systematic review was to investigate the studies that evaluated the sensitivity and specificity of serologic tests using recombinant protein antigens from Mycobacterium leprae for leprosy diagnosis. We included 13 studies that were available in PubMed, Brazilian Virtual Library of Health, Web of Science, ScienceDirect and Scopus. From these studies, we found that the recombinant serine-rich 45-kDa protein of M. leprae (ML0411) demonstrated high performance for multibacillary (MB) also to paucibacillary (PB) patients, although this study was tested only for Indian population. Despite that, studies using the ND-O-LID antigen have been able to more accurately identify new cases of leprosy among people living in endemic or non-endemic areas and household contacts in Brazil, Colombia, and the Philippines, especially when combined with other biomarkers. Finally, low sensitivity values for PB patients’ antibodies response remain challenging for tests intended to diagnose clinical forms that comprise this classification in leprosy.
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spelling 2022-05-03T20:45:23Z2022-05-03T20:45:23Z2020111110.1016/j.jiph.2019.12.0111876-0341http://hdl.handle.net/1843/41355The aim of this systematic review was to investigate the studies that evaluated the sensitivity and specificity of serologic tests using recombinant protein antigens from Mycobacterium leprae for leprosy diagnosis. We included 13 studies that were available in PubMed, Brazilian Virtual Library of Health, Web of Science, ScienceDirect and Scopus. From these studies, we found that the recombinant serine-rich 45-kDa protein of M. leprae (ML0411) demonstrated high performance for multibacillary (MB) also to paucibacillary (PB) patients, although this study was tested only for Indian population. Despite that, studies using the ND-O-LID antigen have been able to more accurately identify new cases of leprosy among people living in endemic or non-endemic areas and household contacts in Brazil, Colombia, and the Philippines, especially when combined with other biomarkers. Finally, low sensitivity values for PB patients’ antibodies response remain challenging for tests intended to diagnose clinical forms that comprise this classification in leprosy.O objetivo desta revisão sistemática foi investigar os estudos que avaliaram a sensibilidade e especificidade de testes sorológicos utilizando antígenos proteicos recombinantes do Mycobacterium leprae para o diagnóstico da hanseníase. Foram incluídos 13 estudos que estavam disponíveis no PubMed, Biblioteca Virtual Brasileira de Saúde, Web of Science, ScienceDirect e Scopus. A partir desses estudos, descobrimos que a proteína recombinante de 45 kDa rica em serina do M. leprae (ML0411) demonstrou alto desempenho para pacientes multibacilares (MB) e paucibacilares (PB), embora este estudo tenha sido testado apenas para a população indiana. Apesar disso, estudos com o antígeno ND-O-LID têm conseguido identificar com maior precisão novos casos de hanseníase entre pessoas residentes em áreas endêmicas ou não endêmicas e contatos domiciliares no Brasil, Colômbia e Filipinas, principalmente quando combinados com outros biomarcadores. Por fim, os valores de baixa sensibilidade para a resposta de anticorpos dos pacientes PB permanecem desafiadores para testes destinados a diagnosticar as formas clínicas que compõem essa classificação na hanseníase.engUniversidade Federal de Minas GeraisUFMGBrasilFAR - DEPARTAMENTO DE ANÁLISES CLÍNICAS E TOXICOLÓGICASICB - DEPARTAMENTO DE BIOQUÍMICA E IMUNOLOGIAICB - DEPARTAMENTO DE MORFOLOGIAICB - DEPARTAMENTO DE PARASITOLOGIAJournal of infection and public healthLepraMycobacterium lepraeTestes sorológicosAntígenos de proteínas recombinantesSensibilidadeEspecificidadeDiagnostic accuracy of tests using recombinant protein antigens of Mycobacterium leprae for leprosy: A systematic reviewAcurácia diagnóstica de testes com antígenos de proteínas recombinantes do Mycobacterium leprae para hanseníase: uma revisão sistemáticainfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttps://www.sciencedirect.com/science/article/pii/S187603412030397X?via%3DihubAna Laura Grosside OliveiraVanêssa Gomes FragaNathalia Sernizon-guimarãesMariana Santos CardosoAgostinho Gonçalves VianaLilian Lacerda BuenoDaniella Castanheira BartholomeuCristiane Alves da Silva MenezesRicardo Toshio Fujiwaraapplication/pdfinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFMGinstname:Universidade Federal de Minas Gerais (UFMG)instacron:UFMGLICENSELicense.txtLicense.txttext/plain; charset=utf-82042https://repositorio.ufmg.br/bitstream/1843/41355/1/License.txtfa505098d172de0bc8864fc1287ffe22MD51ORIGINAL2020_Diagnostic accuracy of tests using recombinant protein antigens of mycobacterium leprae for leprosy a systematic review.pdf2020_Diagnostic accuracy of tests using recombinant protein antigens of mycobacterium leprae for leprosy a systematic review.pdfapplication/pdf443050https://repositorio.ufmg.br/bitstream/1843/41355/2/2020_Diagnostic%20accuracy%20of%20tests%20using%20recombinant%20protein%20antigens%20of%20mycobacterium%20leprae%20for%20leprosy%20a%20systematic%20review.pdff0b820ac892713eee60ca316f5dc7660MD521843/413552022-05-03 17:45:23.826oai:repositorio.ufmg.br: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Repositório de PublicaçõesPUBhttps://repositorio.ufmg.br/oaiopendoar:2022-05-03T20:45:23Repositório Institucional da UFMG - Universidade Federal de Minas Gerais (UFMG)false
dc.title.pt_BR.fl_str_mv Diagnostic accuracy of tests using recombinant protein antigens of Mycobacterium leprae for leprosy: A systematic review
dc.title.alternative.pt_BR.fl_str_mv Acurácia diagnóstica de testes com antígenos de proteínas recombinantes do Mycobacterium leprae para hanseníase: uma revisão sistemática
title Diagnostic accuracy of tests using recombinant protein antigens of Mycobacterium leprae for leprosy: A systematic review
spellingShingle Diagnostic accuracy of tests using recombinant protein antigens of Mycobacterium leprae for leprosy: A systematic review
Ana Laura Grosside Oliveira
Lepra
Mycobacterium leprae
Testes sorológicos
Antígenos de proteínas recombinantes
Sensibilidade
Especificidade
title_short Diagnostic accuracy of tests using recombinant protein antigens of Mycobacterium leprae for leprosy: A systematic review
title_full Diagnostic accuracy of tests using recombinant protein antigens of Mycobacterium leprae for leprosy: A systematic review
title_fullStr Diagnostic accuracy of tests using recombinant protein antigens of Mycobacterium leprae for leprosy: A systematic review
title_full_unstemmed Diagnostic accuracy of tests using recombinant protein antigens of Mycobacterium leprae for leprosy: A systematic review
title_sort Diagnostic accuracy of tests using recombinant protein antigens of Mycobacterium leprae for leprosy: A systematic review
author Ana Laura Grosside Oliveira
author_facet Ana Laura Grosside Oliveira
Vanêssa Gomes Fraga
Nathalia Sernizon-guimarães
Mariana Santos Cardoso
Agostinho Gonçalves Viana
Lilian Lacerda Bueno
Daniella Castanheira Bartholomeu
Cristiane Alves da Silva Menezes
Ricardo Toshio Fujiwara
author_role author
author2 Vanêssa Gomes Fraga
Nathalia Sernizon-guimarães
Mariana Santos Cardoso
Agostinho Gonçalves Viana
Lilian Lacerda Bueno
Daniella Castanheira Bartholomeu
Cristiane Alves da Silva Menezes
Ricardo Toshio Fujiwara
author2_role author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Ana Laura Grosside Oliveira
Vanêssa Gomes Fraga
Nathalia Sernizon-guimarães
Mariana Santos Cardoso
Agostinho Gonçalves Viana
Lilian Lacerda Bueno
Daniella Castanheira Bartholomeu
Cristiane Alves da Silva Menezes
Ricardo Toshio Fujiwara
dc.subject.other.pt_BR.fl_str_mv Lepra
Mycobacterium leprae
Testes sorológicos
Antígenos de proteínas recombinantes
Sensibilidade
Especificidade
topic Lepra
Mycobacterium leprae
Testes sorológicos
Antígenos de proteínas recombinantes
Sensibilidade
Especificidade
description The aim of this systematic review was to investigate the studies that evaluated the sensitivity and specificity of serologic tests using recombinant protein antigens from Mycobacterium leprae for leprosy diagnosis. We included 13 studies that were available in PubMed, Brazilian Virtual Library of Health, Web of Science, ScienceDirect and Scopus. From these studies, we found that the recombinant serine-rich 45-kDa protein of M. leprae (ML0411) demonstrated high performance for multibacillary (MB) also to paucibacillary (PB) patients, although this study was tested only for Indian population. Despite that, studies using the ND-O-LID antigen have been able to more accurately identify new cases of leprosy among people living in endemic or non-endemic areas and household contacts in Brazil, Colombia, and the Philippines, especially when combined with other biomarkers. Finally, low sensitivity values for PB patients’ antibodies response remain challenging for tests intended to diagnose clinical forms that comprise this classification in leprosy.
publishDate 2020
dc.date.issued.fl_str_mv 2020
dc.date.accessioned.fl_str_mv 2022-05-03T20:45:23Z
dc.date.available.fl_str_mv 2022-05-03T20:45:23Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/1843/41355
dc.identifier.doi.pt_BR.fl_str_mv 10.1016/j.jiph.2019.12.011
dc.identifier.issn.pt_BR.fl_str_mv 1876-0341
identifier_str_mv 10.1016/j.jiph.2019.12.011
1876-0341
url http://hdl.handle.net/1843/41355
dc.language.iso.fl_str_mv eng
language eng
dc.relation.ispartof.pt_BR.fl_str_mv Journal of infection and public health
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Universidade Federal de Minas Gerais
dc.publisher.initials.fl_str_mv UFMG
dc.publisher.country.fl_str_mv Brasil
dc.publisher.department.fl_str_mv FAR - DEPARTAMENTO DE ANÁLISES CLÍNICAS E TOXICOLÓGICAS
ICB - DEPARTAMENTO DE BIOQUÍMICA E IMUNOLOGIA
ICB - DEPARTAMENTO DE MORFOLOGIA
ICB - DEPARTAMENTO DE PARASITOLOGIA
publisher.none.fl_str_mv Universidade Federal de Minas Gerais
dc.source.none.fl_str_mv reponame:Repositório Institucional da UFMG
instname:Universidade Federal de Minas Gerais (UFMG)
instacron:UFMG
instname_str Universidade Federal de Minas Gerais (UFMG)
instacron_str UFMG
institution UFMG
reponame_str Repositório Institucional da UFMG
collection Repositório Institucional da UFMG
bitstream.url.fl_str_mv https://repositorio.ufmg.br/bitstream/1843/41355/1/License.txt
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