Convergence of virulence and resistance in international clones of WHO critical priority enterobacterales isolated from Marine Bivalves

Detalhes bibliográficos
Autor(a) principal: Vanessa Bueris
Data de Publicação: 2022
Outros Autores: Fábio P. Sellera, Bruna Fuga, Elder Sano, Marcelo Pires Nogueira de Carvalho, Samuel Campanelli Freitas Couto, Quezia Moura, Nilton Lincopan
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFMG
Texto Completo: http://dx.doi.org/10.1038/s41598-022-09598-8
http://hdl.handle.net/1843/68769
https://orcid.org/0000-0002-0210-8352
https://orcid.org/0000-0002-3758-4148
https://orcid.org/0000-0003-0161-5800
Resumo: CNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico
id UFMG_f1d6d0185ae18d40aa1fc79b4e6b907c
oai_identifier_str oai:repositorio.ufmg.br:1843/68769
network_acronym_str UFMG
network_name_str Repositório Institucional da UFMG
repository_id_str
spelling 2024-05-29T18:15:43Z2024-05-29T18:15:43Z202212http://dx.doi.org/10.1038/s41598-022-09598-82045-2322http://hdl.handle.net/1843/68769https://orcid.org/0000-0002-0210-8352https://orcid.org/0000-0002-3758-4148https://orcid.org/0000-0003-0161-5800CNPq - Conselho Nacional de Desenvolvimento Científico e TecnológicoFAPESP - Fundação de Amparo à Pesquisa do Estado de São PauloThe global spread of critical-priority antimicrobial-resistant Enterobacterales by food is a public health problem. Wild-caught seafood are broadly consumed worldwide, but exposure to land-based pollution can favor their contamination by clinically relevant antimicrobial-resistant bacteria. As part of the Grand Challenges Explorations: New Approaches to Characterize the Global Burden of Antimicrobial Resistance Program, we performed genomic surveillance and cell culture-based virulence investigation of WHO critical priority Enterobacterales isolated from marine bivalves collected in the Atlantic Coast of South America. Broad-spectrum cephalosporin-resistant Klebsiella pneumoniae and Escherichia coli isolates were recovered from eight distinct geographical locations. These strains harbored blaCTX-M-type or blaCMY-type genes. Most of the surveyed genomes confirmed the convergence of wide virulome and resistome (i.e., antimicrobials, heavy metals, biocides, and pesticides resistance). We identified strains belonging to the international high-risk clones K. pneumoniae ST307 and E. coli ST131 carrying important virulence genes, whereas in vitro experiments confirmed the high virulence potential of these strains. Thermolabile and thermostable toxins were identified in some strains, and all of them were biofilm producers. These data point to an alarming presence of resistance and virulence genes in marine environments, which may favor horizontal gene transfer and the spread of these traits to other bacterial species.engUniversidade Federal de Minas GeraisUFMGBrasilVET - DEPARTAMENTO DE CLÍNICA E CIRURGIAScientific ReportsEnterobacteriaceaeOrganização Mundial da SaúdeBivalvesIntoxicação por frutos do marEnterobacteralesWHOMarine bivalvesSeafoodConvergence of virulence and resistance in international clones of WHO critical priority enterobacterales isolated from Marine Bivalvesinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttps://www.nature.com/articles/s41598-022-09598-8Vanessa BuerisFábio P. SelleraBruna FugaElder SanoMarcelo Pires Nogueira de CarvalhoSamuel Campanelli Freitas CoutoQuezia MouraNilton Lincopaninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFMGinstname:Universidade Federal de Minas Gerais (UFMG)instacron:UFMGLICENSELicense.txtLicense.txttext/plain; charset=utf-82042https://repositorio.ufmg.br/bitstream/1843/68769/1/License.txtfa505098d172de0bc8864fc1287ffe22MD51ORIGINALConvergence of virulence and resistance in international clones of WHO critical priority enterobacterales isolated from Marine Bivalves.pdfConvergence of virulence and resistance in international clones of WHO critical priority enterobacterales isolated from Marine Bivalves.pdfapplication/pdf1500590https://repositorio.ufmg.br/bitstream/1843/68769/2/Convergence%20of%20virulence%20and%20resistance%20in%20international%20clones%20of%20WHO%20critical%20priority%20enterobacterales%20isolated%20from%20Marine%20Bivalves.pdf9500dba164cc21ee108ba502d17dcd40MD521843/687692024-05-29 15:15:44.557oai:repositorio.ufmg.br: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Repositório de PublicaçõesPUBhttps://repositorio.ufmg.br/oaiopendoar:2024-05-29T18:15:44Repositório Institucional da UFMG - Universidade Federal de Minas Gerais (UFMG)false
dc.title.pt_BR.fl_str_mv Convergence of virulence and resistance in international clones of WHO critical priority enterobacterales isolated from Marine Bivalves
title Convergence of virulence and resistance in international clones of WHO critical priority enterobacterales isolated from Marine Bivalves
spellingShingle Convergence of virulence and resistance in international clones of WHO critical priority enterobacterales isolated from Marine Bivalves
Vanessa Bueris
Enterobacterales
WHO
Marine bivalves
Seafood
Enterobacteriaceae
Organização Mundial da Saúde
Bivalves
Intoxicação por frutos do mar
title_short Convergence of virulence and resistance in international clones of WHO critical priority enterobacterales isolated from Marine Bivalves
title_full Convergence of virulence and resistance in international clones of WHO critical priority enterobacterales isolated from Marine Bivalves
title_fullStr Convergence of virulence and resistance in international clones of WHO critical priority enterobacterales isolated from Marine Bivalves
title_full_unstemmed Convergence of virulence and resistance in international clones of WHO critical priority enterobacterales isolated from Marine Bivalves
title_sort Convergence of virulence and resistance in international clones of WHO critical priority enterobacterales isolated from Marine Bivalves
author Vanessa Bueris
author_facet Vanessa Bueris
Fábio P. Sellera
Bruna Fuga
Elder Sano
Marcelo Pires Nogueira de Carvalho
Samuel Campanelli Freitas Couto
Quezia Moura
Nilton Lincopan
author_role author
author2 Fábio P. Sellera
Bruna Fuga
Elder Sano
Marcelo Pires Nogueira de Carvalho
Samuel Campanelli Freitas Couto
Quezia Moura
Nilton Lincopan
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Vanessa Bueris
Fábio P. Sellera
Bruna Fuga
Elder Sano
Marcelo Pires Nogueira de Carvalho
Samuel Campanelli Freitas Couto
Quezia Moura
Nilton Lincopan
dc.subject.por.fl_str_mv Enterobacterales
WHO
Marine bivalves
Seafood
topic Enterobacterales
WHO
Marine bivalves
Seafood
Enterobacteriaceae
Organização Mundial da Saúde
Bivalves
Intoxicação por frutos do mar
dc.subject.other.pt_BR.fl_str_mv Enterobacteriaceae
Organização Mundial da Saúde
Bivalves
Intoxicação por frutos do mar
description CNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico
publishDate 2022
dc.date.issued.fl_str_mv 2022
dc.date.accessioned.fl_str_mv 2024-05-29T18:15:43Z
dc.date.available.fl_str_mv 2024-05-29T18:15:43Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/1843/68769
dc.identifier.doi.pt_BR.fl_str_mv http://dx.doi.org/10.1038/s41598-022-09598-8
dc.identifier.issn.pt_BR.fl_str_mv 2045-2322
dc.identifier.orcid.pt_BR.fl_str_mv https://orcid.org/0000-0002-0210-8352
https://orcid.org/0000-0002-3758-4148
https://orcid.org/0000-0003-0161-5800
url http://dx.doi.org/10.1038/s41598-022-09598-8
http://hdl.handle.net/1843/68769
https://orcid.org/0000-0002-0210-8352
https://orcid.org/0000-0002-3758-4148
https://orcid.org/0000-0003-0161-5800
identifier_str_mv 2045-2322
dc.language.iso.fl_str_mv eng
language eng
dc.relation.ispartof.pt_BR.fl_str_mv Scientific Reports
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Universidade Federal de Minas Gerais
dc.publisher.initials.fl_str_mv UFMG
dc.publisher.country.fl_str_mv Brasil
dc.publisher.department.fl_str_mv VET - DEPARTAMENTO DE CLÍNICA E CIRURGIA
publisher.none.fl_str_mv Universidade Federal de Minas Gerais
dc.source.none.fl_str_mv reponame:Repositório Institucional da UFMG
instname:Universidade Federal de Minas Gerais (UFMG)
instacron:UFMG
instname_str Universidade Federal de Minas Gerais (UFMG)
instacron_str UFMG
institution UFMG
reponame_str Repositório Institucional da UFMG
collection Repositório Institucional da UFMG
bitstream.url.fl_str_mv https://repositorio.ufmg.br/bitstream/1843/68769/1/License.txt
https://repositorio.ufmg.br/bitstream/1843/68769/2/Convergence%20of%20virulence%20and%20resistance%20in%20international%20clones%20of%20WHO%20critical%20priority%20enterobacterales%20isolated%20from%20Marine%20Bivalves.pdf
bitstream.checksum.fl_str_mv fa505098d172de0bc8864fc1287ffe22
9500dba164cc21ee108ba502d17dcd40
bitstream.checksumAlgorithm.fl_str_mv MD5
MD5
repository.name.fl_str_mv Repositório Institucional da UFMG - Universidade Federal de Minas Gerais (UFMG)
repository.mail.fl_str_mv
_version_ 1803589290959044608

Registros relacionados