Clinicopathological analysis of head and neck rhabdomyosarcoma: a series of 10 cases and literature review
Autor(a) principal: | |
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Data de Publicação: | 2018 |
Outros Autores: | , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFMG |
Texto Completo: | https://doi.org/10.4317%2Fmedoral.22106 http://hdl.handle.net/1843/60526 |
Resumo: | Background To describe the clinicopathological characteristics of a series of head and neck rhabdomyosarcoma (RMS) and to review the literature. Material and Methods Cases diagnosed as RMS affecting the head and neck region were retrospectively retrieved from the files of two Brazilian institutions from January 2006 to January 2017. Data on clinical features (sex, age and affected site), microscopic subtype, immunohistochemical results, treatment employed and follow-up status were obtained from the patient’s medical charts. Results During the period considered, 10 cases of RMS were identified. Females predominated (4M:6F), the mean age at diagnosis was 16.5 years-old and the orbit was the most affected site (4 cases). Microscopically, most cases were classified as embryonal RMS (6 cases) and the Desmin/Myogenin/Myo-D1 immunohistochemical positivity was useful to confirm the diagnosis. Chemotherapy and radiotherapy were applied to 9 and 8 patients respectively, whereas 2 patients were treated by surgery. Recurrences occurred in 3 patients and distant metastasis in 2 cases. Nine patients were alive in their last follow-up, 3 of them with disease, whereas 1 patient died due to the disease. Conclusions Head and neck RMS is an aggressive malignant neoplasm which demands especial concern to achieve early diagnosis and successful treatment. |
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2023-11-06T20:46:16Z2023-11-06T20:46:16Z2018-02-252e188e197https://doi.org/10.4317%2Fmedoral.2210616986946http://hdl.handle.net/1843/60526Background To describe the clinicopathological characteristics of a series of head and neck rhabdomyosarcoma (RMS) and to review the literature. Material and Methods Cases diagnosed as RMS affecting the head and neck region were retrospectively retrieved from the files of two Brazilian institutions from January 2006 to January 2017. Data on clinical features (sex, age and affected site), microscopic subtype, immunohistochemical results, treatment employed and follow-up status were obtained from the patient’s medical charts. Results During the period considered, 10 cases of RMS were identified. Females predominated (4M:6F), the mean age at diagnosis was 16.5 years-old and the orbit was the most affected site (4 cases). Microscopically, most cases were classified as embryonal RMS (6 cases) and the Desmin/Myogenin/Myo-D1 immunohistochemical positivity was useful to confirm the diagnosis. Chemotherapy and radiotherapy were applied to 9 and 8 patients respectively, whereas 2 patients were treated by surgery. Recurrences occurred in 3 patients and distant metastasis in 2 cases. Nine patients were alive in their last follow-up, 3 of them with disease, whereas 1 patient died due to the disease. Conclusions Head and neck RMS is an aggressive malignant neoplasm which demands especial concern to achieve early diagnosis and successful treatment.engUniversidade Federal de Minas GeraisUFMGBrasilFAO - DEPARTAMENTO DE CLÍNICAMedicina Oral Patologia Oral y Cirugia BucalRhabdomyosarcomaHeadNeckMouthDrug therapyNeoplasmsMedical recordsrevista Medicina oral patologia oral y cirugia bucalfao clinica assunto rabdomiossarcoma busca dia 19 do 09 ano 2023 acesso open pmc key word: Rhabdomyosarcoma, soft tissue tumors, head and neck, oral cavity, chemotherapy .título:Clinicopathological analysis of head and neck rhabdomyosarcoma: a series of 10 cases and literature reviewinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5911360/Flávia Sirotheau Corrêa PontesJonas Ikikame de OliveiraLucas Lacerda de SouzaOslei Paes de AlmeidaEduardo Rodrigues FregnaniRafael Sarlo VilelaWanessa Miranda-SilvaFelipe Paiva FonsecaHélder Antônio Rebelo Pontesinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFMGinstname:Universidade Federal de Minas Gerais (UFMG)instacron:UFMGLICENSELicense.txtLicense.txttext/plain; charset=utf-82042https://repositorio.ufmg.br/bitstream/1843/60526/1/License.txtfa505098d172de0bc8864fc1287ffe22MD51ORIGINALClinicopathological analysis of head and neck rhabdomyosarcoma a series of 10 cases and literature review.pdfClinicopathological analysis of head and neck rhabdomyosarcoma a series of 10 cases and literature review.pdfapplication/pdf2812328https://repositorio.ufmg.br/bitstream/1843/60526/2/Clinicopathological%20analysis%20of%20head%20and%20neck%20rhabdomyosarcoma%20a%20series%20of%2010%20cases%20and%20literature%20review.pdf22b5ccd8491905757a20081304e10ba7MD521843/605262023-11-06 17:46:17.346oai:repositorio.ufmg.br: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Repositório de PublicaçõesPUBhttps://repositorio.ufmg.br/oaiopendoar:2023-11-06T20:46:17Repositório Institucional da UFMG - Universidade Federal de Minas Gerais (UFMG)false |
dc.title.pt_BR.fl_str_mv |
Clinicopathological analysis of head and neck rhabdomyosarcoma: a series of 10 cases and literature review |
title |
Clinicopathological analysis of head and neck rhabdomyosarcoma: a series of 10 cases and literature review |
spellingShingle |
Clinicopathological analysis of head and neck rhabdomyosarcoma: a series of 10 cases and literature review Flávia Sirotheau Corrêa Pontes revista Medicina oral patologia oral y cirugia bucal fao clinica assunto rabdomiossarcoma busca dia 19 do 09 ano 2023 acesso open pmc key word: Rhabdomyosarcoma, soft tissue tumors, head and neck, oral cavity, chemotherapy .título: Rhabdomyosarcoma Head Neck Mouth Drug therapy Neoplasms Medical records |
title_short |
Clinicopathological analysis of head and neck rhabdomyosarcoma: a series of 10 cases and literature review |
title_full |
Clinicopathological analysis of head and neck rhabdomyosarcoma: a series of 10 cases and literature review |
title_fullStr |
Clinicopathological analysis of head and neck rhabdomyosarcoma: a series of 10 cases and literature review |
title_full_unstemmed |
Clinicopathological analysis of head and neck rhabdomyosarcoma: a series of 10 cases and literature review |
title_sort |
Clinicopathological analysis of head and neck rhabdomyosarcoma: a series of 10 cases and literature review |
author |
Flávia Sirotheau Corrêa Pontes |
author_facet |
Flávia Sirotheau Corrêa Pontes Jonas Ikikame de Oliveira Lucas Lacerda de Souza Oslei Paes de Almeida Eduardo Rodrigues Fregnani Rafael Sarlo Vilela Wanessa Miranda-Silva Felipe Paiva Fonseca Hélder Antônio Rebelo Pontes |
author_role |
author |
author2 |
Jonas Ikikame de Oliveira Lucas Lacerda de Souza Oslei Paes de Almeida Eduardo Rodrigues Fregnani Rafael Sarlo Vilela Wanessa Miranda-Silva Felipe Paiva Fonseca Hélder Antônio Rebelo Pontes |
author2_role |
author author author author author author author author |
dc.contributor.author.fl_str_mv |
Flávia Sirotheau Corrêa Pontes Jonas Ikikame de Oliveira Lucas Lacerda de Souza Oslei Paes de Almeida Eduardo Rodrigues Fregnani Rafael Sarlo Vilela Wanessa Miranda-Silva Felipe Paiva Fonseca Hélder Antônio Rebelo Pontes |
dc.subject.por.fl_str_mv |
revista Medicina oral patologia oral y cirugia bucal fao clinica assunto rabdomiossarcoma busca dia 19 do 09 ano 2023 acesso open pmc key word: Rhabdomyosarcoma, soft tissue tumors, head and neck, oral cavity, chemotherapy .título: |
topic |
revista Medicina oral patologia oral y cirugia bucal fao clinica assunto rabdomiossarcoma busca dia 19 do 09 ano 2023 acesso open pmc key word: Rhabdomyosarcoma, soft tissue tumors, head and neck, oral cavity, chemotherapy .título: Rhabdomyosarcoma Head Neck Mouth Drug therapy Neoplasms Medical records |
dc.subject.other.pt_BR.fl_str_mv |
Rhabdomyosarcoma Head Neck Mouth Drug therapy Neoplasms Medical records |
description |
Background To describe the clinicopathological characteristics of a series of head and neck rhabdomyosarcoma (RMS) and to review the literature. Material and Methods Cases diagnosed as RMS affecting the head and neck region were retrospectively retrieved from the files of two Brazilian institutions from January 2006 to January 2017. Data on clinical features (sex, age and affected site), microscopic subtype, immunohistochemical results, treatment employed and follow-up status were obtained from the patient’s medical charts. Results During the period considered, 10 cases of RMS were identified. Females predominated (4M:6F), the mean age at diagnosis was 16.5 years-old and the orbit was the most affected site (4 cases). Microscopically, most cases were classified as embryonal RMS (6 cases) and the Desmin/Myogenin/Myo-D1 immunohistochemical positivity was useful to confirm the diagnosis. Chemotherapy and radiotherapy were applied to 9 and 8 patients respectively, whereas 2 patients were treated by surgery. Recurrences occurred in 3 patients and distant metastasis in 2 cases. Nine patients were alive in their last follow-up, 3 of them with disease, whereas 1 patient died due to the disease. Conclusions Head and neck RMS is an aggressive malignant neoplasm which demands especial concern to achieve early diagnosis and successful treatment. |
publishDate |
2018 |
dc.date.issued.fl_str_mv |
2018-02-25 |
dc.date.accessioned.fl_str_mv |
2023-11-06T20:46:16Z |
dc.date.available.fl_str_mv |
2023-11-06T20:46:16Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/1843/60526 |
dc.identifier.doi.pt_BR.fl_str_mv |
https://doi.org/10.4317%2Fmedoral.22106 |
dc.identifier.issn.pt_BR.fl_str_mv |
16986946 |
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https://doi.org/10.4317%2Fmedoral.22106 http://hdl.handle.net/1843/60526 |
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16986946 |
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eng |
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eng |
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Medicina Oral Patologia Oral y Cirugia Bucal |
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info:eu-repo/semantics/openAccess |
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openAccess |
dc.publisher.none.fl_str_mv |
Universidade Federal de Minas Gerais |
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UFMG |
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Brasil |
dc.publisher.department.fl_str_mv |
FAO - DEPARTAMENTO DE CLÍNICA |
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Universidade Federal de Minas Gerais |
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Universidade Federal de Minas Gerais (UFMG) |
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UFMG |
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UFMG |
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Repositório Institucional da UFMG |
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Repositório Institucional da UFMG |
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