Materiais para ortopedia contendo gálio na matriz da hidroxiapatita modificada pelo estrôncio e vanádio
Autor(a) principal: | |
---|---|
Data de Publicação: | 2021 |
Tipo de documento: | Tese |
Idioma: | por |
Título da fonte: | Repositório Institucional da UFMS |
Texto Completo: | https://repositorio.ufms.br/handle/123456789/3870 |
Resumo: | The modified hydroxyapatite through the introduction of bioactive elements gallium and strontium was obtained. Vanadatoapatite containing gallium was synthesized, its composition was confirmed and the physicochemical properties studied, in particular, the morphology and basic structural parameters. It was demonstrated that the gallium is homogeneously distributed in the structure in the form of solid intercalation solution without producing distortions in the hexagonal network of hydroxyapatite. Vanadatoapatite was also synthesized by replacing calcium with strontium and, at the same time, containing gallium as a doping element. Conditions for the preparation of the compost and its morphological and structural characteristics were established. It has been shown that in the case of vanadatoapatite with calcium, the dopant is evenly distributed in the form of a solid replacement solution. With regard to the position of the strontium, this, according to X-ray diffractometry, remains at the calcium ion sites, as a result of the isovalent substitution. It was evident that the structural characteristics of materials obtained that contain one or two bioactive elements in question, respond to the requirements of natural hydroxyapatite and, at the same time, to a material similar to the structure of human hydroxyapatite. It was demonstrated, through in vitro toxicity tests, that the composition containing gallium as a dopant meets the acceptability criteria in orthopedic procedures. The obtained structural parameters are available to be included in the international biomaterials databases, in particular for a future application in orthopedics. |
id |
UFMS_1b2ee4d272e94d122ee6f81103dc3fbb |
---|---|
oai_identifier_str |
oai:repositorio.ufms.br:123456789/3870 |
network_acronym_str |
UFMS |
network_name_str |
Repositório Institucional da UFMS |
repository_id_str |
2124 |
spelling |
2021-07-29T14:10:27Z2021-09-30T19:57:27Z2021https://repositorio.ufms.br/handle/123456789/3870The modified hydroxyapatite through the introduction of bioactive elements gallium and strontium was obtained. Vanadatoapatite containing gallium was synthesized, its composition was confirmed and the physicochemical properties studied, in particular, the morphology and basic structural parameters. It was demonstrated that the gallium is homogeneously distributed in the structure in the form of solid intercalation solution without producing distortions in the hexagonal network of hydroxyapatite. Vanadatoapatite was also synthesized by replacing calcium with strontium and, at the same time, containing gallium as a doping element. Conditions for the preparation of the compost and its morphological and structural characteristics were established. It has been shown that in the case of vanadatoapatite with calcium, the dopant is evenly distributed in the form of a solid replacement solution. With regard to the position of the strontium, this, according to X-ray diffractometry, remains at the calcium ion sites, as a result of the isovalent substitution. It was evident that the structural characteristics of materials obtained that contain one or two bioactive elements in question, respond to the requirements of natural hydroxyapatite and, at the same time, to a material similar to the structure of human hydroxyapatite. It was demonstrated, through in vitro toxicity tests, that the composition containing gallium as a dopant meets the acceptability criteria in orthopedic procedures. The obtained structural parameters are available to be included in the international biomaterials databases, in particular for a future application in orthopedics.A hidroxiapatita modificada por meio de introdução do elemento bioativo gálio na hidroxiapatita contendo dois outros elementos bioativos vanádio e estrôncio foi obtida. Na primeira etapa foi sintetizada a vanadatoapatita na qual posteriormente foram introduzidos íons de gálio. Sua composição foi confirmada e as propriedades físico-químicas estudadas, em particular, a morfologia e parâmetros básicos estruturais. Demonstrou-se que o gálio fica distribuído homogeneamente na estrutura na forma de solução sólida de intercalação sem produzir distorções na rede hexagonal da hidroxiapatita. Também foi sintetizada vanadatoapatita substituindo o cálcio pelo estrôncio e, ao mesmo tempo, contendo o gálio como elemento dopante. Estabeleceram-se condições da preparação do composto e suas características morfológicas e estruturais. Foi demonstrado que no caso de vanadatoapatita com cálcio o dopante está distribuído uniformemente na forma de solução sólida de substituição. No que diz respeito à posição do estrôncio, este, conforme a difratometria de raios-X, fica nos sítios dos íons de cálcio, como resultado da substituição isovalente. Evidenciou-se que as características estruturais de materiais obtidos que contém um ou dois elementos bioativos em questão, respondem aos requisitos da hidroxiapatita natural e, ao mesmo tempo, às de um material semelhante à estrutura da hidroxiapatita humana. Foi demonstrado, através de testes de toxicidade in vitro, que a composição contendo gálio como dopante responde aos critérios de aceitabilidade nos procedimentos ortopédicos. Os parâmetros estruturais obtidos estão disponíveis para serem incluídos nos bancos de dados internacionais de biomateriais, em particular para uma futura aplicação na ortopedia.Fundação Universidade Federal de Mato Grosso do SulUFMSBrasilEstrôncioGálioVanádioMateriais BiocompatíveisOrtopediaHidroxiapatitaDurapatitaGalliumStrontiumVanadiumBiocompatible MaterialsOrthopedicsDurapatiteHydroxyapatiteMateriais para ortopedia contendo gálio na matriz da hidroxiapatita modificada pelo estrôncio e vanádioinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/doctoralThesisNascimento, Valter Aragão doAlbuquerque, Diogo Muniz deinfo:eu-repo/semantics/openAccessporreponame:Repositório Institucional da UFMSinstname:Universidade Federal de Mato Grosso do Sul (UFMS)instacron:UFMSTHUMBNAILTese revisada.pdf.jpgTese revisada.pdf.jpgGenerated Thumbnailimage/jpeg1279https://repositorio.ufms.br/bitstream/123456789/3870/3/Tese%20revisada.pdf.jpg681cd3877310a28364b129f0db914263MD53TEXTTese revisada.pdf.txtTese revisada.pdf.txtExtracted texttext/plain193730https://repositorio.ufms.br/bitstream/123456789/3870/2/Tese%20revisada.pdf.txtb37e37a6b21ac8c1b08fd4096c8dcae9MD52ORIGINALTese revisada.pdfTese revisada.pdfapplication/pdf10715464https://repositorio.ufms.br/bitstream/123456789/3870/1/Tese%20revisada.pdff6d31fec956cdd40db371da92c65169fMD51123456789/38702022-10-17 13:31:56.661oai:repositorio.ufms.br:123456789/3870Repositório InstitucionalPUBhttps://repositorio.ufms.br/oai/requestri.prograd@ufms.bropendoar:21242022-10-17T17:31:56Repositório Institucional da UFMS - Universidade Federal de Mato Grosso do Sul (UFMS)false |
dc.title.pt_BR.fl_str_mv |
Materiais para ortopedia contendo gálio na matriz da hidroxiapatita modificada pelo estrôncio e vanádio |
title |
Materiais para ortopedia contendo gálio na matriz da hidroxiapatita modificada pelo estrôncio e vanádio |
spellingShingle |
Materiais para ortopedia contendo gálio na matriz da hidroxiapatita modificada pelo estrôncio e vanádio Albuquerque, Diogo Muniz de Estrôncio Gálio Vanádio Materiais Biocompatíveis Ortopedia Hidroxiapatita Durapatita Gallium Strontium Vanadium Biocompatible Materials Orthopedics Durapatite Hydroxyapatite |
title_short |
Materiais para ortopedia contendo gálio na matriz da hidroxiapatita modificada pelo estrôncio e vanádio |
title_full |
Materiais para ortopedia contendo gálio na matriz da hidroxiapatita modificada pelo estrôncio e vanádio |
title_fullStr |
Materiais para ortopedia contendo gálio na matriz da hidroxiapatita modificada pelo estrôncio e vanádio |
title_full_unstemmed |
Materiais para ortopedia contendo gálio na matriz da hidroxiapatita modificada pelo estrôncio e vanádio |
title_sort |
Materiais para ortopedia contendo gálio na matriz da hidroxiapatita modificada pelo estrôncio e vanádio |
author |
Albuquerque, Diogo Muniz de |
author_facet |
Albuquerque, Diogo Muniz de |
author_role |
author |
dc.contributor.advisor1.fl_str_mv |
Nascimento, Valter Aragão do |
dc.contributor.author.fl_str_mv |
Albuquerque, Diogo Muniz de |
contributor_str_mv |
Nascimento, Valter Aragão do |
dc.subject.por.fl_str_mv |
Estrôncio Gálio Vanádio Materiais Biocompatíveis Ortopedia Hidroxiapatita Durapatita Gallium Strontium Vanadium Biocompatible Materials Orthopedics Durapatite Hydroxyapatite |
topic |
Estrôncio Gálio Vanádio Materiais Biocompatíveis Ortopedia Hidroxiapatita Durapatita Gallium Strontium Vanadium Biocompatible Materials Orthopedics Durapatite Hydroxyapatite |
description |
The modified hydroxyapatite through the introduction of bioactive elements gallium and strontium was obtained. Vanadatoapatite containing gallium was synthesized, its composition was confirmed and the physicochemical properties studied, in particular, the morphology and basic structural parameters. It was demonstrated that the gallium is homogeneously distributed in the structure in the form of solid intercalation solution without producing distortions in the hexagonal network of hydroxyapatite. Vanadatoapatite was also synthesized by replacing calcium with strontium and, at the same time, containing gallium as a doping element. Conditions for the preparation of the compost and its morphological and structural characteristics were established. It has been shown that in the case of vanadatoapatite with calcium, the dopant is evenly distributed in the form of a solid replacement solution. With regard to the position of the strontium, this, according to X-ray diffractometry, remains at the calcium ion sites, as a result of the isovalent substitution. It was evident that the structural characteristics of materials obtained that contain one or two bioactive elements in question, respond to the requirements of natural hydroxyapatite and, at the same time, to a material similar to the structure of human hydroxyapatite. It was demonstrated, through in vitro toxicity tests, that the composition containing gallium as a dopant meets the acceptability criteria in orthopedic procedures. The obtained structural parameters are available to be included in the international biomaterials databases, in particular for a future application in orthopedics. |
publishDate |
2021 |
dc.date.accessioned.fl_str_mv |
2021-07-29T14:10:27Z |
dc.date.available.fl_str_mv |
2021-09-30T19:57:27Z |
dc.date.issued.fl_str_mv |
2021 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/doctoralThesis |
format |
doctoralThesis |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://repositorio.ufms.br/handle/123456789/3870 |
url |
https://repositorio.ufms.br/handle/123456789/3870 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.publisher.none.fl_str_mv |
Fundação Universidade Federal de Mato Grosso do Sul |
dc.publisher.initials.fl_str_mv |
UFMS |
dc.publisher.country.fl_str_mv |
Brasil |
publisher.none.fl_str_mv |
Fundação Universidade Federal de Mato Grosso do Sul |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UFMS instname:Universidade Federal de Mato Grosso do Sul (UFMS) instacron:UFMS |
instname_str |
Universidade Federal de Mato Grosso do Sul (UFMS) |
instacron_str |
UFMS |
institution |
UFMS |
reponame_str |
Repositório Institucional da UFMS |
collection |
Repositório Institucional da UFMS |
bitstream.url.fl_str_mv |
https://repositorio.ufms.br/bitstream/123456789/3870/3/Tese%20revisada.pdf.jpg https://repositorio.ufms.br/bitstream/123456789/3870/2/Tese%20revisada.pdf.txt https://repositorio.ufms.br/bitstream/123456789/3870/1/Tese%20revisada.pdf |
bitstream.checksum.fl_str_mv |
681cd3877310a28364b129f0db914263 b37e37a6b21ac8c1b08fd4096c8dcae9 f6d31fec956cdd40db371da92c65169f |
bitstream.checksumAlgorithm.fl_str_mv |
MD5 MD5 MD5 |
repository.name.fl_str_mv |
Repositório Institucional da UFMS - Universidade Federal de Mato Grosso do Sul (UFMS) |
repository.mail.fl_str_mv |
ri.prograd@ufms.br |
_version_ |
1815448049198039040 |