Tendência temporal das hospitalizações por diarreia em crianças da Mesorregião Norte Mato-grossense

• Autor(a) principal: Telles, Luciana Ortega
• Data de Publicação: 2018
• Tipo de documento: Trabalho de conclusão de curso
• Idioma: por
• Título da fonte: Biblioteca Digital de Monografias da UFMT
• Texto Completo: http://bdm.ufmt.br/handle/1/957
• topic: CNPQ::CIENCIAS DA SAUDE::ENFERMAGEM; Rotavírus; Doenças diarreicas; Criança; Análise de séries temporais; Rotavirus; Diarrhea diseases; Childhood; Time-series analysis

Rotavirus is a member of the family Reoviridae and is the most frequent causative agent of severe diarrhea in Brazil and worldwide. Vaccination is one of the most effective intervention method to prevent rotavirus in childhood. In 2006, the Brazilian Immunization Program introduced the oral live attenuated human rotavirus vaccine (RotarixTM), and since then, several studies have reported a significant decrease in morbidity and mortality in children aged <5 years. However, evidence of the impact of the Rotarix TM in Northern Mato-Grosso region is not yet known. We analyzed the trends of rates of all-cause diarrhea hospitalizations in children less than 5 years of age, living in the Northern Mato-Grosso region during 2008 to 2016.A time-series analysis was conducted using secondary data from admissions obtained from the Hospitalization Information System of the National Unified Health System. The study outcome was the rates of all-cause diarrhea hospitalizations consisting of ICD-10: A00-A03, A04, A05, A06.0-A06.3, A06.9, A07.0-A07.2, A07.9, A08-A09. Monthly and annual rates were calculated considering the number of hospitalizations (numerator) divided by the estimated population at risk (denominator) multiplied by 10,000. Rates were analyzed by microregion, age group (<1 year, 1 to 4 years and <5 years of age) and year. The time-series analysis for rates of all-cause diarrhea hospitalizations was based on a Prais-Winsten generalized linear regression. Data management and statistical analyses were conducted using Stata software v. 12.0.During the study period, 7,899 hospitalization for all-causes of diarrhea of children aged <5 years were identified, corresponding to an average rate of 9.25/10,000 children. The microregions of Colíder (15.23/10,000 children) and Paranatinga (4.96/10,000 children) had the highest and lowest hospitalization rates, respectively. Annual rates were decreasing during 2008 to 2016 for the age groups <1 year, 1 to 4 years and <5 years of age. The decrease of montlhy rates was confirmed statistically by time-series analysis. It was estimated a decreasing trend for the age groups of the study, with the greatest reduction in children aged<1 year (p = 0.02). Rates of hospitalizations related to all-cause diarrhea in children <5 years of age decreased from 2008 to 2016. The reduction observed is compatible with Rotarix TMvaccination in Brazilian Immunization Program, showing evidence of vaccination impact on hospitalization rates due to diarrhea.