Efeito imuno-metabólico do extrato aquoso da Roupala montana (Proteácea) em modelo experimental

• Autor(a) principal: Fonseca Junior, Hugo Rodrigues da
• Data de Publicação: 2022
• Tipo de documento: Trabalho de conclusão de curso
• Idioma: por
• Título da fonte: Biblioteca Digital de Monografias da UFMT
• Texto Completo: http://bdm.ufmt.br/handle/1/2695
• topic: CNPQ::CIENCIAS DA SAUDE::FARMACIA; Diabetes melittus; Roupala montana; extrato aquoso; ratos; Diabetes Mellitus; Roupala montana; aqueous extract; rats

Diabetes Mellitus is characterized by a chronic metabolic disorder characterized by hyperglycemia and disorder in the metabolism of lipids, carbohydrates and proteins, resulting from the non-production, little production and misuse of the insulin, and with vascular consequences, which are closely intertwined. This has become a growing epidemic in the last century, with the exponential increase in obesity, poor eating habits and other factors. For many years people use medicinal herbs to control blood glucose, by popular culture or information without any proof, or just an alternative to the synthetic drugs available today.That being said, this work aimed to assess the effect of the aqueous extract of the Roupala montana species tree (Proteaceae), in male Winstar lineage rats, on the biochemical and immunological profiles and on some toxic response. The animals were randomly divided into four groups (n total 24), control group – rats with standard diet; sucrose group – standard diet and water with 10% sucrose; sucrose and treated group - 10% sucrose and extract gavage; and treated group – only extract gavage, all fed with standardized ration. The extract was administered via gavage at a concentration of 250mg/kg throughout the study daily for five consecutive weeks. All subjects had access to water and food ad libitum. Parameters such as body weight, water intake, feed consumption and blood glucose were evaluated weekly. After five weeks, the animals were anesthetized and sacrificed to obtain blood and weigh the organs. With the blood, analyzes of biochemical parameters and quantification of oxidized lipoprotein via monoclonal antibody IgG assay were performed. No major changes were observed in the groups tested, only a slight increase in the ALT enzyme in those using sucrose, and a high in triglycerides in those using sucrose. There was no change in the weight of the organs of the animals. There was water consumption in the animals and feed consumption was reduced in the groups using sucrose and a slight decrease in the group treated with extract. There were no changes in the experimental lipoprotein profiles.