ANALYSIS OF JABUTICABA AQUEOUS EXTRACT AGAINST REDOX STATUS AND MUTAGENESS IN MICE

• Autor(a) principal: Cunha, Ana Paula Simões da
• Data de Publicação: 2023
• Outros Autores: Braga, Ana Júlia Lopes, Schafranski Kaefer, Uanderson Queslei, Sugui, Marina Mariko, Dornelles Gindri Sinhorin, Valéria
• Tipo de documento: Artigo
• Idioma: por
• Título da fonte: Nativa (Sinop)
• Texto Completo: https://periodicoscientificos.ufmt.br/ojs/index.php/nativa/article/view/13435
• topic: Cyclophosphamide; Oxidative stress; Myrciaria ssp; Micronucleus test; Ciclofosfamida; estresse oxidativo; Myrciaria ssp; teste de micronúcleo

Jabuticaba (Myrciaria ssp) is well known for having in its bark phenolic compounds with high antioxidant activity. Thus, this study aimed to evaluate antioxidant effects in the liver and brain and antimutagenic effects in the bone marrow of male Swiss mice with the aqueous extract of jabuticaba (MYR) and as a mutagenic damage-inducing agent to cyclophosphamide (CPA). Four groups were analyzed (N = 6): Control (C), CPA (25 mg.kg-1), Aqueous jabuticaba extract + CPA (MYR + CPA) and Aqueous jabuticaba extract (MYR). Through the micronucleus test in bone marrow cells, the frequency of micronuclei in polychromatic erythrocytes was evaluated for antimutagenic/mutagenic activity. The biochemical parameters evaluated were: Superoxide dismutase (SOD), Catalase (CAT), Glutathione-S-transferase (GST), Reduced Glutathione (GSH), Ascorbic Acid (VIT C) and Carbonyl. The results obtained showed that the aqueous extract of jabuticaba did not have an antimutagenic or mutagenic effect. Vit C increased in liver tissue in the MYR group when compared to the MYR + CPA group. It is concluded that, under the experimental conditions used, the jabuticaba extract did not show protective potential against damage induced by CPA, nor did it significantly modify the parameters of oxidative stress in animals treated with MYR.