Identification of a bioactive compound isolated from Brazilian propolis type 6.

Detalhes bibliográficos
Autor(a) principal: Castro, Myrella Lessio
Data de Publicação: 2009
Outros Autores: Nascimento, Andréa Mendes do, Ikegaki, Masaharu, Costa Neto, Cláudio Miguel da, Alencar, Severino Matias de, Rosalen, Pedro Luiz
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFOP
Texto Completo: http://www.repositorio.ufop.br/handle/123456789/1582
Resumo: A prenylated benzophenone, hyperibone A, was isolated from the hexane fraction of Brazilianpropolistype6. Its structure was determined by spectral analysis including 2D NMR. This compound exhibited cytotoxic activity against HeLa tumor cells (IC50 = 0.1756 μM), strong antimicrobial activity (MIC range—0.73–6.6 μg/mL; MBC range—2.92–106 μg/mL) against Streptococcus mutans, Streptococcus sobrinus, Streptococcus oralis, Staphylococcus aureus, and Actinomyces naeslundii, and the results of its cytotoxic and antimicrobial activities were considered good.
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spelling Castro, Myrella LessioNascimento, Andréa Mendes doIkegaki, MasaharuCosta Neto, Cláudio Miguel daAlencar, Severino Matias deRosalen, Pedro Luiz2012-10-09T12:29:02Z2012-10-09T12:29:02Z2009CASTRO, M. L. et al. Identification of a bioactive compound isolated from Brazilian propolis type 6. Bioorganic & Medicinal Chemistry, v. 17, n. 14, p. 5332-5335, jul. 2009. Disponível em: <https://www.sciencedirect.com/science/article/pii/S0968089609004350>. Acesso em: 09 out. 2012.09680896http://www.repositorio.ufop.br/handle/123456789/1582A prenylated benzophenone, hyperibone A, was isolated from the hexane fraction of Brazilianpropolistype6. Its structure was determined by spectral analysis including 2D NMR. This compound exhibited cytotoxic activity against HeLa tumor cells (IC50 = 0.1756 μM), strong antimicrobial activity (MIC range—0.73–6.6 μg/mL; MBC range—2.92–106 μg/mL) against Streptococcus mutans, Streptococcus sobrinus, Streptococcus oralis, Staphylococcus aureus, and Actinomyces naeslundii, and the results of its cytotoxic and antimicrobial activities were considered good.Prenylated benzophenone hyperibone ABiological activityBrazilian propolisIdentification of a bioactive compound isolated from Brazilian propolis type 6.info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleO periódico Bioorganic & Medicinal Chemistry concede permissão para depósito deste artigo no Repositório Institucional da UFOP. Número da licença: 3310910618604.info:eu-repo/semantics/openAccessengreponame:Repositório Institucional da UFOPinstname:Universidade Federal de Ouro Preto (UFOP)instacron:UFOPLICENSElicense.txtlicense.txttext/plain; charset=utf-81748http://www.repositorio.ufop.br/bitstream/123456789/1582/5/license.txt8a4605be74aa9ea9d79846c1fba20a33MD55ORIGINALARTIGO_IdentificationBioactiveCompound.pdfARTIGO_IdentificationBioactiveCompound.pdfapplication/pdf213593http://www.repositorio.ufop.br/bitstream/123456789/1582/1/ARTIGO_IdentificationBioactiveCompound.pdf383c757009963b3c16f60d2efc4efb39MD51123456789/15822019-03-11 13:46:00.784oai:localhost: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Repositório InstitucionalPUBhttp://www.repositorio.ufop.br/oai/requestrepositorio@ufop.edu.bropendoar:32332019-03-11T17:46Repositório Institucional da UFOP - Universidade Federal de Ouro Preto (UFOP)false
dc.title.pt_BR.fl_str_mv Identification of a bioactive compound isolated from Brazilian propolis type 6.
title Identification of a bioactive compound isolated from Brazilian propolis type 6.
spellingShingle Identification of a bioactive compound isolated from Brazilian propolis type 6.
Castro, Myrella Lessio
Prenylated benzophenone hyperibone A
Biological activity
Brazilian propolis
title_short Identification of a bioactive compound isolated from Brazilian propolis type 6.
title_full Identification of a bioactive compound isolated from Brazilian propolis type 6.
title_fullStr Identification of a bioactive compound isolated from Brazilian propolis type 6.
title_full_unstemmed Identification of a bioactive compound isolated from Brazilian propolis type 6.
title_sort Identification of a bioactive compound isolated from Brazilian propolis type 6.
author Castro, Myrella Lessio
author_facet Castro, Myrella Lessio
Nascimento, Andréa Mendes do
Ikegaki, Masaharu
Costa Neto, Cláudio Miguel da
Alencar, Severino Matias de
Rosalen, Pedro Luiz
author_role author
author2 Nascimento, Andréa Mendes do
Ikegaki, Masaharu
Costa Neto, Cláudio Miguel da
Alencar, Severino Matias de
Rosalen, Pedro Luiz
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Castro, Myrella Lessio
Nascimento, Andréa Mendes do
Ikegaki, Masaharu
Costa Neto, Cláudio Miguel da
Alencar, Severino Matias de
Rosalen, Pedro Luiz
dc.subject.por.fl_str_mv Prenylated benzophenone hyperibone A
Biological activity
Brazilian propolis
topic Prenylated benzophenone hyperibone A
Biological activity
Brazilian propolis
description A prenylated benzophenone, hyperibone A, was isolated from the hexane fraction of Brazilianpropolistype6. Its structure was determined by spectral analysis including 2D NMR. This compound exhibited cytotoxic activity against HeLa tumor cells (IC50 = 0.1756 μM), strong antimicrobial activity (MIC range—0.73–6.6 μg/mL; MBC range—2.92–106 μg/mL) against Streptococcus mutans, Streptococcus sobrinus, Streptococcus oralis, Staphylococcus aureus, and Actinomyces naeslundii, and the results of its cytotoxic and antimicrobial activities were considered good.
publishDate 2009
dc.date.issued.fl_str_mv 2009
dc.date.accessioned.fl_str_mv 2012-10-09T12:29:02Z
dc.date.available.fl_str_mv 2012-10-09T12:29:02Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv CASTRO, M. L. et al. Identification of a bioactive compound isolated from Brazilian propolis type 6. Bioorganic & Medicinal Chemistry, v. 17, n. 14, p. 5332-5335, jul. 2009. Disponível em: <https://www.sciencedirect.com/science/article/pii/S0968089609004350>. Acesso em: 09 out. 2012.
dc.identifier.uri.fl_str_mv http://www.repositorio.ufop.br/handle/123456789/1582
dc.identifier.issn.none.fl_str_mv 09680896
identifier_str_mv CASTRO, M. L. et al. Identification of a bioactive compound isolated from Brazilian propolis type 6. Bioorganic & Medicinal Chemistry, v. 17, n. 14, p. 5332-5335, jul. 2009. Disponível em: <https://www.sciencedirect.com/science/article/pii/S0968089609004350>. Acesso em: 09 out. 2012.
09680896
url http://www.repositorio.ufop.br/handle/123456789/1582
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