Synthesis by click reactions and antiplasmodial activity of Lupeol 1,2,3-Triazole derivatives.

• Autor(a) principal: Borgati, Tatiane Freitas
• Data de Publicação: 2017
• Outros Autores: Pereira, Guilherme Rocha, Brandão, Geraldo Célio, Santos, Juliana de Oliveira, Fernandes, Dayane Aparecida Morais, Paula, Renata Cristina de, Nascimento, Maria Fernanda Alves do, Soares, Luciana Ferreira, Lopes, Júlio César Dias, Souza Filho, José Dias de, Oliveira, Alaíde Braga de
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Institucional da UFOP
• dARK ID: ark:/61566/001300000d5qk
• Texto Completo: http://www.repositorio.ufop.br/handle/123456789/8597; http://dx.doi.org/10.21577/0103-5053.20170013
• topic: Terpenoids; Click chemistry

Lupeol, a triterpene frequently found in Asteraceae plant species, showed moderate to low activity in different strains of Plasmodium falciparum, the most virulent malaria etiological agents. In this work, lupeol was isolated from Parahancornia fasciculata, a plant that is used to treat malaria in the Amazonia region. In the search of more activity lupeol derivatives, five new 1,2,3-triazole hybrid molecules were synthetized by copper-catalyzed azide-alkyne cycloaddition. The antiplasmodial activity of the semi-synthetic compounds were evaluated by the lactate dehydrogenase assay; the lupeol propargyl ether was the only one to disclosing increased activity (half maximal inhibitory concentration-IC50-62.0 ± 1.92 μmol L-1) in relation to lupeol (IC50 117.00 μmol L-1). Therefore, this work revealed a new class of interesting lupeol derivatives that can be obtained by linking electron donors to the hydroxy group at C-3.