Targeting N-type calcium channels in young-onset of some neurological diseases.
Autor(a) principal: | |
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Data de Publicação: | 2022 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFOP |
Texto Completo: | http://www.repositorio.ufop.br/jspui/handle/123456789/17582 https://doi.org/10.3389/fcell.2022.1090765 |
Resumo: | Calcium (Ca 2+) is an important second messenger in charge of many critical processes in the central nervous system (CNS), including membrane excitability, neurotransmission, learning, memory, cell proliferation, and apoptosis. In this way, the voltage-gated calcium channels (VGCCs) act as a key supply for Ca2+ entry into the cytoplasm and organelles. Importantly, the dysregulation of these channels has been reported in many neurological diseases of young-onset, with associated genetic factors, such as migraine, multiple sclerosis, and Huntington’s disease. Notably, the literature has pointed to the role of N-type Ca2+ channels (NTCCs) in controlling a variety of processes, including pain, inflammation, and excitotoxicity. Moreover, several Ca2+ channel blockers that are used for therapeutic purposes have been shown to act on the N-type channels. Therefore, this review provides an overview of the NTCCs in neurological disorders focusing mainly on Huntington’s disease, multiple sclerosis, and migraine. It will discuss possible strategies to generate novel therapeutic strategies. |
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Targeting N-type calcium channels in young-onset of some neurological diseases.Cav2.2 channelsHuntington disease - HDMultiple sclerosis - MSMigraineVoltage-gated calcium channel - VGCCCalcium (Ca 2+) is an important second messenger in charge of many critical processes in the central nervous system (CNS), including membrane excitability, neurotransmission, learning, memory, cell proliferation, and apoptosis. In this way, the voltage-gated calcium channels (VGCCs) act as a key supply for Ca2+ entry into the cytoplasm and organelles. Importantly, the dysregulation of these channels has been reported in many neurological diseases of young-onset, with associated genetic factors, such as migraine, multiple sclerosis, and Huntington’s disease. Notably, the literature has pointed to the role of N-type Ca2+ channels (NTCCs) in controlling a variety of processes, including pain, inflammation, and excitotoxicity. Moreover, several Ca2+ channel blockers that are used for therapeutic purposes have been shown to act on the N-type channels. Therefore, this review provides an overview of the NTCCs in neurological disorders focusing mainly on Huntington’s disease, multiple sclerosis, and migraine. It will discuss possible strategies to generate novel therapeutic strategies.2023-10-17T19:55:44Z2023-10-17T19:55:44Z2022info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfANTUNES. F. T. T. et al. Targeting N-type calcium channels in young-onset of some neurological diseases. Frontiers in Cell and Developmental Biology, v. 10, 2022. Disponível em: <https://www.frontiersin.org/articles/10.3389/fcell.2022.1090765/full>. Acesso em: 01 ago. 2023.2296-634Xhttp://www.repositorio.ufop.br/jspui/handle/123456789/17582https://doi.org/10.3389/fcell.2022.1090765This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). Fonte: PDF do artigo.info:eu-repo/semantics/openAccessAntunes, Flavia Tasmin TecheraSouza, Alessandra Hubner deSilva, Juliana Figueira daBinda, Nancy ScarduaCarvalho, Vanice Paula RicardoVieira, Luciene BrunoGomez, Marcus Viniciusengreponame:Repositório Institucional da UFOPinstname:Universidade Federal de Ouro Preto (UFOP)instacron:UFOP2023-10-17T19:55:53Zoai:repositorio.ufop.br:123456789/17582Repositório InstitucionalPUBhttp://www.repositorio.ufop.br/oai/requestrepositorio@ufop.edu.bropendoar:32332023-10-17T19:55:53Repositório Institucional da UFOP - Universidade Federal de Ouro Preto (UFOP)false |
dc.title.none.fl_str_mv |
Targeting N-type calcium channels in young-onset of some neurological diseases. |
title |
Targeting N-type calcium channels in young-onset of some neurological diseases. |
spellingShingle |
Targeting N-type calcium channels in young-onset of some neurological diseases. Antunes, Flavia Tasmin Techera Cav2.2 channels Huntington disease - HD Multiple sclerosis - MS Migraine Voltage-gated calcium channel - VGCC |
title_short |
Targeting N-type calcium channels in young-onset of some neurological diseases. |
title_full |
Targeting N-type calcium channels in young-onset of some neurological diseases. |
title_fullStr |
Targeting N-type calcium channels in young-onset of some neurological diseases. |
title_full_unstemmed |
Targeting N-type calcium channels in young-onset of some neurological diseases. |
title_sort |
Targeting N-type calcium channels in young-onset of some neurological diseases. |
author |
Antunes, Flavia Tasmin Techera |
author_facet |
Antunes, Flavia Tasmin Techera Souza, Alessandra Hubner de Silva, Juliana Figueira da Binda, Nancy Scardua Carvalho, Vanice Paula Ricardo Vieira, Luciene Bruno Gomez, Marcus Vinicius |
author_role |
author |
author2 |
Souza, Alessandra Hubner de Silva, Juliana Figueira da Binda, Nancy Scardua Carvalho, Vanice Paula Ricardo Vieira, Luciene Bruno Gomez, Marcus Vinicius |
author2_role |
author author author author author author |
dc.contributor.author.fl_str_mv |
Antunes, Flavia Tasmin Techera Souza, Alessandra Hubner de Silva, Juliana Figueira da Binda, Nancy Scardua Carvalho, Vanice Paula Ricardo Vieira, Luciene Bruno Gomez, Marcus Vinicius |
dc.subject.por.fl_str_mv |
Cav2.2 channels Huntington disease - HD Multiple sclerosis - MS Migraine Voltage-gated calcium channel - VGCC |
topic |
Cav2.2 channels Huntington disease - HD Multiple sclerosis - MS Migraine Voltage-gated calcium channel - VGCC |
description |
Calcium (Ca 2+) is an important second messenger in charge of many critical processes in the central nervous system (CNS), including membrane excitability, neurotransmission, learning, memory, cell proliferation, and apoptosis. In this way, the voltage-gated calcium channels (VGCCs) act as a key supply for Ca2+ entry into the cytoplasm and organelles. Importantly, the dysregulation of these channels has been reported in many neurological diseases of young-onset, with associated genetic factors, such as migraine, multiple sclerosis, and Huntington’s disease. Notably, the literature has pointed to the role of N-type Ca2+ channels (NTCCs) in controlling a variety of processes, including pain, inflammation, and excitotoxicity. Moreover, several Ca2+ channel blockers that are used for therapeutic purposes have been shown to act on the N-type channels. Therefore, this review provides an overview of the NTCCs in neurological disorders focusing mainly on Huntington’s disease, multiple sclerosis, and migraine. It will discuss possible strategies to generate novel therapeutic strategies. |
publishDate |
2022 |
dc.date.none.fl_str_mv |
2022 2023-10-17T19:55:44Z 2023-10-17T19:55:44Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
ANTUNES. F. T. T. et al. Targeting N-type calcium channels in young-onset of some neurological diseases. Frontiers in Cell and Developmental Biology, v. 10, 2022. Disponível em: <https://www.frontiersin.org/articles/10.3389/fcell.2022.1090765/full>. Acesso em: 01 ago. 2023. 2296-634X http://www.repositorio.ufop.br/jspui/handle/123456789/17582 https://doi.org/10.3389/fcell.2022.1090765 |
identifier_str_mv |
ANTUNES. F. T. T. et al. Targeting N-type calcium channels in young-onset of some neurological diseases. Frontiers in Cell and Developmental Biology, v. 10, 2022. Disponível em: <https://www.frontiersin.org/articles/10.3389/fcell.2022.1090765/full>. Acesso em: 01 ago. 2023. 2296-634X |
url |
http://www.repositorio.ufop.br/jspui/handle/123456789/17582 https://doi.org/10.3389/fcell.2022.1090765 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UFOP instname:Universidade Federal de Ouro Preto (UFOP) instacron:UFOP |
instname_str |
Universidade Federal de Ouro Preto (UFOP) |
instacron_str |
UFOP |
institution |
UFOP |
reponame_str |
Repositório Institucional da UFOP |
collection |
Repositório Institucional da UFOP |
repository.name.fl_str_mv |
Repositório Institucional da UFOP - Universidade Federal de Ouro Preto (UFOP) |
repository.mail.fl_str_mv |
repositorio@ufop.edu.br |
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1813002806090530816 |