Targeting N-type calcium channels in young-onset of some neurological diseases.

Detalhes bibliográficos
Autor(a) principal: Antunes, Flavia Tasmin Techera
Data de Publicação: 2022
Outros Autores: Souza, Alessandra Hubner de, Silva, Juliana Figueira da, Binda, Nancy Scardua, Carvalho, Vanice Paula Ricardo, Vieira, Luciene Bruno, Gomez, Marcus Vinicius
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFOP
Texto Completo: http://www.repositorio.ufop.br/jspui/handle/123456789/17582
https://doi.org/10.3389/fcell.2022.1090765
Resumo: Calcium (Ca 2+) is an important second messenger in charge of many critical processes in the central nervous system (CNS), including membrane excitability, neurotransmission, learning, memory, cell proliferation, and apoptosis. In this way, the voltage-gated calcium channels (VGCCs) act as a key supply for Ca2+ entry into the cytoplasm and organelles. Importantly, the dysregulation of these channels has been reported in many neurological diseases of young-onset, with associated genetic factors, such as migraine, multiple sclerosis, and Huntington’s disease. Notably, the literature has pointed to the role of N-type Ca2+ channels (NTCCs) in controlling a variety of processes, including pain, inflammation, and excitotoxicity. Moreover, several Ca2+ channel blockers that are used for therapeutic purposes have been shown to act on the N-type channels. Therefore, this review provides an overview of the NTCCs in neurological disorders focusing mainly on Huntington’s disease, multiple sclerosis, and migraine. It will discuss possible strategies to generate novel therapeutic strategies.
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spelling Targeting N-type calcium channels in young-onset of some neurological diseases.Cav2.2 channelsHuntington disease - HDMultiple sclerosis - MSMigraineVoltage-gated calcium channel - VGCCCalcium (Ca 2+) is an important second messenger in charge of many critical processes in the central nervous system (CNS), including membrane excitability, neurotransmission, learning, memory, cell proliferation, and apoptosis. In this way, the voltage-gated calcium channels (VGCCs) act as a key supply for Ca2+ entry into the cytoplasm and organelles. Importantly, the dysregulation of these channels has been reported in many neurological diseases of young-onset, with associated genetic factors, such as migraine, multiple sclerosis, and Huntington’s disease. Notably, the literature has pointed to the role of N-type Ca2+ channels (NTCCs) in controlling a variety of processes, including pain, inflammation, and excitotoxicity. Moreover, several Ca2+ channel blockers that are used for therapeutic purposes have been shown to act on the N-type channels. Therefore, this review provides an overview of the NTCCs in neurological disorders focusing mainly on Huntington’s disease, multiple sclerosis, and migraine. It will discuss possible strategies to generate novel therapeutic strategies.2023-10-17T19:55:44Z2023-10-17T19:55:44Z2022info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfANTUNES. F. T. T. et al. Targeting N-type calcium channels in young-onset of some neurological diseases. Frontiers in Cell and Developmental Biology, v. 10, 2022. Disponível em: <https://www.frontiersin.org/articles/10.3389/fcell.2022.1090765/full>. Acesso em: 01 ago. 2023.2296-634Xhttp://www.repositorio.ufop.br/jspui/handle/123456789/17582https://doi.org/10.3389/fcell.2022.1090765This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). Fonte: PDF do artigo.info:eu-repo/semantics/openAccessAntunes, Flavia Tasmin TecheraSouza, Alessandra Hubner deSilva, Juliana Figueira daBinda, Nancy ScarduaCarvalho, Vanice Paula RicardoVieira, Luciene BrunoGomez, Marcus Viniciusengreponame:Repositório Institucional da UFOPinstname:Universidade Federal de Ouro Preto (UFOP)instacron:UFOP2023-10-17T19:55:53Zoai:repositorio.ufop.br:123456789/17582Repositório InstitucionalPUBhttp://www.repositorio.ufop.br/oai/requestrepositorio@ufop.edu.bropendoar:32332023-10-17T19:55:53Repositório Institucional da UFOP - Universidade Federal de Ouro Preto (UFOP)false
dc.title.none.fl_str_mv Targeting N-type calcium channels in young-onset of some neurological diseases.
title Targeting N-type calcium channels in young-onset of some neurological diseases.
spellingShingle Targeting N-type calcium channels in young-onset of some neurological diseases.
Antunes, Flavia Tasmin Techera
Cav2.2 channels
Huntington disease - HD
Multiple sclerosis - MS
Migraine
Voltage-gated calcium channel - VGCC
title_short Targeting N-type calcium channels in young-onset of some neurological diseases.
title_full Targeting N-type calcium channels in young-onset of some neurological diseases.
title_fullStr Targeting N-type calcium channels in young-onset of some neurological diseases.
title_full_unstemmed Targeting N-type calcium channels in young-onset of some neurological diseases.
title_sort Targeting N-type calcium channels in young-onset of some neurological diseases.
author Antunes, Flavia Tasmin Techera
author_facet Antunes, Flavia Tasmin Techera
Souza, Alessandra Hubner de
Silva, Juliana Figueira da
Binda, Nancy Scardua
Carvalho, Vanice Paula Ricardo
Vieira, Luciene Bruno
Gomez, Marcus Vinicius
author_role author
author2 Souza, Alessandra Hubner de
Silva, Juliana Figueira da
Binda, Nancy Scardua
Carvalho, Vanice Paula Ricardo
Vieira, Luciene Bruno
Gomez, Marcus Vinicius
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Antunes, Flavia Tasmin Techera
Souza, Alessandra Hubner de
Silva, Juliana Figueira da
Binda, Nancy Scardua
Carvalho, Vanice Paula Ricardo
Vieira, Luciene Bruno
Gomez, Marcus Vinicius
dc.subject.por.fl_str_mv Cav2.2 channels
Huntington disease - HD
Multiple sclerosis - MS
Migraine
Voltage-gated calcium channel - VGCC
topic Cav2.2 channels
Huntington disease - HD
Multiple sclerosis - MS
Migraine
Voltage-gated calcium channel - VGCC
description Calcium (Ca 2+) is an important second messenger in charge of many critical processes in the central nervous system (CNS), including membrane excitability, neurotransmission, learning, memory, cell proliferation, and apoptosis. In this way, the voltage-gated calcium channels (VGCCs) act as a key supply for Ca2+ entry into the cytoplasm and organelles. Importantly, the dysregulation of these channels has been reported in many neurological diseases of young-onset, with associated genetic factors, such as migraine, multiple sclerosis, and Huntington’s disease. Notably, the literature has pointed to the role of N-type Ca2+ channels (NTCCs) in controlling a variety of processes, including pain, inflammation, and excitotoxicity. Moreover, several Ca2+ channel blockers that are used for therapeutic purposes have been shown to act on the N-type channels. Therefore, this review provides an overview of the NTCCs in neurological disorders focusing mainly on Huntington’s disease, multiple sclerosis, and migraine. It will discuss possible strategies to generate novel therapeutic strategies.
publishDate 2022
dc.date.none.fl_str_mv 2022
2023-10-17T19:55:44Z
2023-10-17T19:55:44Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv ANTUNES. F. T. T. et al. Targeting N-type calcium channels in young-onset of some neurological diseases. Frontiers in Cell and Developmental Biology, v. 10, 2022. Disponível em: <https://www.frontiersin.org/articles/10.3389/fcell.2022.1090765/full>. Acesso em: 01 ago. 2023.
2296-634X
http://www.repositorio.ufop.br/jspui/handle/123456789/17582
https://doi.org/10.3389/fcell.2022.1090765
identifier_str_mv ANTUNES. F. T. T. et al. Targeting N-type calcium channels in young-onset of some neurological diseases. Frontiers in Cell and Developmental Biology, v. 10, 2022. Disponível em: <https://www.frontiersin.org/articles/10.3389/fcell.2022.1090765/full>. Acesso em: 01 ago. 2023.
2296-634X
url http://www.repositorio.ufop.br/jspui/handle/123456789/17582
https://doi.org/10.3389/fcell.2022.1090765
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Repositório Institucional da UFOP
instname:Universidade Federal de Ouro Preto (UFOP)
instacron:UFOP
instname_str Universidade Federal de Ouro Preto (UFOP)
instacron_str UFOP
institution UFOP
reponame_str Repositório Institucional da UFOP
collection Repositório Institucional da UFOP
repository.name.fl_str_mv Repositório Institucional da UFOP - Universidade Federal de Ouro Preto (UFOP)
repository.mail.fl_str_mv repositorio@ufop.edu.br
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