Susceptibility to re-infection in C57BL/6 mice with recombinant strains of Toxoplasma gondii.
Autor(a) principal: | |
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Data de Publicação: | 2011 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFOP |
Texto Completo: | http://www.repositorio.ufop.br/handle/123456789/1382 |
Resumo: | This work reports results of re-infection of BALB/c and C57BL/6 mice with different recombinant strains of Toxoplasma gondii. Mice were prime-infected with the non-virulent D8 strain and challenged with virulent strains. PCR–RFLP of cS10-A6 genetic marker of T. gondii demonstrated that BALB/c mice were reinfected with the EGS strain, while C57BL/6 mice were re-infected with the EGS and CH3 strains. Levels of IFN-c and IL-10 after D8 prime-infection were lower in C57BL/6 than in BALB/c mice. Brain inflammation after D8 prime-infection was more intense in C57BL/6 than in BALB/c mice. It was shown that reinfection depends on mice lineage and genotype of the strain used in the challenge. |
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Brandão, Geane PeroniMelo, Maria NormaCaetano, Bráulia CostaCarneiro, Cláudia MartinsSilva, Letícia de AzevedoVitor, Ricardo Wagner de Almeida2012-09-11T15:55:13Z2012-09-11T15:55:13Z2011BRANDÃO, G. P. et al. Susceptibility to re-infection in C57BL/6 mice with recombinant strains of Toxoplasma gondii. Experimental Parasitology, v. 128, n. 4, p. 433–437, ago. 2011. Disponível em: <https://www.sciencedirect.com/science/article/pii/S0014489411001640>. Acesso em: 11 set. 2012.00144894http://www.repositorio.ufop.br/handle/123456789/1382This work reports results of re-infection of BALB/c and C57BL/6 mice with different recombinant strains of Toxoplasma gondii. Mice were prime-infected with the non-virulent D8 strain and challenged with virulent strains. PCR–RFLP of cS10-A6 genetic marker of T. gondii demonstrated that BALB/c mice were reinfected with the EGS strain, while C57BL/6 mice were re-infected with the EGS and CH3 strains. Levels of IFN-c and IL-10 after D8 prime-infection were lower in C57BL/6 than in BALB/c mice. Brain inflammation after D8 prime-infection was more intense in C57BL/6 than in BALB/c mice. It was shown that reinfection depends on mice lineage and genotype of the strain used in the challenge.Experimental toxoplasmosisRe-infectionRecombinant strainsSusceptibility to re-infection in C57BL/6 mice with recombinant strains of Toxoplasma gondii.info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleO periódico Experimental Parasitology concede permissão para depósito deste artigo no Repositório Institucional da UFOP. Número da licença: 3280861265494.info:eu-repo/semantics/openAccessengreponame:Repositório Institucional da UFOPinstname:Universidade Federal de Ouro Preto (UFOP)instacron:UFOPLICENSElicense.txtlicense.txttext/plain; charset=utf-81748http://www.repositorio.ufop.br/bitstream/123456789/1382/5/license.txt8a4605be74aa9ea9d79846c1fba20a33MD55ORIGINALARTIGO_SusceptibilityInfectionC57BL/6.pdfARTIGO_SusceptibilityInfectionC57BL/6.pdfapplication/pdf220518http://www.repositorio.ufop.br/bitstream/123456789/1382/1/ARTIGO_SusceptibilityInfectionC57BL/6.pdfccdff21c268d54433aa69a5bd629c592MD51123456789/13822019-03-08 10:35:08.594oai:localhost:123456789/1382Tk9URTogUExBQ0UgWU9VUiBPV04gTElDRU5TRSBIRVJFClRoaXMgc2FtcGxlIGxpY2Vuc2UgaXMgcHJvdmlkZWQgZm9yIGluZm9ybWF0aW9uYWwgcHVycG9zZXMgb25seS4KCk5PTi1FWENMVVNJVkUgRElTVFJJQlVUSU9OIExJQ0VOU0UKCkJ5IHNpZ25pbmcgYW5kIHN1Ym1pdHRpbmcgdGhpcyBsaWNlbnNlLCB5b3UgKHRoZSBhdXRob3Iocykgb3IgY29weXJpZ2h0Cm93bmVyKSBncmFudHMgdG8gRFNwYWNlIFVuaXZlcnNpdHkgKERTVSkgdGhlIG5vbi1leGNsdXNpdmUgcmlnaHQgdG8gcmVwcm9kdWNlLAp0cmFuc2xhdGUgKGFzIGRlZmluZWQgYmVsb3cpLCBhbmQvb3IgZGlzdHJpYnV0ZSB5b3VyIHN1Ym1pc3Npb24gKGluY2x1ZGluZwp0aGUgYWJzdHJhY3QpIHdvcmxkd2lkZSBpbiBwcmludCBhbmQgZWxlY3Ryb25pYyBmb3JtYXQgYW5kIGluIGFueSBtZWRpdW0sCmluY2x1ZGluZyBidXQgbm90IGxpbWl0ZWQgdG8gYXVkaW8gb3IgdmlkZW8uCgpZb3UgYWdyZWUgdGhhdCBEU1UgbWF5LCB3aXRob3V0IGNoYW5naW5nIHRoZSBjb250ZW50LCB0cmFuc2xhdGUgdGhlCnN1Ym1pc3Npb24gdG8gYW55IG1lZGl1bSBvciBmb3JtYXQgZm9yIHRoZSBwdXJwb3NlIG9mIHByZXNlcnZhdGlvbi4KCllvdSBhbHNvIGFncmVlIHRoYXQgRFNVIG1heSBrZWVwIG1vcmUgdGhhbiBvbmUgY29weSBvZiB0aGlzIHN1Ym1pc3Npb24gZm9yCnB1cnBvc2VzIG9mIHNlY3VyaXR5LCBiYWNrLXVwIGFuZCBwcmVzZXJ2YXRpb24uCgpZb3UgcmVwcmVzZW50IHRoYXQgdGhlIHN1Ym1pc3Npb24gaXMgeW91ciBvcmlnaW5hbCB3b3JrLCBhbmQgdGhhdCB5b3UgaGF2ZQp0aGUgcmlnaHQgdG8gZ3JhbnQgdGhlIHJpZ2h0cyBjb250YWluZWQgaW4gdGhpcyBsaWNlbnNlLiBZb3UgYWxzbyByZXByZXNlbnQKdGhhdCB5b3VyIHN1Ym1pc3Npb24gZG9lcyBub3QsIHRvIHRoZSBiZXN0IG9mIHlvdXIga25vd2xlZGdlLCBpbmZyaW5nZSB1cG9uCmFueW9uZSdzIGNvcHlyaWdodC4KCklmIHRoZSBzdWJtaXNzaW9uIGNvbnRhaW5zIG1hdGVyaWFsIGZvciB3aGljaCB5b3UgZG8gbm90IGhvbGQgY29weXJpZ2h0LAp5b3UgcmVwcmVzZW50IHRoYXQgeW91IGhhdmUgb2J0YWluZWQgdGhlIHVucmVzdHJpY3RlZCBwZXJtaXNzaW9uIG9mIHRoZQpjb3B5cmlnaHQgb3duZXIgdG8gZ3JhbnQgRFNVIHRoZSByaWdodHMgcmVxdWlyZWQgYnkgdGhpcyBsaWNlbnNlLCBhbmQgdGhhdApzdWNoIHRoaXJkLXBhcnR5IG93bmVkIG1hdGVyaWFsIGlzIGNsZWFybHkgaWRlbnRpZmllZCBhbmQgYWNrbm93bGVkZ2VkCndpdGhpbiB0aGUgdGV4dCBvciBjb250ZW50IG9mIHRoZSBzdWJtaXNzaW9uLgoKSUYgVEhFIFNVQk1JU1NJT04gSVMgQkFTRUQgVVBPTiBXT1JLIFRIQVQgSEFTIEJFRU4gU1BPTlNPUkVEIE9SIFNVUFBPUlRFRApCWSBBTiBBR0VOQ1kgT1IgT1JHQU5JWkFUSU9OIE9USEVSIFRIQU4gRFNVLCBZT1UgUkVQUkVTRU5UIFRIQVQgWU9VIEhBVkUKRlVMRklMTEVEIEFOWSBSSUdIVCBPRiBSRVZJRVcgT1IgT1RIRVIgT0JMSUdBVElPTlMgUkVRVUlSRUQgQlkgU1VDSApDT05UUkFDVCBPUiBBR1JFRU1FTlQuCgpEU1Ugd2lsbCBjbGVhcmx5IGlkZW50aWZ5IHlvdXIgbmFtZShzKSBhcyB0aGUgYXV0aG9yKHMpIG9yIG93bmVyKHMpIG9mIHRoZQpzdWJtaXNzaW9uLCBhbmQgd2lsbCBub3QgbWFrZSBhbnkgYWx0ZXJhdGlvbiwgb3RoZXIgdGhhbiBhcyBhbGxvd2VkIGJ5IHRoaXMKbGljZW5zZSwgdG8geW91ciBzdWJtaXNzaW9uLgo=Repositório InstitucionalPUBhttp://www.repositorio.ufop.br/oai/requestrepositorio@ufop.edu.bropendoar:32332019-03-08T15:35:08Repositório Institucional da UFOP - Universidade Federal de Ouro Preto (UFOP)false |
dc.title.pt_BR.fl_str_mv |
Susceptibility to re-infection in C57BL/6 mice with recombinant strains of Toxoplasma gondii. |
title |
Susceptibility to re-infection in C57BL/6 mice with recombinant strains of Toxoplasma gondii. |
spellingShingle |
Susceptibility to re-infection in C57BL/6 mice with recombinant strains of Toxoplasma gondii. Brandão, Geane Peroni Experimental toxoplasmosis Re-infection Recombinant strains |
title_short |
Susceptibility to re-infection in C57BL/6 mice with recombinant strains of Toxoplasma gondii. |
title_full |
Susceptibility to re-infection in C57BL/6 mice with recombinant strains of Toxoplasma gondii. |
title_fullStr |
Susceptibility to re-infection in C57BL/6 mice with recombinant strains of Toxoplasma gondii. |
title_full_unstemmed |
Susceptibility to re-infection in C57BL/6 mice with recombinant strains of Toxoplasma gondii. |
title_sort |
Susceptibility to re-infection in C57BL/6 mice with recombinant strains of Toxoplasma gondii. |
author |
Brandão, Geane Peroni |
author_facet |
Brandão, Geane Peroni Melo, Maria Norma Caetano, Bráulia Costa Carneiro, Cláudia Martins Silva, Letícia de Azevedo Vitor, Ricardo Wagner de Almeida |
author_role |
author |
author2 |
Melo, Maria Norma Caetano, Bráulia Costa Carneiro, Cláudia Martins Silva, Letícia de Azevedo Vitor, Ricardo Wagner de Almeida |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Brandão, Geane Peroni Melo, Maria Norma Caetano, Bráulia Costa Carneiro, Cláudia Martins Silva, Letícia de Azevedo Vitor, Ricardo Wagner de Almeida |
dc.subject.por.fl_str_mv |
Experimental toxoplasmosis Re-infection Recombinant strains |
topic |
Experimental toxoplasmosis Re-infection Recombinant strains |
description |
This work reports results of re-infection of BALB/c and C57BL/6 mice with different recombinant strains of Toxoplasma gondii. Mice were prime-infected with the non-virulent D8 strain and challenged with virulent strains. PCR–RFLP of cS10-A6 genetic marker of T. gondii demonstrated that BALB/c mice were reinfected with the EGS strain, while C57BL/6 mice were re-infected with the EGS and CH3 strains. Levels of IFN-c and IL-10 after D8 prime-infection were lower in C57BL/6 than in BALB/c mice. Brain inflammation after D8 prime-infection was more intense in C57BL/6 than in BALB/c mice. It was shown that reinfection depends on mice lineage and genotype of the strain used in the challenge. |
publishDate |
2011 |
dc.date.issued.fl_str_mv |
2011 |
dc.date.accessioned.fl_str_mv |
2012-09-11T15:55:13Z |
dc.date.available.fl_str_mv |
2012-09-11T15:55:13Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
BRANDÃO, G. P. et al. Susceptibility to re-infection in C57BL/6 mice with recombinant strains of Toxoplasma gondii. Experimental Parasitology, v. 128, n. 4, p. 433–437, ago. 2011. Disponível em: <https://www.sciencedirect.com/science/article/pii/S0014489411001640>. Acesso em: 11 set. 2012. |
dc.identifier.uri.fl_str_mv |
http://www.repositorio.ufop.br/handle/123456789/1382 |
dc.identifier.issn.none.fl_str_mv |
00144894 |
identifier_str_mv |
BRANDÃO, G. P. et al. Susceptibility to re-infection in C57BL/6 mice with recombinant strains of Toxoplasma gondii. Experimental Parasitology, v. 128, n. 4, p. 433–437, ago. 2011. Disponível em: <https://www.sciencedirect.com/science/article/pii/S0014489411001640>. Acesso em: 11 set. 2012. 00144894 |
url |
http://www.repositorio.ufop.br/handle/123456789/1382 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
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info:eu-repo/semantics/openAccess |
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openAccess |
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