In vitro photoprotective evaluation and development of novel nanoemulsion with chromone derivative.

• Autor(a) principal: Antunes, Amanda dos Santos
• Data de Publicação: 2021
• Outros Autores: Gouveia, Ana Paula Araújo, Diogo, Gabriela Maciel, Taylor, Jason Guy, Sousa, Lucas Resende Dutra, Amparo, Tatiane Roquete, Perasoli, Fernanda Barçante, Santos, Orlando David Henrique dos, Cazati, Thiago, Vieira, Paula Melo de Abreu, Penido, Ricardo Gonçalves, Santos, Viviane Martins Rebello dos
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Institucional da UFOP
• Texto Completo: http://www.repositorio.ufop.br/jspui/handle/123456789/14284; https://dx.doi.org/10.21577/0103-5053.20210072
• topic: Mansur; Organic UV filters; Cytotoxicity

Chromone derivatives exhibiting high absorbance values in the UVA/UVB region were synthesized, and their photoprotective properties were evaluated. Chromones were prepared according to known literature procedures and characterized by high resolution mass spectrometry, infrared (IR) and nuclear magnetic resonance (NMR) spectroscopy. The in vitro solar protection factor (SPF) was determined by the Mansur method and cytotoxicity was evaluated using the sulforhodamine B assay. Two of the chromones synthesized demonstrated suitable SPF values and displayed no cytotoxic effect towards MRC-5 human fibroblasts at the tested concentrations, indicating great potential for future in vivo assays and clinical trials. Finally, the lead compound was incorporated into a nanoemulsion. Nanoemulsions showed high droplet size homogeneity and excellent stability. Chromones bearing methoxy substituents were found to be the most promising compounds with ideal photoprotective properties desirable for utilization and incorporation in sunscreen formulations.