Antitumor and anti-Mycobacterium tuberculosis agents based on cationic ruthenium complexes with amino acids.
Autor(a) principal: | |
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Data de Publicação: | 2017 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFOP |
Texto Completo: | http://www.repositorio.ufop.br/handle/123456789/9628 https://doi.org/10.1016/j.ica.2017.04.012 |
Resumo: | Six new complexes of Ru(II)/phenanthroline/1,4-bis(diphenylphosphino)butane containing amino acids (Glycine, L-Alanine, L-Valine, L-Tyrosine, L-Methionine or L-Tryptophan) were synthesized and characterized by IR, 31P{1H}, 13C and 1H NMR spectroscopies and cyclic voltammetry experiments. These data suggest the presence of diastereoisomers, except for the complex with glycine, amino acid that does not exhibit chiral carbon. The compounds are active against the MDA-MB-231 tumor cells and against Mycobacterium tuberculosis. The cationic ruthenium complexes with amino acids, reported here, show similar cytotoxicity against the MDA-MB-231 tumor cells. When compared with analogs complexes containing 2,20-bipyridine as ligands, instead of 1,10-phenatroline, the new complexes studied here are, in general, roughly twice more active than the 2,20-bipyridine ones and their IC50 values comparable with the cisplatin. In addition, low MICs values were obtained against Mycobacterium tuberculosis compared with the reference drugs, cycloserine and ethambutol. |
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Antitumor and anti-Mycobacterium tuberculosis agents based on cationic ruthenium complexes with amino acids.Ruthenium complexesCytotoxicityDiastereoisomersAmino acidSix new complexes of Ru(II)/phenanthroline/1,4-bis(diphenylphosphino)butane containing amino acids (Glycine, L-Alanine, L-Valine, L-Tyrosine, L-Methionine or L-Tryptophan) were synthesized and characterized by IR, 31P{1H}, 13C and 1H NMR spectroscopies and cyclic voltammetry experiments. These data suggest the presence of diastereoisomers, except for the complex with glycine, amino acid that does not exhibit chiral carbon. The compounds are active against the MDA-MB-231 tumor cells and against Mycobacterium tuberculosis. The cationic ruthenium complexes with amino acids, reported here, show similar cytotoxicity against the MDA-MB-231 tumor cells. When compared with analogs complexes containing 2,20-bipyridine as ligands, instead of 1,10-phenatroline, the new complexes studied here are, in general, roughly twice more active than the 2,20-bipyridine ones and their IC50 values comparable with the cisplatin. In addition, low MICs values were obtained against Mycobacterium tuberculosis compared with the reference drugs, cycloserine and ethambutol.2018-03-14T13:08:57Z2018-03-14T13:08:57Z2017info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfSANTOS, E. R. dos et al. Antitumor and anti-Mycobacterium tuberculosis agents based on cationic ruthenium complexes with amino acids. Inorganica Chimica Acta, v. 463, p. 1-6, jul. 2017. Disponível em: <http://www.sciencedirect.com/science/article/pii/S0020169317304681>. Acesso em: 15 set. 2017.0020-1693http://www.repositorio.ufop.br/handle/123456789/9628https://doi.org/10.1016/j.ica.2017.04.012O periódico Inorganica Chimica Acta concede permissão para depósito deste artigo no Repositório Institucional da UFOP. Número da licença: 4211380089785.info:eu-repo/semantics/openAccessSantos, Edjane Rocha dosCorrea, Rodrigo de SouzaCunha, Lucas Vinícius Pozzi daGraminha, Angelica EllenAraujo, Heloisa Sobreiro Selistre dePavan, Fernando RogérioBatista, Alzir Azevedoengreponame:Repositório Institucional da UFOPinstname:Universidade Federal de Ouro Preto (UFOP)instacron:UFOP2020-03-16T15:06:33Zoai:repositorio.ufop.br:123456789/9628Repositório InstitucionalPUBhttp://www.repositorio.ufop.br/oai/requestrepositorio@ufop.edu.bropendoar:32332020-03-16T15:06:33Repositório Institucional da UFOP - Universidade Federal de Ouro Preto (UFOP)false |
dc.title.none.fl_str_mv |
Antitumor and anti-Mycobacterium tuberculosis agents based on cationic ruthenium complexes with amino acids. |
title |
Antitumor and anti-Mycobacterium tuberculosis agents based on cationic ruthenium complexes with amino acids. |
spellingShingle |
Antitumor and anti-Mycobacterium tuberculosis agents based on cationic ruthenium complexes with amino acids. Santos, Edjane Rocha dos Ruthenium complexes Cytotoxicity Diastereoisomers Amino acid |
title_short |
Antitumor and anti-Mycobacterium tuberculosis agents based on cationic ruthenium complexes with amino acids. |
title_full |
Antitumor and anti-Mycobacterium tuberculosis agents based on cationic ruthenium complexes with amino acids. |
title_fullStr |
Antitumor and anti-Mycobacterium tuberculosis agents based on cationic ruthenium complexes with amino acids. |
title_full_unstemmed |
Antitumor and anti-Mycobacterium tuberculosis agents based on cationic ruthenium complexes with amino acids. |
title_sort |
Antitumor and anti-Mycobacterium tuberculosis agents based on cationic ruthenium complexes with amino acids. |
author |
Santos, Edjane Rocha dos |
author_facet |
Santos, Edjane Rocha dos Correa, Rodrigo de Souza Cunha, Lucas Vinícius Pozzi da Graminha, Angelica Ellen Araujo, Heloisa Sobreiro Selistre de Pavan, Fernando Rogério Batista, Alzir Azevedo |
author_role |
author |
author2 |
Correa, Rodrigo de Souza Cunha, Lucas Vinícius Pozzi da Graminha, Angelica Ellen Araujo, Heloisa Sobreiro Selistre de Pavan, Fernando Rogério Batista, Alzir Azevedo |
author2_role |
author author author author author author |
dc.contributor.author.fl_str_mv |
Santos, Edjane Rocha dos Correa, Rodrigo de Souza Cunha, Lucas Vinícius Pozzi da Graminha, Angelica Ellen Araujo, Heloisa Sobreiro Selistre de Pavan, Fernando Rogério Batista, Alzir Azevedo |
dc.subject.por.fl_str_mv |
Ruthenium complexes Cytotoxicity Diastereoisomers Amino acid |
topic |
Ruthenium complexes Cytotoxicity Diastereoisomers Amino acid |
description |
Six new complexes of Ru(II)/phenanthroline/1,4-bis(diphenylphosphino)butane containing amino acids (Glycine, L-Alanine, L-Valine, L-Tyrosine, L-Methionine or L-Tryptophan) were synthesized and characterized by IR, 31P{1H}, 13C and 1H NMR spectroscopies and cyclic voltammetry experiments. These data suggest the presence of diastereoisomers, except for the complex with glycine, amino acid that does not exhibit chiral carbon. The compounds are active against the MDA-MB-231 tumor cells and against Mycobacterium tuberculosis. The cationic ruthenium complexes with amino acids, reported here, show similar cytotoxicity against the MDA-MB-231 tumor cells. When compared with analogs complexes containing 2,20-bipyridine as ligands, instead of 1,10-phenatroline, the new complexes studied here are, in general, roughly twice more active than the 2,20-bipyridine ones and their IC50 values comparable with the cisplatin. In addition, low MICs values were obtained against Mycobacterium tuberculosis compared with the reference drugs, cycloserine and ethambutol. |
publishDate |
2017 |
dc.date.none.fl_str_mv |
2017 2018-03-14T13:08:57Z 2018-03-14T13:08:57Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
SANTOS, E. R. dos et al. Antitumor and anti-Mycobacterium tuberculosis agents based on cationic ruthenium complexes with amino acids. Inorganica Chimica Acta, v. 463, p. 1-6, jul. 2017. Disponível em: <http://www.sciencedirect.com/science/article/pii/S0020169317304681>. Acesso em: 15 set. 2017. 0020-1693 http://www.repositorio.ufop.br/handle/123456789/9628 https://doi.org/10.1016/j.ica.2017.04.012 |
identifier_str_mv |
SANTOS, E. R. dos et al. Antitumor and anti-Mycobacterium tuberculosis agents based on cationic ruthenium complexes with amino acids. Inorganica Chimica Acta, v. 463, p. 1-6, jul. 2017. Disponível em: <http://www.sciencedirect.com/science/article/pii/S0020169317304681>. Acesso em: 15 set. 2017. 0020-1693 |
url |
http://www.repositorio.ufop.br/handle/123456789/9628 https://doi.org/10.1016/j.ica.2017.04.012 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UFOP instname:Universidade Federal de Ouro Preto (UFOP) instacron:UFOP |
instname_str |
Universidade Federal de Ouro Preto (UFOP) |
instacron_str |
UFOP |
institution |
UFOP |
reponame_str |
Repositório Institucional da UFOP |
collection |
Repositório Institucional da UFOP |
repository.name.fl_str_mv |
Repositório Institucional da UFOP - Universidade Federal de Ouro Preto (UFOP) |
repository.mail.fl_str_mv |
repositorio@ufop.edu.br |
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1813002808342872064 |