Antitumor and anti-Mycobacterium tuberculosis agents based on cationic ruthenium complexes with amino acids.

Detalhes bibliográficos
Autor(a) principal: Santos, Edjane Rocha dos
Data de Publicação: 2017
Outros Autores: Correa, Rodrigo de Souza, Cunha, Lucas Vinícius Pozzi da, Graminha, Angelica Ellen, Araujo, Heloisa Sobreiro Selistre de, Pavan, Fernando Rogério, Batista, Alzir Azevedo
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFOP
Texto Completo: http://www.repositorio.ufop.br/handle/123456789/9628
https://doi.org/10.1016/j.ica.2017.04.012
Resumo: Six new complexes of Ru(II)/phenanthroline/1,4-bis(diphenylphosphino)butane containing amino acids (Glycine, L-Alanine, L-Valine, L-Tyrosine, L-Methionine or L-Tryptophan) were synthesized and characterized by IR, 31P{1H}, 13C and 1H NMR spectroscopies and cyclic voltammetry experiments. These data suggest the presence of diastereoisomers, except for the complex with glycine, amino acid that does not exhibit chiral carbon. The compounds are active against the MDA-MB-231 tumor cells and against Mycobacterium tuberculosis. The cationic ruthenium complexes with amino acids, reported here, show similar cytotoxicity against the MDA-MB-231 tumor cells. When compared with analogs complexes containing 2,20-bipyridine as ligands, instead of 1,10-phenatroline, the new complexes studied here are, in general, roughly twice more active than the 2,20-bipyridine ones and their IC50 values comparable with the cisplatin. In addition, low MICs values were obtained against Mycobacterium tuberculosis compared with the reference drugs, cycloserine and ethambutol.
id UFOP_46f0f984e9bc1320db48263ffa467632
oai_identifier_str oai:repositorio.ufop.br:123456789/9628
network_acronym_str UFOP
network_name_str Repositório Institucional da UFOP
repository_id_str 3233
spelling Antitumor and anti-Mycobacterium tuberculosis agents based on cationic ruthenium complexes with amino acids.Ruthenium complexesCytotoxicityDiastereoisomersAmino acidSix new complexes of Ru(II)/phenanthroline/1,4-bis(diphenylphosphino)butane containing amino acids (Glycine, L-Alanine, L-Valine, L-Tyrosine, L-Methionine or L-Tryptophan) were synthesized and characterized by IR, 31P{1H}, 13C and 1H NMR spectroscopies and cyclic voltammetry experiments. These data suggest the presence of diastereoisomers, except for the complex with glycine, amino acid that does not exhibit chiral carbon. The compounds are active against the MDA-MB-231 tumor cells and against Mycobacterium tuberculosis. The cationic ruthenium complexes with amino acids, reported here, show similar cytotoxicity against the MDA-MB-231 tumor cells. When compared with analogs complexes containing 2,20-bipyridine as ligands, instead of 1,10-phenatroline, the new complexes studied here are, in general, roughly twice more active than the 2,20-bipyridine ones and their IC50 values comparable with the cisplatin. In addition, low MICs values were obtained against Mycobacterium tuberculosis compared with the reference drugs, cycloserine and ethambutol.2018-03-14T13:08:57Z2018-03-14T13:08:57Z2017info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfSANTOS, E. R. dos et al. Antitumor and anti-Mycobacterium tuberculosis agents based on cationic ruthenium complexes with amino acids. Inorganica Chimica Acta, v. 463, p. 1-6, jul. 2017. Disponível em: <http://www.sciencedirect.com/science/article/pii/S0020169317304681>. Acesso em: 15 set. 2017.0020-1693http://www.repositorio.ufop.br/handle/123456789/9628https://doi.org/10.1016/j.ica.2017.04.012O periódico Inorganica Chimica Acta concede permissão para depósito deste artigo no Repositório Institucional da UFOP. Número da licença: 4211380089785.info:eu-repo/semantics/openAccessSantos, Edjane Rocha dosCorrea, Rodrigo de SouzaCunha, Lucas Vinícius Pozzi daGraminha, Angelica EllenAraujo, Heloisa Sobreiro Selistre dePavan, Fernando RogérioBatista, Alzir Azevedoengreponame:Repositório Institucional da UFOPinstname:Universidade Federal de Ouro Preto (UFOP)instacron:UFOP2020-03-16T15:06:33Zoai:repositorio.ufop.br:123456789/9628Repositório InstitucionalPUBhttp://www.repositorio.ufop.br/oai/requestrepositorio@ufop.edu.bropendoar:32332020-03-16T15:06:33Repositório Institucional da UFOP - Universidade Federal de Ouro Preto (UFOP)false
dc.title.none.fl_str_mv Antitumor and anti-Mycobacterium tuberculosis agents based on cationic ruthenium complexes with amino acids.
title Antitumor and anti-Mycobacterium tuberculosis agents based on cationic ruthenium complexes with amino acids.
spellingShingle Antitumor and anti-Mycobacterium tuberculosis agents based on cationic ruthenium complexes with amino acids.
Santos, Edjane Rocha dos
Ruthenium complexes
Cytotoxicity
Diastereoisomers
Amino acid
title_short Antitumor and anti-Mycobacterium tuberculosis agents based on cationic ruthenium complexes with amino acids.
title_full Antitumor and anti-Mycobacterium tuberculosis agents based on cationic ruthenium complexes with amino acids.
title_fullStr Antitumor and anti-Mycobacterium tuberculosis agents based on cationic ruthenium complexes with amino acids.
title_full_unstemmed Antitumor and anti-Mycobacterium tuberculosis agents based on cationic ruthenium complexes with amino acids.
title_sort Antitumor and anti-Mycobacterium tuberculosis agents based on cationic ruthenium complexes with amino acids.
author Santos, Edjane Rocha dos
author_facet Santos, Edjane Rocha dos
Correa, Rodrigo de Souza
Cunha, Lucas Vinícius Pozzi da
Graminha, Angelica Ellen
Araujo, Heloisa Sobreiro Selistre de
Pavan, Fernando Rogério
Batista, Alzir Azevedo
author_role author
author2 Correa, Rodrigo de Souza
Cunha, Lucas Vinícius Pozzi da
Graminha, Angelica Ellen
Araujo, Heloisa Sobreiro Selistre de
Pavan, Fernando Rogério
Batista, Alzir Azevedo
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Santos, Edjane Rocha dos
Correa, Rodrigo de Souza
Cunha, Lucas Vinícius Pozzi da
Graminha, Angelica Ellen
Araujo, Heloisa Sobreiro Selistre de
Pavan, Fernando Rogério
Batista, Alzir Azevedo
dc.subject.por.fl_str_mv Ruthenium complexes
Cytotoxicity
Diastereoisomers
Amino acid
topic Ruthenium complexes
Cytotoxicity
Diastereoisomers
Amino acid
description Six new complexes of Ru(II)/phenanthroline/1,4-bis(diphenylphosphino)butane containing amino acids (Glycine, L-Alanine, L-Valine, L-Tyrosine, L-Methionine or L-Tryptophan) were synthesized and characterized by IR, 31P{1H}, 13C and 1H NMR spectroscopies and cyclic voltammetry experiments. These data suggest the presence of diastereoisomers, except for the complex with glycine, amino acid that does not exhibit chiral carbon. The compounds are active against the MDA-MB-231 tumor cells and against Mycobacterium tuberculosis. The cationic ruthenium complexes with amino acids, reported here, show similar cytotoxicity against the MDA-MB-231 tumor cells. When compared with analogs complexes containing 2,20-bipyridine as ligands, instead of 1,10-phenatroline, the new complexes studied here are, in general, roughly twice more active than the 2,20-bipyridine ones and their IC50 values comparable with the cisplatin. In addition, low MICs values were obtained against Mycobacterium tuberculosis compared with the reference drugs, cycloserine and ethambutol.
publishDate 2017
dc.date.none.fl_str_mv 2017
2018-03-14T13:08:57Z
2018-03-14T13:08:57Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv SANTOS, E. R. dos et al. Antitumor and anti-Mycobacterium tuberculosis agents based on cationic ruthenium complexes with amino acids. Inorganica Chimica Acta, v. 463, p. 1-6, jul. 2017. Disponível em: <http://www.sciencedirect.com/science/article/pii/S0020169317304681>. Acesso em: 15 set. 2017.
0020-1693
http://www.repositorio.ufop.br/handle/123456789/9628
https://doi.org/10.1016/j.ica.2017.04.012
identifier_str_mv SANTOS, E. R. dos et al. Antitumor and anti-Mycobacterium tuberculosis agents based on cationic ruthenium complexes with amino acids. Inorganica Chimica Acta, v. 463, p. 1-6, jul. 2017. Disponível em: <http://www.sciencedirect.com/science/article/pii/S0020169317304681>. Acesso em: 15 set. 2017.
0020-1693
url http://www.repositorio.ufop.br/handle/123456789/9628
https://doi.org/10.1016/j.ica.2017.04.012
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Repositório Institucional da UFOP
instname:Universidade Federal de Ouro Preto (UFOP)
instacron:UFOP
instname_str Universidade Federal de Ouro Preto (UFOP)
instacron_str UFOP
institution UFOP
reponame_str Repositório Institucional da UFOP
collection Repositório Institucional da UFOP
repository.name.fl_str_mv Repositório Institucional da UFOP - Universidade Federal de Ouro Preto (UFOP)
repository.mail.fl_str_mv repositorio@ufop.edu.br
_version_ 1813002808342872064