Hydroalcoholic extract of Brazilian green propolis modulates inflammatory process in mice submitted to a low protein diet.
Autor(a) principal: | |
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Data de Publicação: | 2019 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFOP |
Texto Completo: | http://www.repositorio.ufop.br/handle/123456789/10988 |
Resumo: | The occurrence of inflammation and protein malnutrition is an aggravating risk factor for morbidity and mortality in the clinical setting. The green propolis, a natural product made by Apis mellifera bees from Baccharis dracunculifolia resin, has therapeutic potential to modulate chronic inflammation. However, its effect on inflammation in an impaired nutritional status is not known. The aim of this study was to characterize the effects of the administration of the hydroalcoholic extract of the green propolis in the chronic inflammatory process of mice submitted to a low-protein diet. For this, we used the subcutaneous implantation of sponge disks as an inflammatory model and the animals were distributed in the following groups: standard protein diet (12% protein content), control treatment; standard protein diet, propolis treatment; low-protein diet (3% protein content), control treatment; low-protein diet, propolis treatment. Propolis was given daily at a dose of 500 mg/kg (p.o.) during a period of 7 or 15 days. Our main findings show that animals fed with standard protein diet and treated with propolis had low levels of red blood cells, hemoglobin, and hematocrit, with the subsequent reestablishment of these levels, in addition to monocyte count elevation and higher TNF levels after one week of treatment. In the low-protein diet group, the propolis treatment provided a significant recovery in weight and maintenance of total serum protein levels at the end of two weeks of treatment. Histological analysis showed propolis reduced the inflammatory infiltrate in the sponges of both standard and low-protein diet groups. In addition, the propolis extract presented antiangiogenic effect in both groups. Therefore, our data suggests that the hydroalcoholic extract of the green propolis promotes weight recovery and avoid the reduction of protein levels, in addition to inhibit inflammation and angiogenesis in animals fed with a low-protein diet. |
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Hydroalcoholic extract of Brazilian green propolis modulates inflammatory process in mice submitted to a low protein diet.GreenHydroalcoholic extractAngiogenesisInflammationSponge implantationThe occurrence of inflammation and protein malnutrition is an aggravating risk factor for morbidity and mortality in the clinical setting. The green propolis, a natural product made by Apis mellifera bees from Baccharis dracunculifolia resin, has therapeutic potential to modulate chronic inflammation. However, its effect on inflammation in an impaired nutritional status is not known. The aim of this study was to characterize the effects of the administration of the hydroalcoholic extract of the green propolis in the chronic inflammatory process of mice submitted to a low-protein diet. For this, we used the subcutaneous implantation of sponge disks as an inflammatory model and the animals were distributed in the following groups: standard protein diet (12% protein content), control treatment; standard protein diet, propolis treatment; low-protein diet (3% protein content), control treatment; low-protein diet, propolis treatment. Propolis was given daily at a dose of 500 mg/kg (p.o.) during a period of 7 or 15 days. Our main findings show that animals fed with standard protein diet and treated with propolis had low levels of red blood cells, hemoglobin, and hematocrit, with the subsequent reestablishment of these levels, in addition to monocyte count elevation and higher TNF levels after one week of treatment. In the low-protein diet group, the propolis treatment provided a significant recovery in weight and maintenance of total serum protein levels at the end of two weeks of treatment. Histological analysis showed propolis reduced the inflammatory infiltrate in the sponges of both standard and low-protein diet groups. In addition, the propolis extract presented antiangiogenic effect in both groups. Therefore, our data suggests that the hydroalcoholic extract of the green propolis promotes weight recovery and avoid the reduction of protein levels, in addition to inhibit inflammation and angiogenesis in animals fed with a low-protein diet.2019-04-09T15:31:44Z2019-04-09T15:31:44Z2019info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfMIRANDA, M. B. de et al. Hydroalcoholic extract of Brazilian green propolis modulates inflammatory process in mice submitted to a low protein diet. Biomedicine & Pharmacotherapy, v. 109, p. 610-620, jan. 2019. Disponível em: <https://www.sciencedirect.com/science/article/pii/S0753332218341623?via%3Dihub>. Acesso em: 25 fev. 2019.07533322http://www.repositorio.ufop.br/handle/123456789/10988This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/BY-NC-ND/4.0/).Fonte: O próprio artigoinfo:eu-repo/semantics/openAccessMiranda, Marina Barcelos deLanna, Mariana FerreiraNascimento, Ana Luiza BarrosPaula, Carmen Aparecida deSilva, Marcelo EustáquioSilva, Mariane Felipetto daBarcelos, Luciola da SilvaMoura, Sandra Aparecida Lima deengreponame:Repositório Institucional da UFOPinstname:Universidade Federal de Ouro Preto (UFOP)instacron:UFOP2019-04-09T15:31:44Zoai:repositorio.ufop.br:123456789/10988Repositório InstitucionalPUBhttp://www.repositorio.ufop.br/oai/requestrepositorio@ufop.edu.bropendoar:32332019-04-09T15:31:44Repositório Institucional da UFOP - Universidade Federal de Ouro Preto (UFOP)false |
dc.title.none.fl_str_mv |
Hydroalcoholic extract of Brazilian green propolis modulates inflammatory process in mice submitted to a low protein diet. |
title |
Hydroalcoholic extract of Brazilian green propolis modulates inflammatory process in mice submitted to a low protein diet. |
spellingShingle |
Hydroalcoholic extract of Brazilian green propolis modulates inflammatory process in mice submitted to a low protein diet. Miranda, Marina Barcelos de Green Hydroalcoholic extract Angiogenesis Inflammation Sponge implantation |
title_short |
Hydroalcoholic extract of Brazilian green propolis modulates inflammatory process in mice submitted to a low protein diet. |
title_full |
Hydroalcoholic extract of Brazilian green propolis modulates inflammatory process in mice submitted to a low protein diet. |
title_fullStr |
Hydroalcoholic extract of Brazilian green propolis modulates inflammatory process in mice submitted to a low protein diet. |
title_full_unstemmed |
Hydroalcoholic extract of Brazilian green propolis modulates inflammatory process in mice submitted to a low protein diet. |
title_sort |
Hydroalcoholic extract of Brazilian green propolis modulates inflammatory process in mice submitted to a low protein diet. |
author |
Miranda, Marina Barcelos de |
author_facet |
Miranda, Marina Barcelos de Lanna, Mariana Ferreira Nascimento, Ana Luiza Barros Paula, Carmen Aparecida de Silva, Marcelo Eustáquio Silva, Mariane Felipetto da Barcelos, Luciola da Silva Moura, Sandra Aparecida Lima de |
author_role |
author |
author2 |
Lanna, Mariana Ferreira Nascimento, Ana Luiza Barros Paula, Carmen Aparecida de Silva, Marcelo Eustáquio Silva, Mariane Felipetto da Barcelos, Luciola da Silva Moura, Sandra Aparecida Lima de |
author2_role |
author author author author author author author |
dc.contributor.author.fl_str_mv |
Miranda, Marina Barcelos de Lanna, Mariana Ferreira Nascimento, Ana Luiza Barros Paula, Carmen Aparecida de Silva, Marcelo Eustáquio Silva, Mariane Felipetto da Barcelos, Luciola da Silva Moura, Sandra Aparecida Lima de |
dc.subject.por.fl_str_mv |
Green Hydroalcoholic extract Angiogenesis Inflammation Sponge implantation |
topic |
Green Hydroalcoholic extract Angiogenesis Inflammation Sponge implantation |
description |
The occurrence of inflammation and protein malnutrition is an aggravating risk factor for morbidity and mortality in the clinical setting. The green propolis, a natural product made by Apis mellifera bees from Baccharis dracunculifolia resin, has therapeutic potential to modulate chronic inflammation. However, its effect on inflammation in an impaired nutritional status is not known. The aim of this study was to characterize the effects of the administration of the hydroalcoholic extract of the green propolis in the chronic inflammatory process of mice submitted to a low-protein diet. For this, we used the subcutaneous implantation of sponge disks as an inflammatory model and the animals were distributed in the following groups: standard protein diet (12% protein content), control treatment; standard protein diet, propolis treatment; low-protein diet (3% protein content), control treatment; low-protein diet, propolis treatment. Propolis was given daily at a dose of 500 mg/kg (p.o.) during a period of 7 or 15 days. Our main findings show that animals fed with standard protein diet and treated with propolis had low levels of red blood cells, hemoglobin, and hematocrit, with the subsequent reestablishment of these levels, in addition to monocyte count elevation and higher TNF levels after one week of treatment. In the low-protein diet group, the propolis treatment provided a significant recovery in weight and maintenance of total serum protein levels at the end of two weeks of treatment. Histological analysis showed propolis reduced the inflammatory infiltrate in the sponges of both standard and low-protein diet groups. In addition, the propolis extract presented antiangiogenic effect in both groups. Therefore, our data suggests that the hydroalcoholic extract of the green propolis promotes weight recovery and avoid the reduction of protein levels, in addition to inhibit inflammation and angiogenesis in animals fed with a low-protein diet. |
publishDate |
2019 |
dc.date.none.fl_str_mv |
2019-04-09T15:31:44Z 2019-04-09T15:31:44Z 2019 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
MIRANDA, M. B. de et al. Hydroalcoholic extract of Brazilian green propolis modulates inflammatory process in mice submitted to a low protein diet. Biomedicine & Pharmacotherapy, v. 109, p. 610-620, jan. 2019. Disponível em: <https://www.sciencedirect.com/science/article/pii/S0753332218341623?via%3Dihub>. Acesso em: 25 fev. 2019. 07533322 http://www.repositorio.ufop.br/handle/123456789/10988 |
identifier_str_mv |
MIRANDA, M. B. de et al. Hydroalcoholic extract of Brazilian green propolis modulates inflammatory process in mice submitted to a low protein diet. Biomedicine & Pharmacotherapy, v. 109, p. 610-620, jan. 2019. Disponível em: <https://www.sciencedirect.com/science/article/pii/S0753332218341623?via%3Dihub>. Acesso em: 25 fev. 2019. 07533322 |
url |
http://www.repositorio.ufop.br/handle/123456789/10988 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UFOP instname:Universidade Federal de Ouro Preto (UFOP) instacron:UFOP |
instname_str |
Universidade Federal de Ouro Preto (UFOP) |
instacron_str |
UFOP |
institution |
UFOP |
reponame_str |
Repositório Institucional da UFOP |
collection |
Repositório Institucional da UFOP |
repository.name.fl_str_mv |
Repositório Institucional da UFOP - Universidade Federal de Ouro Preto (UFOP) |
repository.mail.fl_str_mv |
repositorio@ufop.edu.br |
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1813002830542274560 |