Hydroalcoholic extract of Brazilian green propolis modulates inflammatory process in mice submitted to a low protein diet.

Detalhes bibliográficos
Autor(a) principal: Miranda, Marina Barcelos de
Data de Publicação: 2019
Outros Autores: Lanna, Mariana Ferreira, Nascimento, Ana Luiza Barros, Paula, Carmen Aparecida de, Silva, Marcelo Eustáquio, Silva, Mariane Felipetto da, Barcelos, Luciola da Silva, Moura, Sandra Aparecida Lima de
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFOP
Texto Completo: http://www.repositorio.ufop.br/handle/123456789/10988
Resumo: The occurrence of inflammation and protein malnutrition is an aggravating risk factor for morbidity and mortality in the clinical setting. The green propolis, a natural product made by Apis mellifera bees from Baccharis dracunculifolia resin, has therapeutic potential to modulate chronic inflammation. However, its effect on inflammation in an impaired nutritional status is not known. The aim of this study was to characterize the effects of the administration of the hydroalcoholic extract of the green propolis in the chronic inflammatory process of mice submitted to a low-protein diet. For this, we used the subcutaneous implantation of sponge disks as an inflammatory model and the animals were distributed in the following groups: standard protein diet (12% protein content), control treatment; standard protein diet, propolis treatment; low-protein diet (3% protein content), control treatment; low-protein diet, propolis treatment. Propolis was given daily at a dose of 500 mg/kg (p.o.) during a period of 7 or 15 days. Our main findings show that animals fed with standard protein diet and treated with propolis had low levels of red blood cells, hemoglobin, and hematocrit, with the subsequent reestablishment of these levels, in addition to monocyte count elevation and higher TNF levels after one week of treatment. In the low-protein diet group, the propolis treatment provided a significant recovery in weight and maintenance of total serum protein levels at the end of two weeks of treatment. Histological analysis showed propolis reduced the inflammatory infiltrate in the sponges of both standard and low-protein diet groups. In addition, the propolis extract presented antiangiogenic effect in both groups. Therefore, our data suggests that the hydroalcoholic extract of the green propolis promotes weight recovery and avoid the reduction of protein levels, in addition to inhibit inflammation and angiogenesis in animals fed with a low-protein diet.
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spelling Hydroalcoholic extract of Brazilian green propolis modulates inflammatory process in mice submitted to a low protein diet.GreenHydroalcoholic extractAngiogenesisInflammationSponge implantationThe occurrence of inflammation and protein malnutrition is an aggravating risk factor for morbidity and mortality in the clinical setting. The green propolis, a natural product made by Apis mellifera bees from Baccharis dracunculifolia resin, has therapeutic potential to modulate chronic inflammation. However, its effect on inflammation in an impaired nutritional status is not known. The aim of this study was to characterize the effects of the administration of the hydroalcoholic extract of the green propolis in the chronic inflammatory process of mice submitted to a low-protein diet. For this, we used the subcutaneous implantation of sponge disks as an inflammatory model and the animals were distributed in the following groups: standard protein diet (12% protein content), control treatment; standard protein diet, propolis treatment; low-protein diet (3% protein content), control treatment; low-protein diet, propolis treatment. Propolis was given daily at a dose of 500 mg/kg (p.o.) during a period of 7 or 15 days. Our main findings show that animals fed with standard protein diet and treated with propolis had low levels of red blood cells, hemoglobin, and hematocrit, with the subsequent reestablishment of these levels, in addition to monocyte count elevation and higher TNF levels after one week of treatment. In the low-protein diet group, the propolis treatment provided a significant recovery in weight and maintenance of total serum protein levels at the end of two weeks of treatment. Histological analysis showed propolis reduced the inflammatory infiltrate in the sponges of both standard and low-protein diet groups. In addition, the propolis extract presented antiangiogenic effect in both groups. Therefore, our data suggests that the hydroalcoholic extract of the green propolis promotes weight recovery and avoid the reduction of protein levels, in addition to inhibit inflammation and angiogenesis in animals fed with a low-protein diet.2019-04-09T15:31:44Z2019-04-09T15:31:44Z2019info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfMIRANDA, M. B. de et al. Hydroalcoholic extract of Brazilian green propolis modulates inflammatory process in mice submitted to a low protein diet. Biomedicine & Pharmacotherapy, v. 109, p. 610-620, jan. 2019. Disponível em: <https://www.sciencedirect.com/science/article/pii/S0753332218341623?via%3Dihub>. Acesso em: 25 fev. 2019.07533322http://www.repositorio.ufop.br/handle/123456789/10988This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/BY-NC-ND/4.0/).Fonte: O próprio artigoinfo:eu-repo/semantics/openAccessMiranda, Marina Barcelos deLanna, Mariana FerreiraNascimento, Ana Luiza BarrosPaula, Carmen Aparecida deSilva, Marcelo EustáquioSilva, Mariane Felipetto daBarcelos, Luciola da SilvaMoura, Sandra Aparecida Lima deengreponame:Repositório Institucional da UFOPinstname:Universidade Federal de Ouro Preto (UFOP)instacron:UFOP2019-04-09T15:31:44Zoai:repositorio.ufop.br:123456789/10988Repositório InstitucionalPUBhttp://www.repositorio.ufop.br/oai/requestrepositorio@ufop.edu.bropendoar:32332019-04-09T15:31:44Repositório Institucional da UFOP - Universidade Federal de Ouro Preto (UFOP)false
dc.title.none.fl_str_mv Hydroalcoholic extract of Brazilian green propolis modulates inflammatory process in mice submitted to a low protein diet.
title Hydroalcoholic extract of Brazilian green propolis modulates inflammatory process in mice submitted to a low protein diet.
spellingShingle Hydroalcoholic extract of Brazilian green propolis modulates inflammatory process in mice submitted to a low protein diet.
Miranda, Marina Barcelos de
Green
Hydroalcoholic extract
Angiogenesis
Inflammation
Sponge implantation
title_short Hydroalcoholic extract of Brazilian green propolis modulates inflammatory process in mice submitted to a low protein diet.
title_full Hydroalcoholic extract of Brazilian green propolis modulates inflammatory process in mice submitted to a low protein diet.
title_fullStr Hydroalcoholic extract of Brazilian green propolis modulates inflammatory process in mice submitted to a low protein diet.
title_full_unstemmed Hydroalcoholic extract of Brazilian green propolis modulates inflammatory process in mice submitted to a low protein diet.
title_sort Hydroalcoholic extract of Brazilian green propolis modulates inflammatory process in mice submitted to a low protein diet.
author Miranda, Marina Barcelos de
author_facet Miranda, Marina Barcelos de
Lanna, Mariana Ferreira
Nascimento, Ana Luiza Barros
Paula, Carmen Aparecida de
Silva, Marcelo Eustáquio
Silva, Mariane Felipetto da
Barcelos, Luciola da Silva
Moura, Sandra Aparecida Lima de
author_role author
author2 Lanna, Mariana Ferreira
Nascimento, Ana Luiza Barros
Paula, Carmen Aparecida de
Silva, Marcelo Eustáquio
Silva, Mariane Felipetto da
Barcelos, Luciola da Silva
Moura, Sandra Aparecida Lima de
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Miranda, Marina Barcelos de
Lanna, Mariana Ferreira
Nascimento, Ana Luiza Barros
Paula, Carmen Aparecida de
Silva, Marcelo Eustáquio
Silva, Mariane Felipetto da
Barcelos, Luciola da Silva
Moura, Sandra Aparecida Lima de
dc.subject.por.fl_str_mv Green
Hydroalcoholic extract
Angiogenesis
Inflammation
Sponge implantation
topic Green
Hydroalcoholic extract
Angiogenesis
Inflammation
Sponge implantation
description The occurrence of inflammation and protein malnutrition is an aggravating risk factor for morbidity and mortality in the clinical setting. The green propolis, a natural product made by Apis mellifera bees from Baccharis dracunculifolia resin, has therapeutic potential to modulate chronic inflammation. However, its effect on inflammation in an impaired nutritional status is not known. The aim of this study was to characterize the effects of the administration of the hydroalcoholic extract of the green propolis in the chronic inflammatory process of mice submitted to a low-protein diet. For this, we used the subcutaneous implantation of sponge disks as an inflammatory model and the animals were distributed in the following groups: standard protein diet (12% protein content), control treatment; standard protein diet, propolis treatment; low-protein diet (3% protein content), control treatment; low-protein diet, propolis treatment. Propolis was given daily at a dose of 500 mg/kg (p.o.) during a period of 7 or 15 days. Our main findings show that animals fed with standard protein diet and treated with propolis had low levels of red blood cells, hemoglobin, and hematocrit, with the subsequent reestablishment of these levels, in addition to monocyte count elevation and higher TNF levels after one week of treatment. In the low-protein diet group, the propolis treatment provided a significant recovery in weight and maintenance of total serum protein levels at the end of two weeks of treatment. Histological analysis showed propolis reduced the inflammatory infiltrate in the sponges of both standard and low-protein diet groups. In addition, the propolis extract presented antiangiogenic effect in both groups. Therefore, our data suggests that the hydroalcoholic extract of the green propolis promotes weight recovery and avoid the reduction of protein levels, in addition to inhibit inflammation and angiogenesis in animals fed with a low-protein diet.
publishDate 2019
dc.date.none.fl_str_mv 2019-04-09T15:31:44Z
2019-04-09T15:31:44Z
2019
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv MIRANDA, M. B. de et al. Hydroalcoholic extract of Brazilian green propolis modulates inflammatory process in mice submitted to a low protein diet. Biomedicine & Pharmacotherapy, v. 109, p. 610-620, jan. 2019. Disponível em: <https://www.sciencedirect.com/science/article/pii/S0753332218341623?via%3Dihub>. Acesso em: 25 fev. 2019.
07533322
http://www.repositorio.ufop.br/handle/123456789/10988
identifier_str_mv MIRANDA, M. B. de et al. Hydroalcoholic extract of Brazilian green propolis modulates inflammatory process in mice submitted to a low protein diet. Biomedicine & Pharmacotherapy, v. 109, p. 610-620, jan. 2019. Disponível em: <https://www.sciencedirect.com/science/article/pii/S0753332218341623?via%3Dihub>. Acesso em: 25 fev. 2019.
07533322
url http://www.repositorio.ufop.br/handle/123456789/10988
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Repositório Institucional da UFOP
instname:Universidade Federal de Ouro Preto (UFOP)
instacron:UFOP
instname_str Universidade Federal de Ouro Preto (UFOP)
instacron_str UFOP
institution UFOP
reponame_str Repositório Institucional da UFOP
collection Repositório Institucional da UFOP
repository.name.fl_str_mv Repositório Institucional da UFOP - Universidade Federal de Ouro Preto (UFOP)
repository.mail.fl_str_mv repositorio@ufop.edu.br
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