High resolution mass spectrometry elucidation of captopril´s ozonation and chlorination by-products.
Autor(a) principal: | |
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Data de Publicação: | 2017 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFOP |
Texto Completo: | http://www.repositorio.ufop.br/handle/123456789/8595 https://doi.org/10.4236/ajac.2017.84020 |
Resumo: | The article evaluated the degradation of the captopril in aqueous solution after ozonation and chlorination. The process was continuously monitored focusing on the identification, mass spectrometry and elucidation of its by-products by applying direct infusion and high performance liquid chromatography, electrospray ionization high resolution mass spectrometry, in the negative ion mode. The cytotoxicity of its by-products solutions were evaluated with 3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide (MTT) assay. It was observed through that after 30 min of ozonation and chlorination, there was complete oxidation of captopril, i .e ., 100% removal efficiency. At these conditions, the rate of mineralization, by total organic carbon, was only 7.63% for ozonation and 6.40% for chlorination, evidencing the formation of degradation by-products. Ten captopril by-products were identified and their respective chemical structures elucidations are proposed. The treated samples and their by-products were nontoxic to HepG2 cells by MTT assay. |
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Quintão, Frederico Jehár OliveiraBrandão, Geraldo CélioSilva, Silvana de QueirozAquino, Sergio Francisco deAfonso, Robson José de Cássia Franco2017-08-30T17:40:08Z2017-08-30T17:40:08Z2017QUINTÃO, F. J. O. et al. High resolution mass spectrometry elucidation of captopril´s ozonation and chlorination by-products. American Journal Of Analytical Chemistry, v. 08, p. 264-279, 2017. Disponível em: <http://www.scirp.org/journal/PaperInforCitation.aspx?PaperID=75798>. Acesso em: 29 ago. 2017.2156-8278http://www.repositorio.ufop.br/handle/123456789/8595https://doi.org/10.4236/ajac.2017.84020The article evaluated the degradation of the captopril in aqueous solution after ozonation and chlorination. The process was continuously monitored focusing on the identification, mass spectrometry and elucidation of its by-products by applying direct infusion and high performance liquid chromatography, electrospray ionization high resolution mass spectrometry, in the negative ion mode. The cytotoxicity of its by-products solutions were evaluated with 3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide (MTT) assay. It was observed through that after 30 min of ozonation and chlorination, there was complete oxidation of captopril, i .e ., 100% removal efficiency. At these conditions, the rate of mineralization, by total organic carbon, was only 7.63% for ozonation and 6.40% for chlorination, evidencing the formation of degradation by-products. Ten captopril by-products were identified and their respective chemical structures elucidations are proposed. The treated samples and their by-products were nontoxic to HepG2 cells by MTT assay.This work is licensed under the Creative Commons Attribution International License (CC BY 4.0). http://creativecommons.org/licenses/by/4.0/. Fonte o próprio artigoinfo:eu-repo/semantics/openAccessLiquid chromatographyHigh resolution mass spectrometry elucidation of captopril´s ozonation and chlorination by-products.info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleengreponame:Repositório Institucional da UFOPinstname:Universidade Federal de Ouro Preto (UFOP)instacron:UFOPLICENSElicense.txtlicense.txttext/plain; charset=utf-8924http://www.repositorio.ufop.br/bitstream/123456789/8595/2/license.txt62604f8d955274beb56c80ce1ee5dcaeMD52ORIGINALARTIGO_HighResolutionMass.pdfARTIGO_HighResolutionMass.pdfapplication/pdf1242809http://www.repositorio.ufop.br/bitstream/123456789/8595/1/ARTIGO_HighResolutionMass.pdf9dbab4f4a7a565788498a408e6b2f7feMD51123456789/85952020-01-23 05:48:25.206oai:localhost: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ório InstitucionalPUBhttp://www.repositorio.ufop.br/oai/requestrepositorio@ufop.edu.bropendoar:32332020-01-23T10:48:25Repositório Institucional da UFOP - Universidade Federal de Ouro Preto (UFOP)false |
dc.title.pt_BR.fl_str_mv |
High resolution mass spectrometry elucidation of captopril´s ozonation and chlorination by-products. |
title |
High resolution mass spectrometry elucidation of captopril´s ozonation and chlorination by-products. |
spellingShingle |
High resolution mass spectrometry elucidation of captopril´s ozonation and chlorination by-products. Quintão, Frederico Jehár Oliveira Liquid chromatography |
title_short |
High resolution mass spectrometry elucidation of captopril´s ozonation and chlorination by-products. |
title_full |
High resolution mass spectrometry elucidation of captopril´s ozonation and chlorination by-products. |
title_fullStr |
High resolution mass spectrometry elucidation of captopril´s ozonation and chlorination by-products. |
title_full_unstemmed |
High resolution mass spectrometry elucidation of captopril´s ozonation and chlorination by-products. |
title_sort |
High resolution mass spectrometry elucidation of captopril´s ozonation and chlorination by-products. |
author |
Quintão, Frederico Jehár Oliveira |
author_facet |
Quintão, Frederico Jehár Oliveira Brandão, Geraldo Célio Silva, Silvana de Queiroz Aquino, Sergio Francisco de Afonso, Robson José de Cássia Franco |
author_role |
author |
author2 |
Brandão, Geraldo Célio Silva, Silvana de Queiroz Aquino, Sergio Francisco de Afonso, Robson José de Cássia Franco |
author2_role |
author author author author |
dc.contributor.author.fl_str_mv |
Quintão, Frederico Jehár Oliveira Brandão, Geraldo Célio Silva, Silvana de Queiroz Aquino, Sergio Francisco de Afonso, Robson José de Cássia Franco |
dc.subject.por.fl_str_mv |
Liquid chromatography |
topic |
Liquid chromatography |
description |
The article evaluated the degradation of the captopril in aqueous solution after ozonation and chlorination. The process was continuously monitored focusing on the identification, mass spectrometry and elucidation of its by-products by applying direct infusion and high performance liquid chromatography, electrospray ionization high resolution mass spectrometry, in the negative ion mode. The cytotoxicity of its by-products solutions were evaluated with 3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide (MTT) assay. It was observed through that after 30 min of ozonation and chlorination, there was complete oxidation of captopril, i .e ., 100% removal efficiency. At these conditions, the rate of mineralization, by total organic carbon, was only 7.63% for ozonation and 6.40% for chlorination, evidencing the formation of degradation by-products. Ten captopril by-products were identified and their respective chemical structures elucidations are proposed. The treated samples and their by-products were nontoxic to HepG2 cells by MTT assay. |
publishDate |
2017 |
dc.date.accessioned.fl_str_mv |
2017-08-30T17:40:08Z |
dc.date.available.fl_str_mv |
2017-08-30T17:40:08Z |
dc.date.issued.fl_str_mv |
2017 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
QUINTÃO, F. J. O. et al. High resolution mass spectrometry elucidation of captopril´s ozonation and chlorination by-products. American Journal Of Analytical Chemistry, v. 08, p. 264-279, 2017. Disponível em: <http://www.scirp.org/journal/PaperInforCitation.aspx?PaperID=75798>. Acesso em: 29 ago. 2017. |
dc.identifier.uri.fl_str_mv |
http://www.repositorio.ufop.br/handle/123456789/8595 |
dc.identifier.issn.none.fl_str_mv |
2156-8278 |
dc.identifier.doi.none.fl_str_mv |
https://doi.org/10.4236/ajac.2017.84020 |
identifier_str_mv |
QUINTÃO, F. J. O. et al. High resolution mass spectrometry elucidation of captopril´s ozonation and chlorination by-products. American Journal Of Analytical Chemistry, v. 08, p. 264-279, 2017. Disponível em: <http://www.scirp.org/journal/PaperInforCitation.aspx?PaperID=75798>. Acesso em: 29 ago. 2017. 2156-8278 |
url |
http://www.repositorio.ufop.br/handle/123456789/8595 https://doi.org/10.4236/ajac.2017.84020 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
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info:eu-repo/semantics/openAccess |
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openAccess |
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reponame:Repositório Institucional da UFOP instname:Universidade Federal de Ouro Preto (UFOP) instacron:UFOP |
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