Splenectomy does not interfere with immune response to Leishmania major infection in mice.

Detalhes bibliográficos
Autor(a) principal: Maioli, Tatiani Uceli
Data de Publicação: 2007
Outros Autores: Carneiro, Cláudia Martins, Assis, Frankcinéia Aparecida de, Faria, Ana Maria Caetano de
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFOP
Texto Completo: http://www.repositorio.ufop.br/handle/123456789/1409
Resumo: Spleen is one of the largest lymphoid organs in the body; it harbors immune cells including antigen presenting cells, B and T lymphocytes. It has an important role in humoral and cellular immune responses. Herein we investigated the role of spleen in the immune response to experimental Leishmania major infection. It is known that C57BL/6 mice are resistant to L. major infection whereas BALB/c mice are susceptible. Although splenectomy was associated with reduced serum levels of IFN-gamma, absence of the spleen did not change the profile of L. major infection in the resistant C57BL/6 and BALB/c susceptible mice. Both strains of mice maintained the same profile of cytokine production in regional lymph nodes after splenectomy and responded in the same way against the infection. Only splenectomized BALB/c mice had a reduction in IL-4 and IL-10 production by lymph node cells early in infection. Our data suggest that, in localized infections, regional lymph nodes may replace efficiently the immunological role of spleen in the cellular and humoral immune responses.
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spelling Splenectomy does not interfere with immune response to Leishmania major infection in mice.Leishmania majorImmune protectionSpleenSpleen is one of the largest lymphoid organs in the body; it harbors immune cells including antigen presenting cells, B and T lymphocytes. It has an important role in humoral and cellular immune responses. Herein we investigated the role of spleen in the immune response to experimental Leishmania major infection. It is known that C57BL/6 mice are resistant to L. major infection whereas BALB/c mice are susceptible. Although splenectomy was associated with reduced serum levels of IFN-gamma, absence of the spleen did not change the profile of L. major infection in the resistant C57BL/6 and BALB/c susceptible mice. Both strains of mice maintained the same profile of cytokine production in regional lymph nodes after splenectomy and responded in the same way against the infection. Only splenectomized BALB/c mice had a reduction in IL-4 and IL-10 production by lymph node cells early in infection. Our data suggest that, in localized infections, regional lymph nodes may replace efficiently the immunological role of spleen in the cellular and humoral immune responses.2012-09-19T17:48:06Z2012-09-19T17:48:06Z2007info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfMAIOLI, T. U. et al. Splenectomy does not interfere with immune response to Leishmania major infection in mice. Cellular Immunology, v. 249, n. 1, p. 1-7, set. 2007. Disponível em: <https://www.sciencedirect.com/science/article/pii/S0008874907002225>. Acesso em: 19 set. 2012.00088749http://www.repositorio.ufop.br/handle/123456789/1409O periódico Cellular Immunology concede permissão para depósito deste artigo no Repositório Institucional da UFOP. Número da licença: 3281990466243.info:eu-repo/semantics/openAccessMaioli, Tatiani UceliCarneiro, Cláudia MartinsAssis, Frankcinéia Aparecida deFaria, Ana Maria Caetano deengreponame:Repositório Institucional da UFOPinstname:Universidade Federal de Ouro Preto (UFOP)instacron:UFOP2019-04-24T14:53:27Zoai:repositorio.ufop.br:123456789/1409Repositório InstitucionalPUBhttp://www.repositorio.ufop.br/oai/requestrepositorio@ufop.edu.bropendoar:32332019-04-24T14:53:27Repositório Institucional da UFOP - Universidade Federal de Ouro Preto (UFOP)false
dc.title.none.fl_str_mv Splenectomy does not interfere with immune response to Leishmania major infection in mice.
title Splenectomy does not interfere with immune response to Leishmania major infection in mice.
spellingShingle Splenectomy does not interfere with immune response to Leishmania major infection in mice.
Maioli, Tatiani Uceli
Leishmania major
Immune protection
Spleen
title_short Splenectomy does not interfere with immune response to Leishmania major infection in mice.
title_full Splenectomy does not interfere with immune response to Leishmania major infection in mice.
title_fullStr Splenectomy does not interfere with immune response to Leishmania major infection in mice.
title_full_unstemmed Splenectomy does not interfere with immune response to Leishmania major infection in mice.
title_sort Splenectomy does not interfere with immune response to Leishmania major infection in mice.
author Maioli, Tatiani Uceli
author_facet Maioli, Tatiani Uceli
Carneiro, Cláudia Martins
Assis, Frankcinéia Aparecida de
Faria, Ana Maria Caetano de
author_role author
author2 Carneiro, Cláudia Martins
Assis, Frankcinéia Aparecida de
Faria, Ana Maria Caetano de
author2_role author
author
author
dc.contributor.author.fl_str_mv Maioli, Tatiani Uceli
Carneiro, Cláudia Martins
Assis, Frankcinéia Aparecida de
Faria, Ana Maria Caetano de
dc.subject.por.fl_str_mv Leishmania major
Immune protection
Spleen
topic Leishmania major
Immune protection
Spleen
description Spleen is one of the largest lymphoid organs in the body; it harbors immune cells including antigen presenting cells, B and T lymphocytes. It has an important role in humoral and cellular immune responses. Herein we investigated the role of spleen in the immune response to experimental Leishmania major infection. It is known that C57BL/6 mice are resistant to L. major infection whereas BALB/c mice are susceptible. Although splenectomy was associated with reduced serum levels of IFN-gamma, absence of the spleen did not change the profile of L. major infection in the resistant C57BL/6 and BALB/c susceptible mice. Both strains of mice maintained the same profile of cytokine production in regional lymph nodes after splenectomy and responded in the same way against the infection. Only splenectomized BALB/c mice had a reduction in IL-4 and IL-10 production by lymph node cells early in infection. Our data suggest that, in localized infections, regional lymph nodes may replace efficiently the immunological role of spleen in the cellular and humoral immune responses.
publishDate 2007
dc.date.none.fl_str_mv 2007
2012-09-19T17:48:06Z
2012-09-19T17:48:06Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv MAIOLI, T. U. et al. Splenectomy does not interfere with immune response to Leishmania major infection in mice. Cellular Immunology, v. 249, n. 1, p. 1-7, set. 2007. Disponível em: <https://www.sciencedirect.com/science/article/pii/S0008874907002225>. Acesso em: 19 set. 2012.
00088749
http://www.repositorio.ufop.br/handle/123456789/1409
identifier_str_mv MAIOLI, T. U. et al. Splenectomy does not interfere with immune response to Leishmania major infection in mice. Cellular Immunology, v. 249, n. 1, p. 1-7, set. 2007. Disponível em: <https://www.sciencedirect.com/science/article/pii/S0008874907002225>. Acesso em: 19 set. 2012.
00088749
url http://www.repositorio.ufop.br/handle/123456789/1409
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Repositório Institucional da UFOP
instname:Universidade Federal de Ouro Preto (UFOP)
instacron:UFOP
instname_str Universidade Federal de Ouro Preto (UFOP)
instacron_str UFOP
institution UFOP
reponame_str Repositório Institucional da UFOP
collection Repositório Institucional da UFOP
repository.name.fl_str_mv Repositório Institucional da UFOP - Universidade Federal de Ouro Preto (UFOP)
repository.mail.fl_str_mv repositorio@ufop.edu.br
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