The scavenger receptor MARCO is involved in Leishmania major infection by CBA/J macrophages

Detalhes bibliográficos
Autor(a) principal: Gomes, I. N.
Data de Publicação: 2009
Outros Autores: Palma, L. C., Campos, G. O., Santos, R. R. dos, Buck, G. A., Manque, P. A. M., Freitas, L. A. R. de
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFBA
Texto Completo: http://www.repositorio.ufba.br/ri/handle/ri/13267
Resumo: Texto completo: acesso restrito. p. 188-198
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spelling Gomes, I. N.Palma, L. C.Campos, G. O.Santos, R. R. dosBuck, G. A.Manque, P. A. M.Freitas, L. A. R. deGomes, I. N.Palma, L. C.Campos, G. O.Santos, R. R. dosBuck, G. A.Manque, P. A. M.Freitas, L. A. R. de2013-10-15T18:22:10Z20090141-9838http://www.repositorio.ufba.br/ri/handle/ri/13267v. 31, n. 4Texto completo: acesso restrito. p. 188-198CBA/J mice are resistant to Leishmania major infection but are permissive to L. amazonensis infection. In addition, CBA/J macrophages control L. major but not L. amazonensis infection in vitro. Phagocytosis by macrophages is known to determine the outcome of Leishmania infection. Pattern recognition receptors (PRR) adorning antigen presenting cell surfaces are known to coordinate the link between innate and adaptive immunity. The macrophage receptor with collagenous structure (MARCO) is a PRR that is preferably expressed by macrophages and is capable of binding Gram-positive and Gram-negative bacteria. No research on the role of MARCO in Leishmania–macrophage interactions has been reported. Here, we demonstrate, for the first time, that MARCO expression by CBA/J macrophages is increased in response to both in vitro and in vivo L. major infections, but not to L. amazonensis infection. In addition, a specific anti-MARCO monoclonal antibody reduced L. major infection of macrophages by 30%–40% in vitro. The draining lymph nodes of anti-MARCO-treated mice displayed a reduced presence of immunolabelled parasite and parasite antigens, as well as a reduced inflammatory response. These results support the hypothesis that MARCO has a role in macrophage infection by L. major in vitro as well as in vivo.Submitted by Suelen Reis (suziy.ellen@gmail.com) on 2013-10-15T15:39:56Z No. of bitstreams: 1 j.1365-3024.2009.01093.x.pdf: 1392501 bytes, checksum: 640b34171f4feddc4ee0e5a29a9168f3 (MD5)Approved for entry into archive by Alda Lima da Silva(sivalda@ufba.br) on 2013-10-15T18:22:10Z (GMT) No. of bitstreams: 1 j.1365-3024.2009.01093.x.pdf: 1392501 bytes, checksum: 640b34171f4feddc4ee0e5a29a9168f3 (MD5)Made available in DSpace on 2013-10-15T18:22:10Z (GMT). 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dc.title.pt_BR.fl_str_mv The scavenger receptor MARCO is involved in Leishmania major infection by CBA/J macrophages
dc.title.alternative.pt_BR.fl_str_mv Parasite Immunology
title The scavenger receptor MARCO is involved in Leishmania major infection by CBA/J macrophages
spellingShingle The scavenger receptor MARCO is involved in Leishmania major infection by CBA/J macrophages
Gomes, I. N.
Leishmania major
Macrophage
MARCO
title_short The scavenger receptor MARCO is involved in Leishmania major infection by CBA/J macrophages
title_full The scavenger receptor MARCO is involved in Leishmania major infection by CBA/J macrophages
title_fullStr The scavenger receptor MARCO is involved in Leishmania major infection by CBA/J macrophages
title_full_unstemmed The scavenger receptor MARCO is involved in Leishmania major infection by CBA/J macrophages
title_sort The scavenger receptor MARCO is involved in Leishmania major infection by CBA/J macrophages
author Gomes, I. N.
author_facet Gomes, I. N.
Palma, L. C.
Campos, G. O.
Santos, R. R. dos
Buck, G. A.
Manque, P. A. M.
Freitas, L. A. R. de
author_role author
author2 Palma, L. C.
Campos, G. O.
Santos, R. R. dos
Buck, G. A.
Manque, P. A. M.
Freitas, L. A. R. de
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Gomes, I. N.
Palma, L. C.
Campos, G. O.
Santos, R. R. dos
Buck, G. A.
Manque, P. A. M.
Freitas, L. A. R. de
Gomes, I. N.
Palma, L. C.
Campos, G. O.
Santos, R. R. dos
Buck, G. A.
Manque, P. A. M.
Freitas, L. A. R. de
dc.subject.por.fl_str_mv Leishmania major
Macrophage
MARCO
topic Leishmania major
Macrophage
MARCO
description Texto completo: acesso restrito. p. 188-198
publishDate 2009
dc.date.issued.fl_str_mv 2009
dc.date.accessioned.fl_str_mv 2013-10-15T18:22:10Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://www.repositorio.ufba.br/ri/handle/ri/13267
dc.identifier.issn.none.fl_str_mv 0141-9838
dc.identifier.number.pt_BR.fl_str_mv v. 31, n. 4
identifier_str_mv 0141-9838
v. 31, n. 4
url http://www.repositorio.ufba.br/ri/handle/ri/13267
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.source.pt_BR.fl_str_mv http://dx.doi.org/10.1111/j.1365-3024.2009.01093.x
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