Fortified interpenetrating polymers - bacteria resistant coatings for medical devices.

Detalhes bibliográficos
Autor(a) principal: Venkateswaran, Seshasailam
Data de Publicação: 2016
Outros Autores: Santos, Orlando David Henrique dos, Scholefield, Emma, Lilienkampf, Annamaria, Gwynne, Peter J., Swann, David G., Dhaliwal, Kevin, Gallagher, Maurice P., Bradley, Mark
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFOP
Texto Completo: http://www.repositorio.ufop.br/handle/123456789/8609
https://doi.org/10.1039/C6TB01110A
Resumo: Infections arising from contaminated medical devices are a serious global issue, contributing to antibiotic resistance and imposing significant strain on healthcare systems. Since the majority of medical deviceassociated infections are biofilm related, efforts are being made to generate either bacteria-repellent or antibacterial coatings aimed at preventing bacterial colonisation. Here, we utilise a nanocapsule mediated slow release of a natural antimicrobial to improve the performance of a bacteria repellent polymer coating. Poly(lauryl acrylate) nanocapsules containing eugenol (4-allyl-2-methoxyphenol) were prepared and entrapped within a interpenetrating network designed to repel bacteria. When coated on a catheter and an endotracheal tube, this hemocompatible system allowed slow-release of eugenol, resulting in notable reduction in surface-bound Klebsiella pneumoniae and methicillin resistant Staphylococcus aureus.
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spelling Venkateswaran, SeshasailamSantos, Orlando David Henrique dosScholefield, EmmaLilienkampf, AnnamariaGwynne, Peter J.Swann, David G.Dhaliwal, KevinGallagher, Maurice P.Bradley, Mark2017-08-30T18:20:45Z2017-08-30T18:20:45Z2016VENKATESWARAN, S. et al. Fortified interpenetrating polymers - bacteria resistant coatings for medical devices. J Mater Chem B, v. 14, p. 5405-5411, 2016. Disponível em: <http://pubs.rsc.org/en/Content/ArticleLanding/2016/TB/C6TB01110A#!divAbstract>. Acesso em: 29 ago. 2017.2050-7518http://www.repositorio.ufop.br/handle/123456789/8609https://doi.org/10.1039/C6TB01110AInfections arising from contaminated medical devices are a serious global issue, contributing to antibiotic resistance and imposing significant strain on healthcare systems. Since the majority of medical deviceassociated infections are biofilm related, efforts are being made to generate either bacteria-repellent or antibacterial coatings aimed at preventing bacterial colonisation. Here, we utilise a nanocapsule mediated slow release of a natural antimicrobial to improve the performance of a bacteria repellent polymer coating. Poly(lauryl acrylate) nanocapsules containing eugenol (4-allyl-2-methoxyphenol) were prepared and entrapped within a interpenetrating network designed to repel bacteria. When coated on a catheter and an endotracheal tube, this hemocompatible system allowed slow-release of eugenol, resulting in notable reduction in surface-bound Klebsiella pneumoniae and methicillin resistant Staphylococcus aureus.This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. Fonte: o próprio artigo.info:eu-repo/semantics/openAccessFortified interpenetrating polymers - bacteria resistant coatings for medical devices.info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleengreponame:Repositório Institucional da UFOPinstname:Universidade Federal de Ouro Preto (UFOP)instacron:UFOPLICENSElicense.txtlicense.txttext/plain; charset=utf-8924http://www.repositorio.ufop.br/bitstream/123456789/8609/2/license.txt62604f8d955274beb56c80ce1ee5dcaeMD52ORIGINALARTIGO_FortifiedInterpenetratingPolymer.pdfARTIGO_FortifiedInterpenetratingPolymer.pdfapplication/pdf3455622http://www.repositorio.ufop.br/bitstream/123456789/8609/1/ARTIGO_FortifiedInterpenetratingPolymer.pdfd32a56765316738b094f20e545d85e36MD51123456789/86092020-01-23 06:19:05.805oai:localhost:123456789/8609RGVjbGFyYcOnw6NvIGRlIGRpc3RyaWJ1acOnw6NvIG7Do28tZXhjbHVzaXZhCgpPIHJlZmVyaWRvIGF1dG9yOgoKYSlEZWNsYXJhIHF1ZSBvIGRvY3VtZW50byBlbnRyZWd1ZSDDqSBzZXUgdHJhYmFsaG8gb3JpZ2luYWwgZSBxdWUgZGV0w6ltIG8gZGlyZWl0byBkZSBjb25jZWRlciBvcyBkaXJlaXRvcyBjb250aWRvcyBuZXN0YSBsaWNlbsOnYS4gRGVjbGFyYSB0YW1iw6ltIHF1ZSBhIGVudHJlZ2EgZG8gZG9jdW1lbnRvIG7Do28gaW5mcmluZ2UsIHRhbnRvIHF1YW50byBsaGUgw6kgcG9zc8OtdmVsIHNhYmVyLCBvcyBkaXJlaXRvcyBkZSBxdWFscXVlciBwZXNzb2Egb3UgZW50aWRhZGUuCgpiKVNlIG8gZG9jdW1lbnRvIGVudHJlZ3VlIGNvbnTDqW0gbWF0ZXJpYWwgZG8gcXVhbCBuw6NvIGRldMOpbSBvcyBkaXJlaXRvcyBkZSBhdXRvciwgZGVjbGFyYSBxdWUgb2J0ZXZlIGF1dG9yaXphw6fDo28gZG8gZGV0ZW50b3IgZG9zIGRpcmVpdG9zIGRlIGF1dG9yIHBhcmEgY29uY2VkZXIgw6AgVW5pdmVyc2lkYWRlIEZlZGVyYWwgZGUgT3VybyBQcmV0by9VRk9QIG9zIGRpcmVpdG9zIHJlcXVlcmlkb3MgcG9yIGVzdGEgbGljZW7Dp2EgZSBxdWUgZXNzZSBtYXRlcmlhbCwgY3Vqb3MgZGlyZWl0b3Mgc8OjbyBkZSB0ZXJjZWlyb3MsIGVzdMOhIGNsYXJhbWVudGUgaWRlbnRpZmljYWRvIGUgcmVjb25oZWNpZG8gbm8gdGV4dG8gb3UgY29udGXDumRvcyBkbyBkb2N1bWVudG8gZW50cmVndWUuCgpjKVNlIG8gZG9jdW1lbnRvIGVudHJlZ3VlIMOpIGJhc2VhZG8gZW0gdHJhYmFsaG8gZmluYW5jaWFkbyBvdSBhcG9pYWRvIHBvciBvdXRyYSBpbnN0aXR1acOnw6NvIHF1ZSBuw6NvIGEgVUZPUCwgZGVjbGFyYSBxdWUgY3VtcHJpdSBxdWFpc3F1ZXIgb2JyaWdhw6fDtWVzIGV4aWdpZGFzIHBlbG8gY29udHJhdG8gb3UgYWNvcmRvLgoKRepositório InstitucionalPUBhttp://www.repositorio.ufop.br/oai/requestrepositorio@ufop.edu.bropendoar:32332020-01-23T11:19:05Repositório Institucional da UFOP - Universidade Federal de Ouro Preto (UFOP)false
dc.title.pt_BR.fl_str_mv Fortified interpenetrating polymers - bacteria resistant coatings for medical devices.
title Fortified interpenetrating polymers - bacteria resistant coatings for medical devices.
spellingShingle Fortified interpenetrating polymers - bacteria resistant coatings for medical devices.
Venkateswaran, Seshasailam
title_short Fortified interpenetrating polymers - bacteria resistant coatings for medical devices.
title_full Fortified interpenetrating polymers - bacteria resistant coatings for medical devices.
title_fullStr Fortified interpenetrating polymers - bacteria resistant coatings for medical devices.
title_full_unstemmed Fortified interpenetrating polymers - bacteria resistant coatings for medical devices.
title_sort Fortified interpenetrating polymers - bacteria resistant coatings for medical devices.
author Venkateswaran, Seshasailam
author_facet Venkateswaran, Seshasailam
Santos, Orlando David Henrique dos
Scholefield, Emma
Lilienkampf, Annamaria
Gwynne, Peter J.
Swann, David G.
Dhaliwal, Kevin
Gallagher, Maurice P.
Bradley, Mark
author_role author
author2 Santos, Orlando David Henrique dos
Scholefield, Emma
Lilienkampf, Annamaria
Gwynne, Peter J.
Swann, David G.
Dhaliwal, Kevin
Gallagher, Maurice P.
Bradley, Mark
author2_role author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Venkateswaran, Seshasailam
Santos, Orlando David Henrique dos
Scholefield, Emma
Lilienkampf, Annamaria
Gwynne, Peter J.
Swann, David G.
Dhaliwal, Kevin
Gallagher, Maurice P.
Bradley, Mark
description Infections arising from contaminated medical devices are a serious global issue, contributing to antibiotic resistance and imposing significant strain on healthcare systems. Since the majority of medical deviceassociated infections are biofilm related, efforts are being made to generate either bacteria-repellent or antibacterial coatings aimed at preventing bacterial colonisation. Here, we utilise a nanocapsule mediated slow release of a natural antimicrobial to improve the performance of a bacteria repellent polymer coating. Poly(lauryl acrylate) nanocapsules containing eugenol (4-allyl-2-methoxyphenol) were prepared and entrapped within a interpenetrating network designed to repel bacteria. When coated on a catheter and an endotracheal tube, this hemocompatible system allowed slow-release of eugenol, resulting in notable reduction in surface-bound Klebsiella pneumoniae and methicillin resistant Staphylococcus aureus.
publishDate 2016
dc.date.issued.fl_str_mv 2016
dc.date.accessioned.fl_str_mv 2017-08-30T18:20:45Z
dc.date.available.fl_str_mv 2017-08-30T18:20:45Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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dc.identifier.citation.fl_str_mv VENKATESWARAN, S. et al. Fortified interpenetrating polymers - bacteria resistant coatings for medical devices. J Mater Chem B, v. 14, p. 5405-5411, 2016. Disponível em: <http://pubs.rsc.org/en/Content/ArticleLanding/2016/TB/C6TB01110A#!divAbstract>. Acesso em: 29 ago. 2017.
dc.identifier.uri.fl_str_mv http://www.repositorio.ufop.br/handle/123456789/8609
dc.identifier.issn.none.fl_str_mv 2050-7518
dc.identifier.doi.none.fl_str_mv https://doi.org/10.1039/C6TB01110A
identifier_str_mv VENKATESWARAN, S. et al. Fortified interpenetrating polymers - bacteria resistant coatings for medical devices. J Mater Chem B, v. 14, p. 5405-5411, 2016. Disponível em: <http://pubs.rsc.org/en/Content/ArticleLanding/2016/TB/C6TB01110A#!divAbstract>. Acesso em: 29 ago. 2017.
2050-7518
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https://doi.org/10.1039/C6TB01110A
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