Fortified interpenetrating polymers - bacteria resistant coatings for medical devices.
Autor(a) principal: | |
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Data de Publicação: | 2016 |
Outros Autores: | , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFOP |
Texto Completo: | http://www.repositorio.ufop.br/handle/123456789/8609 https://doi.org/10.1039/C6TB01110A |
Resumo: | Infections arising from contaminated medical devices are a serious global issue, contributing to antibiotic resistance and imposing significant strain on healthcare systems. Since the majority of medical deviceassociated infections are biofilm related, efforts are being made to generate either bacteria-repellent or antibacterial coatings aimed at preventing bacterial colonisation. Here, we utilise a nanocapsule mediated slow release of a natural antimicrobial to improve the performance of a bacteria repellent polymer coating. Poly(lauryl acrylate) nanocapsules containing eugenol (4-allyl-2-methoxyphenol) were prepared and entrapped within a interpenetrating network designed to repel bacteria. When coated on a catheter and an endotracheal tube, this hemocompatible system allowed slow-release of eugenol, resulting in notable reduction in surface-bound Klebsiella pneumoniae and methicillin resistant Staphylococcus aureus. |
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Venkateswaran, SeshasailamSantos, Orlando David Henrique dosScholefield, EmmaLilienkampf, AnnamariaGwynne, Peter J.Swann, David G.Dhaliwal, KevinGallagher, Maurice P.Bradley, Mark2017-08-30T18:20:45Z2017-08-30T18:20:45Z2016VENKATESWARAN, S. et al. Fortified interpenetrating polymers - bacteria resistant coatings for medical devices. J Mater Chem B, v. 14, p. 5405-5411, 2016. Disponível em: <http://pubs.rsc.org/en/Content/ArticleLanding/2016/TB/C6TB01110A#!divAbstract>. Acesso em: 29 ago. 2017.2050-7518http://www.repositorio.ufop.br/handle/123456789/8609https://doi.org/10.1039/C6TB01110AInfections arising from contaminated medical devices are a serious global issue, contributing to antibiotic resistance and imposing significant strain on healthcare systems. Since the majority of medical deviceassociated infections are biofilm related, efforts are being made to generate either bacteria-repellent or antibacterial coatings aimed at preventing bacterial colonisation. Here, we utilise a nanocapsule mediated slow release of a natural antimicrobial to improve the performance of a bacteria repellent polymer coating. Poly(lauryl acrylate) nanocapsules containing eugenol (4-allyl-2-methoxyphenol) were prepared and entrapped within a interpenetrating network designed to repel bacteria. When coated on a catheter and an endotracheal tube, this hemocompatible system allowed slow-release of eugenol, resulting in notable reduction in surface-bound Klebsiella pneumoniae and methicillin resistant Staphylococcus aureus.This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. Fonte: o próprio artigo.info:eu-repo/semantics/openAccessFortified interpenetrating polymers - bacteria resistant coatings for medical devices.info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleengreponame:Repositório Institucional da UFOPinstname:Universidade Federal de Ouro Preto (UFOP)instacron:UFOPLICENSElicense.txtlicense.txttext/plain; charset=utf-8924http://www.repositorio.ufop.br/bitstream/123456789/8609/2/license.txt62604f8d955274beb56c80ce1ee5dcaeMD52ORIGINALARTIGO_FortifiedInterpenetratingPolymer.pdfARTIGO_FortifiedInterpenetratingPolymer.pdfapplication/pdf3455622http://www.repositorio.ufop.br/bitstream/123456789/8609/1/ARTIGO_FortifiedInterpenetratingPolymer.pdfd32a56765316738b094f20e545d85e36MD51123456789/86092020-01-23 06:19:05.805oai:localhost: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ório InstitucionalPUBhttp://www.repositorio.ufop.br/oai/requestrepositorio@ufop.edu.bropendoar:32332020-01-23T11:19:05Repositório Institucional da UFOP - Universidade Federal de Ouro Preto (UFOP)false |
dc.title.pt_BR.fl_str_mv |
Fortified interpenetrating polymers - bacteria resistant coatings for medical devices. |
title |
Fortified interpenetrating polymers - bacteria resistant coatings for medical devices. |
spellingShingle |
Fortified interpenetrating polymers - bacteria resistant coatings for medical devices. Venkateswaran, Seshasailam |
title_short |
Fortified interpenetrating polymers - bacteria resistant coatings for medical devices. |
title_full |
Fortified interpenetrating polymers - bacteria resistant coatings for medical devices. |
title_fullStr |
Fortified interpenetrating polymers - bacteria resistant coatings for medical devices. |
title_full_unstemmed |
Fortified interpenetrating polymers - bacteria resistant coatings for medical devices. |
title_sort |
Fortified interpenetrating polymers - bacteria resistant coatings for medical devices. |
author |
Venkateswaran, Seshasailam |
author_facet |
Venkateswaran, Seshasailam Santos, Orlando David Henrique dos Scholefield, Emma Lilienkampf, Annamaria Gwynne, Peter J. Swann, David G. Dhaliwal, Kevin Gallagher, Maurice P. Bradley, Mark |
author_role |
author |
author2 |
Santos, Orlando David Henrique dos Scholefield, Emma Lilienkampf, Annamaria Gwynne, Peter J. Swann, David G. Dhaliwal, Kevin Gallagher, Maurice P. Bradley, Mark |
author2_role |
author author author author author author author author |
dc.contributor.author.fl_str_mv |
Venkateswaran, Seshasailam Santos, Orlando David Henrique dos Scholefield, Emma Lilienkampf, Annamaria Gwynne, Peter J. Swann, David G. Dhaliwal, Kevin Gallagher, Maurice P. Bradley, Mark |
description |
Infections arising from contaminated medical devices are a serious global issue, contributing to antibiotic resistance and imposing significant strain on healthcare systems. Since the majority of medical deviceassociated infections are biofilm related, efforts are being made to generate either bacteria-repellent or antibacterial coatings aimed at preventing bacterial colonisation. Here, we utilise a nanocapsule mediated slow release of a natural antimicrobial to improve the performance of a bacteria repellent polymer coating. Poly(lauryl acrylate) nanocapsules containing eugenol (4-allyl-2-methoxyphenol) were prepared and entrapped within a interpenetrating network designed to repel bacteria. When coated on a catheter and an endotracheal tube, this hemocompatible system allowed slow-release of eugenol, resulting in notable reduction in surface-bound Klebsiella pneumoniae and methicillin resistant Staphylococcus aureus. |
publishDate |
2016 |
dc.date.issued.fl_str_mv |
2016 |
dc.date.accessioned.fl_str_mv |
2017-08-30T18:20:45Z |
dc.date.available.fl_str_mv |
2017-08-30T18:20:45Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
VENKATESWARAN, S. et al. Fortified interpenetrating polymers - bacteria resistant coatings for medical devices. J Mater Chem B, v. 14, p. 5405-5411, 2016. Disponível em: <http://pubs.rsc.org/en/Content/ArticleLanding/2016/TB/C6TB01110A#!divAbstract>. Acesso em: 29 ago. 2017. |
dc.identifier.uri.fl_str_mv |
http://www.repositorio.ufop.br/handle/123456789/8609 |
dc.identifier.issn.none.fl_str_mv |
2050-7518 |
dc.identifier.doi.none.fl_str_mv |
https://doi.org/10.1039/C6TB01110A |
identifier_str_mv |
VENKATESWARAN, S. et al. Fortified interpenetrating polymers - bacteria resistant coatings for medical devices. J Mater Chem B, v. 14, p. 5405-5411, 2016. Disponível em: <http://pubs.rsc.org/en/Content/ArticleLanding/2016/TB/C6TB01110A#!divAbstract>. Acesso em: 29 ago. 2017. 2050-7518 |
url |
http://www.repositorio.ufop.br/handle/123456789/8609 https://doi.org/10.1039/C6TB01110A |
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eng |
language |
eng |
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openAccess |
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