Identification of a bioactive compound isolated from Brazilian propolis type 6.

Detalhes bibliográficos
Autor(a) principal: Castro, Myrella Lessio
Data de Publicação: 2009
Outros Autores: Nascimento, Andréa Mendes do, Ikegaki, Masaharu, Costa Neto, Cláudio Miguel da, Alencar, Severino Matias de, Rosalen, Pedro Luiz
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFOP
Texto Completo: http://www.repositorio.ufop.br/handle/123456789/1582
Resumo: A prenylated benzophenone, hyperibone A, was isolated from the hexane fraction of Brazilianpropolistype6. Its structure was determined by spectral analysis including 2D NMR. This compound exhibited cytotoxic activity against HeLa tumor cells (IC50 = 0.1756 μM), strong antimicrobial activity (MIC range—0.73–6.6 μg/mL; MBC range—2.92–106 μg/mL) against Streptococcus mutans, Streptococcus sobrinus, Streptococcus oralis, Staphylococcus aureus, and Actinomyces naeslundii, and the results of its cytotoxic and antimicrobial activities were considered good.
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spelling Identification of a bioactive compound isolated from Brazilian propolis type 6.Prenylated benzophenone hyperibone ABiological activityBrazilian propolisA prenylated benzophenone, hyperibone A, was isolated from the hexane fraction of Brazilianpropolistype6. Its structure was determined by spectral analysis including 2D NMR. This compound exhibited cytotoxic activity against HeLa tumor cells (IC50 = 0.1756 μM), strong antimicrobial activity (MIC range—0.73–6.6 μg/mL; MBC range—2.92–106 μg/mL) against Streptococcus mutans, Streptococcus sobrinus, Streptococcus oralis, Staphylococcus aureus, and Actinomyces naeslundii, and the results of its cytotoxic and antimicrobial activities were considered good.2012-10-09T12:29:02Z2012-10-09T12:29:02Z2009info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfCASTRO, M. L. et al. Identification of a bioactive compound isolated from Brazilian propolis type 6. Bioorganic & Medicinal Chemistry, v. 17, n. 14, p. 5332-5335, jul. 2009. Disponível em: <https://www.sciencedirect.com/science/article/pii/S0968089609004350>. Acesso em: 09 out. 2012.09680896http://www.repositorio.ufop.br/handle/123456789/1582O periódico Bioorganic & Medicinal Chemistry concede permissão para depósito deste artigo no Repositório Institucional da UFOP. Número da licença: 3310910618604.info:eu-repo/semantics/openAccessCastro, Myrella LessioNascimento, Andréa Mendes doIkegaki, MasaharuCosta Neto, Cláudio Miguel daAlencar, Severino Matias deRosalen, Pedro Luizengreponame:Repositório Institucional da UFOPinstname:Universidade Federal de Ouro Preto (UFOP)instacron:UFOP2019-03-11T17:46:00Zoai:repositorio.ufop.br:123456789/1582Repositório InstitucionalPUBhttp://www.repositorio.ufop.br/oai/requestrepositorio@ufop.edu.bropendoar:32332019-03-11T17:46Repositório Institucional da UFOP - Universidade Federal de Ouro Preto (UFOP)false
dc.title.none.fl_str_mv Identification of a bioactive compound isolated from Brazilian propolis type 6.
title Identification of a bioactive compound isolated from Brazilian propolis type 6.
spellingShingle Identification of a bioactive compound isolated from Brazilian propolis type 6.
Castro, Myrella Lessio
Prenylated benzophenone hyperibone A
Biological activity
Brazilian propolis
title_short Identification of a bioactive compound isolated from Brazilian propolis type 6.
title_full Identification of a bioactive compound isolated from Brazilian propolis type 6.
title_fullStr Identification of a bioactive compound isolated from Brazilian propolis type 6.
title_full_unstemmed Identification of a bioactive compound isolated from Brazilian propolis type 6.
title_sort Identification of a bioactive compound isolated from Brazilian propolis type 6.
author Castro, Myrella Lessio
author_facet Castro, Myrella Lessio
Nascimento, Andréa Mendes do
Ikegaki, Masaharu
Costa Neto, Cláudio Miguel da
Alencar, Severino Matias de
Rosalen, Pedro Luiz
author_role author
author2 Nascimento, Andréa Mendes do
Ikegaki, Masaharu
Costa Neto, Cláudio Miguel da
Alencar, Severino Matias de
Rosalen, Pedro Luiz
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Castro, Myrella Lessio
Nascimento, Andréa Mendes do
Ikegaki, Masaharu
Costa Neto, Cláudio Miguel da
Alencar, Severino Matias de
Rosalen, Pedro Luiz
dc.subject.por.fl_str_mv Prenylated benzophenone hyperibone A
Biological activity
Brazilian propolis
topic Prenylated benzophenone hyperibone A
Biological activity
Brazilian propolis
description A prenylated benzophenone, hyperibone A, was isolated from the hexane fraction of Brazilianpropolistype6. Its structure was determined by spectral analysis including 2D NMR. This compound exhibited cytotoxic activity against HeLa tumor cells (IC50 = 0.1756 μM), strong antimicrobial activity (MIC range—0.73–6.6 μg/mL; MBC range—2.92–106 μg/mL) against Streptococcus mutans, Streptococcus sobrinus, Streptococcus oralis, Staphylococcus aureus, and Actinomyces naeslundii, and the results of its cytotoxic and antimicrobial activities were considered good.
publishDate 2009
dc.date.none.fl_str_mv 2009
2012-10-09T12:29:02Z
2012-10-09T12:29:02Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv CASTRO, M. L. et al. Identification of a bioactive compound isolated from Brazilian propolis type 6. Bioorganic & Medicinal Chemistry, v. 17, n. 14, p. 5332-5335, jul. 2009. Disponível em: <https://www.sciencedirect.com/science/article/pii/S0968089609004350>. Acesso em: 09 out. 2012.
09680896
http://www.repositorio.ufop.br/handle/123456789/1582
identifier_str_mv CASTRO, M. L. et al. Identification of a bioactive compound isolated from Brazilian propolis type 6. Bioorganic & Medicinal Chemistry, v. 17, n. 14, p. 5332-5335, jul. 2009. Disponível em: <https://www.sciencedirect.com/science/article/pii/S0968089609004350>. Acesso em: 09 out. 2012.
09680896
url http://www.repositorio.ufop.br/handle/123456789/1582
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Repositório Institucional da UFOP
instname:Universidade Federal de Ouro Preto (UFOP)
instacron:UFOP
instname_str Universidade Federal de Ouro Preto (UFOP)
instacron_str UFOP
institution UFOP
reponame_str Repositório Institucional da UFOP
collection Repositório Institucional da UFOP
repository.name.fl_str_mv Repositório Institucional da UFOP - Universidade Federal de Ouro Preto (UFOP)
repository.mail.fl_str_mv repositorio@ufop.edu.br
_version_ 1813002849841315840

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